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    METHODS FOR MEASURING PH USINF NMR METHODS
    1.
    发明申请
    METHODS FOR MEASURING PH USINF NMR METHODS 审中-公开

    公开(公告)号：WO2020123244A1

    公开(公告)日：2020-06-18

    申请号：PCT/US2019/064581

    申请日：2019-12-05

    Applicant: COLGATE-PALMOLIVE COMPANY

    Inventor： CHENG, Chi-Yuan ,  HAO, Zhigang ,  PAN, Long ,  BALSANDORJ, Zolijargal

    IPC: G01N24/08 ,  G01N33/02 ,  G01N33/15 ,  G01R33/48

    Abstract: Methods for measuring pH of gel, paste, colloid, and aqueous solutions, such as a consumer product, a food product, a pet food product, a beverage product, a pharmaceutical product, and/or a medical product, are provided. The method may include preparing a calibration curve of a chemical species including or having an acid dissociation constant. Preparing the calibration curve may include plotting a chemical shift of the chemical species relative to pH. The method may also include determining a chemical shift of a gel, paste, and colloid, aqueous solutions, such as a consumer product, a food product, a pet food product, a beverage product, a pharmaceutical product, and/or a medical product, including the chemical species. The method may further include determining the pH of the gel, paste, colloid, and aqueous solutions, such as a consumer product, a food product, a pet food product, a beverage product, a pharmaceutical product, and/or a medical product, with the chemical shift of the product and the calibration curve.

    METHOD FOR TESTING ORAL MALODOR
    4.
    发明申请
    METHOD FOR TESTING ORAL MALODOR 审中-公开
    检测口腔恶性肿瘤的方法

    公开(公告)号：WO2014098895A1

    公开(公告)日：2014-06-26

    申请号：PCT/US2012/071262

    申请日：2012-12-21

    Applicant: COLGATE-PALMOLIVE COMPANY

    Inventor： HAO, Zhigang ,  MONK, Jessica ,  PERU, Deborah A. ,  VAZQUEZ, Joe ,  TRIVEDI, Harsh M. ,  VINCENTI, Paul Joseph ,  KHALID, Osman

    IPC: A61Q11/00 ,  G01N33/50

    CPC classification number: A61B5/08 ,  A61B5/082 ,  A61B10/00 ,  A61B2010/0087 ,  A61K8/33 ,  A61K8/35 ,  A61K8/55 ,  A61Q11/00 ,  G01N33/497 ,  G01N2033/4975 ,  Y10T436/182

    Abstract: The present invention relates to a method for testing oral malodor, in particular oral malodor from onion and garlic. Described herein are methods for testing the efficacy of an oral care composition to reduce oral malodor, the method comprising the steps of: a) cleaning at least a part of the oral cavity with an oral care composition; b) testing a first sample of exhaled breath from the cleaned oral cavity to provide a first test result representing a first amount of at least one oral malodor component detected in the exhaled breath; c) exposing the oral cavity to an oral malodor material including or capable of forming the at least one oral malodor component; and d) testing a second sample of exhaled breath from the oral cavity to provide a second test result representing a second amount of the at least one oral malodor component detected in the exhaled breath.

    Abstract translation: 本发明涉及一种口服恶臭的检测方法，特别是洋葱和大蒜口服恶臭。 本文描述了用于测试口腔护理组合物降低口腔恶臭的功效的方法，该方法包括以下步骤：a）用口腔护理组合物清洁至少一部分口腔; b）从清洁的口腔测试呼出呼吸的第一样品，以提供代表在呼出气中检测到的第一量口服恶臭成分的第一测试结果; c）将口腔暴露于包含或能够形成至少一种口腔恶臭成分的口腔恶臭物质; 以及d）从所述口腔测试第二呼出呼气样品，以提供第二测试结果，所述第二测试结果代表在所述呼出气体中检测到的所述至少一种口腔恶臭成分的第二量。

    ORAL CARE COMPOSITION COMPRISING AN AMADORI COMPOUND
    5.
    发明申请
    ORAL CARE COMPOSITION COMPRISING AN AMADORI COMPOUND 审中-公开
    口服护理组合物包含阿马可乐化合物

    公开(公告)号：WO2014098793A1

    公开(公告)日：2014-06-26

    申请号：PCT/US2012/070101

    申请日：2012-12-17

    Applicant: COLGATE-PALMOLIVE COMPANY

    Inventor： HAO, Zhigang ,  YANG, Ying ,  LIU, Zhiqiang ,  HU, Katherine ,  XU, Guofeng ,  VINCENTI, Paul Joseph

    IPC: A61K8/60 ,  A61Q11/00

    CPC classification number: A61K8/60 ,  A61K2800/92 ,  A61Q11/00

    Abstract: The present invention relates to oral care compositions and methods of inhibiting microbial biofilm formation and/or degrading a microbial biofilm. Disclosed herein are oral care compositions comprising an Amadori compound having a glucose moiety and an amino acid moiety. The Amadori compound has use for inhibiting oral microbial biofilm formation and/or degrading an oral microbial biofilm in the oral cavity of a mammalian subject.

    Abstract translation: 本发明涉及口腔护理组合物和抑制微生物生物膜形成和/或降解微生物生物膜的方法。 本文公开了包含具有葡萄糖部分和氨基酸部分的阿马多里化合物的口腔护理组合物。 阿马多利化合物可用于抑制口腔微生物生物膜形成和/或降解哺乳动物受试者口腔中的口腔微生物生物膜。

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