公开(公告)号：CA2350165C

公开(公告)日：2011-12-13

申请号：CA2350165

申请日：1999-11-19

Applicant: FUSO PHARMACEUTICAL IND

Inventor： UEMURA HIDETOSHI ,  OKUI AKIRA ,  KOMINAMI KATSUYA ,  YAMAGUCHI NOZOMI ,  MITSUI SHINICHI

IPC: C12N15/12 ,  A01K67/027 ,  C07K16/40 ,  C12N1/21 ,  C12N9/64 ,  C12N15/57 ,  C12P21/02 ,  C12P21/08 ,  G01N33/573

Abstract: The present invention teaches proteins having amino acid sequences represented by SEQ ID NOS: 2, 4 and 6; proteins having amino acid sequences derived from these amino acid sequences by deletion, substitution or addition of one to several amino acids; and nucleotide sequences encoding the same; transgenic non-human animals with altered expression level of a serine protease BSSP6; an antibody against BSSP6; and a method for detecting BSSP6 in a specimen using the antibody.

公开(公告)号：CA2616940C

公开(公告)日：2011-08-09

申请号：CA2616940

申请日：1999-11-19

Applicant: FUSO PHARMACEUTICAL IND

Inventor： UEMURA HIDETOSHI ,  OKUI AKIRA ,  KOMINAMI KATSUYA ,  YAMAGUCHI NOZOMI ,  MITSUI SHINICHI

IPC: C12N15/57 ,  C07K16/40 ,  C12N5/10 ,  C12N9/64 ,  C12P21/02 ,  C12P21/08 ,  G01N33/573

Abstract: There are provided proteins having amino acid sequences represented by SEQ ID NOS: 2, 4, 6, 8 and 10; proteins having amino acid sequences derived from these amino acid sequences by deletion, substitution or addition of one to several amino acids; and nucleotide sequences encoding the same; transgenic non-human animals with altered expression level of a serine protease BSSP2; an antibody against BSSP2; and a method for detecting BSSP2 in a specimen by using the antibody.

公开(公告)号：AT496131T

公开(公告)日：2011-02-15

申请号：AT99972686

申请日：1999-11-19

Applicant: FUSO PHARMACEUTICAL IND

Inventor： UEMURA HIDETOSHI ,  OKUI AKIRA ,  KOMINAMI KATSUYA ,  YAMAGUCHI NOZOMI ,  MITSUI SHINICHI

IPC: C12N15/52 ,  C07K16/40 ,  C12N1/21 ,  C12N5/10 ,  C12N9/64 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/68

Abstract: There are provided proteins having the amino acid sequences represented by SEQ ID NOS: 2, 4, 6, 8 and 10; proteins having amino acid sequences derived from these amino acid sequences by deletion, substitution or addition of one to several amino acids; and nucleotide sequences encoding the same; transgenic non-human animals with altered expression level of a serine protease BSSP2; an antibody against BSSP2; and a method for detecting BSSP2 in a specimen by using the antibody.

公开(公告)号：DE69941224D1

公开(公告)日：2009-09-17

申请号：DE69941224

申请日：1999-11-19

Applicant: FUSO PHARMACEUTICAL IND

Inventor： UEMURA HIDETOSHI ,  OKUI AKIRA ,  KOMINAMI KATSUYA ,  YAMAGUCHI ,  MITSUI SHINICHI

IPC: C12N9/50 ,  A61K38/00 ,  C12N1/21 ,  C12N9/64 ,  C12N15/57 ,  C12P21/08 ,  G01N33/573

公开(公告)号：DE69933565T2

公开(公告)日：2007-07-05

申请号：DE69933565

申请日：1999-07-02

Applicant: FUSO PHARMACEUTICAL IND

Inventor： KOMINAMI KATSUYA ,  OKUI AKIRA ,  MITSUI SHINICHI ,  YAMAGUCHI NOZOMI

IPC: C12N15/02 ,  A61K39/395 ,  C07K16/40 ,  C12N5/12 ,  C12N5/20 ,  C12P21/08 ,  G01N33/573 ,  G01N33/577 ,  G01N33/68

Abstract: A monoclonal antibody binding selectively to neurosin obtained from hybridomas, in particular, strain 2B2-6 and strain S2E5 showing stable proliferation ability. These hydridomas are obtained by fusing mouse spleen cells having a high antibody titer against neurosin with mouse-derived myeloma cells, screening fused cells being highly reactive with neurosin, and thus producing an antibody binding specifically to neurosin. By using this antibody, various diseases in which neurosin participates can be diagnosed.

公开(公告)号：ES2273496T3

公开(公告)日：2007-05-01

申请号：ES99926899

申请日：1999-07-02

Applicant: FUSO PHARMACEUTICAL IND

Inventor： KOMINAMI KATSUYA ,  OKUI AKIRA ,  MITSUI SHINICHI ,  YAMAGUCHI NOZOMI

IPC: C12N15/02 ,  A61K39/395 ,  C07K16/40 ,  C12N5/12 ,  C12N5/20 ,  C12P21/08 ,  G01N33/573 ,  G01N33/577 ,  G01N33/68

Abstract: Un anticuerpo monoclonal que se une selectivamente a la neurosina y/o su precursor, donde dicho anticuerpo monoclonal es producido por la cepa de Hibridoma 2B2-6 (FERM P-16843) o la cepa de Hibridoma S2E5 (FERM P-16844).

公开(公告)号：AT342354T

公开(公告)日：2006-11-15

申请号：AT99926899

申请日：1999-07-02

Applicant: FUSO PHARMACEUTICAL IND

Inventor： KOMINAMI KATSUYA ,  OKUI AKIRA ,  MITSUI SHINICHI ,  YAMAGUCHI NOZOMI

IPC: C07K16/40 ,  C12N5/20 ,  C12P21/08 ,  G01N33/573 ,  G01N33/68 ,  C12N15/02 ,  C12N5/12 ,  G01N33/577 ,  A61K39/395

Abstract: A monoclonal antibody binding selectively to neurosin obtained from hybridomas, in particular, strain 2B2-6 and strain S2E5 showing stable proliferation ability. These hydridomas are obtained by fusing mouse spleen cells having a high antibody titer against neurosin with mouse-derived myeloma cells, screening fused cells being highly reactive with neurosin, and thus producing an antibody binding specifically to neurosin. By using this antibody, various diseases in which neurosin participates can be diagnosed.

公开(公告)号：AU771666B2

公开(公告)日：2004-04-01

申请号：AU1183900

申请日：1999-11-19

Applicant: FUSO PHARMACEUTICAL IND

Inventor： UEMURA HIDETOSHI ,  OKUI AKIRA ,  KOMINAMI KATSUYA ,  YAMAGUCHI NOZOMI ,  MITSUI SHINICHI

IPC: A61K38/00 ,  C12N1/21 ,  C12N9/64 ,  C12N15/57 ,  C12P21/08 ,  G01N33/573 ,  C12N9/50 ,  A01K67/027 ,  C07K16/40 ,  G01N33/53

公开(公告)号：AU768239B2

公开(公告)日：2003-12-04

申请号：AU1184100

申请日：1999-11-19

Applicant: FUSO PHARMACEUTICAL IND

Inventor： UEMURA HIDETOSHI ,  OKUI AKIRA ,  KOMINAMI KATSUYA ,  YAMAGUCHI NOZOMI ,  MITSUI SHINICHI

IPC: C12N1/21 ,  C12N9/64 ,  C12P21/08 ,  C12N15/52 ,  A01K67/027 ,  C07K16/40 ,  C12N5/10 ,  C12P21/02 ,  C12Q1/68 ,  G01N33/53

Abstract: There are provided proteins having the amino acid sequences represented by SEQ ID NOS: 2, 4, 6, 8 and 10; proteins having amino acid sequences derived from these amino acid sequences by deletion, substitution or addition of one to several amino acids; and nucleotide sequences encoding the same; transgenic non-human animals with altered expression level of a serine protease BSSP2; an antibody against BSSP2; and a method for detecting BSSP2 in a specimen by using the antibody.

公开(公告)号：CA2350226A1

公开(公告)日：2000-06-02

申请号：CA2350226

申请日：1999-11-19

Applicant: FUSO PHARMACEUTICAL IND

Inventor： YAMAGUCHI NOZOMI ,  MITSUI SHINICHI ,  OKUI AKIRA ,  KOMINAMI KATSUYA ,  UEMURA HIDETOSHI

IPC: C07K14/47 ,  C12N5/10 ,  C12N9/64 ,  C12N15/85 ,  C12N15/86 ,  C12P21/02

Abstract: A protein expression vector characterized by containing a secretory signal nucleic acid sequence and, in the 3'-downstream side thereof, a Tag nucleic acid sequence, a scissile nucleic acid sequence and a cloning site, into whi ch a nucleic sequence encoding a target protein can be inserted, in this order.