公开(公告)号：WO2016077688A3

公开(公告)日：2016-05-19

申请号：PCT/US2015/060563

申请日：2015-11-13

Applicant: COLGATE-PALMOLIVE COMPANY

Inventor： SUBRAMANYAM, Ravi ,  JOGUN, Suzanne ,  HASSAN, Mahmoud ,  XU, Shao Peng ,  LEWIS, Navin ,  HUANG, Xiao Yi

IPC: A61K8/27 ,  A61K8/365 ,  A61Q11/00 ,  A61K8/02 ,  A61K8/04 ,  A61K8/19 ,  A61K8/25

Abstract: The present invention provides an oral care composition comprising: (a) a first composition comprising a silica abrasive and a first zinc compound selected from zinc citrate, zinc chloride, zinc acetate, zinc lactate, zinc salicylate, zinc sulfate, and zinc nitrate; and (b) a second composition comprising a calcium carbonate abrasive; wherein the first composition and/or the second composition further comprises a second zinc compound selected from zinc oxide, zinc carbonate and zinc tartrate; and wherein the oral care composition optionally further comprises from 0.1 to 1.75 weight % of a tartar control agent, based on the total weight of the oral care composition.

公开(公告)号：WO2011106003A1

公开(公告)日：2011-09-01

申请号：PCT/US2010/025378

申请日：2010-02-25

Applicant: COLGATE-PALMOLIVE COMPANY ,  INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY ,  REDDY, Basi, V., Subba ,  YADAV, Jhillu, S. ,  SUBRAMANYAM, Ravi

Inventor： REDDY, Basi, V., Subba ,  YADAV, Jhillu, S. ,  SUBRAMANYAM, Ravi

IPC: C07C37/055 ,  C07C37/62 ,  C07C39/21 ,  C07C41/48 ,  C07C41/52 ,  C07C43/313 ,  C07C43/30 ,  A61K31/05 ,  A61P31/04

CPC classification number: C07C41/48 ,  C07C37/055 ,  C07C37/62 ,  C07C41/52 ,  Y02P20/55 ,  C07C39/21 ,  C07C39/367 ,  C07C43/30 ,  C07C43/313

Abstract: A method is described for producing magnolol, or a derivative or analogue thereof. The method includes obtaining MOM ether of 5,5'-diallylbiphenyl-2,2'-diol or a derivative or analogue thereof and subsequently converting the MOM ether of 5,5'-diallylbiphenyl-2,2'-diol into magnolol or a derivative or analogue thereof.

Abstract translation: 描述了制备厚朴酚或其衍生物或类似物的方法。 该方法包括获得5,5'-二烯丙基联苯-2,2'-二醇或其衍生物或类似物的MOM醚，随后将5,5'-二烯丙基联苯-2,2'-二醇的MOM醚转化成厚朴酚或 衍生物或类似物。

公开(公告)号：WO2011106002A8

公开(公告)日：2011-09-01

申请号：PCT/US2010/025371

申请日：2010-02-25

Applicant: COLGATE-PALMOLIVE COMPANY ,  COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH ,  PANDEY, Ashok ,  NAMPOOTHIRI, Madhaven ,  SUBRAMANYAM, Ravi

Inventor： PANDEY, Ashok ,  NAMPOOTHIRI, Madhaven ,  SUBRAMANYAM, Ravi

IPC: C12P13/10

Abstract: Disclosed are processes for producing Arginine by fermentation in which sugars obtained by enzymatic starch hydrolysis from inexpensive starch containing agro-wastes, such as Cassava bagasse and Jackfruit seed powder, are fermented in the presence of microorganisms to produce a fermentated liquor containing Arginine, and recovering Arginine from the liquor. The process can economically be scaled up for the production of Arginine from unrefined sugar sources as it produced Arginine in higher yields, when compared to more expensive synthetic carbon sources, like dextrose or sucrose.

Abstract translation: 公开了通过发酵生产精氨酸的方法，其中通过由包含农业废料的廉价淀粉（例如木薯甘蔗渣和菠萝蜜种子粉）的酶促淀粉水解获得的糖在微生物存在下发酵以产生 含有精氨酸的发酵液，并从液体中回收精氨酸。 与更昂贵的合成碳源如葡萄糖或蔗糖相比，该方法可以经济地放大生产来自未精制糖源的精氨酸，因为它产生更高产量的精氨酸。

公开(公告)号：WO2011079163A1

公开(公告)日：2011-06-30

申请号：PCT/US2010/061703

申请日：2010-12-22

Applicant: COLGATE-PALMOLIVE COMPANY ,  MISNER, Steve ,  PAN, Long ,  SCALA, Diana ,  HOURIGAN, Regina ,  SUBRAMANYAM, Ravi ,  FLETCHER, Dennis ,  HALL-PUZIO, Patricia ,  ANSARI, Shamim ,  LE, Derek

Inventor： MISNER, Steve ,  PAN, Long ,  SCALA, Diana ,  HOURIGAN, Regina ,  SUBRAMANYAM, Ravi ,  FLETCHER, Dennis ,  HALL-PUZIO, Patricia ,  ANSARI, Shamim ,  LE, Derek

IPC: C11D3/12 ,  C11D3/48 ,  C11D17/00 ,  C11D3/18 ,  C11D3/382

CPC classification number: A61K8/0216 ,  A61K8/24 ,  A61K8/25 ,  A61Q19/10 ,  C11D3/126 ,  C11D3/18 ,  C11D3/382 ,  C11D3/48 ,  C11D17/006

Abstract: A cleansing bar comprising at least one member chosen from clay and talc, wherein a total amount of clay and talc is present in an amount that is greater than any other material in the cleansing bar, at least one cleanser chosen from soap and surfactant, and a binder present in an amount to structure the cleansing bar into a bar.

Abstract translation: 一种清洁棒，其包含选自粘土和滑石的至少一种，其中粘土和滑石的总量以大于清洁条中的任何其它材料的量存在，至少一种选自肥皂和表面活性剂的清洁剂，以及 一种以将清洁棒结构成棒材的量存在的粘合剂。

公开(公告)号：WO2009124310A1

公开(公告)日：2009-10-08

申请号：PCT/US2009/039651

申请日：2009-04-06

Applicant: COLGATE-PALMOLIVE COMPANY ,  HALUKO SCHAEFFER, Jennifer ,  XU, Guofeng ,  PERU, Deborah, A. ,  SUBRAMANYAM, Ravi

Inventor： HALUKO SCHAEFFER, Jennifer ,  XU, Guofeng ,  PERU, Deborah, A. ,  SUBRAMANYAM, Ravi

IPC: G01N21/33 ,  G01N21/35 ,  A61C17/00 ,  A61Q11/00 ,  G01N1/28

CPC classification number: G01N21/33 ,  A46B15/0002 ,  A46B15/0004 ,  A46B15/0034 ,  A46B2200/1066 ,  A61B5/0075 ,  A61B5/4547 ,  A61B5/4552 ,  A61B5/6887 ,  G01N21/359

Abstract: Improved analytical, diagnostic, monitoring, and other methods (and their associated devices) for evaluating the extent of deposition of an agent onto a substrate are described. Exemplary methods may be used in the in the monitoring of the dental health of patients or in the fast, efficient screening and/ or characterization of formulations in terms of their use for depositing oral actives onto tooth surfaces. The methods involve the direct or in situ analysis of substrates, onto which agents are deposited, using Near-IR spectroscopy and/ or UV spectroscopy.

Abstract translation: 描述了用于评估试剂沉积到基底上的程度的改进的分析，诊断，监测和其它方法（及其相关的装置）。 就口服活性成分在牙齿表面上的使用而言，可以使用示例性的方法来监测患者的牙齿健康状况，或用于快速有效地筛选和/或表征制剂。 该方法涉及使用近红外光谱和/或紫外光谱直接或原位分析沉积有试剂的底物。

公开(公告)号：WO2009073382A2

公开(公告)日：2009-06-11

申请号：PCT/US2008/084178

申请日：2008-11-20

Applicant: COLGATE-PALMOLIVE COMPANY ,  SUBRAMANYAM, Ravi ,  MATTAI, Jairajh ,  POTNIS, Shashank ,  WU, Qiang ,  XU, Guofeng

Inventor： SUBRAMANYAM, Ravi ,  MATTAI, Jairajh ,  POTNIS, Shashank ,  WU, Qiang ,  XU, Guofeng

IPC: A61K8/92 ,  A61K8/36 ,  A61Q19/00

CPC classification number: A61K8/922 ,  A61K8/375 ,  A61Q15/00 ,  A61Q19/007 ,  A61Q19/10 ,  C11C3/00 ,  C11C3/006 ,  C11C3/12 ,  C11D1/74 ,  C11D3/2082 ,  C11D3/2086 ,  C11D3/2093 ,  C11D3/382

Abstract: A composition of matter comprising an oil adduct synthesized by an oil and an addition material, wherein the oil includes at least one member chosen from an ethoxylated oil, a hydrogenated oil, and an ethoxylated and hydrogenated oil; wherein the average degree of ethoxylation in the ethoxylated (optionally hydrogenated) oil is less than about 10 based on moles of ethylene oxide per mole of oil; wherein the hydrogenated (optionally ethoxylated) oil has an iodine value of less than about 75; wherein the oil is capable of undergoing reaction with the addition material through a hydroxyl group of the oil; and wherein the addition material includes at least one member chosen from carboxylic acid anhydrides, maleic anhydride, dicarboxylic acids, fumaric acid, maleic acid, succinic acid, alpha hydroxy acids, beta hydroxy acids, lactic acid, glycolic acid, lactobionic acid, carnitine, salicylic acid, and (meth)acrylic acid.

Abstract translation: 包含由油和添加材料合成的油加合物的物质组合物，其中所述油包括选自乙氧基化油，氢化油和乙氧基化和氢化油中的至少一种; 其中乙氧基化（任选氢化的）油中的平均乙氧基化度基于每摩尔油的环氧乙烷摩尔数小于约10; 其中所述氢化（任选乙氧基化）油具有小于约75的碘值; 其中所述油能够通过所述油的羟基与所述添加材料发生反应; 并且其中所述添加材料包括选自羧酸酐，马来酸酐，二羧酸，富马酸，马来酸，琥珀酸，α-羟基酸，β-羟基酸，乳酸，羟基乙酸，乳糖酸，肉碱， 水杨酸和（甲基）丙烯酸。

公开(公告)号：WO2007051098A1

公开(公告)日：2007-05-03

申请号：PCT/US2006/060175

申请日：2006-10-24

Applicant: COLGATE-PALMOLIVE COMPANY ,  CAMERON, Ryan, B. ,  SUBRAMANYAM, Ravi ,  TRIVEDI, Harsh ,  WORRELL, Cortney

Inventor： CAMERON, Ryan, B. ,  SUBRAMANYAM, Ravi ,  TRIVEDI, Harsh ,  WORRELL, Cortney

IPC: A61K8/49 ,  A61Q11/00

CPC classification number: A61K8/498 ,  A61K2800/522 ,  A61Q11/00

Abstract: The present invention relates to an oral composition useful to reduce inflammatory processes. More specifically, the invention relates to a composition consisting essentially of an anti-oxidative effective amount of morin and a water-humectant phase, and to a composition comprising an anti-oxidative effective amount of morin, one or more anti-bacterial agents and a water-humectant phase. In an embodiment, the composition is used in a method of preventing or treating inflammatory dental diseases such as gingivitis and periodontitis.

Abstract translation: 本发明涉及可用于减少炎症过程的口服组合物。 更具体地，本发明涉及基本上由抗氧化有效量的莽草酮和水 - 保湿剂相组成的组合物，以及包含抗氧化有效量的莽草酮，一种或多种抗菌剂和 水保湿阶段。 在一个实施方案中，组合物用于预防或治疗诸如牙龈炎和牙周炎的炎症性牙科疾病的方法。

公开(公告)号：WO2002053116A3

公开(公告)日：2002-07-11

申请号：PCT/US2001/049004

申请日：2001-12-19

Applicant: COLGATE-PALMOLIVE COMPANY

Inventor： SUBRAMANYAM, Ravi ,  WILLIAMS, Malcolm ,  GEBRESELASSIE, Petros ,  LIU, Xiaoyan ,  ZACCAGNINO, Angelo ,  MASTERS, James, G.

IPC: A61K7/16

Abstract: A dual component oral composition to suppress oral malodor and provide long lasting breath protection in the oral cavity which comprises a first dentifrice component having a substantially neutral pH and containing a zinc ion releasable compound and a chlorite ion releasable compound, the second dentifrice component having an acid pH, the first and second components being maintained separate from each other until dispensed and combined for application to teeth, the combined components having a pH of no greater than 7.

公开(公告)号：WO1995016022A1

公开(公告)日：1995-06-15

申请号：PCT/US1993011743

申请日：1993-12-09

Applicant: COLGATE-PALMOLIVE COMPANY

Inventor： COLGATE-PALMOLIVE COMPANY ,  SUBRAMANYAM, Ravi ,  VU, Liem, D. ,  GU, Ben

IPC: C11D17/00

CPC classification number: C11D3/2079 ,  C11D1/126 ,  C11D10/042 ,  C11D13/14 ,  C11D17/006

Abstract: An improved process for making a mild, detergent-soap, toilet bar containing a C6 - C18 acyl isethionate as the principal surfactant in combination with minor proportions of C12 - C20 fatty acids, a water soluble soap and water which comprises the step of forming a liquid mixture of said acyl isethionate, fatty acids and soap at a temperature of about 85 DEG C to 105 DEG C in the presence of about 0.5 % to 2.5 % by weight, based upon the bar, of vegetable oil prior to processing said liquid mixture on a chill roll to form particles which are further processed to yield said bar, said liquid mixture having reduced viscosity and being readily pumpable as compared to a liquid mixture prepared in the absence of said vegetable oil. The bar produced by the foregoing process also is part of the invention.

Abstract translation: 一种改进的制备含有C 6 -C 18酰基羟乙基磺酸盐作为主要表面活性剂与少量C 12 -C 20脂肪酸，水溶性皂和水的组合的洗涤皂，马桶条的方法，该方法包括形成 所述酰基羟乙基磺酸盐，脂肪酸和皂的液体混合物在约85℃至105℃的温度下，在加工所述液体混合物之前的约0.5％至2.5％（重量）存在下的植物油 在冷却辊上形成进一步加工以产生所述棒的颗粒，所述液体混合物与在不存在所述植物油的情况下制备的液体混合物相比具有降低的粘度并且易于泵送。 由上述方法生产的棒也是本发明的一部分。

公开(公告)号：WO2019125413A1

公开(公告)日：2019-06-27

申请号：PCT/US2017/067317

申请日：2017-12-19

Applicant: COLGATE-PALMOLIVE COMPANY

Inventor： HAO, Zhigang ,  CHENG, Chi-Yuan ,  PAN, Long ,  SUBRAMANYAM, Ravi

IPC: A61K8/43 ,  A61K8/46 ,  A61Q11/00 ,  A61Q17/00

CPC classification number: A61Q11/00 ,  A61K8/43 ,  A61K8/466 ,  A61Q17/005

Abstract: The present disclosure provides a chlorhexidine-cyclamate complex having a formula [C 22 H 32 Cl 2 N 10 ][C 6 H 12 NO 3 S] 2 having antibacterial and antiplaque properties, together with oral care compositions comprising the complex, and methods of making and using these complexes and compositions.