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    DIBENZOCYCLOHEPTENE COMPOUND
    34.
    发明公开
    DIBENZOCYCLOHEPTENE COMPOUND 审中-公开
    DIBENZOCYCLOHEPTENVERBINDUNG

    公开(公告)号：EP1408033A4

    公开(公告)日：2004-11-24

    申请号：EP02738813

    申请日：2002-06-27

    Applicant: UBE INDUSTRIES

    Inventor： KUROKI YOSHIAKI ,  UENO HITOSHI ,  KATSUBE TETSUSHI ,  KAWAGUCHI TETSUO ,  OKANARI EIJI ,  TANAKA ICHIRO ,  TANAKA MASAYUKI ,  HAGIHARA MASAHIKO

    IPC: A61P11/06 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07D215/12 ,  C07D215/18 ,  C07D215/14 ,  A61K31/47

    CPC classification number: C07D215/18 ,  C07D215/12

    Abstract: A dibenzocycloheptene compound represented by the general formula (I): (I) (wherein R1 represents hydrogen, halogeno, etc.; R2 represents hydrogen, halogeno, etc.; A represents, e.g., a 5- or 6-membered heterocyclic aromatic group containing one to three heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur, the heterocyclic aromatic group optionally having halogeno, nitro, etc. as a substituent; B represents -CH=CH-, -CH2O-, etc.; Y represents C1-10 alkylene optionally having halogeno, etc. as a substituent; Z represents optionally protected carboxyl, etc.; m is an integer of 1 to 4; n is an integer of 1 to 3; and …… indicates a single bond or double bond) or a pharmacologically acceptable salt of the compound; and a medicinal composition which contains the compound or salt as the active ingredient. The composition has not only strong leucotriene D4 antagonism but leucotriene C4 antagonism and leucotriene E4 antagonism. It is useful as an antasthmatic, antiallergic, or antiphlogistic.

    Abstract translation: 由通式（I）表示的二苯并环庚烯化合物：（I）（其中R1表示氢，卤素等; R2表示氢，卤素等; A表示例如5或6元杂环芳基 含有1-3个选自氮，氧和硫的杂原子，该杂环芳族基团任选具有卤素，硝基等作为取代基; B表示-CH = CH - ， - CH 2 O-等; Y 表示任选具有卤素等的C 1-10亚烷基等作为取代基; Z表示任选被保护的羧基等; m是1至4的整数; n是1至3的整数;并且......表示单键或 双键）或该化合物的药理学上可接受的盐; 以及含有该化合物或盐作为有效成分的药物组合物。 该组合物不但具有强烈的白三烯D4拮抗作用，而且具有白三烯C4拮抗作用和白三烯E4拮抗作用。 它可用作平喘药，抗过敏药或抗炎药。

    HUMAN CU, ZN TYPE SUPEROXIDE DISMUTASE DERIVATIVE AND ITS PRODUCTION
    38.
    发明专利
    HUMAN CU, ZN TYPE SUPEROXIDE DISMUTASE DERIVATIVE AND ITS PRODUCTION 失效

    公开(公告)号：JPH06199895A

    公开(公告)日：1994-07-19

    申请号：JP202593

    申请日：1993-01-08

    Applicant: UBE INDUSTRIES

    Inventor： FUKUI KIYOSHI ,  KUBO FUMIO ,  TANAKA MASAYUKI ,  IWAMOTO YOSHITADA

    IPC: C07K1/113 ,  C07K1/00 ,  C07K1/08 ,  C07K14/00 ,  C12N9/02 ,  C07K13/00

    Abstract: PURPOSE:To obtain the subject derivative useful for treating rheumatoid arthritis, cataract, etc., having uniform electric charge and molecular weight and stable activity by reacting a human Cu, Zn type superoxide dismutase with a specific alkyl disulfide. CONSTITUTION:Human Cu, Zn type superoxide dismutase is mixed with an alkyl disulfide of formula I (X is amino, 1-10C alkyl, amino replaced with 1-10C alkyl or 2-10C acyl group or hydroxyl; R and R are H or 1-IOC alkyl), adjusted to pH 7.0, incorporated with water and reacted at 4 deg.C for 24 hours while stirring to give the objective enzyme derivative of formula II (SOD' is group obtained by removing H from mercapto group of cystine residue at 111st of human Cu, Zn type superoxide dismutase) having uniformity with respect to electronic charge and molecular weight, stable activity, useful as a preventive and a therapeutic agent for rheumatoid arthritis, oxygen retinopathy of immature baby, cataract, etc., in which superoxide exists.

    Pyridylaminoacetic acid compound
    39.
    发明专利
    Pyridylaminoacetic acid compound 有权
    吡啶酰胺酸化合物

    公开(公告)号：JP2013063994A

    公开(公告)日：2013-04-11

    申请号：JP2012251011

    申请日：2012-11-15

    Applicant: Ube Industries Ltd ,  宇部興産株式会社

    Inventor： IWAMURA AKIRA ,  TANAKA MASAYUKI ,  KATSUBE TETSUTSUGU ,  SHIGETOMI MANABU ,  OKASEI EIJI ,  TOKUNAGA HIROHITO ,  FUJIWARA HIROSHI

    IPC: C07D213/75 ,  C07D401/12 ,  C07D409/12 ,  C07D417/12

    CPC classification number: C07D417/14 ,  C07D213/74 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/12

    Abstract: PROBLEM TO BE SOLVED: To provide a synthesis intermediate of a pyridylaminoacetic acid compound having an EP2 agonistic activity and therefore useful as a therapeutic and/or prophylactic agent for respiratory diseases including asthma and chronic obstructive pulmonary disease.SOLUTION: A sulfonylaminomethylpyridine compound is represented by formula (11) wherein: Rand Rare each independently a hydrogen atom, or a 1-6C alkyl group; Ris a 1-6C alkyl group; Boc is a tert-butoxycarbonyl group; and Z is an aromatic ring group or a 5- or 6-membered heteroaromatic ring group which may be replaced with a group selected from the group consisting of a halogen atom, a 1-6C alkyl group, a halogeno 1-6C alkyl group, a 1-6C alkoxy group and a halogeno 1-6C alkoxy group.

    Abstract translation: 待解决的问题：提供具有EP2激动活性的吡啶基氨基乙酸化合物的合成中间体，因此可用作呼吸系统疾病（包括哮喘和慢性阻塞性肺病）的治疗和/或预防剂。 解决方案：磺酰氨基甲基吡啶化合物由式（11）表示，其中：R 2 和R 3 各自独立地为 氢原子或1-6C烷基; R 4 是1-6C烷基; Boc是叔丁氧基羰基; Z为芳环基或可以被选自卤素原子，1-6C烷基，卤代C 1-6烷基，C 1 -C 6烷基， 1-6C烷氧基和卤代C 1-6烷氧基。 版权所有（C）2013，JPO＆INPIT

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