公开(公告)号：CZ280492A3

公开(公告)日：1993-04-14

申请号：CS280492

申请日：1992-09-11

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER DR ,  WAGNER ADALBERT DR ,  KLEEMANN HEINZ-WERNER DR ,  GERHARDS HERMANN DR ,  SCHOLKENS BERNWARD PROF DR

IPC: A61K31/33 ,  A61K31/415 ,  A61K31/4184 ,  A61K31/435 ,  A61K31/4375 ,  A61K31/44 ,  A61K31/495 ,  A61K31/505 ,  A61P9/10 ,  A61P9/12 ,  C07D235/06 ,  C07D235/08 ,  C07D235/22 ,  C07D235/24 ,  C07D403/10 ,  C07D409/06 ,  C07D471/04 ,  C07D487/04 ,  C07D519/00

Abstract: Compounds of the formula (I) in which the symbols have the following meaning: X represents a monocyclic radical having 3, 4 or 5 ring atoms, R , R , R , R , R , R and R is, for example, an alkyl radical q is zero or 1 L is, for example, the methylene group A is the radical, for example, of a heterocycle are highly effective as antagonists of angiotensin II receptors. They can be used as pharmaceuticals or diagnostics.

公开(公告)号：DE4131325A1

公开(公告)日：1993-04-01

申请号：DE4131325

申请日：1991-09-20

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER DR ,  WAGNER ADALBERT DR ,  KLEEMANN HEINZ-WERNER DR ,  GERHARDS HERMANN DR ,  SCHOELKENS BERNWARD PROF DR

IPC: C07D235/08 ,  C07D409/06 ,  C07D471/04 ,  C07D487/04 ,  C07D519/00

Abstract: Fused imidazole derivs. of formula (I) and their physiologically acceptable salts are new. In (I) X = a monocyclic gp. with 3, 4 or 5 ring atoms or a bicyclic gp. with 8-10 ring atoms, which is completely or partially hydrogenated and in which one or more CH or CH2 gps. are replaced with N, NH or O; R1 = 1-10C alkyl, 3-10C alkenyl, 3-10C alkynyl, (these 3 gps. being opt. mono-substd. with CO2R6 and opt. having 1 to all of their H atoms replaced with F), etc.. R2, R3, R4 and R5 = each H, halogen, OH, CN, NO2, sulpho, formyl, benzoyl, 1-8C acyl, 1-8C acyloxy, SH, etc.. R6 = H, 1-8C alkyl (in which 1 to all H atoms are opt. replaced with F) 3-8C cycloalkyl, Ph, benzyl; L = 1-3C alkane diyl; R12 and R13 = each H, halogen, NO2, 1-4C alkyl or 1-2C alkoxy; q = 0-1; A = either a heterocycle with 5-10 ring atoms, which is mono or bicyclic and in which up to 9 ring atoms are C and which is opt. substd. with up to 6 (esp. up to 3) opt. different gps. R14 and R15; or A is opt. substd. biphenyl.

公开(公告)号：CS9200010A3

公开(公告)日：1992-07-15

申请号：CS1092

申请日：1992-01-03

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT DR ,  ENGLERT HEINRICH DR ,  KLEEMANN HEINZ-WERNER DR ,  GERHARDS HERMANN DR ,  SCHOLKENS BERNWARD PROF DR ,  BECKER REINHARD DR ,  LINZ WOLFGANG DR

IPC: A61K31/40 ,  A61K31/415 ,  A61K31/425 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61K31/505 ,  A61K31/535 ,  A61K31/54 ,  A61K31/64 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P43/00 ,  C07D207/34 ,  C07D207/36 ,  C07D233/54 ,  C07D233/66 ,  C07D233/68 ,  C07D233/70 ,  C07D233/84 ,  C07D233/90 ,  C07D249/02 ,  C07D255/02 ,  C07D257/02 ,  C07D257/04 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D453/02 ,  C07D521/00 ,  A61K31/41 ,  C07D207/30 ,  C07D231/10 ,  C07D249/04 ,  C07D249/08

CPC classification number: C07D231/12 ,  C07D233/56 ,  C07D233/68 ,  C07D233/70 ,  C07D233/90 ,  C07D249/08 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D453/02

公开(公告)号：CS9003688A3

公开(公告)日：1992-02-19

申请号：CS368890

申请日：1990-07-24

Applicant: HOECHST AG

Inventor： KLEEMANN HEINZ-WERNER DR ,  URBACH HANSJORG DR ,  WAGNER ADALBERT DR ,  RUPPERT DIETER DR ,  LINZ WOLFGANG DR ,  KRAMES WERNER DR

IPC: C12N9/99 ,  A61K31/38 ,  A61K31/381 ,  A61K31/415 ,  A61K31/445 ,  A61K31/535 ,  A61K38/55 ,  A61P9/12 ,  C07C237/08 ,  C07C237/22 ,  C07D211/26 ,  C07D211/58 ,  C07D233/54 ,  C07D233/64 ,  C07D295/20 ,  C07D333/24 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12 ,  C07D521/00 ,  C07K1/113 ,  C07K5/06 ,  C07K5/065 ,  C07K5/078 ,  C07K14/81

CPC classification number: C07D233/64 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12 ,  C07K5/06078 ,  C07K5/06139

公开(公告)号：DE3913290A1

公开(公告)日：1990-10-25

申请号：DE3913290

申请日：1989-04-22

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT DR ,  URBACH HANSJOERG DR ,  RUPPERT DIETER DR ,  LINZ WOLFGANG DR ,  SCHOELKENS BERNWARD DR

IPC: A61K38/55 ,  A61K38/00 ,  A61P9/00 ,  A61P9/12 ,  C07K1/06 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K5/065 ,  C07K14/81

Abstract: The present invention relates to compounds of the formula I in which A and B are, independently of one another, an amino acid, and R , R , R and R are as defined in the description, to processes for the preparation thereof, to their use as medicines and to pharmaceutical agents containing them.

公开(公告)号：DE3913272A1

公开(公告)日：1990-10-25

申请号：DE3913272

申请日：1989-04-22

Applicant: HOECHST AG

Inventor： NICKEL WOLF-ULRICH DR ,  LINZ WOLFGANG DR ,  RUPPERT DIETER DR ,  URBACH HANSJOERG ,  WAGNER ADALBERT DR

IPC: A61K38/55 ,  A61K38/00 ,  A61K38/05 ,  A61P9/12 ,  C07K1/06 ,  C07K1/113 ,  C07K5/06 ,  C07K5/065 ,  C07K14/81

Abstract: The present invention relates to compounds of the formula I in which A and B are, independently of one another, an amino acid, and W, R , R , R and R are as defined in the description, to processes for the preparation thereof, to the use thereof and to pharmaceutical compositions containing them.

公开(公告)号：DK0533058T3

公开(公告)日：2003-11-24

申请号：DK92115500

申请日：1992-09-10

Applicant: HOECHST AG

Inventor： KLEEMANN HEINZ-WERNER DR ,  HEITSCH HOLGER DR ,  WAGNER ADALBERT DR ,  GERHARDS HERMANN DR ,  SCHOELKENS BERNWARD PROF DR

IPC: A61K31/33 ,  A61K31/415 ,  A61K31/4184 ,  A61K31/435 ,  A61K31/4375 ,  A61K31/44 ,  A61K31/495 ,  A61K31/505 ,  A61P9/10 ,  A61P9/12 ,  C07D235/06 ,  C07D235/08 ,  C07D235/22 ,  C07D235/24 ,  C07D403/10 ,  C07D409/06 ,  C07D471/04 ,  C07D487/04 ,  C07D519/00

Abstract: Compounds of the formula (I) in which the symbols have the following meaning: X represents a monocyclic radical having 3, 4 or 5 ring atoms, R , R , R , R , R , R and R is, for example, an alkyl radical q is zero or 1 L is, for example, the methylene group A is the radical, for example, of a heterocycle are highly effective as antagonists of angiotensin II receptors. They can be used as pharmaceuticals or diagnostics.

公开(公告)号：AT242215T

公开(公告)日：2003-06-15

申请号：AT97103611

申请日：1997-03-05

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT DR ,  HEITSCH HOLGER DR ,  NOELKNE GERHARD DR ,  WIRTH KLAUS DR ,  BERNARD PROF-DR

IPC: C07D237/28 ,  A61K31/345 ,  A61K31/47 ,  A61K31/495 ,  A61K31/53 ,  A61P43/00 ,  C07D215/04 ,  C07D215/26 ,  C07D239/72 ,  C07D239/74 ,  C07D241/36 ,  C07D241/44 ,  C07D253/04 ,  C07D253/065 ,  C07D257/10

Abstract: Fluoroalkyl- and fluoroalkoxy-substituted benzyloxy-azaheterocyclic compounds of formula (I) and their salts are new: X1-X3 = N or CR ; R , R = H or halo; R , R = H, halo, 1-5C alkyl or 2-5C alkenyl; R = 2-5C alkenediyl, halo, OR , SR , NHR , -COOR or COOH; 1-6C alkyl, 6-12C aryl or 6-12C aryl-1-3C alkyl (all optionally substituted by e.g. OR , SR , NO2, CN, NHR or halo); R , R = H, 1-5C alkyl, 3-5C alkenyl or 6-12C aryl-1-3C alkyl; R = 1-5C alkyl or 1-5C alkoxy (both substituted by 1 or more F or Cl); B = amino acid; D = 2-5C alkanediyl, 1-5C alkanediyl or -(CH2)n-Yp-(CH2)m-; E = O or S; Y = O, S or NR ; n, m = 0-3; o = 1-3; and p = 0 or 1.

公开(公告)号：GR3031852T3

公开(公告)日：2000-02-29

申请号：GR990402946

申请日：1999-11-17

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT DR ,  BHATNAGAR NEERJA DR ,  BUENDIA JEAN DR ,  GRIFFOUL CHRISTINE DR

IPC: B01J23/44 ,  A61K31/235 ,  A61K31/41 ,  C07B37/04 ,  C07B61/00 ,  C07C41/48 ,  C07C45/61 ,  C07C45/71 ,  C07C47/546 ,  C07C67/30 ,  C07C67/343 ,  C07C69/76 ,  C07C69/767 ,  C07C253/30 ,  C07C255/37 ,  C07C255/40 ,  C07C255/56 ,  C07C303/40 ,  C07C311/09 ,  C07C311/48 ,  C07C311/51 ,  C07C311/52 ,  C07C311/53 ,  C07C311/54 ,  C07C311/57 ,  C07C311/58 ,  C07D257/04

Abstract: The invention relates to a method for the preparation of a compound of the general formula (I) in which X represents an optionally protected formyl group and R denotes a group which is itself inert to the reaction conditions of the synthesis, for example -CN, characterised in that a compound of the general formula (II) where X is as defined above, is reacted with a substituted phenyl halogen compound of the formula (III) where Hal denotes e.g. bromine. The compounds are useful intermediates for pharmaceutical synthesis.

公开(公告)号：DK0503162T3

公开(公告)日：1998-12-07

申请号：DK91122406

申请日：1992-01-01

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT DR ,  ENGLERT HEINRICH DR ,  KLEEMANN HEINZ-WERNER DR ,  GERHARDS HERMANN DR ,  SCHOELKENS BERNWARD PROF DR ,  BECKER REINHARD DR ,  LINZ WOLFGANG DR ,  CAILLE JEAN-CLAUDE ,  VEVERT JEAN-PAUL

IPC: A61K31/40 ,  A61K31/415 ,  A61K31/425 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61K31/505 ,  A61K31/535 ,  A61K31/54 ,  A61K31/64 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P43/00 ,  C07D207/34 ,  C07D207/36 ,  C07D233/54 ,  C07D233/66 ,  C07D233/68 ,  C07D233/70 ,  C07D233/84 ,  C07D233/90 ,  C07D249/02 ,  C07D255/02 ,  C07D257/02 ,  C07D257/04 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D453/02 ,  C07D521/00

Abstract: Azole derivative of the general formula (I) in which A, L, O, R , X, Y, Z and q have the meanings given, a process for their preparation, pharmaceutical preparations and the use of the compounds are described. Azole derivatives of the formula I where the symbols have, for example, the following meanings: R = (C2-C10)-alkyl Z = nitrogen X and Y = independently of one another CR L = -CH2- q = zero or 1 A = biphenyl radical which is substituted, for example, by R R = halogen or hydrogen R = SO2-NH-CO-OR and R = phenyl, are highly active antagonists of angiotensin II receptors.