公开(公告)号：AU4845400A

公开(公告)日：2000-12-05

申请号：AU4845400

申请日：2000-05-12

Applicant: MICELL TECHNOLOGIES INC

Inventor： DEYOUNG JAMES P ,  ROMACK TIMOTHY J ,  MCCLAIN JAMES B

IPC: B08B7/00 ,  C11D3/12 ,  C11D3/43 ,  C11D17/08 ,  D06F43/00 ,  D06F43/08

Abstract: A system for the controlled addition of detergent formulations and the like to a carbon dioxide cleaning apparatus comprises: (a) a high pressure wash vessel; (b) an auxiliary vessel; (c) a drain line connecting the auxiliary vessel to the wash vessel; (d) optionally but preferably, a separate vent line connecting the auxiliary vessel to the wash vessel; (e) a detergent reservoir; and (f) a detergent supply line connecting the detergent reservoir to the auxiliary vessel. An advantage of this apparatus is that, because the detergent formulation can be pumped into the auxiliary vessel in a predetermined aliquot or amount, which predetermined aliquot or amount can then be transferred into the wash vessel where it combines with the liquid carbon dioxide cleaning solution, the detergent formulation can be added to the cleaning solution in a more controlled or accurate manner. An alternate embodiment adapted for the addition of aqueous detergent formulations and the like to a carbon dioxide dry cleaning system under turbulent conditions comprises: (a) a high pressure wash vessel; (b) a filter; (c) a carbon dioxide cleaning solution drain line interconnecting the wash vessel to the filter; (d) a carbon dioxide cleaning solution supply line connecting the filter to the wash vessel; (e) a first high pressure pump (i.e., a pump that is capable of pumping liquid solutions comprising liquid carbon dioxide) operably connected to the drain line; (f) a detergent formulation reservoir; (g) a detergent formulation supply line connecting the reservoir to the carbon dioxide cleaning solution supply line; and (h) a second high pressure pump operably connected to the detergent formulation supply line for transferring detergent formulation from the detergent formulation reservoir into the carbon dioxide cleaning solution under turbulent conditions.

公开(公告)号：CA2301636A1

公开(公告)日：1999-03-04

申请号：CA2301636

申请日：1998-08-27

Applicant: MICELL TECHNOLOGIES INC

Inventor： CAUBLE DAVID F ,  ROMACK TIMOTHY J ,  MCCLAIN JAMES B

IPC: C11D3/04 ,  D06L1/00 ,  D06L1/02 ,  D06L1/04 ,  D06L1/12 ,  C11D1/00

Abstract: A method for dry-cleaning articles such as fabrics and clothing in carbon dioxide comprises contacting an article to be cleaned with a liquid dry cleaning composition for a time sufficient to clean the fabric. The liquid drycleaning composition comprises a mixture of carbon dioxide, water, a surfactant, and an organic co-solvent. After the contacting step, the article is separated from the liquid dry cleaning composition. The method is preferably carried out at ambient temperature. The surfactant is preferably one that does not contain a CO2-philic group. The organic co-solvent is preferably an alkane and has a flash point above 140 ~F.

公开(公告)号：WO2004070071A3

公开(公告)日：2004-11-11

申请号：PCT/US0338324

申请日：2003-12-02

Applicant: MICELL TECHNOLOGIES INC ,  DEYOUNG JAMES P ,  MCCLAIN JAMES B ,  GROSS STEPHEN M ,  TAYLOR DOUG ,  WAGNER MARK I ,  BRAINARD DAVID E

Inventor： DEYOUNG JAMES P ,  MCCLAIN JAMES B ,  GROSS STEPHEN M ,  TAYLOR DOUG ,  WAGNER MARK I ,  BRAINARD DAVID E

IPC: B05D1/18 ,  H01L21/00 ,  H01L21/02 ,  H01L21/285 ,  H01L21/288 ,  B05D1/00

CPC classification number: H01L21/283 ,  B05D1/18 ,  B05D2401/90 ,  H01L21/28556 ,  H01L21/288 ,  H01L21/67028 ,  H01L28/65

Abstract: A method of coating a substrate comprises the steps of: (a) providing a substrate in an enclosed vessel, the substrate having a surface portion; (b) at least partially filling the enclosed vessel with a first supercritical fluid so that said first supercritical fluid contacts the surface portion, with the first supercritical fluid carrying or containing a coating component; then (c) adding a separate compressed gas atmosphere to the reaction vessel so that a boundary is formed between the first supercritical fluid and the separate compressed gas atmosphere, said separate compressed gas atmosphere having a density less than said first supercritical fluid; and then (d) displacing said first supercritical fluid from said vessel by continuing adding said separate compressed gas atmosphere to said vessel so that said boundary moves across said surface portion and a thin film of coating component is deposited on said microelectronic substrate.

Abstract translation: 一种涂布基材的方法包括以下步骤：（a）在封闭容器中提供基材，基材具有表面部分; （b）用第一超临界流体至少部分地填充封闭容器，使得所述第一超临界流体接触表面部分，第一超临界流体携带或含有涂层组分; 然后（c）将单独的压缩气体气氛添加到反应容器中，使得在第一超临界流体和单独的压缩气体气氛之间形成边界，所述单独的压缩气体气氛的密度小于所述第一超临界流体的密度; 然后（d）通过继续将所述分开的压缩气体气氛加入所述容器，使所述边界移过所述表面部分，并将涂层组分的薄膜沉积在所述微电子基底上，从所述容器中置换所述第一超临界流体。

公开(公告)号：WO2010120552A3

公开(公告)日：2011-03-31

申请号：PCT/US2010029494

申请日：2010-03-31

Applicant: MICELL TECHNOLOGIES INC ,  TAYLOR DOUGLAS ,  MCCLAIN JAMES B

Inventor： TAYLOR DOUGLAS ,  MCCLAIN JAMES B

IPC: A61F2/82 ,  A61L27/04 ,  A61L27/34 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58

CPC classification number: A61L31/10 ,  A61F2/82 ,  A61F2210/0004 ,  A61F2250/0067 ,  A61L31/16 ,  C08L67/04

Abstract: Provided herein is a coated coronary stent, comprising: a. stent; b. a plurality of layers deposited on said stent to form said coronary stent; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.

Abstract translation: 本文提供了一种涂覆的冠状动脉支架，包括：a。 支架; 湾 沉积在所述支架上以形成所述冠状动脉支架的多个层; 其中所述层中的至少一层包含生物可吸收聚合物，并且所述层中的至少一层包含一种或多种活性剂; 其中至少部分活性剂为结晶形式。

公开(公告)号：WO2008052000A3

公开(公告)日：2008-06-26

申请号：PCT/US2007082275

申请日：2007-10-23

Applicant: MICELL TECHNOLOGIES INC ,  MCCLAIN JAMES B ,  TAYLOR DOUG ,  DICKINSON ED ,  WORM STEVE

Inventor： MCCLAIN JAMES B ,  TAYLOR DOUG ,  DICKINSON ED ,  WORM STEVE

IPC: B05D1/04

CPC classification number: B05B5/0533 ,  A61L31/10 ,  B05B5/082 ,  B05B13/0207 ,  B05C13/025

Abstract: A stent holder for mounting and electrically charging a stent during coating of the stent using dry particles, the particles comprising inert polymers, pharmaceutical or biological agents, is provided. An assembly for supporting and electrically charging a stent during the coating of the stent using dry particles, the particles comprising inert polymers, pharmaceutical or biological agents, is provided. A chamber for creating an electrical field around a stent and for supporting, electrically charging, and exposing the stent to dry particles, the particles comprising inert polymers, pharmaceutical or biological agents, is provided. A method for creating an electrical field around a stent and for supporting, electrically charging, and exposing the stent to dry particles comprising inert polymers, pharmaceutical or biological agents is provided.

Abstract translation: 提供了一种支架保持器，用于在使用干颗粒涂覆支架期间安装和充电支架，所述颗粒包含惰性聚合物，药物或生物制剂。 提供了在使用干颗粒涂覆支架期间支撑和给支架充电的组件，所述颗粒包含惰性聚合物，药物或生物制剂。 提供了用于在支架周围产生电场并用于支撑，充电和暴露支架以干燥颗粒的腔室，所述颗粒包含惰性聚合物，药物或生物制剂。 提供了用于在支架周围产生电场并用于支撑，充电和暴露支架以干燥包含惰性聚合物，药物或生物制剂的颗粒的方法。

公开(公告)号：WO0157303A9

公开(公告)日：2002-10-31

申请号：PCT/US0103545

申请日：2001-02-01

Applicant: MICELL TECHNOLOGIES INC ,  MCCLAIN JAMES B ,  ROMACK TIMOTHY J ,  DEYOUNG JAMES P ,  LIENHART R BRADLEY ,  DESIMONE JOSEPH M ,  HUGGINS KENNETH L

Inventor： MCCLAIN JAMES B ,  ROMACK TIMOTHY J ,  DEYOUNG JAMES P ,  LIENHART R BRADLEY ,  DESIMONE JOSEPH M ,  HUGGINS KENNETH L

IPC: D06L1/02 ,  D06L1/04 ,  D06L1/08 ,  D06L1/10

CPC classification number: D06L1/02

Abstract: The present invention provides a dry cleaning process that facilitates distribution of detergent and solvent and (optionally) facilitates recovery of cleaning by-products in conjunction with the cleaning of articles at a dry cleaning facility. The proces comprises the steps of: (a) receiving from a source a dry cleaning solvent at the dry cleaning facility, the solvent consisting essentially of carbon dioxide; (b) receiving a concentrated detergent formulation (preferably a liquid formulation) at the cleaning facility; (c) accepting from customers soiled articles to be cleaned at the cleaning facility; (d) mixing the dry cleaning solvent and the concentrated detergent formulation to provide a dry cleaning formulation comprised of from 30 or 40 to 99 percent by weight of carbon dioxide solvent; (e) cleaning the articles in a cleaning apparatus to produce cleaned articles; (f) at least periodically distilling the dry cleaning formulation to produce a still residue comprising surfactant and soil; and then (g) returning the cleaned articles to the customers. Optionally but preferably, the process further comprises the step of: (h) returning the still residue to a waste collector or reprocessor for suitable disposal.

Abstract translation: 本发明提供了一种便于洗涤剂和溶剂的分配的干洗方法，并且（任选地）便于在干洗设施处清洁物品的同时回收清洁副产物。 方法包括以下步骤：（a）在干洗设备处从干燥清洁设备处获得干洗溶剂，所述溶剂基本上由二氧化碳组成; （b）在清洁设施处接收浓缩洗涤剂配制剂（优选液体制剂）; （c）客户接受在清洁设施上清洁的污物; （d）混合干洗溶剂和浓缩洗涤剂配方以提供由30或40至99重量％的二氧化碳溶剂组成的干洗制剂; （e）清洁清洁设备中的物品以产生清洁物品; （f）至少定期蒸馏干洗制剂以产生包含表面活性剂和土壤的残余物; 然后（g）将清洁的物品送回顾客。 可选地，但优选地，该方法还包括以下步骤：（h）将残余物返回到废物收集器或再处理器以进行适当处置。

公开(公告)号：WO0231253A3

公开(公告)日：2002-08-01

申请号：PCT/US0131507

申请日：2001-10-10

Applicant: MICELL TECHNOLOGIES INC ,  WORM STEVE L ,  DEYOUNG JAMES P ,  MCCLAIN JAMES B ,  BRAINARD DAVID E

Inventor： WORM STEVE L ,  DEYOUNG JAMES P ,  MCCLAIN JAMES B ,  BRAINARD DAVID E

IPC: A23L27/10 ,  D06F43/00 ,  D06L1/08 ,  F17C1/00 ,  F17C5/00 ,  F17C7/00

CPC classification number: D06L1/08 ,  A23L27/11 ,  D06F43/00 ,  D06F43/081 ,  F17C1/00 ,  F17C1/005 ,  F17C5/00 ,  F17C7/00 ,  F17C2201/0109 ,  F17C2201/0171 ,  F17C2201/032 ,  F17C2201/035 ,  F17C2201/056 ,  F17C2203/0643 ,  F17C2205/0347 ,  F17C2205/0397 ,  F17C2221/013 ,  F17C2221/014 ,  F17C2221/017 ,  F17C2221/033 ,  F17C2221/035 ,  F17C2227/0157 ,  F17C2227/0383 ,  F17C2250/0408 ,  F17C2265/012 ,  F17C2270/02 ,  F17C2270/0518

Abstract: Processing systems employing one or more divided pressure vessels (653) are described. These systems may allow for multiple solvent baths each having a different chemical composition to be stored and/or processed in a single pressure vessel (653) while maintaining the different chemical compositions of the multiple solvent baths. Thus, such systems employing one or more divided pressure vessels (653) may provide the improved operational efficiency of a carbon dioxide based system having multiple solvent baths while decreasing the capital costs that may be associated with such systems.

Abstract translation: 描述了采用一个或多个分压的压力容器（653）的处理系统。 这些系统可以允许具有不同化学组成的多个溶剂浴在单个压力容器（653）中储存和/或加工，同时保持多个溶剂浴的不同化学组成。 因此，采用一个或多个分压的压力容器（653）的这种系统可以提供具有多个溶剂浴的具有二氧化碳的系统的改进的操作效率，同时减少可能与这种系统相关联的资本成本。

公开(公告)号：WO2012092504A2

公开(公告)日：2012-07-05

申请号：PCT/US2011067921

申请日：2011-12-29

Applicant: MICELL TECHNOLOGIES INC ,  MCCLAIN JAMES B ,  TAYLOR CHARLES DOUGLAS ,  ZANI BRETT G ,  KIORPES TIMOTHY CHARLES

Inventor： MCCLAIN JAMES B ,  TAYLOR CHARLES DOUGLAS ,  ZANI BRETT G ,  KIORPES TIMOTHY CHARLES

IPC: A61K9/00 ,  A61K31/436 ,  A61P37/06 ,  B05D7/00 ,  B82Y5/00

CPC classification number: B82Y5/00 ,  A61K31/436 ,  A61L29/085 ,  A61L29/143 ,  A61L29/16 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2300/624 ,  A61L2300/802 ,  A61L2400/12

Abstract: Devices, coatings, and methods therefore comprise a medical device for delivering nanoparticles of an active agent to a treatment site. A coating on the medical device comprises active agent nanoparticles, which delivers coating to the treatment site and releases active agent nanoparticles into the treatment site over at least one day. A coating may comprise a polymer, a surfactant, and the nanoparticles. The coating may be prepared by forming a nanoemulsion. A coating may comprise encapsulated active agent nanoparticles which comprise active agent nanoparticles encapsulated in a polymer. The coating may have a positive surface charge. The coating may deliver active agent nanoparticles into the treatment site over at least about one day. The coating may be formed of a surfactant and nanoparticles mixture. The active agent nanoparticles may be deposited on the medical device using electrostatic capture.

Abstract translation: 因此，装置，涂层和方法包括用于将活性剂的纳米颗粒递送到治疗部位的医疗装置。 医疗装置上的涂层包括活性剂纳米颗粒，其将涂层递送至治疗部位并在至少一天内将活性剂纳米颗粒释放到治疗部位。 涂层可以包括聚合物，表面活性剂和纳米颗粒。 可以通过形成纳米乳液来制备涂层。 涂层可以包含包封在聚合物中的活性剂纳米颗粒的包封的活性剂纳米颗粒。 涂层可能具有正表面电荷。 涂层可在至少约一天内将活性剂纳米颗粒递送至治疗部位。 涂层可以由表面活性剂和纳米颗粒混合物形成。 活性剂纳米颗粒可以使用静电捕获沉积在医疗装置上。

公开(公告)号：WO2012009684A3

公开(公告)日：2012-04-19

申请号：PCT/US2011044263

申请日：2011-07-15

Applicant: MICELL TECHNOLOGIES INC ,  MCCLAIN JAMES B ,  TAYLOR DOUGLAS ,  ZANI BRETT G ,  NEET JOHN ,  KIORPES TIMOTHY CHARLES

Inventor： MCCLAIN JAMES B ,  TAYLOR DOUGLAS ,  ZANI BRETT G ,  NEET JOHN ,  KIORPES TIMOTHY CHARLES

IPC: A61F2/06

CPC classification number: A61M25/10 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61M25/1011

Abstract: Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on the substrate, wherein the coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within the coating and on the substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of the medical device in the body of the subject a portion of the pharmaceutical agent and/or active biological agent is delivered at the intervention site along with at least a portion of the polymer and/or a at least a portion of the pharmaceutical carrying agents.

Abstract translation: 提供一种涂覆的可植入医疗装置，包括：基底; 以及涂层，其设置在所述基底上，其中所述涂层包含至少一种聚合物和至少一种治疗期望形态的药剂和/或至少一种活性生物剂和任选的一种或多种药物载体; 其中基本上所有的药剂和/或活性生物制剂都保留在涂层内和衬底上，直到可植入装置部署在受试者身体内部的介入部位，并且其中在将医疗装置部署在受试者的身体中时 一部分药剂和/或活性生物剂在干预部位与至少一部分聚合物和/或药物载体的至少一部分一起递送。

公开(公告)号：WO2010111232A3

公开(公告)日：2011-04-21

申请号：PCT/US2010028253

申请日：2010-03-23

Applicant: MICELL TECHNOLOGIES INC ,  NEET JOHN ,  TAYLOR DOUGLAS ,  MCCLAIN JAMES B

Inventor： NEET JOHN ,  TAYLOR DOUGLAS ,  MCCLAIN JAMES B

IPC: A61M37/00 ,  A61F2/06 ,  A61L27/34 ,  A61L27/54

CPC classification number: A61L31/16 ,  A61L27/16 ,  A61L27/34 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/602 ,  A61L2300/608 ,  A61L2300/63 ,  A61L2420/08 ,  A61M25/0045

Abstract: Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on said substrate, wherein said coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within said coating and on said substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of said medical device in the body of said subject a portion of said pharmaceutical agent and/or active biological agent is delivered at said intervention site along with at least a portion of said polymer and/or a at least a portion of said pharmaceutical carrying agents.

Abstract translation: 提供一种涂覆的可植入医疗装置，包括：基底; 以及设置在所述基底上的涂层，其中所述涂层包含至少一种聚合物和至少一种治疗上需要的形态和/或至少一种活性生物试剂和任选的一种或多种药物载体的药剂; 其中基本上所有的药剂和/或活性生物制剂都保留在所述涂层内和所述衬底上，直到所述可植入装置部署在受试者身体内部的介入部位，并且其中在将所述医疗装置部署在所述受试者的身体中时 所述药剂和/或活性生物剂的一部分与所述聚合物的至少一部分和/或所述药物载体的至少一部分在所述介入部位递送。