公开(公告)号：JPH0232100A

公开(公告)日：1990-02-01

申请号：JP13937789

申请日：1989-06-02

Applicant: HOECHST AG

Inventor： BONIN WERNER ,  HABERMANN PAUL ,  TRIPIER DOMINIQUE ,  WOEHNER ELISABET

IPC: A61K38/55 ,  A61K35/56 ,  A61K38/00 ,  A61P7/02 ,  C07K1/14 ,  C07K1/16 ,  C07K14/00 ,  C07K14/435 ,  C07K14/44 ,  C07K14/81

公开(公告)号：CA1339189C

公开(公告)日：1997-07-29

申请号：CA601594

申请日：1989-06-02

Applicant: HOECHST AG

Inventor： BONIN WERNER ,  HABERMANN PAUL ,  TRIPIER DOMINIQUE ,  WOEHNER ELISABET

IPC: A61K38/55 ,  A61K35/56 ,  A61K38/00 ,  A61P7/02 ,  C07K1/14 ,  C07K1/16 ,  C07K14/00 ,  C07K14/435 ,  C07K14/44 ,  C07K14/81 ,  A61K38/57

Abstract: Amblyommin, a new active substance for anticoagulant therapy The invention relates to a new active substance amblyommin - for anticoagulant therapy and to a process for the isolation thereof from hard ticks. The isolated protein having a thrombin-inhibitory action has a molecular weight of 20000 to 30000 dalton, an isoelectric point between 5.05 and 5.65 and the partial amino acid sequences - Ile-Leu-Phe-Thr-Gln-Gly-Asn-X-Gly-Glu-Leu-Glu-Asn- X-Phe-Glu-, - Lys-Ile-Leu-Phe-X-Gln-Gly- and - Ala-Ser-Tyr-Ile-Val-X-Ser-Glu-Ser-Ile-Gln-Ile-Leu- X-Leu-Ser-Glu-Gly-Ile-in which each radical X can be identical or different and each represents a naturally occurring amino acid.

公开(公告)号：CA2131545A1

公开(公告)日：1993-09-30

申请号：CA2131545

申请日：1993-03-10

Applicant: HOECHST AG

Inventor： SCHAPER WOLFGANG ,  FREUSS RAINER ,  SALBECK GERHARD ,  BRAUN PETER ,  KNAUF WERNER ,  SACHSE BURKHARD ,  WALTERSDORFER ANNA ,  KERN MANFRED ,  LUMMEN PETER ,  BONIN WERNER

IPC: A01N43/54 ,  A01N43/90 ,  A01P3/00 ,  A01P7/02 ,  A01P7/04 ,  C07D239/34 ,  C07D239/42 ,  C07D239/46 ,  C07D239/52 ,  C07D239/60 ,  C07D239/88 ,  C07D239/94 ,  C07D401/12 ,  C07D405/12 ,  C07D491/048 ,  C07D495/04 ,  C07D239/28 ,  C07D239/72 ,  C07D401/00 ,  C07D409/12 ,  C07F7/10 ,  A01N55/00 ,  A61K31/505 ,  A61K31/695

Abstract: The invention relates to compounds of the formula defined in the description, X is NH or oxygen and E is a bond or a 1- to 4-membered carbon chain, to a process for their preparation, to agents containing them, and to their use in the control of pests and as fungicides.

公开(公告)号：NZ231829A

公开(公告)日：1992-05-26

申请号：NZ23182989

申请日：1989-12-18

Applicant: HOECHST AG

Inventor： STARK HERBERT ,  SALBECK GERHARD ,  BONIN WERNER

IPC: A61K31/415 ,  A61P33/00 ,  C07D233/20 ,  C07D233/22 ,  C07D233/24 ,  A23K1/00 ,  A23K1/17 ,  A01N43/50

Abstract: The present invention relates to agents for systemic combating of ectoperasites in host animals, containing a compound of the formul I (I) in which R1 denotes hydrogen, (C1-C5)-alkyl, (C1-C3)-halogenoalkyl or halogen; R2 and R3 independently of one another denote (c1-C5)-alkyl, (C2-C5)-alkenyl, (C2-C5)-alkynyl, (C3-C7)-cycloalkyl, (C3-C7)-cycloalkenyl, (C1-C3)-halogenoalkyl, halogen, cyano, nitro, (C1-C5)-alkoxy, (C1 -C3)-alkoxy-C1-C3)-alkyl, (C1-C3)-halogenoalkoxy or (C1-C3)-alkylthio, or R2 and R3 together form a polymethylene chain having 2 to 5 carbon atoms: R4 denotes hydrogen, (c1-C10)-alkyl, (C2-C5)-alkenyl or (C3-C7)-cycloalkyl; R5 denotes hydrogen, (C1-C10)-alkyl, (C3-C5)-alkenyl, C3-C5)-alkynyl, (C3-C7)- cycloalkyl, (C3-C7)-cycloalkenyl, (C1-C3)-halogenoalkyl or (C1-C3)-alkoxy-(C hd 1-C3)-alkyl; X denotes oxygen, sulfur or an -NR6-group; and R6 denotes hydrogen, (C1-C5)-alkyl, (C3-C5)-alkenyl, C3-C5)-alkynyl, (C3-C7)-cycloalkyl, C3-C7)-cycloalkenyl, (C1-C3)-halogenoalkyl or (C1-C3)-alkoxy-(C1 -C3)-alkyl, or biologically tolerated acid addition salts thereof. The compounds of the formulas I are novel in some cases and are likewise included in the invention.

公开(公告)号：AU618364B2

公开(公告)日：1991-12-19

申请号：AU3595489

申请日：1989-06-01

Applicant: HOECHST AG

Inventor： BONIN WERNER ,  HABERMANN PAUL ,  TRIPIER DOMINIQUE ,  WOEHNER ELISABET

IPC: A61K38/55 ,  A61K35/56 ,  A61K38/00 ,  A61P7/02 ,  C07K1/14 ,  C07K1/16 ,  C07K14/00 ,  C07K14/435 ,  C07K14/44 ,  C07K14/81 ,  C07K15/12 ,  C12N9/68 ,  A61K37/02 ,  C07K15/08

Abstract: The invention relates to a new active substance-amblyommin-for anticoagulant therapy and to a process for the isolation thereof from hard ticks. The isolated protein having a thrombin-inhibitory action has a molecular weight of 20000 to 30000 dalton, an isoelectric point between 5.05 and 5.65 and the partial amino acid sequences Ile-Leu-Phe-Thr-Gln-Gly-Asn-X-Gly-Glu-Leu-Glu-Asn-X-Phe-Glu-, Lys-Ile-Leu-Phe-X-Gln-Gly- and Ala-Ser-Tyr-Ile-Val-X-Ser-Glu-Ser-Ile-Gln-Ile-Leu-X-Leu-Ser-Glu-Gly-Ile- in which each radical X can be identical or different and each represents a naturally occurring amino acid.

公开(公告)号：BR9000504A

公开(公告)日：1991-01-15

申请号：BR9000504

申请日：1990-02-06

Applicant: HOECHST AG

Inventor： KRATT GUENTER ,  SALBECK GERHARD ,  BONIN WERNER ,  DUEWEL DIETER

IPC: C07D239/557 ,  A01N43/54 ,  A01N57/36 ,  C07C217/84 ,  C07C265/12 ,  C07C323/36 ,  C07D239/54 ,  C07D239/545 ,  C07D239/553 ,  C07D239/60 ,  C07D239/62 ,  C07D319/12 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07F9/6584 ,  A61K31/53 ,  A61K31/675 ,  C07D239/46 ,  C07D239/64

公开(公告)号：HU200324B

公开(公告)日：1990-05-28

申请号：HU616088

申请日：1988-12-02

Applicant: HOECHST AG

Inventor： SCHATTERER STEFAN ,  BONIN WERNER ,  KNAUF WERNER ,  KOCH VOLKTER ,  KERN MANFRED ,  WALTERSDORFER ANNA

IPC: A01N43/88 ,  A01N47/30 ,  A01N47/34 ,  A01P7/02 ,  A01P7/04 ,  C07C317/24 ,  C07C317/42 ,  C07C323/22 ,  C07C323/27 ,  C07C323/44 ,  C07C335/26 ,  C07D273/04 ,  C07C323/37 ,  A01N47/38 ,  C07C273/04 ,  C07C317/32 ,  C07C317/36

公开(公告)号：NO892266L

公开(公告)日：1989-12-05

申请号：NO892266

申请日：1989-06-02

Applicant: HOECHST AG

Inventor： BONIN WERNER ,  HABERMANN PAUL ,  TRIPIER DOMINIQUE ,  WOEHNER ELISABET

IPC: A61K38/55 ,  A61K35/56 ,  A61K38/00 ,  A61P7/02 ,  C07K1/14 ,  C07K1/16 ,  C07K14/00 ,  C07K14/435 ,  C07K14/44 ,  C07K14/81 ,  C07K3/02 ,  C07K15/08

Abstract: The invention relates to a new active substance-amblyommin-for anticoagulant therapy and to a process for the isolation thereof from hard ticks. The isolated protein having a thrombin-inhibitory action has a molecular weight of 20000 to 30000 dalton, an isoelectric point between 5.05 and 5.65 and the partial amino acid sequences Ile-Leu-Phe-Thr-Gln-Gly-Asn-X-Gly-Glu-Leu-Glu-Asn-X-Phe-Glu-, Lys-Ile-Leu-Phe-X-Gln-Gly- and Ala-Ser-Tyr-Ile-Val-X-Ser-Glu-Ser-Ile-Gln-Ile-Leu-X-Leu-Ser-Glu-Gly-Ile- in which each radical X can be identical or different and each represents a naturally occurring amino acid.

公开(公告)号：AU588409B2

公开(公告)日：1989-09-14

申请号：AU6675786

申请日：1986-12-19

Applicant: HOECHST AG

Inventor： KOCH VOLKER ,  FUSS ANDREAS ,  BONIN WERNER ,  KNAUF WERNER ,  WALTERSDORFER ANNA

IPC: A01N43/824 ,  A01N43/88 ,  A01N47/34 ,  A01N47/36 ,  C07D213/64 ,  C07D213/69 ,  C07D213/75 ,  C07D213/89 ,  C07D413/12 ,  A01N43/50 ,  A01N43/54 ,  A01N43/78 ,  A01N43/76

Abstract: The compounds of the formula (I) (I) in which A denotes N or N->0, R denotes a radical of the formula R4-CY1-NR5-CY2-NR6-, +TR R1 denotes halogen, alkyl, alkenyl, alkynyl, alkoxy, alkoxycarbonyl or alkylcarbonyl, where these radicals may be halogenated, nitro, cyano or carboxyl, R2 denotes halogenated alkoxy, halogenated alkenyloxy or halogenated alkynloxy, R3 denotes halogen, n denotes 0, 1 or 2, m denotes 0, 1, 2 or 3, and p denotes 0 or 1, and also the salts thereof, are advantageously suitable for combating noxious insects, acarides, nematodes or mollusks.

公开(公告)号：ZA873879B

公开(公告)日：1988-02-24

申请号：ZA873879

申请日：1987-05-29

Applicant: HOECHST AG

Inventor： GIENCKE WOLFGANG ,  WOLFGANG GIENCKE ,  MILDENBERGER HILMAR ,  HILMAR MILDENBERGER ,  HEUBACH GUENTHER ,  GUENTHER HEUBACH ,  SACHSE BURKHARD ,  BURKHARD SACHSE ,  FUSS ANDREAS ,  ANDREAS FUSS ,  WALTERSDORFER ANNA ,  ANNA WALTERSDORFER ,  KNAUF WERNER ,  WERNER KNAUF ,  KERN MANFRED ,  MANFRED KERN ,  BONIN WERNER ,  WERNER BONIN

IPC: A01N43/54 ,  C07D239/42 ,  C07D239/46 ,  C07D239/47 ,  C07D239/48 ,  A01N ,  C07D