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    31.
    发明专利
    未知

    公开(公告)号：DD213917A5

    公开(公告)日：1984-09-26

    申请号：DD25954984

    申请日：1984-01-23

    Applicant: CIBA GEIGY AG

    Inventor： BASCHANG GERHARD ,  HARTMANN ALBERT ,  WACKER OSKAR

    IPC: A61K38/00 ,  A61P31/04 ,  A61P31/12 ,  A61P37/04 ,  C07K1/02 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K5/08 ,  C07K5/083 ,  C07K5/10 ,  C07K5/103 ,  C07K7/02 ,  C07K7/06 ,  C07K9/00 ,  C07C103/52

    Abstract: The invention relates to lipopeptides of the formula I, (I) * = -R** = -R or -S*** = -R in which each of Ra1 and Rb1, independently of the other, represents an aliphatic or cycloaliphatic-aliphatic hydrocarbon radical having from 7 to 21 carbon atoms that is optionally substituted by oxygen functions, or one of the radicals Ra1-CO- and Rb1-CO- represents hydrogen and the other of the radicals Ra1-CO- and Rb1-CO- represents an acyl radical, wherein Ra1 and Rb1 have the meanings given above, R2 represents an aliphatic or cycloaliphatic-aliphatic hydrocarbon radical having from 1 to 21 carbon atoms that is optionally substituted by oxygen functions, n=0 or 1, As DEG represents a radical of the formula -O-Kw-CO- or -NH-Kw-CO- wherein Kw represents an aliphatic hydrocarbon radical having a maximum of 12 carbon atoms, As1 represents a D- or L- alpha -amino acid, each of Z1 and Z2, independently of the other, represents hydroxy or the N-terminal radical of a D- or L- alpha -aminocarboxylic acid, of an amino-lower alkanesulphonic acid or of a peptide having a maximum of 6 amino acids from the group consisting of D- or L- alpha -aminocarboxylic acids and amino-lower alkanesulphonic acids, and Z3 represents hydrogen or -CO-Z4 wherein Z4 represents hydroxy or the N-terminal radical of a D- or L- alpha -amino acid, of an amino-lower alkanesulphonic acid or of a peptide having a maximum of 6 amino acids from the group consisting of D- or L- alpha -aminocarboxylic acids and amino-lower alkanesulphonic acids, and the amides and esters of such compounds that contain carboxy groups. The novel lipopeptides have an immunity-stimulating action.

    INCREASING ANTIBIOTIC ACTION OF ANTIBIOTICS
    32.
    发明专利
    INCREASING ANTIBIOTIC ACTION OF ANTIBIOTICS 未知

    公开(公告)号：AU6658181A

    公开(公告)日：1982-11-04

    申请号：AU6658181

    申请日：1981-01-23

    Applicant: CIBA GEIGY AG

    Inventor： TARCSAY LAJOS ,  BASCHANG GERHARD ,  HARTMANN ALBERT ,  STANEK JAROSLAV

    IPC: C07H13/00 ,  A61K38/00 ,  A61K38/14 ,  A61K39/39 ,  A61P37/04 ,  C07K1/06 ,  C07K1/113 ,  C07K9/00 ,  C07K14/52 ,  C07K14/53 ,  C07K14/535 ,  A23K1/16 ,  A23K1/17 ,  A61K31/43 ,  A61K31/545 ,  A61K31/70

    Abstract: The invention relates to pharmaceutical preparations that contain an antibiotic and a muramylpeptide of the formula I or a salt thereof, to processes for their manufacture and to a method for increasing the antibiotic effectiveness of antibiotics. (I) In the formula I, X represents carbonyl or carbonyloxy, R1 represents optionally substituted alkyl or aryl, R2, R3, R4 and R6 represent hydrogen or lower alkyl, R5 represents hydrogen, optionally substituted lower alkyl, cycloalkyl, aryl or nitrogen-containing heterocyclyl, or R4 and R5 together represent also C3-C4 alkylene, R7 represents hydrogen or free, esterified or amidated carboxyl, one of the radicals A1 and A2 represents a radical of the formula II and the other of the radicals A1 and A2 represents optionally substituted or functionally modified hydroxy or amino. (II) In the formula II, T represents NH or O, Y represents an optionally substituted alkylene group that can also be interrupted by oxycarbonyl or iminocarbonyl, W represents hydrogen and Z represents an optionally esterified or etherified 1,2-dihydroxyethyl or 2-hydroxyethyl group, or W and Z represent an optionally esterified or etherified hydroxymethyl group.

    34.
    发明专利
    未知

    公开(公告)号：FI820178L

    公开(公告)日：1982-07-24

    申请号：FI820178

    申请日：1982-01-20

    Applicant: CIBA GEIGY AG

    Inventor： BASCHANG GERHARD ,  HARTMANN ALBERT ,  WACKER OSKAR ,  TARCSAY LAJOS

    IPC: A61K39/39 ,  A61P31/04 ,  A61P37/00 ,  C07K1/113 ,  C07K9/00 ,  C07K14/52 ,  C07K14/53 ,  C07K14/535 ,  C07H

    Abstract: There are described hexopyranose compounds of the formula I and salts thereof having immunomodulatory action, which can be used, for example, in the form of pharmaceutical preparations, and also together with antibiotics, and processes for their manufacture. (I) The variables are as described in the disclosure. The invention relates to the above-mentioned compounds as immunomodulators, especially as immunostimulants, their use as pharmacologically active substances, especially their use as immunomodulators, particularly as immunostimulants, and their use for the manufacture of pharmaceutical preparations, and to pharmaceutical preparations containing these compounds.

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