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    AEDES AEGYPTI DENSOVIRUS EXPRESSION SYSTEM
    31.
    发明申请
    AEDES AEGYPTI DENSOVIRUS EXPRESSION SYSTEM 审中-公开
    AEDES AEGYPTI DENSOVIRUS表达系统

    公开(公告)号：WO1996014423A1

    公开(公告)日：1996-05-17

    申请号：PCT/US1995014170

    申请日：1995-11-01

    Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.

    Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC. ,  AFANASIEV, Boris, N. ,  CARLSON, Jonathan, O. ,  BEATY, Barry ,  HIGGINS, David, R. ,  THIBAULT, Kelly, J.

    IPC: C12N15/86

    CPC classification number: C12N15/86 ,  C12N2750/14043

    Abstract: The present invention is directed to use of Aedes aegypti densonucleosis virus (Aedes DNV or AeDNV) as a heterologous gene expression system. The invention described herein provides promoters from the Aedes aegypti genome such as the p.05, p7 and p61 promoters to generate expression vectors with cloning sites for insertion of heterologous genes. The invention further provides expression vectors comprising an AeDNV promoter operably linked to a heterologous gene and insect host cells comprising the vectors of the invention. Methods of producing recombinant proteins utilizing the vectors of the invention are also provided. The present invention further provides a kit containing the vectors of the invention for production of a recombinant protein.

    Abstract translation: 本发明涉及埃及伊蚊密集型核酸病毒（Aedes DNV或AeDNV）作为异源基因表达系统的用途。 本文描述的本发明提供了来自埃及伊蚊的基因组的启动子，例如p.05，p7和p61启动子，以产生具有用于插入异源基因的克隆位点的表达载体。 本发明还提供了包含可操作地连接到异源基因的AeDNV启动子和包含本发明载体的昆虫宿主细胞的表达载体。 还提供了利用本发明的载体生产重组蛋白的方法。 本发明还提供了含有用于产生重组蛋白的本发明载体的试剂盒。

    DETECTION AND PREVENTION OF MYCOPLASMA HOMINIS INFECTION
    33.
    发明申请
    DETECTION AND PREVENTION OF MYCOPLASMA HOMINIS INFECTION 审中-公开
    检测和预防MYCOPLASMA HOMINIS感染

    公开(公告)号：WO1995006123A1

    公开(公告)日：1995-03-02

    申请号：PCT/US1994009668

    申请日：1994-08-25

    Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.

    Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC. ,  DELVECCHIO, Vito, G. ,  GALLIA, Gary, L. ,  MCCLESKEY, Ferne, K.

    IPC: C12N15/31

    CPC classification number: C07K14/30 ,  A61K39/00 ,  C07K16/1253 ,  C12Q1/689

    Abstract: The present invention is directed to a rapid and sensitive method for detecting Mycoplasma hominis using M. hominis-specific probes, oligonucleotides or antibodies. In particular a target sequence can be amplified by in vitro nucleic acid amplification techniques, detected by nucleic acid hybridization using the subject probes and oligonucleotides or detected by immunoassay using M. hominis-specific antibodies. M. hominis-specific nucleic acids which do not recognize or hybridize to genomic nucleic acid of other Mycoplasma species are also provided.

    Abstract translation: 本发明涉及使用人源特异性探针，寡核苷酸或抗体检测人支原体的快速且灵敏的方法。 特别地，靶序列可以通过体外核酸扩增技术进行扩增，通过使用目标探针和寡核苷酸进行核酸杂交检测，或通过免疫测定法使用人源特异性抗体进行检测。 还提供了不识别或与其他支原体物种的基因组核酸杂交的人源特异性核酸。

    METHODS AND COMPOSITIONS FOR DELAYING OR PREVENTING THE ONSET OF AUTOIMMUNE DISEASE
    35.
    发明申请
    METHODS AND COMPOSITIONS FOR DELAYING OR PREVENTING THE ONSET OF AUTOIMMUNE DISEASE 审中-公开
    延迟或预防自发性疾病发作的方法和组合

    公开(公告)号：WO1994023737A1

    公开(公告)日：1994-10-27

    申请号：PCT/US1994004179

    申请日：1994-04-15

    Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.

    Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC. ,  MACLAREN, Noel, K. ,  MUIR, Andrew

    IPC: A61K37/02

    CPC classification number: A61K38/51 ,  A61K38/26 ,  A61K38/28 ,  A61K2300/00

    Abstract: The subject invention concerns compositions and methods useful for the prevention or amelioration of autoimmune diseases. Specifically exemplified are compositions and methods useful in immunizing to delay or prevent insulin dependent diabetes. In a preferred embodiment, diabetes is prevented or delayed by the parenteral administration of a composition comprising specific antigenic peptides of B-chain insulin and further comprising incomplete Freund's adjuvant. The specifically exemplified insulin B-chain composition stimulates the immune response, and depresses the synthesis of cytotoxic lymphokines in the target tissue.

    Abstract translation: 本发明涉及可用于预防或改善自身免疫疾病的组合物和方法。 具体示例的是用于免疫延迟或预防胰岛素依赖性糖尿病的组合物和方法。 在优选的实施方案中，通过胃肠外给药包含B链胰岛素的特异性抗原肽的组合物并进一步包含不完全弗氏佐剂来预防或延迟糖尿病。 具体示例的胰岛素B链组合物刺激免疫应答，并抑制靶组织中细胞毒性淋巴因子的合成。

    ULTRATHIN COMPOSITE MEMBRANES
    38.
    发明申请
    ULTRATHIN COMPOSITE MEMBRANES 审中-公开
    超薄复合膜

    公开(公告)号：WO1993025300A1

    公开(公告)日：1993-12-23

    申请号：PCT/US1993005384

    申请日：1993-06-07

    Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC. ,  MARTIN, Charles, R. ,  LIU, Chao

    Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC.

    IPC: B01D69/12

    CPC classification number: B01D69/125 ,  B01D69/02 ,  G01N27/40

    Abstract: The present invention relates to a method of forming defect-free ultrathin film composite membranes by the photochemical synthesis of an ultrathin polymer film on the surface of a microporous support membrane. In one particular embodiment, the method entails placing a support membrane on a filter paper which is saturated with a solution of the desired monomer(s). The solution then wicks to the top of the membrane, covering the surface with a thin solution film, where it is subjected to irradiation by ultraviolet (UV) light to initiate the polymerization of the ultrathin polymer film. The rate of polymerization can be enhanced by adding a photoinitiator to the gas phase above the membrane or into solution with the monomer or monomers to induce radical polymerization. The method results in a defect-free ultrathin composite membrane. In addition, to minimize photon penetration depth and confine the polymerization predominantly to the membrane surface, the incident at which the UV light strikes the membrane surface is kept at an acute angle. The ultrathin film composite membranes can be used in a vast number of chemical separation processes, bioreactors and sensors, energy conversion and drug delivery systems.

    Abstract translation: 本发明涉及通过微孔聚合物膜的光化学合成在微孔载体膜的表面上形成无缺陷的超薄膜复合膜的方法。 在一个具体实施方案中，该方法需要将支撑膜放置在用所需单体的溶液饱和的滤纸上。 然后将溶液吸到膜的顶部，用薄的溶液膜覆盖表面，在那里用紫外线（UV）光照射以引发超薄聚合物膜的聚合。 通过向膜上方的气相或与单体或单体的溶液中加入光引发剂以引发自由基聚合，可以提高聚合速率。 该方法产生无缺陷的超薄复合膜。 此外，为了使光子穿透深度最小化并将聚合主要限制在膜表面，UV光照射到膜表面的入射处被保持为锐角。 超薄膜复合膜可用于大量化学分离过程，生物反应器和传感器，能量转换和药物输送系统。

    PROCESS FOR THE HYDROGENATION OF ARYL PHOSPHINES AND PRODUCTS OBTTAINED THEREFROM
    40.
    发明申请
    PROCESS FOR THE HYDROGENATION OF ARYL PHOSPHINES AND PRODUCTS OBTTAINED THEREFROM 审中-公开
    芳烃磷酸氢盐加氢处理方法

    公开(公告)号：WO1993021192A1

    公开(公告)日：1993-10-28

    申请号：PCT/US1993003453

    申请日：1993-04-13

    Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC. ,  ROTHWELL, Ian, Paul ,  YU, S., Joyce

    Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC.

    IPC: C07F09/50

    CPC classification number: C08F8/04 ,  C07F9/5018 ,  C07F9/5027 ,  C07F9/5045 ,  C07F9/5054

    Abstract: A process for making a cycloalkyl phosphine comprising hydrogenating an aryl phosphine in the presence of an effective amount of an aryloxide of a metal selected from the group consisting of niobium and tantalum is disclosed. Cycloalkyl phosphine products of this process, useful as ligands in a complex of a transition metal which acts as a catalyst in the formation of stereoisomers, are also set forth. Furthermore, niobium or tantalum organometallic compounds, generated in this process, useful in the catalytic hydrogenation of aryl phosphines and arene-containing polymers, is also described.

    Abstract translation: 公开了一种制备环烷基膦的方法，包括在有效量的选自铌和钽的金属的芳氧化物存在下氢化芳基膦。 还阐述了该方法的环烷基膦产物，其可用作在形成立体异构体中起催化剂作用的过渡金属络合物中的配体。 此外，还描述了在该方法中产生的用于芳基膦和含芳烃聚合物的催化氢化的铌或钽有机金属化合物。

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