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公开(公告)号：WO2009145828A2
公开(公告)日：2009-12-03
申请号：PCT/US2009002003
申请日：2009-03-30
Applicant: PACIFIC BIOSCIENCES CALIFORNIA , BJORNSON KEITH , LEE HAROLD , KORLACH JONAS , TURNER STEPHEN , BIBILLO AREK , CHRISTIANS FRED , EMIG ROBIN , HE MOLLY , PARK INSIL , JIA LEI , FEDOROV ANDREI , LYLE JOHN
Inventor： BJORNSON KEITH , LEE HAROLD , KORLACH JONAS , TURNER STEPHEN , BIBILLO AREK , CHRISTIANS FRED , EMIG ROBIN , HE MOLLY , PARK INSIL , JIA LEI , FEDOROV ANDREI , LYLE JOHN
CPC classification number: C12Q1/6869 , C12Q1/6874 , C12Q2527/125 , C12Q2527/119 , C12Q2527/101 , C12Q2565/1015 , C12Q2527/137 , C12Q2521/101
Abstract: Compositions, kits, methods and systems for nucleotide sequencing comprising producing polymerase reactions that exhibit two kinetically observable steps within an observable phase of the polymerase reaction. Two slow step systems can be produced, for example, by selecting the appropriate polymerase enzyme, polymerase reaction conditions including cofactors, and polymerase reaction substrates including the primed template and nucleotides.
Abstract translation: 用于核苷酸测序的组合物，试剂盒，方法和系统，其包括产生聚合酶反应，其在聚合酶反应的可观察期内显示两个动力学可观察步骤。 可以通过例如选择合适的聚合酶，包括辅因子的聚合酶反应条件和包括引发的模板和核苷酸的聚合酶反应底物来产生两个缓慢的步骤系统。
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公开(公告)号：WO2009073201A2
公开(公告)日：2009-06-11
申请号：PCT/US2008013363
申请日：2008-12-03
Applicant: PACIFIC BIOSCIENCES CALIFORNIA , KORLACH JONAS , ROITMAN DANIEL , EID JOHN , OTTO GEOFF , HARDENBOL PAUL , FLUSBERG BENJAMIN
Inventor： KORLACH JONAS , ROITMAN DANIEL , EID JOHN , OTTO GEOFF , HARDENBOL PAUL , FLUSBERG BENJAMIN
IPC: G01N33/573 , G01N33/53
CPC classification number: G01N33/54373 , C12Q1/6874 , G01N33/542 , G01N33/54313 , G01N33/573 , G01N33/58 , G01N33/585 , C12Q2565/607 , C12Q2565/531 , C12Q2563/143 , C12Q2563/137
Abstract: Systems and methods of enhancing fluorescent labeling strategies as well as systems and methods of using non-fluorescent and/or non-optic labeling strategies, e.g., as with single molecule sequencing using ZMWs, are described.
Abstract translation: 描述了增强荧光标记策略的系统和方法以及使用非荧光和/或非光学标记策略的系统和方法，例如与使用ZMW的单分子测序一样。
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公开(公告)号：EP2425023A4
公开(公告)日：2012-10-17
申请号：EP10772361
申请日：2010-04-26
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： KORLACH JONAS , TURNER STEPHEN , SCHADT ERIC
CPC classification number: C12Q1/6869 , C12Q1/702 , C12Q2565/518 , C12Q2547/101
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公开(公告)号：WO2010144151A3
公开(公告)日：2011-05-12
申请号：PCT/US2010001692
申请日：2010-06-11
Applicant: PACIFIC BIOSCIENCES CALIFORNIA , FLUSBERG BENJAMIN , TURNER STEPHEN , KORLACH JONAS , SCHADT ERIC
Inventor： FLUSBERG BENJAMIN , TURNER STEPHEN , KORLACH JONAS , SCHADT ERIC
IPC: C12Q1/68
CPC classification number: G01N33/542 , G01N33/6818 , Y10T436/13 , Y10T436/143333
Abstract: The present invention is generally directed to compositions, methods, and systems for performing single-molecule, real-time analysis of analytical reactions in which protein synthesis is occurring. The ability to analyze such reactions provides an opportunity to study those reactions as well as to potentially identify factors and/or approaches for impacting such reactions, e.g., to either enhance, inhibit, or otherwise affect such reactions including, but not limited to, affecting the reaction rate, processivity, fidelity, duration, and the like.
Abstract translation: 本发明一般涉及用于进行蛋白质合成发生的分析反应的单分子实时分析的组合物，方法和系统。 分析这些反应的能力提供了研究这些反应的机会，并且潜在地鉴定影响这些反应的因素和/或方法，例如增强，抑制或以其他方式影响这些反应，包括但不限于影响 反应速度，持续性，持续时间等。
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公开(公告)号：WO2010059206A3
公开(公告)日：2010-08-05
申请号：PCT/US2009006177
申请日：2009-11-18
Applicant: PACIFIC BIOSCIENCES CALIFORNIA , KORLACH JONAS , WEGENER JEFFREY
Inventor： KORLACH JONAS , WEGENER JEFFREY
CPC classification number: C12Q1/6869 , C07H19/10 , C12Q1/6818 , C12Q1/6874 , G01N33/5308
Abstract: Nucleic acid compositions, methods of making and using such compositions that comprise modular functional groups that can be configured to provide desired functionality to different nucleotide types through a swappable and preferably non-covalent linkage component. Such compositions are useful in a variety of applications including nucleic acid analyses.
Abstract translation: 核酸组合物，制备和使用这样的组合物的方法，所述组合物包含模块化官能团，其可被配置为通过可交换且优选非共价连接组分为不同核苷酸类型提供所需功能。 这样的组合物可用于各种应用，包括核酸分析。
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Patent Agency Ranking
公开(公告)号：WO2007075987A3
公开(公告)日：2009-01-29
申请号：PCT/US2006048973
申请日：2006-12-21
Applicant: PACIFIC BIOSCIENCES CALIFORNIA , HANZEL DAVID , KORLACH JONAS , PELUSO PAUL , OTTO GEOFFREY , PHAM THANG , RANK DAVID , TURNER STEPHEN
Inventor： HANZEL DAVID , KORLACH JONAS , PELUSO PAUL , OTTO GEOFFREY , PHAM THANG , RANK DAVID , TURNER STEPHEN
CPC classification number: C12Q1/6837 , C07K2319/23 , C12N9/1252 , C12Q1/6844 , C12Q2521/101 , C12Q2565/531
Abstract: Active surface coupled polymerases, surfaces that include such polymerases, and methods of making and using surface-attached polymerases are provided.
Abstract translation: 提供活性表面偶联的聚合酶，包括这种聚合酶的表面，以及制备和使用表面连接的聚合酶的方法。
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公开(公告)号：WO2008121374A4
公开(公告)日：2009-01-15
申请号：PCT/US2008004148
申请日：2008-03-27
Applicant: PACIFIC BIOSCIENCES CALIFORNIA , KORLACH JONAS , SAMIEE KEVAN , TURNER STEPHEN W , FREUDENTHAL JAKE
Inventor： KORLACH JONAS , SAMIEE KEVAN , TURNER STEPHEN W , FREUDENTHAL JAKE
CPC classification number: G01N21/6452 , G01N21/648
Abstract: Composition, systems, apparatus and methods of enhancing fluorescent signals in biochemical are described. Metal particle proximity to enzymes that produce fluorescent products provide enhanced fluorescence of the product and plasmon resonance of the metal particle. Multi-labeled nucleotides enhance signal production. Reflectance of illumination light and emitted fluorescence increase signal strength for a given illumination light.
Abstract translation: 描述了增强生物化学荧光信号的组成，系统，装置和方法。 与产生荧光产物的酶接近的金属颗粒提供产物的增强的荧光和金属颗粒的等离子体共振。 多标记核苷酸增强信号产生。 照明光的反射和发出的荧光增加给定照明光的信号强度。
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38.发明申请ARTICLES HAVING LOCALIZED MOLECULES DISPOSED THEREON AND METHODS OF PRODUCING SAME 审中-公开具有本地化分子的制品及其生产方法
公开(公告)号：WO2007123763A3
公开(公告)日：2008-11-06
申请号：PCT/US2007008019
申请日：2007-03-29
Applicant: PACIFIC BIOSCIENCES CALIFORNIA , RANK DAVID R , WEGENER JEFFERY , KORLACH JONAS , ROITMAN DANIEL , XU YUE , LYLE JOHN , TURNER STEPHEN , PELUSO PAUL , OTTO GEOFF
Inventor： RANK DAVID R , WEGENER JEFFERY , KORLACH JONAS , ROITMAN DANIEL , XU YUE , LYLE JOHN , TURNER STEPHEN , PELUSO PAUL , OTTO GEOFF
CPC classification number: C12Q1/6874 , B01J19/0046 , B01J2219/00427 , B01J2219/0045 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00639 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B82Y20/00 , B82Y30/00 , C12Q1/6837 , Y10T29/49002 , C12Q2565/629 , C12Q2527/127
Abstract: Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate.
Abstract translation: 通过使用底物的元素来辅助活性化学基团在基底的所需区域中的定位来制备具有选定的活性化学区域的基底的方法。 所述方法可以包括用于沉积，去除，激活和/或去活衬底的选定区域中的化学基团的光学，化学和/或机械方法，以提供衬底的选择性活性区域。
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39.发明申请UNIFORM SURFACES FOR HYBRID MATERIAL SUBSTRATES AND METHODS FOR MAKING AND USING SAME 审中-公开混合材料基材的均匀表面及其制作和使用方法
公开(公告)号：WO2007064597A3
公开(公告)日：2007-10-04
申请号：PCT/US2006045429
申请日：2006-11-27
Applicant: PACIFIC BIOSCIENCES CALIFORNIA , KORLACH JONAS
Inventor： KORLACH JONAS
IPC: C23C16/00
CPC classification number: G01N21/0303 , B01J2219/00317 , B01J2219/00527 , B01J2219/00576 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00635 , B01J2219/00637 , B01J2219/00722 , B01L3/5088 , G01N21/6452 , G01N21/648 , G01N21/7703 , Y10T428/24942 , Y10T428/24967 , Y10T428/31612
Abstract: Devices, systems and methods of using same where hybrid substrate materials are provided with a substantially uniform surface to provide uniformity of properties, including interaction with their environments. Uniform surfaces are applied as coatings over, e.g., hybrid metal/silica, metal/polymer, metal/metal surfaces to mask different chemical properties of differing regions of the surface and to afford a protective surface for the hybrid structure.
Abstract translation: 在混合衬底材料被提供有基本均匀的表面以提供包括与其环境的相互作用的特性的均匀性的情况下使用其的设备，系统和方法。 均匀表面作为涂层施加在例如混合金属/二氧化硅，金属/聚合物，金属/金属表面上以覆盖表面的不同区域的不同化学性质并且为混合结构提供保护表面。
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公开(公告)号：EP1963530A4
公开(公告)日：2009-08-05
申请号：EP06848008
申请日：2006-12-21
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： HANZEL DAVID , KORLACH JONAS , PELUSO PAUL , OTTO GEOFFREY , PHAM THANG , RANK DAVID , TURNER STEPHEN
CPC classification number: C12Q1/6837 , C07K2319/23 , C12N9/1252 , C12Q1/6844 , C12Q2521/101 , C12Q2565/531
Abstract: Active surface coupled polymerases, surfaces that include such polymerases, and methods of making and using surface-attached polymerases are provided.
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