公开(公告)号：AT518010T

公开(公告)日：2011-08-15

申请号：AT06848008

申请日：2006-12-21

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： HANZEL DAVID ,  KORLACH JONAS ,  PELUSO PAUL ,  OTTO GEOFFREY ,  PHAM THANG ,  RANK DAVID ,  TURNER STEPHEN

IPC: C12Q1/68 ,  C12N11/14

Abstract: Active surface coupled polymerases, surfaces that include such polymerases, and methods of making and using surface-attached polymerases are provided.

公开(公告)号：CA2633476A1

公开(公告)日：2007-07-05

申请号：CA2633476

申请日：2006-12-21

Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC

Inventor： KORLACH JONAS ,  HANZEL DAVID ,  RANK DAVID ,  PHAM THANG ,  TURNER STEPHEN ,  PELUSO PAUL ,  OTTO GEOFFREY

IPC: C12Q1/68 ,  C12M3/00

Abstract: Active surface coupled polymerases, surfaces that include such polymerases, and methods of making and using surface-attached polymerases are provided.

公开(公告)号：CA2633476C

公开(公告)日：2015-04-21

申请号：CA2633476

申请日：2006-12-21

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： HANZEL DAVID ,  KORLACH JONAS ,  PELUSO PAUL ,  OTTO GEOFFREY ,  PHAM THANG ,  RANK DAVID ,  TURNER STEPHEN

IPC: C12N9/12 ,  C12N9/22 ,  C12N11/00 ,  C12P19/34 ,  C12Q1/68

Abstract: Active surface coupled polymerases, surfaces that include such polymerases, and methods of making and using surface-attached polymerases are provided.

公开(公告)号：AU2006331677A1

公开(公告)日：2007-07-05

申请号：AU2006331677

申请日：2006-12-21

Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC

Inventor： RANK DAVID ,  KORLACH JONAS ,  HANZEL DAVID ,  PHAM THANG ,  OTTO GEOFF ,  TURNER STEPHEN ,  PELUSO PAUL

IPC: C12N11/00 ,  C12N11/16 ,  G01N33/53

公开(公告)号：AU2006331512A1

公开(公告)日：2007-07-05

申请号：AU2006331512

申请日：2006-12-21

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： KORLACH JONAS ,  OTTO GEOFFREY ,  HANZEL DAVID ,  PELUSO PAUL ,  TURNER STEPHEN ,  RANK DAVID ,  PHAM THANG

IPC: C12Q1/68 ,  C12M3/00

Abstract: Active surface coupled polymerases, surfaces that include such polymerases, and methods of making and using surface-attached polymerases are provided.

公开(公告)号：ES2648313T3

公开(公告)日：2017-12-29

申请号：ES16157104

申请日：2006-12-21

Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC

Inventor： HANZEL DAVID ,  OTTO GEOFF ,  MURPHY DEVON ,  PELUSO PAUL ,  PHAM THANG ,  RANK DAVID ,  MITSIS PAUL ,  CHRISTIANS FRED ,  BIBILLO AREK ,  PARK INSIL ,  CLARK SONYA ,  LYLE JOHN

IPC: C12Q1/68

Abstract: Una composición que comprende: una ADN polimerasa recombinante, comprendiendo dicha polimerasa recombinante una secuencia de aminoácidos que es al menos un 70 % idéntica a la SEQ ID NO:1 y comprende una sustitución de aminoácido en un sitio correspondiente a K512 respecto a la SEQ ID NO:1; y un análogo nucleotídico que está marcado en un grupo fosfato, en el que el resto de base del análogo se selecciona del grupo que consiste en adenina, timina, guanina y citidina.

公开(公告)号：AT546522T

公开(公告)日：2012-03-15

申请号：AT07754529

申请日：2007-03-29

Applicant: PACIFIC BIOSCIENCES CALIFORNIA

Inventor： RANK DAVID ,  WEGENER JEFFERY ,  KORLACH JONAS ,  ROITMAN DANIEL ,  XU YUE ,  LYLE JOHN ,  TURNER STEPHEN ,  PELUSO PAUL ,  OTTO GEOFF ,  CICERO RONALD

IPC: C12N11/00 ,  C40B40/04

Abstract: Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate.

公开(公告)号：AU2006331512B2

公开(公告)日：2012-02-23

申请号：AU2006331512

申请日：2006-12-21

Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC

Inventor： KORLACH JONAS ,  OTTO GEOFFREY ,  HANZEL DAVID ,  PELUSO PAUL ,  TURNER STEPHEN ,  RANK DAVID ,  PHAM THANG

IPC: C12Q1/68 ,  C12N11/14

Abstract: Active surface coupled polymerases, surfaces that include such polymerases, and methods of making and using surface-attached polymerases are provided.

公开(公告)号：WO2007075987A3

公开(公告)日：2009-01-29

申请号：PCT/US2006048973

申请日：2006-12-21

Applicant: PACIFIC BIOSCIENCES CALIFORNIA ,  HANZEL DAVID ,  KORLACH JONAS ,  PELUSO PAUL ,  OTTO GEOFFREY ,  PHAM THANG ,  RANK DAVID ,  TURNER STEPHEN

Inventor： HANZEL DAVID ,  KORLACH JONAS ,  PELUSO PAUL ,  OTTO GEOFFREY ,  PHAM THANG ,  RANK DAVID ,  TURNER STEPHEN

IPC: C12Q1/68 ,  C12N11/14

CPC classification number: C12Q1/6837 ,  C07K2319/23 ,  C12N9/1252 ,  C12Q1/6844 ,  C12Q2521/101 ,  C12Q2565/531

Abstract: Active surface coupled polymerases, surfaces that include such polymerases, and methods of making and using surface-attached polymerases are provided.

Abstract translation: 提供活性表面偶联的聚合酶，包括这种聚合酶的表面，以及制备和使用表面连接的聚合酶的方法。

公开(公告)号：WO2010027497A3

公开(公告)日：2010-07-01

申请号：PCT/US2009005013

申请日：2009-09-03

Applicant: PACIFIC BIOSCIENCES CALIFORNIA ,  RANK DAVID ,  PELUSO PAUL STEPHEN

Inventor： RANK DAVID ,  PELUSO PAUL STEPHEN

IPC: C12Q1/68 ,  C12N15/10

CPC classification number: C12Q1/6869 ,  C12Q2565/537 ,  C12Q2535/122 ,  C12Q2535/101

Abstract: Preparations, compositions and methods of sequencing nucleic acids are provided. The preparations, methods and compositions employ multiple priming sites on a target nucleic acid and typically utilize single molecule sequencing processes to identify sequence portions of the target which are then assembled to obtain the sequence of the target.

Abstract translation: 提供了测序核酸的制备，组合物和方法。 制备，方法和组合物在靶核酸上采用多个引发位点，并且通常利用单分子测序过程来鉴定靶的序列部分，然后将其组装以获得靶序列。