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公开(公告)号：BR112014017215B8
公开(公告)日：2022-02-22
申请号：BR112014017215
申请日：2013-01-11
Applicant: TORAY INDUSTRIES
Inventor： YAMADA KATSUSHIGE , SAWAI KENJI , KOBAYASHI KOJI , ISOBE KYOHEI , NA KYUNGSU , HIRAMATSU SHINGO , WATANABE SHIOMI
Abstract: método para produzir um produto químico a presente invenção se refere a um método para a produção de um produto químico com um rendimento elevado utilizando um açúcar misto de hexoses e pentoses como uma matéria prima de fermentação. a presente invenção também se refere a um método para a produção de um produto químico através da fermentação contínua, esse método compreende a filtração de um líquido de cultura de um microrganismo(s) através de uma membrana de separação, retendo o líquido não filtrado dentro, ou submetendo o líquido não filtrado ao refluxo para o líquido de cultura; adicionando uma matéria prima de fermentação para o líquido de cultura; e recuperando um produto no filtrado, em que o(s) microrganismo(s) é/são um microrganismo(s) que sofre(m) a repressão catabólica, e a matéria prima da fermentação compreende as hexoses e pentoses.
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公开(公告)号：ES2837800T3
公开(公告)日：2021-07-01
申请号：ES13735747
申请日：2013-01-11
Applicant: TORAY INDUSTRIES
Inventor： KOBAYASHI KOJI , WATANABE SHIOMI , ISOBE KYOHEI , SAWAI KENJI , NA KYUNGSU , HIRAMATSU SHINGO , YAMADA KATSUSHIGE
Abstract: Procedimiento para producir un producto químico mediante fermentación continua, comprendiendo dicho procedimiento filtrar un líquido de cultivo de uno o más microorganismos a través de una membrana de separación; retener el líquido no filtrado en el líquido de cultivo o someter a reflujo el líquido no filtrado en el líquido de cultivo; añadir una materia prima de fermentación al líquido de cultivo; y recuperar un producto en el filtrado, en el que dicho microorganismo o microorganismos son uno o más microorganismos que metabolizan hexosa y pentosa y experimentan represión catabólica, y cuyo consumo de pentosa se suprime cuando la fermentación se lleva a cabo con una materia prima de fermentación que comprende un azúcar mixto que contiene hexosa y pentosa, dicha materia prima de fermentación comprende hexosa y pentosa, la proporción en peso entre la hexosa y la pentosa contenidas en dicha materia prima de fermentación es de 1:9 a 9:1, la concentración de la fuente de carbono es de 20 a 300 g/l, la concentración de dicha pentosa en una cantidad total de dicho filtrado no es superior a 5 g/l, y el producto es (i) un alcohol seleccionado del grupo que consiste en etanol, 1,3-propanodiol, 1,3-butanodiol, 2,3- butanodiol, 1,4-butanodiol, glicerol, butanol, isobutanol, 2-butanol e isopropanol, (ii) un ácido orgánico seleccionado del grupo que consiste en ácido acético, ácido láctico, ácido adípico, ácido pirúvico, ácido succínico, ácido málico, ácido itacónico y ácido cítrico, o (iii) un aminoácido.
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公开(公告)号：AU2019329357A1
公开(公告)日：2021-03-18
申请号：AU2019329357
申请日：2019-08-28
Applicant: TORAY INDUSTRIES
Inventor： KAGAWA YUSUKE , SAITO HARUKA , HIRAMATSU SHINGO , YAMADA KATSUSHIGE
Abstract: The present invention is a mutant strain of Trichoderma reesei in which the function of a polypeptide comprising an amino acid sequence represented by any of SEQ ID NOS: 4-6 is deleted or decreased, and a method for producing a high level of protein by culturing the mutant strain in medium containing lactose.
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公开(公告)号：CA3019297A1
公开(公告)日：2017-10-05
申请号：CA3019297
申请日：2017-03-30
Applicant: TORAY INDUSTRIES
Inventor： KOBAYASHI KOJI , HIRAMATSU SHINGO , YAMADA KATSUSHIGE
Abstract: Disclosed is a method for producing protein by filamentous fungi with which it is possible to suppress a decrease in the degree of dissolved oxygen saturation during culturing, even when the culturing of filamentous fungi is scaled up. This method for producing protein comprises culturing a BXL1-gene-disrupted Trichoderma fungus by employing, as an inducer, a biomass including cellulose and xylan. By using a BXL1-gene-disrupted Trichoderma fungus, it is possible to suppress a decrease in the degree of dissolved oxygen saturation, even when xylose and cellulose are employed as an inducer.
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公开(公告)号：AU2013208441B2
公开(公告)日：2016-12-01
申请号：AU2013208441
申请日：2013-01-11
Applicant: TORAY INDUSTRIES
Inventor： ISOBE KYOHEI , WATANABE SHIOMI , KOBAYASHI KOJI , SAWAI KENJI , NA KYUNGSU , HIRAMATSU SHINGO , YAMADA KATSUSHIGE
Abstract: [Problem] To provide a method for producing a chemical substance with high yield using a mixed sugar composed of a hexose and a pentose as a fermentation raw material. [Solution] Provided is a method for producing a chemical substance through continuous fermentation, said method comprising filtrating a culture solution of a microorganism using a separation membrane, retaining an unfiltered portion of the culture solution in the culture solution or refluxing the unfiltered portion through the culture solution, adding a new fermentation raw material to the culture solution and collecting a product from the culture solution, wherein the fermentation raw material comprises a pentose and a hexose and the microorganism has a pathway through which a pentose can be metabolized with a pentose isomerase.
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Patent Agency Ranking
公开(公告)号：CA2713532A1
公开(公告)日：2009-08-06
申请号：CA2713532
申请日：2009-01-27
Applicant: TORAY INDUSTRIES
Inventor： ISHII KENTARO , HIGASA MASASHI , HIRAMATSU SHINGO
Abstract: Disclosed is a separating chip for separating an insoluble component from a suspension by using a rotating centrifugal force. The separating chip comprises a suspension holding bath, a separated liquid holding bath and an insoluble component holding bath, which are arranged sequentially in the recited order from the inner circumference side at the rotating time. The separating chip is constituted such that the suspension holding bath and the insoluble component holding bath are connected, such that the insoluble component holding bath and the separated liquid holding bath are connected by a narrow portion, and such that the portion of the insoluble component holding bath, as connected to the suspension holding bath, is positioned closer to the outer circumference side than the narrow portion.
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公开(公告)号：CA2706402A1
公开(公告)日：2009-05-28
申请号：CA2706402
申请日：2008-11-20
Applicant: TORAY INDUSTRIES
Inventor： ISHII KENTARO , HIGASA MASASHI , HIRAMATSU SHINGO
Abstract: This aims to provide a liquid-feeding chip for feeding a liquid by rotating the chip on an axis of rotation thereby to utilize the actions of a centrifugal force and a gravitational force. The liquid-feeding chip comprises a first liquid-reserving bath (1-1) capable of introducing the liquid at a chip-rotation stopping time, and at least two liquid-feeding units (U-1, U-2 and U-3) individually including first holding baths (10-1, 20-1 and 30-1), second holding baths (10-2, 20-2 and 30-2) positioned in the gravitational direction of the first holding baths, and passages B (B-1, B-2 and B-3) extending in the gravitational direction from the first holding baths for providing the communications between the first holding baths and the second holding baths and arranged adjacently to each other in multiple stages such that the first holding bath of the first stage is connected to a passage A (A-1) extending from the first liquid-reserving bath to the outer circumference. The adjacent liquid-feeding units are connected by passages C (C-1 and C-2) extending from the second holding bath of the liquid-feeding unit of the upper stage to the outer circumference of the rotations and communicating with the first holding baths of the liquid-feeding unit of the lower stage.
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38.发明专利
公开(公告)号：AU2003211765A1
公开(公告)日：2003-09-16
申请号：AU2003211765
申请日：2003-03-06
Applicant: TORAY INDUSTRIES , NAT INST OF AGROBIO SCIENCES
Inventor： HIRAMATSU SHINGO , TANAKA TAKASHI , YAMADA KATSUSHIGE , TAMURA TOSHIKI
Abstract: Producing (M1) a recombinant protein comprising inserting the gene for the protein placed downstream of a promoter of silkworm origin into the genome of silkworms, the silk threads or cocoons of the silkworms (containing the protein), harvesting and recovering the recombinant protein from the thread or cocoons, is new. Independent claims are also included for (1) transformed silkworms for use in (M1); (2) vectors for introduction of the foreign gene into the silkworm genome; (3) producing the foreign protein by culture of transformed silkworm cells; and (4) silk containing the foreign protein.
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公开(公告)号：EP2803731A4
公开(公告)日：2015-08-26
申请号：EP13736377
申请日：2013-01-11
Applicant: TORAY INDUSTRIES
Inventor： ISOBE KYOHEI , WATANABE SHIOMI , KOBAYASHI KOJI , SAWAI KENJI , NA KYUNGSU , HIRAMATSU SHINGO , YAMADA KATSUSHIGE
Abstract: [PROBLEMS] To provide a method for producing a chemical product with a high yield using a mixed sugar of hexose and pentose as a fermentation feedstock. [MEANS FOR SOLUTION] A method for producing a chemical product by continuous fermentation, which method comprises filtering a culture liquid of a microorganism(s) through a separation membrane; retaining unfiltered liquid in, or refluxing unfiltered liquid to, the culture liquid; adding a fermentation feedstock to the culture liquid; and recovering a product in the filtrate, wherein the fermentation feedstock contains pentose and hexose, and wherein the microorganism(s) has/have a pathway in which pentose isomerase is used to metabolize pentose, was provided.
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公开(公告)号：JP2004254681A
公开(公告)日：2004-09-16
申请号：JP2003310426
申请日：2003-09-02
Applicant: NAT INST OF AGROBIO SCIENCES , TORAY INDUSTRIES
Inventor： TAMURA TOSHIKI , YAMADA MASANARI , HIRAMATSU SHINGO , TANAKA TAKASHI
IPC: A01K67/033 , C07K14/435 , C07K19/00 , C12N5/10 , C12N15/09 , C12P21/02
Abstract: PROBLEM TO BE SOLVED: To obtain a gene engineering material for easily purifying an objective protein without requiring use of recombinant baculovirus, and provide a method for producing a foreign protein by using the gene engineering material. SOLUTION: A large amount of the foreign protein is produced in silk gland cells, outside of silk gland cells or brought to produce silk by introducing an expression gene cassette prepared by fusing a DNA sequence of 5' terminal and a DNA sequence of 3' terminal of fibroin H chain gene with a foreign protein gene. By the new method, foreign protein easily purified is produced using the silk gland without using the recombinant baclovirus, and a technique for producing the foreign protein is established. COPYRIGHT: (C)2004,JPO&NCIPI
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