公开(公告)号：JPS6062991A

公开(公告)日：1985-04-11

申请号：JP16904283

申请日：1983-09-13

Applicant: TORAY INDUSTRIES

Inventor： IMAMURA SHINZOU ,  TANAKA NORIKO ,  MIYATA REIKO

IPC: C12P13/04 ,  C12P41/00 ,  C12R1/01 ,  C12R1/37 ,  C12R1/72

Abstract: PURPOSE:To collect a converted L-amino acid in high yield, by treating an L- acyl-DL-amino acid with acylase produced by a fungus belonging to the genus Cryptococcus. CONSTITUTION:A fungus capable of producing acylase, belonging to the genus Cryptococcus, Candida, Trichosporon, is cultivated in a liquid medium. This cultivation is usually carried out by aerated spinner culture at 30-35 deg.C at 6- 8pH. The culture is directly used as an enzyme source, or a culture such as a cell-free extracted solution obtained by grinding the separated mold or mold, or separated acylase is used as the enzyme source. Namely, this acylase is made to act on an N-acyl-DL-amino acid at 30-35 deg.C at 6.0-7.0pH, it is asymmetrically hydrolyzed, to give an L-amino acid (e.g., L-methionine). In the asymmetric hydrolysis, the presence of a metal ion such as Co ion in the reaction solution promotes the reaction, and the reaction can be completed in 3-20hr.

公开(公告)号：JPS58150552A

公开(公告)日：1983-09-07

申请号：JP3228982

申请日：1982-03-03

Applicant: TORAY INDUSTRIES

Inventor： SATOU HARUYO ,  IMAMURA SHINZOU

IPC: C07C255/61 ,  C07C67/00 ,  C07C241/00 ,  C07C251/24 ,  C07C253/00

Abstract: NEW MATERIAL:The compound of formulaI(R is alkoxycarbonyl or cyano). EXAMPLE:4-Ethoxycarbonyl-4-(diphenylmethylene)aminobutanal. USE:Useful as a synthetic intermediate of amino acids. It can be prepared with simple operation in high yield. PROCESS:The compound of formulaIcan be prepared by reacting the Schiff base of formula II e.g. N-(diphenylmethylene)glycine methyl ester, etc. when R is alkoxycarbonyl, and N -(diphenylmethylene)-glycinonitrile, etc. when R is cyano with acrolein preferably in a uniform solvent system in the presence of a base (e.g. potassium hydroxide) at

公开(公告)号：JPS57197266A

公开(公告)日：1982-12-03

申请号：JP8157381

申请日：1981-05-28

Applicant: TORAY INDUSTRIES

Inventor： SATOU HARUYO ,  IMAMURA SHINZOU

IPC: C07D211/88

Abstract: PURPOSE:N-(Diphenylmethylene)glutamic diester is cyclized in the presence of ammonia and the product is hydrolyzed in the presence of an acid to produce the titled compound used as an intermediate of drugs under mild conditions in high yield. CONSTITUTION:The cyclization of N-(diphenylmethylene)glutamic diester, which is prepared in high yield by reaction between N-(diphenylmethylene)glycine ester and acrylic ester in the presence of a base, is effected in the presence of ammonia to give 2-(diphenylmethyleneamino)glutarimide of formulaII. Then, the product is hydrolyzed in the presence of an acid to give 2-aminoglutarimide. EFFECT:The process is simplified. Further, by-products can be reused as starting substances.

公开(公告)号：JPS57193433A

公开(公告)日：1982-11-27

申请号：JP7724581

申请日：1981-05-21

Applicant: TORAY INDUSTRIES

Inventor： SATOU HARUYO ,  IMAMURA SHINZOU

IPC: C07C231/02 ,  C07C67/00 ,  C07C231/00 ,  C07C231/12 ,  C07C237/06

Abstract: PURPOSE:The reaction of N-(diphenylmethylene)glycine ester, which is readily available in industry, with acrylamide gives a very specific glutamine ester and hydrolysis follows the above reaction to give the titled compound simply in high yield. CONSTITUTION:The reaction of an N-(diphenylmethylene)glycine ester of formulaI(R is 1-4C alkyl) with acrylamide gives an N-(diphenylmethylene) glutamine ester of formula II. Then, the product is hydrolyzed in the presence of a base to produce a glutamine derivative of formula III. Further, the derivative is hydrolyzed in the presence of an acid. EFFECT:The by-product is used as a starting material again.

公开(公告)号：JPS5524122A

公开(公告)日：1980-02-21

申请号：JP9664578

申请日：1978-08-10

Applicant: TORAY INDUSTRIES

Inventor： SATOU HARUYO ,  IMAMURA SHINZOU

IPC: C07D223/12

Abstract: NEW MATERIAL:An alpha-(3-methacryloxy-2-hydroxy-propylamino)-epsilon-caprolactam of formula I, and an alpha-[bis(3-methacryloxy-2-hydroxypropyl)-amino]-epsilon-caprolactam of formula II. USE:Pesticides, raw materials for polymers, curing accelerators for epoxy resins, and intermediates for them and other compounds. PROCESS:alpha-Amino-epsilon-caprolactam is reacted with glycidyl methacrylate in a reaction solvent, e.g. an alcohol, alkyl halide, or glycidyl methacrylate itself, at room temperature to 80 deg.C to give the objective compound of formula I or II. If the temperature is low, the one-mole adduct is formed. If the temperature is high, the two-mole adduct is formed. Too high temperature causes gelation.

公开(公告)号：JPS5520744A

公开(公告)日：1980-02-14

申请号：JP9405678

申请日：1978-08-01

Applicant: TORAY INDUSTRIES

Inventor： SATOU HARUYO ,  IMAMURA SHINZOU

IPC: C07D223/12

Abstract: NEW MATERIAL:alpha-Substituted amino-epsilon-caprolactams of formula I [R1 is -CH2- CH(OH)-CH2Cl; R2 is H, -CH2-CH(OH)-CH2Cl]. EXAMPLE:alpha-(3-Chloro-2-hydroxypropylamino)-epsilon-caprolactam. USE:Agricultural chemicals, raw material of polymers, epoxy curing accelerator, or their intermediate or intermediate of other compounds. PREPARATION:alpha-Amino-epsilon-caprolactam of formula II resulting from Beckmann rearrangement of alpha-aminocyclohexanone oxime is made to react with epichlorohydrin of formula III in a solvent of ether at room temperature -100 deg.C to give the compound of formula I. The reaction at low temperatures gives monosubstituted product whereas at high temperatures disubstituted product in high selectivity.

公开(公告)号：JPS54106472A

公开(公告)日：1979-08-21

申请号：JP1147278

申请日：1978-02-06

Applicant: TORAY INDUSTRIES

Inventor： SHIBAHARA TERUROU ,  FURUYA MASAAKI ,  IMAMURA SHINZOU

IPC: C07D235/28

Abstract: PURPOSE:To obtain the title compound which is an intermediate for medicines in simple procedures in high yield, by treating a specific compound, readily prepared through addition reaction between 2-amino-cyclohexanone oxime and a thioisocyanate, with an acidic substance. CONSTITUTION:A N-(2-hydroxyimino-cyclohexyl)-thiourea of formula I: (R is alkyl, allyl, or aralkyl group) is brought into contact with an acidic substance, e.g. hydrogen chloride, hydrogen bromide, sulfuric or benzenesulfonic acid, at 0- 150 deg.C, preferably 10-100 deg.C to give the objective compound of formula II. The thiourea of formula I is obtained by addition reaction of 2-amino-cyclohexanone oxime with a thiocyanate of formula IV according to the well-known method. Preferably, the amount of the acidic substance is 0.01 mole or more per mole of the compound of formula I.

公开(公告)号：JPS54103748A

公开(公告)日：1979-08-15

申请号：JP1080678

申请日：1978-02-02

Applicant: TORAY INDUSTRIES

Inventor： SUGII KENJI ,  IMAMURA SHINZOU ,  FURUYA MASAAKI

IPC: C23C18/40

Abstract: PURPOSE:To produce a Cu film excellent in the adhesivity, luster, and color tone with addition of specified imidazole compound to the acid solution in non-electrolytic Cu plating on the iron surface using the acid solution containing Cu ion. CONSTITUTION:With an iron immersed into an acid solution containing CuSO4 or the like in an amount of 0.05 to 8 g/1, preferably 0.1 to 5 g/l, a non-electrolytic Cu plating is applied to the Fe surface under the following condition: Imidazole compound (i.g. 2-mercapto-4, 5, 6, 7-tetrahydrobenzoimidazole and 2-mercaptobenzoimidazole) as shown by the formula I (R represents alkyl group excluding H and C4) and the formula II is allowed to be present at a rate of 0.03 to 0.1 mol per mol of Cu and a plating is performed at a bath temperature of 40 to 80 deg.C for 0.5 to 30 minutes.

公开(公告)号：JPS5412346A

公开(公告)日：1979-01-30

申请号：JP7549777

申请日：1977-06-27

Applicant: TORAY INDUSTRIES

Inventor： IMAMURA SHINZOU ,  MATSUKUMA YOSHIHISA

IPC: C07C251/44 ,  C07C251/46

Abstract: PURPOSE:To obtain the title compound, which is an intermediate for preparing lysine, from alpha-aminocyclohexanone oxime and ammonium chloride in a high yield, economically and continuously, by using an aqueous solution of a specific compound as a solvent.

公开(公告)号：JPS615793A

公开(公告)日：1986-01-11

申请号：JP12520584

申请日：1984-06-20

Applicant: TORAY INDUSTRIES

Inventor： MIYATA AKIRA ,  IMAMURA SHINZOU ,  OONO AKIRA

IPC: C12P13/20 ,  C12R1/645 ,  C12R1/72

Abstract: PURPOSE:In the biochemical production of the titled substance from DL-aspartic acid by action of a microorganism, a microorganism in Cryptococcus or Candida is brought into contact with substrates to give the titled substance of high purity. CONSTITUTION:A microorganism in Cryptococcus, Candida, Tricosporon and being capable of convering L-aspartic acid into an organic acid selected from hydroxycarboxylic acids and aliphatic carboxylic acids is used. In the presence of the microorganism or its processed product, DL-aspartic acid and/or its salt is subjected to the reaction and the unreacting D-aspartic acid is separated by treatment with ion-exchange resin or direct crystallization.