公开(公告)号：DE1943905A1

公开(公告)日：1971-03-11

申请号：DE1943905

申请日：1969-08-29

Applicant: HOECHST AG

Inventor： STURM KARL DIPL-CHEM DR ,  MUSCHAWECK ROMAN DR

IPC: C07C311/37 ,  C07D405/12 ,  F21V5/02

Abstract: Diuretic/saluretic sulphamoyl anthranilic acid derivs Title cpds. of formula (I) (where R is pyrrolidino, piperidino, piperazino, morpholino or thiomorpholino opt. substd. byalkyl residues) which are diuretics are saluretics with a milder action and more favourable Na/K excretion ratio than the parent compound N-furfuryl-4-chloro-5-sulphamoyl anthranilic acid (II), may be prepd. by subjecting (II) to a Mannich reaction with formaldehyde and the amine R-H.

公开(公告)号：CH498851A

公开(公告)日：1970-11-15

申请号：CH1196570

申请日：1968-07-04

Applicant: HOECHST AG

Inventor： PROF RUSCHIG HEINRICH DR ,  SCHORR MANFRED DR ,  MUSCHAWECK ROMAN DR ,  RIPPEL ROBERT DR

IPC: C07D333/36 ,  C07D333/38 ,  C07D63/12

公开(公告)号：CH498850A

公开(公告)日：1970-11-15

申请号：CH1196470

申请日：1968-07-04

Applicant: HOECHST AG

Inventor： PROF RUSCHIG HEINRICH DR ,  SCHORR MANFRED DR ,  MUSCHAWECK ROMAN DR ,  RIPPEL ROBERT DR

IPC: C07D333/36 ,  C07D333/38 ,  C07D63/12

公开(公告)号：DE3366181D1

公开(公告)日：1986-10-23

申请号：DE3366181

申请日：1983-03-02

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH CHRISTIAN DR ,  MANIA DIETER DR ,  MUSCHAWECK ROMAN DR ,  HROPOT MAX DR

IPC: A61K31/18 ,  A61K31/40 ,  A61P3/00 ,  A61P7/10 ,  A61P9/12 ,  C07C67/00 ,  C07C301/00 ,  C07C303/02 ,  C07C303/38 ,  C07C303/40 ,  C07C311/15 ,  C07C311/37 ,  C07D295/22 ,  C07D295/26 ,  C07C143/78

Abstract: The invention relates to 2-aminomethylphenols of the formula I in which R1 and R2 represent hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl or benzyl which is optionally substituted by alkyl, alkoxy or halogen, R3 and R5 denote hydrogen, halogen, alkyl or alkoxy, R4 denotes halogen, alkyl or cycloalkyl and R6 and R7 represent hydrogen or alkyl, it being possible for the radicals R1 and R2, R6 R7 and/or two of the radicals R3, R4 and R5 to form an alkylene chain which is optionally substituted by methyl groups and which, in the case of the radicals R1, R2, R6 and R7, can also be interrupted by oxygen atoms, sulfur atoms and/or imino groups, and to physiologically acceptable salts thereof, a process for their preparation, and their use and to pharmaceutical formulations based on these compounds.

公开(公告)号：GR82065B

公开(公告)日：1984-12-13

申请号：GR840174708

申请日：1984-05-15

Applicant: HOECHST AG

Inventor： SEURING BERNHARD DR ,  LANG HANS-JOCHEN DR ,  HROPOT MAX DR ,  MUSCHAWECK ROMAN DR

IPC: A61K31/34 ,  A61K31/343 ,  A61P19/06 ,  C07D307/80 ,  C07D307/85

Abstract: 5-(4-Chloro-3-sulfamoylbenzoyl)-2,3-dihydro-2-benzofurancarboxylic acids of the formula I I in which R1 and R2 are identical or different and represent hydrogen, halogen or methyl, both as racemic mixtures and in the form of their optical isomers, and their physiologically tolerated salts are described, as is their preparation. They are outstanding diuretics and saluretics with an additional uricosuric component.

公开(公告)号：DE3317884A1

公开(公告)日：1984-11-22

申请号：DE3317884

申请日：1983-05-17

Applicant: HOECHST AG

Inventor： SEURING BERNHARD DR ,  LANG HANS-JOCHEN DR ,  HROPOT MAX DR ,  MUSCHAWECK ROMAN DR

IPC: A61K31/34 ,  A61K31/343 ,  A61P19/06 ,  C07D307/80 ,  C07D307/85

Abstract: 5-(4-Chloro-3-sulfamoylbenzoyl)-2,3-dihydro-2-benzofurancarboxylic acids of the formula I I in which R1 and R2 are identical or different and represent hydrogen, halogen or methyl, both as racemic mixtures and in the form of their optical isomers, and their physiologically tolerated salts are described, as is their preparation. They are outstanding diuretics and saluretics with an additional uricosuric component.

公开(公告)号：GR78942B

公开(公告)日：1984-10-02

申请号：GR830172362

申请日：1983-09-02

Applicant: HOECHST AG

Inventor： SEURING BERNHARD DR ,  LANG HANS-JOCHEM DR ,  HROPOT MAX DR ,  MUSCHAWECK ROMAN DR

IPC: A61K31/255 ,  A61K20060101 ,  A61K31/18 ,  A61K31/19 ,  A61K31/215 ,  A61K31/41 ,  A61P3/00 ,  A61P3/12 ,  A61P19/06 ,  C07C20060101 ,  C07C67/00 ,  C07C301/00 ,  C07C303/40 ,  C07C311/29 ,  C07F13/00

Abstract: Compounds of the formula in which R , R and R are identical or different and represent hydrogen, halogen, alkyl having 1 to 4 C atoms or alkoxy having 1 to 4 C atoms, in which however R and R cannot denote simultaneously hydrogen and in which R and R together can also denote a bridge comprising two to 5 methylene groups or methylenedioxy, R and R are identical or different and represent hydrogen or alkyl having 1 to 4 C atoms or are part of a 3- to 7-membered saturated carbocyclic ring and R represents hydrogen, alkyl having 1 to 4 C atoms which are unsubstituted or substituted by hydroxyl or alkoxy having 1 to 3 C atoms, or denotes aralkyl having 7 to 9 C atoms and their physiologically acceptable salts have uricosuric and salidiuretic effects.

公开(公告)号：CH639371A5

公开(公告)日：1983-11-15

申请号：CH593882

申请日：1982-10-08

Applicant: HOECHST AG

Inventor： MERKEL WULF DR ,  BORMANN DIETER DR ,  MANIA DIETER DR ,  MUSCHAWECK ROMAN DR

IPC: C07D207/32 ,  C07D207/327 ,  C07D295/155 ,  C07D317/64 ,  A61K31/40

公开(公告)号：CH638798A5

公开(公告)日：1983-10-14

申请号：CH446378

申请日：1978-04-25

Applicant: HOECHST AG

Inventor： STURM KARL DR ,  MUSCHAWECK ROMAN DR

IPC: A61K31/635 ,  A61P7/10 ,  C07D307/52 ,  C07D333/20 ,  A61K31/34 ,  A61K31/38

公开(公告)号：CH637379A5

公开(公告)日：1983-07-29

申请号：CH109978

申请日：1978-02-01

Applicant: HOECHST AG

Inventor： MERKEL WULF DR ,  BORMANN DIETER DR ,  MANIA DIETER DR ,  MUSCHAWECK ROMAN DR

IPC: C07D207/32 ,  C07D207/327 ,  C07D295/155 ,  C07D317/64