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公开(公告)号:CA3108045A1
公开(公告)日:2020-02-06
申请号:CA3108045
申请日:2019-07-29
Applicant: TORAY INDUSTRIES
Inventor: KAGAWA YUSUKE , HIRAMATSU SHINGO , YAMADA KATSUSHIGE
Abstract: The present invention relates to: a mutant of a trichoderma filamentous fungus having a mutation that results in lost or lowered function of a beta-adaptin large subunit, or a mutation in an amino acid sequence that forms the beta-adaptin large subunit; and a method for producing a protein while maintaining a low viscosity in a culture solution during culturing by using the mutant.
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公开(公告)号:PH12018502082A1
公开(公告)日:2019-07-08
申请号:PH12018502082
申请日:2018-09-27
Applicant: TORAY INDUSTRIES
Inventor: KOBAYASHI KOJI , HIRAMATSU SHINGO , YAMADA KATSUSHIGE
Abstract: Disclosed is a method for producing protein by filamentous fungi with which it is possible to suppress a decrease in the degree of dissolved oxygen saturation during culturing, even when the culturing of filamentous fungi is scaled up. This method for producing protein comprises culturing a BXL1-gene-disrupted Trichoderma fungus by employing, as an inducer, a biomass including cellulose and xylan. By using a BXL1-gene-disrupted Trichoderma fungus, it is possible to suppress a decrease in the degree of dissolved oxygen saturation, even when xylose and cellulose are employed as an inducer.
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公开(公告)号:BRPI0905683A2
公开(公告)日:2015-07-07
申请号:BRPI0905683
申请日:2009-01-27
Applicant: TORAY INDUSTRIES
Inventor: ISHII KENTARO , HIGASA MASASHI , HIRAMATSU SHINGO
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公开(公告)号:AU2013208441A1
公开(公告)日:2014-08-21
申请号:AU2013208441
申请日:2013-01-11
Applicant: TORAY INDUSTRIES
Inventor: ISOBE KYOHEI , WATANABE SHIOMI , KOBAYASHI KOJI , SAWAI KENJI , NA KYUNGSU , HIRAMATSU SHINGO , YAMADA KATSUSHIGE
Abstract: [Problem] To provide a method for producing a chemical substance with high yield using a mixed sugar composed of a hexose and a pentose as a fermentation raw material. [Solution] Provided is a method for producing a chemical substance through continuous fermentation, said method comprising filtrating a culture solution of a microorganism using a separation membrane, retaining an unfiltered portion of the culture solution in the culture solution or refluxing the unfiltered portion through the culture solution, adding a new fermentation raw material to the culture solution and collecting a product from the culture solution, wherein the fermentation raw material comprises a pentose and a hexose and the microorganism has a pathway through which a pentose can be metabolized with a pentose isomerase.
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公开(公告)号:AU2019242425A1
公开(公告)日:2020-10-15
申请号:AU2019242425
申请日:2019-03-25
Applicant: TORAY INDUSTRIES
Inventor: KAGAWA YUSUKE , SAITO HARUKA , HIRAMATSU SHINGO , YAMADA KATSUSHIGE
Abstract: The present invention relates to: a Trichoderma reesei mutant wherein a polypeptide comprising an amino acid sequence represented by SEQ ID NO:2 has a reduced function; and a method for enhanced production of a protein using the mutant.
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公开(公告)号:CA3111169A1
公开(公告)日:2020-03-05
申请号:CA3111169
申请日:2019-08-28
Applicant: TORAY INDUSTRIES
Inventor: KAGAWA YUSUKE , HIRAMATSU SHINGO , YAMADA KATSUSHIGE
Abstract: The present invention provides: a Trichoderma reesei mutant strain having such a mutation that the function of a polypeptide comprising the amino acid sequence represented by SEQ ID NO: 2 is lost or decreased; and a method for the high-throughput production of a protein, comprising culturing the mutant strain.
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公开(公告)号:AU2017239832A1
公开(公告)日:2018-10-25
申请号:AU2017239832
申请日:2017-03-30
Applicant: TORAY INDUSTRIES
Inventor: KOBAYASHI KOJI , HIRAMATSU SHINGO , YAMADA KATSUSHIGE
Abstract: Disclosed is a method for producing protein by filamentous fungi with which it is possible to suppress a decrease in the degree of dissolved oxygen saturation during culturing, even when the culturing of filamentous fungi is scaled up. This method for producing protein comprises culturing a BXL1-gene-disrupted Trichoderma fungus by employing, as an inducer, a biomass including cellulose and xylan. By using a BXL1-gene-disrupted Trichoderma fungus, it is possible to suppress a decrease in the degree of dissolved oxygen saturation, even when xylose and cellulose are employed as an inducer.
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公开(公告)号:AU2013208440B2
公开(公告)日:2016-12-01
申请号:AU2013208440
申请日:2013-01-11
Applicant: TORAY INDUSTRIES
Inventor: WATANABE SHIOMI , KOBAYASHI KOJI , ISOBE KYOHEI , SAWAI KENJI , NA KYUNGSU , HIRAMATSU SHINGO , YAMADA KATSUSHIGE
Abstract: [Problem] To provide a method for producing a chemical substance with high yield using a mixed sugar composed of a hexose and a pentose as a fermentation raw material. [Solution] Provided is a method for producing a chemical substance through continuous fermentation, said method comprising filtrating a culture solution of a microorganism using a separation membrane, retaining an unfiltered portion of the culture solution in the culture solution or refluxing the unfiltered portion through the culture solution, adding a new fermentation raw material to the culture solution and collecting a product from the culture solution, wherein the fermentation raw material comprises a pentose and a hexose and the microorganism has a pathway through which a pentose can be metabolized with a pentose reductase and a pentol dehydrogenase.
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公开(公告)号:CA2706402C
公开(公告)日:2016-05-03
申请号:CA2706402
申请日:2008-11-20
Applicant: TORAY INDUSTRIES
Inventor: ISHII KENTARO , HIGASA MASASHI , HIRAMATSU SHINGO
Abstract: A liquid-feeding chip for feeding a liquid utilizing the action of centrifugal force and gravity by rotating the chip around an axis of rotation, includes a first storage tank (1-1) into which the liquid can be introduced when rotation of the chip is stopped, and two or more liquid-feeding units arranged in a plurality of levels adjacent to each other, each liquid-feeding unit (U-1, U-2, U-3) being composed of a first holding tank (10-1, 20-1, 30-1), a second holding tank (10-2, 20-2, 30-2) positioned in the direction of gravity with respect to the first holding tank, and a channel B(B-1, B-2, B-3) which extends from the first holding tank in the direction of gravity and which connects the first holding tank and the second holding tank, the first holding tank at a first level being connected with a channel A(A-1) which extends from the first storage tank toward an outer circumferential side. In the liquid-feeding chip, the adjacent liquid-feeding units are connected by a channel C (C-1, C-2) which extends from the second holding tank of the liquid-feeding unit at an upper level to an outer circumferential side during rotation, and which is in communication with the first holding tank of the liquid-feeding unit at a lower level.
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公开(公告)号:BRPI0818988A2
公开(公告)日:2015-05-05
申请号:BRPI0818988
申请日:2008-11-20
Applicant: TORAY INDUSTRIES
Inventor: ISHII KENTARO , HIGASA MASASHI , HIRAMATSU SHINGO
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