公开(公告)号：FI892690A

公开(公告)日：1989-12-05

申请号：FI892690

申请日：1989-06-01

Applicant: HOECHST AG

Inventor： BONIN WERNER ,  HABERMANN PAUL ,  TRIPIER DOMINIQUE ,  WOEHNER ELISABET

IPC: A61K38/55 ,  A61K35/56 ,  A61K38/00 ,  A61P7/02 ,  C07K1/14 ,  C07K1/16 ,  C07K14/00 ,  C07K14/435 ,  C07K14/44 ,  C07K14/81 ,  A61K

Abstract: The invention relates to a new active substance-amblyommin-for anticoagulant therapy and to a process for the isolation thereof from hard ticks. The isolated protein having a thrombin-inhibitory action has a molecular weight of 20000 to 30000 dalton, an isoelectric point between 5.05 and 5.65 and the partial amino acid sequences Ile-Leu-Phe-Thr-Gln-Gly-Asn-X-Gly-Glu-Leu-Glu-Asn-X-Phe-Glu-, Lys-Ile-Leu-Phe-X-Gln-Gly- and Ala-Ser-Tyr-Ile-Val-X-Ser-Glu-Ser-Ile-Gln-Ile-Leu-X-Leu-Ser-Glu-Gly-Ile- in which each radical X can be identical or different and each represents a naturally occurring amino acid.

公开(公告)号：PT84713B

公开(公告)日：1989-06-02

申请号：PT8471387

申请日：1987-04-16

Applicant: HOECHST AG

Inventor： KOCH VOLKER ,  FUSS ANDREAS ,  BONIN WERNER ,  KNAUF WERNER ,  WALTERSDORFER ANNA

IPC: A01N43/88 ,  A01N47/34 ,  C07C67/00 ,  C07C275/24 ,  C07C275/44 ,  C07C275/54 ,  C07C325/00 ,  C07C335/26 ,  C07D273/04 ,  C07D319/12 ,  C07C127/22 ,  A01N47/28 ,  C07C93/14 ,  C07C127/19 ,  C07C157/12

公开(公告)号：NO892266D0

公开(公告)日：1989-06-02

申请号：NO892266

申请日：1989-06-02

Applicant: HOECHST AG

Inventor： BONIN WERNER ,  HABERMANN PAUL ,  TRIPIER DOMINIQUE ,  WOEHNER ELISABET

IPC: A61K38/55 ,  A61K35/56 ,  A61K38/00 ,  A61P7/02 ,  C07K1/14 ,  C07K1/16 ,  C07K14/00 ,  C07K14/435 ,  C07K14/44 ,  C07K14/81 ,  C07K

Abstract: The invention relates to a new active substance-amblyommin-for anticoagulant therapy and to a process for the isolation thereof from hard ticks. The isolated protein having a thrombin-inhibitory action has a molecular weight of 20000 to 30000 dalton, an isoelectric point between 5.05 and 5.65 and the partial amino acid sequences Ile-Leu-Phe-Thr-Gln-Gly-Asn-X-Gly-Glu-Leu-Glu-Asn-X-Phe-Glu-, Lys-Ile-Leu-Phe-X-Gln-Gly- and Ala-Ser-Tyr-Ile-Val-X-Ser-Glu-Ser-Ile-Gln-Ile-Leu-X-Leu-Ser-Glu-Gly-Ile- in which each radical X can be identical or different and each represents a naturally occurring amino acid.

公开(公告)号：HUT43924A

公开(公告)日：1988-01-28

申请号：HU535386

申请日：1986-12-19

Applicant: HOECHST AG

Inventor： KOCH VOLKER ,  BONIN WERNER ,  FUSS ANDREAS ,  KNAUF WERNER ,  WALTERSDORFER ANNA

IPC: A01N43/824 ,  A01N43/88 ,  A01N47/34 ,  A01N47/36 ,  C07D213/64 ,  C07D213/69 ,  C07D213/75 ,  C07D213/89 ,  C07D413/12 ,  A01N43/40 ,  A01N57/02 ,  A01N47/10 ,  A01N55/04 ,  A01N53/00 ,  A01N47/28 ,  A01N43/50 ,  A01N43/54 ,  A01N43/82 ,  C07D213/63 ,  C07D401/12

Abstract: The compounds of the formula (I) (I) in which A denotes N or N->0, R denotes a radical of the formula R4-CY1-NR5-CY2-NR6-, +TR R1 denotes halogen, alkyl, alkenyl, alkynyl, alkoxy, alkoxycarbonyl or alkylcarbonyl, where these radicals may be halogenated, nitro, cyano or carboxyl, R2 denotes halogenated alkoxy, halogenated alkenyloxy or halogenated alkynloxy, R3 denotes halogen, n denotes 0, 1 or 2, m denotes 0, 1, 2 or 3, and p denotes 0 or 1, and also the salts thereof, are advantageously suitable for combating noxious insects, acarides, nematodes or mollusks.

公开(公告)号：BR8606340A

公开(公告)日：1987-10-13

申请号：BR8606340

申请日：1986-12-19

Applicant: HOECHST AG

Inventor： KOCH VOLKER ,  FUSS ANDREAS ,  BONIN WERNER ,  KNAUF WERNER ,  WALTERSDORFER ANNA

IPC: A01N43/824 ,  A01N43/88 ,  A01N47/34 ,  A01N47/36 ,  C07D213/64 ,  C07D213/69 ,  C07D213/75 ,  C07D213/89 ,  C07D413/12 ,  C07D213/63 ,  C07D401/12 ,  A01N43/40 ,  A01N57/02 ,  A01N47/10 ,  A01N55/04 ,  A01N53/00 ,  A01N47/28

Abstract: The compounds of the formula (I) (I) in which A denotes N or N->0, R denotes a radical of the formula R4-CY1-NR5-CY2-NR6-, +TR R1 denotes halogen, alkyl, alkenyl, alkynyl, alkoxy, alkoxycarbonyl or alkylcarbonyl, where these radicals may be halogenated, nitro, cyano or carboxyl, R2 denotes halogenated alkoxy, halogenated alkenyloxy or halogenated alkynloxy, R3 denotes halogen, n denotes 0, 1 or 2, m denotes 0, 1, 2 or 3, and p denotes 0 or 1, and also the salts thereof, are advantageously suitable for combating noxious insects, acarides, nematodes or mollusks.

公开(公告)号：DK618986A

公开(公告)日：1987-06-22

申请号：DK618986

申请日：1986-12-19

Applicant: HOECHST AG

Inventor： KOCH VOLKER ,  FUSS ANDREAS ,  BONIN WERNER ,  KNAUF WERNER ,  WALTERSDORFER ANNA

IPC: A01N43/824 ,  A01N43/88 ,  A01N47/34 ,  A01N47/36 ,  C07D213/64 ,  C07D213/69 ,  C07D213/75 ,  C07D213/89 ,  C07D413/12 ,  C07D213/00 ,  C07D413/00 ,  A01N43/00 ,  A01N47/00

Abstract: The compounds of the formula (I) (I) in which A denotes N or N->0, R denotes a radical of the formula R4-CY1-NR5-CY2-NR6-, +TR R1 denotes halogen, alkyl, alkenyl, alkynyl, alkoxy, alkoxycarbonyl or alkylcarbonyl, where these radicals may be halogenated, nitro, cyano or carboxyl, R2 denotes halogenated alkoxy, halogenated alkenyloxy or halogenated alkynloxy, R3 denotes halogen, n denotes 0, 1 or 2, m denotes 0, 1, 2 or 3, and p denotes 0 or 1, and also the salts thereof, are advantageously suitable for combating noxious insects, acarides, nematodes or mollusks.

公开(公告)号：DK275087D0

公开(公告)日：1987-05-29

申请号：DK275087

申请日：1987-05-29

Applicant: HOECHST AG

Inventor： GIENCKE WOLFGANG ,  MILDENBERGER HILMAR ,  HEUBACH GUENTHER ,  SACHSE BURKHARD ,  FUSS ANDREAS ,  WALTERSDORFER ANNA ,  KNAUF WERNER ,  KERN MANFRED ,  BONIN WERNER

IPC: A01N43/54 ,  C07D239/42 ,  C07D239/46 ,  C07D239/47 ,  C07D239/48

公开(公告)号：DD201752A5

公开(公告)日：1983-08-10

申请号：DD23438881

申请日：1981-10-27

Applicant: HOECHST AG

Inventor： WELTER WOLFGANG ,  MILDENBERGER HILMAR ,  KNAUF WERNER ,  WALTERSDORFER ANNA ,  BONIN WERNER

IPC: C07C69/007 ,  A01N37/10 ,  A01N37/34 ,  A01N53/00 ,  A01N53/08 ,  C07C67/00 ,  C07C69/753 ,  C07C253/00 ,  C07C255/38

Abstract: Compounds of the formula wherein R1 denotes H, halogen, alkyl or CF3, R2 denotes H, halogen, alkyl or CF3, R3 denotes H, halogen, CN or alkyl, R4 denotes H, halogen, alkyl, phenyl or halogenophenyl, R5 denotes H, alkyl, alkynyl or CN and R6 denotes substituted dimethylcyclopropyl or 2-phenylisobutyl radicals, are effective insecticides and acaricides of the pyrethroid type.

公开(公告)号：AU5578380A

公开(公告)日：1980-08-28

申请号：AU5578380

申请日：1980-02-21

Applicant: HOECHST AG

Inventor： SINHARAY AKHILESWAR ,  STAHLER GERHARD ,  BONIN WERNER

IPC: A01N37/52 ,  C07C123/00 ,  C07C121/16 ,  C07C121/52

Abstract: Compounds of the formula in which R1 is halogen, alkyl, alkoxy, alkylthio, CF3, NO2, CN2, phenoxy, halophenoxy, phenylthio or halophenylthio, R2 is CN or COOR3, R3 is alkyl, alkoxyalkyl or cycloalkyl and n is 0 to 3 are effective insecticides and acaricides and especially ectoparasiticides.

公开(公告)号：IE64674B1

公开(公告)日：1995-08-23

申请号：IE181489

申请日：1989-06-12

Applicant: HOECHST AG

Inventor： BONIN WERNER ,  HABERMANN PAUL ,  TRIPIER DOMINIQUE ,  WOEHNER ELISABET

IPC: A61K38/55 ,  A61K35/56 ,  A61K38/00 ,  A61P7/02 ,  C07K1/14 ,  C07K1/16 ,  C07K14/00 ,  C07K14/435 ,  C07K14/44 ,  C07K14/81 ,  C07K15/08 ,  A61K37/02

Abstract: The invention relates to a new active substance-amblyommin-for anticoagulant therapy and to a process for the isolation thereof from hard ticks. The isolated protein having a thrombin-inhibitory action has a molecular weight of 20000 to 30000 dalton, an isoelectric point between 5.05 and 5.65 and the partial amino acid sequences Ile-Leu-Phe-Thr-Gln-Gly-Asn-X-Gly-Glu-Leu-Glu-Asn-X-Phe-Glu-, Lys-Ile-Leu-Phe-X-Gln-Gly- and Ala-Ser-Tyr-Ile-Val-X-Ser-Glu-Ser-Ile-Gln-Ile-Leu-X-Leu-Ser-Glu-Gly-Ile- in which each radical X can be identical or different and each represents a naturally occurring amino acid.