公开(公告)号：AU696635B2

公开(公告)日：1998-09-17

申请号：AU7779994

申请日：1994-11-11

Applicant: HOECHST AG

Inventor： PEYMAN ANUSCHIRWAN ,  UHLMANN EUGEN ,  MAG MATTHIAS ,  KRETZSCHMAR GERHARD ,  HELSBERG MATTHIAS ,  WINKLER IRVIN

IPC: C12N15/09 ,  A61K31/70 ,  A61K31/7088 ,  A61P31/12 ,  A61P31/22 ,  A61P35/00 ,  C07H21/00 ,  C07H21/04

Abstract: Oligonucleotides (I) having at least one non-terminal pyrimidine nucleoside modified and additionally having the 5'- and/or 3'-terminal modified are new, with some specific exclusions. Oligonucleotides (I) having at least one non-terminal pyrimidine nucleoside modified and additionally having the 5'- and/or 3'-terminal modified are new, with the exception of oligonucleotides in which all of the nucleosides are modified and Cys asterisk -Ala-Cys-Cys-Ala asterisk -Ala-Cys-Cys-Thr asterisk -Cys-Thr-Thr-Cys asterisk -Cys-Ala-Cys-Ala-, Cys asterisk -Ala-Cys asterisk -Cys-Ala asterisk -Ala-Cys asterisk -Thr-Thr-Cys-Thr asterisk -Thr-Cys asterisk -Cys-Ala asterisk -Cys-Ala-, Cys-Ala asterisk -Cys-Cys asterisk -Ala-Ala asterisk -Cys-Thr asterisk -Thr-Cys asterisk -Thr-Thr asterisk -Cys-Cys asterisk -Ala-Cys asterisk -Ala- and Cys-Ala-Cys asterisk -Cys asterisk -Ala-Ala-Cys asterisk -Thr asterisk -Thr-Cys-Thr asterisk -Thr asterisk -Thr-Cys-Cys-Ala asterisk -Cys asterisk -Ala. An Independent claim is included for the preparation of (I) by chemical synthesis.

公开(公告)号：GR3025797T3

公开(公告)日：1998-03-31

申请号：GR970403443

申请日：1997-12-30

Applicant: HOECHST AG

Inventor： JAEHNE GERHARD ,  HELSBERG MATTHIAS ,  WINKLER IRVIN ,  GROSS GERHARD ,  SCHOLL THOMAS

IPC: A61K31/52 ,  A61P31/12 ,  C07D473/32

公开(公告)号：DE59404784D1

公开(公告)日：1998-01-22

申请号：DE59404784

申请日：1994-03-24

Applicant: HOECHST AG

Inventor： JAEHNE GERHARD ,  HELSBERG MATTHIAS ,  WINKLER IRVIN ,  GROSS GERHARD ,  SCHOLL THOMAS

IPC: A61K31/52 ,  A61P31/12 ,  C07D473/32

公开(公告)号：AT161011T

公开(公告)日：1997-12-15

申请号：AT94912542

申请日：1994-03-24

Applicant: HOECHST AG

Inventor： JAEHNE GERHARD ,  HELSBERG MATTHIAS ,  WINKLER IRVIN ,  GROSS GERHARD ,  SCHOLL THOMAS

IPC: A61K31/52 ,  A61P31/12 ,  C07D473/32

公开(公告)号：AU7779994A

公开(公告)日：1995-05-18

申请号：AU7779994

申请日：1994-11-11

Applicant: HOECHST AG

Inventor： PEYMAN ANUSCHIRWAN ,  UHLMANN EUGEN ,  MAG MATTHIAS ,  KRETZSCHMAR GERHARD ,  HELSBERG MATTHIAS ,  WINKLER IRVIN

IPC: C12N15/09 ,  A61K31/70 ,  A61K31/7088 ,  A61P31/12 ,  A61P31/22 ,  A61P35/00 ,  C07H21/00 ,  C07H21/04

Abstract: Oligonucleotides (I) having at least one non-terminal pyrimidine nucleoside modified and additionally having the 5'- and/or 3'-terminal modified are new, with some specific exclusions. Oligonucleotides (I) having at least one non-terminal pyrimidine nucleoside modified and additionally having the 5'- and/or 3'-terminal modified are new, with the exception of oligonucleotides in which all of the nucleosides are modified and Cys asterisk -Ala-Cys-Cys-Ala asterisk -Ala-Cys-Cys-Thr asterisk -Cys-Thr-Thr-Cys asterisk -Cys-Ala-Cys-Ala-, Cys asterisk -Ala-Cys asterisk -Cys-Ala asterisk -Ala-Cys asterisk -Thr-Thr-Cys-Thr asterisk -Thr-Cys asterisk -Cys-Ala asterisk -Cys-Ala-, Cys-Ala asterisk -Cys-Cys asterisk -Ala-Ala asterisk -Cys-Thr asterisk -Thr-Cys asterisk -Thr-Thr asterisk -Cys-Cys asterisk -Ala-Cys asterisk -Ala- and Cys-Ala-Cys asterisk -Cys asterisk -Ala-Ala-Cys asterisk -Thr asterisk -Thr-Cys-Thr asterisk -Thr asterisk -Thr-Cys-Cys-Ala asterisk -Cys asterisk -Ala. An Independent claim is included for the preparation of (I) by chemical synthesis.

公开(公告)号：AU6505294A

公开(公告)日：1994-11-08

申请号：AU6505294

申请日：1994-03-24

Applicant: HOECHST AG

Inventor： JAHNE GERHARD ,  HELSBERG MATTHIAS ,  WINKLER IRVIN ,  GROSS GERHARD ,  SCHOLL THOMAS

IPC: A61K31/52 ,  A61P31/12 ,  C07D473/32

公开(公告)号：NO174834C

公开(公告)日：1994-07-20

申请号：NO883375

申请日：1988-07-29

Applicant: HOECHST AG

Inventor： SCHRINNER ELMAR ,  WINKLER IRVIN ,  MEICHSNER CHRISTOPH ,  HELSBERG MATTHIAS

IPC: C07D473/06 ,  A61K20060101 ,  A61K31/52 ,  A61K31/70 ,  A61K31/715 ,  A61P31/12 ,  C07D20060101 ,  C07D473/04 ,  C08B20060101 ,  C08B37/00 ,  A61K31/725

Abstract: The preparation contains or consists of… a) at least one sulphated polysaccharide and… b) at least one xanthine derivative. The preparation is suitable for the control and prophylaxis of viral diseases, especially those caused by retroviruses.

公开(公告)号：ZA9307035B

公开(公告)日：1994-04-18

申请号：ZA9307035

申请日：1993-09-23

Applicant: HOECHST AG

Inventor： JAEHNE GERHARD ,  HELSBERG MATTHIAS ,  WINKLER IRVIN ,  GROSS GERHARD ,  SCHOLL THOMAS

IPC: A61K31/505 ,  A61P31/12 ,  C07D487/04 ,  C07F9/6561 ,  C07D ,  A61K ,  C07F

CPC classification number: C07D487/04

公开(公告)号：CA2106818A1

公开(公告)日：1994-03-25

申请号：CA2106818

申请日：1993-09-23

Applicant: HOECHST AG

Inventor： JAEHNE GERHARD ,  HELSBERG MATTHIAS ,  WINKLER IRVING ,  GROSS GERHARD ,  SCHOLL THOMAS

IPC: A61K31/505 ,  A61P31/12 ,  C07D487/04 ,  C07F9/6561 ,  C07F9/547 ,  A61K31/675

Abstract: of the disclosure: N1-Substituted 1H-1,2,3-triazolo¢4,5-d!pyrimidines, a process for their preparation and their use as antiviral agents. Compounds of the formula I (I) in which the substituents X, Y, R1, R2 and R3 have the stated meanings, have antiviral activity.

公开(公告)号：ZA932162B

公开(公告)日：1993-10-14

申请号：ZA932162

申请日：1993-03-26

Applicant: HOECHST AG

Inventor： JAEHNE GERHARD ,  HELSBERG MATTHIAS ,  WINKLER IRVIN ,  GROSS GERHARD ,  SCHOLL THOMAS

IPC: A61K31/52 ,  A61P31/12 ,  C07D473/00 ,  C07D473/32 ,  C07D ,  A61K

Abstract: Compounds of the formula 1 in which the radicals R and/or R independently of one another represent acyl radicals of the formula -C(=O)-R (2> where R denotes C1-C3-alkyl and one of the radicals R and R can also denote hydrogen, and their physiologically tolerable salts have an antiviral action.