公开(公告)号：SE7607330L

公开(公告)日：1976-12-25

申请号：SE7607330

申请日：1976-06-24

Applicant: HOECHST AG

Inventor： REUSCHLING D-B ,  KUHLEIN K ,  SCHOLKENS B ,  KUNSTMANN R ,  LERCH U ,  BARTMANN W ,  TEUFEL H ,  BECK G

IPC: C07D207/26 ,  C07D207/27

Abstract: The present invention relates to pyrrolidones which are analogues of prostaglandins and to a process for their manufacture. The compounds of the invention have prostaglandin-like pharmacological properties and can therefore be used as pharmaceutical compositions.

公开(公告)号：DK281476A

公开(公告)日：1976-12-25

申请号：DK281476

申请日：1976-06-23

Applicant: HOECHST AG

Inventor： REUSCHLING D-B ,  KYHLEIN K ,  SCHOLKENS B ,  KUNSTMANN R ,  LERCH U ,  BARTMANN W ,  TEUFEL H ,  BECK G

IPC: C07D207/26 ,  C07D207/27 ,  C07D

Abstract: The present invention relates to pyrrolidones which are analogues of prostaglandins and to a process for their manufacture. The compounds of the invention have prostaglandin-like pharmacological properties and can therefore be used as pharmaceutical compositions.

公开(公告)号：DK70476A

公开(公告)日：1976-08-22

申请号：DK70476

申请日：1976-02-20

Applicant: HOECHST AG

Inventor： KUNSTMANN R ,  LERCH U ,  SCHOLKENS B ,  TEUFEL H

IPC: C07C405/00 ,  C07D319/08 ,  C07C

Abstract: Prostaglandin analogues of formula (I): (where R1 and R2 together represent oxygen or one of R1 and R2 is H and the other is OH, one of R3 and R4 is H and the other is OH, and R5 is an opt. unsaturated, opt. branched 3-10C aliphatic hydrocarbon residue or is 7-11C aralkyl), e.g. 15-hydroxy-11 -oxo-cis-6,19-prostadienoic acid, their physiologically tolerable salts with organic and inorganic bases, and their esters with aliphatic, cycloaliphatic and araliphatic 1-8C alcohols are new cpds. (I) are their salts and esters have spasmogenic activity as well as and bronchodilating, hypotensive, gastric secretion inhibiting and abortifacient activity. Compared with natural prostagladins, they have greater stability.

公开(公告)号：SE7508380A

公开(公告)日：1976-01-26

申请号：SE7508380

申请日：1975-07-23

Applicant: HOECHST AG

Inventor： BECK G ,  BARTMANN W ,  LERCH U ,  SCHOLKENS B

IPC: A61K31/21 ,  A61K31/557 ,  A61K31/5575 ,  A61P43/00 ,  C07C67/00 ,  C07C271/28 ,  C07C401/00 ,  C07C405/00 ,  C07D307/935 ,  C07C177/00

CPC classification number: C07C405/00

公开(公告)号：DK332275A

公开(公告)日：1976-01-24

申请号：DK332275

申请日：1975-07-22

Applicant: HOECHST AG

Inventor： BECK G ,  BARTMANN W ,  LERCH U ,  SCHOLKENS B

IPC: A61K31/21 ,  A61K31/557 ,  A61K31/5575 ,  A61P43/00 ,  C07C67/00 ,  C07C271/28 ,  C07C401/00 ,  C07C405/00 ,  C07D307/935 ,  C07C

Abstract: The present invention relates to new analogues which do not occur naturally of prostanoic acids of the formula I I The compounds of the invention have spasmogenic, bronchodilatant and hypotensive properties. Therefore, they can be used as medicaments. This invention also relates to a process for preparing the compounds of the invention.

公开(公告)号：NZ213661A

公开(公告)日：1988-01-08

申请号：NZ21366182

申请日：1982-11-03

Applicant: HOECHST AG

Inventor： TEETZ V ,  GEIGER R ,  URBACH H ,  BECKER R ,  SCHOLKENS B

IPC: C07D209/52

公开(公告)号：AU517876B2

公开(公告)日：1981-09-03

申请号：AU2705777

申请日：1977-07-15

Applicant: HOECHST AG

Inventor： BARTMANN W ,  LERCH U ,  TEUFEL H ,  SCHOLKENS B ,  BECK G

IPC: C07D339/08 ,  A61K31/19 ,  A61K31/215 ,  A61P43/00 ,  C07C67/00 ,  C07C401/00 ,  C07C405/00 ,  C07D317/72 ,  C07D339/06 ,  C07C177/00 ,  C07C121/46 ,  C07D319/08 ,  C07D411/08

Abstract: What is disclosed are prostaglandin-analogous cyclopentane derivatives of the formula I wherein R1 is hydrogen or a linear or branched, saturated or unsaturated aliphatic or cycloaliphatic radical having from 1 to 8 carbon atoms, or an araliphatic radical having from 7 to 9 carbon atoms, or a physiologically tolerable metal, NH4 or substituted ammonium ion derived from a primary, secondary or tertiary amine; R2 is a linear or branched, saturated or unsaturated aliphatic hydrocarbon radical having from 1 to 8 carbon atoms; R3 is hydrogen or a R4CO group wherein R4 is a hydrogen atom or a linear or branched alkyl group having up to 10 carbon atoms; A is a saturated, linear or branched alkylene group having from 2 to 5 carbon atoms, and a process for the manufacture thereof.

公开(公告)号：AU502124B2

公开(公告)日：1979-07-12

申请号：AU8326575

申请日：1975-07-22

Applicant: HOECHST AG

Inventor： BECK G ,  BARTMANN W ,  LERCH U ,  SCHOLKENS B

IPC: A61K31/21 ,  A61K31/557 ,  A61K31/5575 ,  A61P43/00 ,  C07C67/00 ,  C07C271/28 ,  C07C401/00 ,  C07C405/00 ,  C07D307/935 ,  C07C177/00 ,  C07D309/12 ,  C07D307/93 ,  C07C131/00 ,  C07D307/40 ,  C07D407/12 ,  C07D407/14 ,  C07C125/06 ,  A61K31/19 ,  A61K31/335 ,  A61K31/34 ,  A61K31/39

Abstract: The present invention relates to new analogues which do not occur naturally of prostanoic acids of the formula I I The compounds of the invention have spasmogenic, bronchodilatant and hypotensive properties. Therefore, they can be used as medicaments. This invention also relates to a process for preparing the compounds of the invention.

公开(公告)号：SE7800688L

公开(公告)日：1978-07-22

申请号：SE7800688

申请日：1978-01-19

Applicant: HOECHST AG

Inventor： BARTMANN W ,  BECK G ,  LERCH U ,  TEUFEL H ,  SCHOLKENS B

IPC: C07D307/42 ,  A61K31/20 ,  A61K31/34 ,  A61K31/341 ,  A61P9/12 ,  A61P43/00 ,  C07C67/00 ,  C07C401/00 ,  C07C405/00 ,  C07C177/00

公开(公告)号：SE7614216L

公开(公告)日：1977-06-20

申请号：SE7614216

申请日：1976-12-17

Applicant: HOECHST AG

Inventor： REUSCHLING D B ,  LINKIES A ,  KUHLEIN K ,  TEUFEL H ,  SCHOLKENS B

IPC: C07D207/27 ,  A61K31/40 ,  A61K31/4015 ,  A61P43/00 ,  C07D207/26