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公开(公告)号：EP1970039A4
公开(公告)日：2011-08-03
申请号：EP06843192
申请日：2006-12-25
Applicant: HISAMITSU PHARMACEUTICAL CO , KYODO PRINTING CO LTD
Inventor： TOKUMOTO SEIJI , ADACHI HIROTOSHI , FUCHITA YASUSHI , TAKAHASHI SAORI , OGAWA TATSUYA
IPC: A61N1/30
CPC classification number: A61N1/0448 , A61N1/0436 , A61N1/044
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32.发明公开ADJUVANT OR PHARMACEUTICAL PREPARATION FOR TRANSDERMAL OR TRANSMUCOSAL ADMINISTRATION 有权ADJUVANS ODER PHARMAZEUTISCHE ZUBEREITUNG ZUR TRANSDERMALEN ODER TRANSMUKOSALEN VERABREICHUNG
公开(公告)号：EP1917976A4
公开(公告)日：2008-12-03
申请号：EP06781981
申请日：2006-07-31
Applicant: HISAMITSU PHARMACEUTICAL CO
Inventor： TOKUMOTO SEIJI , ADACHI HIROTOSHI , KUWAHARA TETSUJI
CPC classification number: A61K39/39 , A61K9/0009 , A61K9/0014 , A61K9/0021 , A61K9/006 , A61K39/145 , A61K47/10 , A61K47/12 , A61K47/26 , A61K47/34 , A61K2039/53 , A61K2039/54 , A61K2039/541 , A61K2039/55511 , A61M37/0092 , A61N1/325 , A61N1/327 , C12N7/00 , C12N2760/16034
Abstract: An adjuvant for transdermal or transmucosal administration which comprises at least one substance selected from an aliphatic alcohol, a free fatty acid and a fatty acid derivative but does not contain a substance represented by the following formula: wherein R 3 and R 4 may together form a cyclic ring, and R 1 and R 2 independently represent an alkyl side chain having 1 to 16 carbon atoms.
Abstract translation: 1。一种透皮或经粘膜给药用佐剂，其含有选自脂肪族醇，游离脂肪酸和脂肪酸衍生物中的至少一种物质，但不含有下式表示的物质：其中R3和R4可以一起形成环 并且R 1和R 2独立地表示具有1至16个碳原子的烷基侧链。
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公开(公告)号：EP2859910A4
公开(公告)日：2016-06-08
申请号：EP13803698
申请日：2013-06-11
Applicant: HISAMITSU PHARMACEUTICAL CO
Inventor： KOMINAMI KAZUYA , NISHIMURA SHINPEI , TOKUMOTO SEIJI , OGURA MAKOTO , MATSUDO TOSHIYUKI , YAMAMOTO NAOKI
CPC classification number: A61M37/0015 , A61M37/0092 , A61M2037/0007 , A61M2037/0023 , A61M2037/0061 , A61N1/325 , A61N2/002 , A61N2/004
Abstract: A microneedle sheet according to an embodiment comprises a plurality of microneedles formed on a sheet substantially along a principal surface of the sheet. The sheet is bent to raise the microneedles from the principal surface, and the raised microneedles pierce a skin.
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公开(公告)号：EP2578265A4
公开(公告)日：2013-12-04
申请号：EP11786694
申请日：2011-05-25
Applicant: HISAMITSU PHARMACEUTICAL CO , TOPPAN PRINTING CO LTD
Inventor： TOKUMOTO SEIJI , ISHITSUKA SHUJI , KODAMA YOSHIHIRO , TAKEMURA NOBUMI
IPC: A61M37/00
CPC classification number: A61K9/00 , A61M37/0015 , A61M2037/0038
Abstract: An array 1 with microprotrusions comprises a base 2 and tapered microprotrusions 3 each disposed on the base 2 and tapering down toward the tip from the bottom. Letting a distance from the tip to the bottom on an arbitrary side of each microprotrusion 3 as a and letting the length of a second line segment prepared by projecting a first line segment representing the distance a onto the base 2 as b, a relationship of 1.0
Abstract translation: 具有微凸体的阵列1包括基体2和逐渐变细的微凸体3，每个微凸体3设置在基体2上并从底部向尖端逐渐变细。 将从微小突起3的任意一侧的前端到下端的距离设为a，将通过将表示距离a的第一线段投影到基底2上而准备的第二线段的长度设为b，则关系为1.0 ＆LT; （a / b）≥7.5。
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公开(公告)号：EP2383013A4
公开(公告)日：2012-11-28
申请号：EP09835035
申请日：2009-12-25
Applicant: HISAMITSU PHARMACEUTICAL CO
Inventor： TOKUMOTO SEIJI , MATSUDO TOSHIYUKI , KUWAHARA TETSUJI , ISHITSUKA SHUJI
CPC classification number: A61K38/29 , A61K9/0021 , A61K38/24 , A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2037/0053
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Patent Agency Ranking36.发明公开MICRONEEDLE DEVICE AND TRANSDERMAL ADMINISTRATION DEVICE PROVIDED WITH MICRONEEDLES 有权微针装置和透皮给药装置WITH MICRO NEEDLES
公开(公告)号：EP2005990A4
公开(公告)日：2011-04-27
申请号：EP07741173
申请日：2007-04-06
Applicant: HISAMITSU PHARMACEUTICAL CO
Inventor： TOKUMOTO SEIJI , MATSUDO TOSHIYUKI , KUWAHARA TETSUJI
CPC classification number: A61M37/0015 , A61B17/205 , A61K9/0021 , A61M2037/0023
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37.发明公开SYSTEM FOR MANUFACTURING MICRONEEDLE PREPARATION, AND AIR-CONDITIONING METHOD 审中-公开SYSTEM ZUR HERSTELLUNG VONMIKRONADELPRÄPARATENUND KLIMATISIERUNGSVERFAHREN
公开(公告)号：EP3006077A4
公开(公告)日：2017-05-24
申请号：EP14804072
申请日：2014-05-29
Applicant: HISAMITSU PHARMACEUTICAL CO INC
Inventor： HASHIMOTO EIJI , MATSUDO TOSHIYUKI , NISHIMURA SHINPEI , TOKUMOTO SEIJI
CPC classification number: B05C15/00 , A61M37/0015 , A61M2037/0053 , B05C3/00 , B05C21/00 , B05D3/0486 , B81B2201/055 , B81C99/0025 , F24F3/14 , F24F3/1603
Abstract: The present invention provides a system for manufacturing a therapeutic microneedle configured to regulate an air environment within a coating chamber for manufacturing a therapeutic microneedle by coating a microneedle with a coating liquid containing a drug, the system for manufacturing a therapeutic microneedle comprising an air compressor, a humidity regulator configured to regulate humidity of air supplied from the air compressor, and an air filter configured to eliminate microorganisms from air to be supplied to the inside of the coating chamber.
Abstract translation: 本发明提供一种用于制造治疗用微针的系统，所述系统用于通过用包含药物的涂布液涂布微针来调节用于制造治疗用微针的涂布室内的空气环境，所述用于制造治疗用微针的系统包括空气压缩机， 湿度调节器，其构造成调节从空气压缩机供应的空气的湿度;以及空气过滤器，其构造成从空气中消除将被供应到涂布室内部的微生物。
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38.发明公开ADJUVANT COMPOSITION, ADJUVANT PREPARATION CONTAINING SAME, AND KIT 审中-公开ADJUVANTIENZUSAMMENSETZUNG，ADJUVANTIENPRÄPARATDAMIT UND KIT
公开(公告)号：EP3064218A4
公开(公告)日：2017-04-05
申请号：EP14858381
申请日：2014-10-30
Applicant: HISAMITSU PHARMACEUTICAL CO INC
Inventor： TOKUMOTO SEIJI , MACHIDA KAZUYA , KUROKAWA NAO , NAMIKI RIE
CPC classification number: A61K39/39 , A61K9/0014 , A61K9/0021 , A61K9/08 , A61K9/7023 , A61K39/0008 , A61K47/10 , A61K2039/54 , A61K2039/55511
Abstract: An adjuvant composition of the present invention contains lauryl alcohol and propylene glycol. Contents of the lauryl alcohol and the propylene glycol are 0.5 to 25% by mass and 8.0 to 99.5% by mass, relative to the total mass of the adjuvant composition, respectively. The lauryl alcohol is dissolved, and the adjuvant composition is used for transdermal or transmucosal administration.
Abstract translation: 本发明的佐剂组合物含有月桂醇和丙二醇。 相对于佐剂组合物的总质量，月桂醇和丙二醇的含量分别为0.5至25质量％和8.0至99.5质量％。 月桂醇溶解，佐剂组合物用于透皮或透粘膜给药。
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39.发明公开MICRONEEDLE DEVICE, AND METHOD FOR ENHANCING THE EFFICACY OF INFLUENZA VACCINE BY USING MICRONEEDLE DEVICE 审中-公开微针装置和方法改进流感疫苗的效率利用微针装置
公开(公告)号：EP2327419A4
公开(公告)日：2015-12-30
申请号：EP09773249
申请日：2009-05-22
Applicant: HISAMITSU PHARMACEUTICAL CO , CHEMO SERO THERAPEUT RES INST
Inventor： NOZAKI CHIKATERU , KAMINAKA KAZUYOSHI , MATSUDA JUNICHI , TERAHARA TAKAAKI , KUWAHARA TETSUJI , TOKUMOTO SEIJI
IPC: A61K39/145 , A61K9/00 , A61K9/70 , A61K39/00 , A61K39/39 , A61K47/10 , A61K47/34 , A61K47/36 , A61L31/00 , A61M37/00 , A61P31/16
CPC classification number: A61K39/145 , A61B17/205 , A61K39/12 , A61K2039/5252 , A61K2039/541 , A61K2039/545 , A61K2039/55511 , A61K2039/70 , A61M37/0015 , A61M2037/0046 , A61M2037/0061 , C12N2760/16134 , C12N2760/16234
Abstract: The present invention provides a method for enhancing the immunogenicity using a microneedle device capable of enhancing the immunogenicity of an influenza vaccine. According to the method for enhancing the immunogenicity using the present microneedle device, a microneedle device having microneedles made of polylactic acid, coated with an influenza vaccine composed of an antigen having type A strain (H1N1), type A strain (H3N2), and type B strain as active ingredients is brought into direct contact with the skin so as to transcutaneously administer the aforementioned influenza vaccine. After the transcutaneous administration, lauryl alcohol is applied to the site of the skin where the microneedle device has been brought into direct contact.
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公开(公告)号：EP2626107A4
公开(公告)日：2014-04-16
申请号：EP11830748
申请日：2011-10-06
Applicant: HISAMITSU PHARMACEUTICAL CO
Inventor： TOKUMOTO SEIJI , OGURA MAKOTO , MACHIDA KAZUYA
IPC: A61M37/00
CPC classification number: A61M5/2033 , A61M37/0015 , A61M2037/0023 , A61M2037/0061
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