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公开(公告)号：AU649226B2
公开(公告)日：1994-05-19
申请号：AU5809590
申请日：1990-07-02
Applicant: CIBA GEIGY AG
Inventor： ODINK KAREL GERRIT , DELABIE JAN , DEWOLF-PEETERS CHRISTIANE , SORG CLEMENS , CERLETTI NICO , WIESENDANGER WALTER , BRUEGGEN JOSEF , TARCSAY LAJOS
IPC: G01N33/53 , A61K38/00 , A61K39/395 , A61P29/00 , C07K14/435 , C07K14/52 , C07K16/00 , C07K16/24 , C07K16/30 , C07K19/00 , C12N1/21 , C12N15/19 , C12P21/00 , C12P21/02 , C12P21/08 , C12R1/19 , C12R1/91 , G01N33/577 , A61K37/02
Abstract: The invention concerns polypeptides with an apparent molecular weight of around 160 kD which are mediators or precursors for mediators of inflammation, derivatives thereof such as mutants and fragments, processes for their preparation, DNAs and hybrid vectors coding for said polypeptides and derivatives and host cells transformed with such hybrid vectors, polyclonal and monoclonal antibodies specific for said polypeptides or their derivatives and antibody derivatives as well as diagnostic and therapeutic methods for inflammatory conditions and Hodgkin lymphomas.
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公开(公告)号：NO171443C
公开(公告)日：1993-03-17
申请号：NO854085
申请日：1985-10-15
Applicant: CIBA GEIGY AG
Inventor： TARCSAY LAJOS , EIBL HANSJOERG , FRANKHAUSER PETER , PEIL ANITA
Abstract: The invention relates to pharmaceutical compositions containing synthetic, substantially pure phosphatidyl serine and phosphatidyl choline and a substance or a mixture of substances having biological activity. The invention also relates to mixtures comprising synthetic, substantially pure phosphatidyl serine and phosphatidyl choline, and also to processes for the manufacture of the pharmaecutical compositions, and the use thereof.
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公开(公告)号：MX9203368A
公开(公告)日：1992-09-01
申请号：MX9203368
申请日：1992-06-25
Applicant: CIBA GEIGY AG
Inventor： TARCSAY LAJOS , BASCHANG GERHARD , HARTMANN ALBERT , STANEK JAROSLAV
IPC: C07H13/00 , A61K38/00 , A61K38/14 , A61K39/39 , A61P37/04 , C07K1/06 , C07K1/113 , C07K9/00 , C07K14/52 , C07K14/53 , C07K14/535 , C07K5/06
Abstract: The invention relates to pharmaceutical preparations that contain an antibiotic and a muramylpeptide of the formula I or a salt thereof, to processes for their manufacture and to a method for increasing the antibiotic effectiveness of antibiotics. (I) In the formula I, X represents carbonyl or carbonyloxy, R1 represents optionally substituted alkyl or aryl, R2, R3, R4 and R6 represent hydrogen or lower alkyl, R5 represents hydrogen, optionally substituted lower alkyl, cycloalkyl, aryl or nitrogen-containing heterocyclyl, or R4 and R5 together represent also C3-C4 alkylene, R7 represents hydrogen or free, esterified or amidated carboxyl, one of the radicals A1 and A2 represents a radical of the formula II and the other of the radicals A1 and A2 represents optionally substituted or functionally modified hydroxy or amino. (II) In the formula II, T represents NH or O, Y represents an optionally substituted alkylene group that can also be interrupted by oxycarbonyl or iminocarbonyl, W represents hydrogen and Z represents an optionally esterified or etherified 1,2-dihydroxyethyl or 2-hydroxyethyl group, or W and Z represent an optionally esterified or etherified hydroxymethyl group.
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公开(公告)号：DD298948A5
公开(公告)日：1992-03-19
申请号：DD34246790
申请日：1990-07-03
Applicant: CIBA GEIGY AG
Inventor： ODINK KAREL GERRIT , TARCSAY LAJOS , BRUEGGEN JOSEF , WIESENDANGER WALTER , CERLETTI NICO , SORG CLEMENS , WOLF-PEETERS CHRISTIANE , DELABIE JAN
IPC: G01N33/53 , A61K38/00 , A61K39/395 , A61P29/00 , C07K14/435 , C07K14/52 , C07K16/00 , C07K16/24 , C07K16/30 , C07K19/00 , C12N1/21 , C12N15/19 , C12P21/00 , C12P21/02 , C12P21/08 , C12R1/19 , C12R1/91 , G01N33/577 , G01N33/68
Abstract: The invention concerns polypeptides with an apparent molecular weight of around 160 kD which are mediators or precursors for mediators of inflammation, derivatives thereof such as mutants and fragments, processes for their preparation, DNAs and hybrid vectors coding for said polypeptides and derivatives and host cells transformed with such hybrid vectors, polyclonal and monoclonal antibodies specific for said polypeptides or their derivatives and antibody derivatives as well as diagnostic and therapeutic methods for inflammatory conditions and Hodgkin lymphomas.
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公开(公告)号：DK161025C
公开(公告)日：1991-10-28
申请号：DK319480
申请日：1980-07-24
Applicant: CIBA GEIGY AG
Inventor： TARCSAY LAJOS , BASCHANG GERHARD , HARTMANN ALBERT , STANEK JAROSLAV
IPC: C07H13/00 , A61K38/00 , A61K38/14 , A61K39/39 , A61P37/04 , C07K1/06 , C07K1/113 , C07K9/00 , C07K14/52 , C07K14/53 , C07K14/535 , C07K5/02 , C07H15/04 , C07F9/09
Abstract: The invention relates to pharmaceutical preparations that contain an antibiotic and a muramylpeptide of the formula I or a salt thereof, to processes for their manufacture and to a method for increasing the antibiotic effectiveness of antibiotics. (I) In the formula I, X represents carbonyl or carbonyloxy, R1 represents optionally substituted alkyl or aryl, R2, R3, R4 and R6 represent hydrogen or lower alkyl, R5 represents hydrogen, optionally substituted lower alkyl, cycloalkyl, aryl or nitrogen-containing heterocyclyl, or R4 and R5 together represent also C3-C4 alkylene, R7 represents hydrogen or free, esterified or amidated carboxyl, one of the radicals A1 and A2 represents a radical of the formula II and the other of the radicals A1 and A2 represents optionally substituted or functionally modified hydroxy or amino. (II) In the formula II, T represents NH or O, Y represents an optionally substituted alkylene group that can also be interrupted by oxycarbonyl or iminocarbonyl, W represents hydrogen and Z represents an optionally esterified or etherified 1,2-dihydroxyethyl or 2-hydroxyethyl group, or W and Z represent an optionally esterified or etherified hydroxymethyl group.
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Patent Agency Ranking
公开(公告)号：DK161025B
公开(公告)日：1991-05-21
申请号：DK319480
申请日：1980-07-24
Applicant: CIBA GEIGY AG
Inventor： TARCSAY LAJOS , BASCHANG GERHARD , HARTMANN ALBERT , STANEK JAROSLAV
IPC: C07H13/00 , A61K38/00 , A61K38/14 , A61K39/39 , A61P37/04 , C07K1/06 , C07K1/113 , C07K9/00 , C07K14/52 , C07K14/53 , C07K14/535 , C07K5/02 , C07H15/04 , C07F9/09
Abstract: The invention relates to pharmaceutical preparations that contain an antibiotic and a muramylpeptide of the formula I or a salt thereof, to processes for their manufacture and to a method for increasing the antibiotic effectiveness of antibiotics. (I) In the formula I, X represents carbonyl or carbonyloxy, R1 represents optionally substituted alkyl or aryl, R2, R3, R4 and R6 represent hydrogen or lower alkyl, R5 represents hydrogen, optionally substituted lower alkyl, cycloalkyl, aryl or nitrogen-containing heterocyclyl, or R4 and R5 together represent also C3-C4 alkylene, R7 represents hydrogen or free, esterified or amidated carboxyl, one of the radicals A1 and A2 represents a radical of the formula II and the other of the radicals A1 and A2 represents optionally substituted or functionally modified hydroxy or amino. (II) In the formula II, T represents NH or O, Y represents an optionally substituted alkylene group that can also be interrupted by oxycarbonyl or iminocarbonyl, W represents hydrogen and Z represents an optionally esterified or etherified 1,2-dihydroxyethyl or 2-hydroxyethyl group, or W and Z represent an optionally esterified or etherified hydroxymethyl group.
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公开(公告)号：PT94575A
公开(公告)日：1991-03-20
申请号：PT9457590
申请日：1990-07-03
Applicant: CIBA GEIGY AG
Inventor： ODINK KAREL GERRIT , BRUEGGEN JOSEF , WIESENDANGER WALTER , CERLETTI NICO , TARCSAY LAJOS , SORG CLEMENS , DEWOLF-PEETERS CHRISTIANE , DELABIE JAN
IPC: G01N33/53 , A61K38/00 , A61K39/395 , A61P29/00 , C07K14/435 , C07K14/52 , C07K16/00 , C07K16/24 , C07K16/30 , C07K19/00 , C12N1/21 , C12N15/19 , C12P21/00 , C12P21/02 , C12P21/08 , C12R1/19 , C12R1/91 , G01N33/577 , C07K3/20 , C07K15/08 , C12P19/34 , C12N5/00 , C07K15/28
Abstract: The invention concerns polypeptides with an apparent molecular weight of around 160 kD which are mediators or precursors for mediators of inflammation, derivatives thereof such as mutants and fragments, processes for their preparation, DNAs and hybrid vectors coding for said polypeptides and derivatives and host cells transformed with such hybrid vectors, polyclonal and monoclonal antibodies specific for said polypeptides or their derivatives and antibody derivatives as well as diagnostic and therapeutic methods for inflammatory conditions and Hodgkin lymphomas.
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38.发明专利
公开(公告)号：FI79330C
公开(公告)日：1989-12-11
申请号：FI832639
申请日：1983-07-20
Applicant: CIBA GEIGY AG
Inventor： HARTMANN ALBERT , WACKER OSKAR , BASCHANG GERHARD , TARCSAY LAJOS
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39.发明专利
公开(公告)号：FI75578C
公开(公告)日：1988-07-11
申请号：FI802294
申请日：1980-07-21
Applicant: CIBA GEIGY AG
Inventor： TARCSAY LAJOS , HARTMANN ALBERT , BASCHANG GERHARD , STANEK JAROSLAV
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公开(公告)号：ZA877417B
公开(公告)日：1988-05-25
申请号：ZA877417
申请日：1987-10-02
Applicant: CIBA GEIGY AG
Inventor： ODINK KAREL GERRIT , KAREL GERRIT ODINK , CLERC ROGER , ROGER CLERC , CERLETTI NICO , NICO CERLETTI , BRUEGGEN JOSEF , JOSEF BRUEGGEN , TARCSAY LAJOS , LAJOS TARCSAY , SORG CLEMENS , CLEMENS SORG , WIESENDANGER WALTER , WALTER WIESENDANGER
IPC: C12N15/09 , A61K20060101 , A61K38/00 , A61P29/00 , C07K20060101 , C07K1/20 , C07K1/22 , C07K14/00 , C07K14/005 , C07K14/195 , C07K14/435 , C07K14/52 , C07K16/00 , C12N1/16 , C12N1/20 , C12N5/00 , C12N5/10 , C12N15/00 , C12P21/02 , C12R1/19 , C12R1/865 , C12R1/91 , G01N33/53 , G01N33/577 , A61K , C07K
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