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公开(公告)号：WO03013345A2
公开(公告)日：2003-02-20
申请号：PCT/US0225366
申请日：2002-08-08
Applicant: OPTISCAN BIOMEDICAL CORP , RULE PETER , BRAIG JAMES R , GOLDBERGER DANIEL S , CORTELLA JULIAN M , SMITH HEIDI M , HERRERA ROGER O , WITTE KENNETH G , HARTSTEIN PHILIP C , AGOSTINO MARK D
Inventor： RULE PETER , BRAIG JAMES R , GOLDBERGER DANIEL S , CORTELLA JULIAN M , SMITH HEIDI M , HERRERA ROGER O , WITTE KENNETH G , HARTSTEIN PHILIP C , AGOSTINO MARK D
CPC classification number: A61B5/01 , A61B5/061 , A61B5/14532 , A61B5/6824 , G01J3/0286 , G01J3/0291 , G01N21/01 , G01N21/35 , G01N2021/0389 , G01N2201/021 , G01N2201/0245
Abstract: A device and method are provided for use with a noninvasive optical measurement system, such as a thermal gradient spectrometer, for improved determination of analyte concentrations within living tissue. In one embodiment, a wearable window is secured to a patient's forearm thereby isolating a measurement site on the patient's skin for determination of blood glucose levels. The wearable window effectively replaces a window of the spectrometer, and thus forms an interface between the patient's skin and a thermal mass window of the spectrometer. When the spectrometer must be temporarily removed from the patient's skin, such as to allow the patient mobility, the wearable window is left secured to the forearm so as to maintain a consistent measurement site on the skin. When the spectrometer is later reattached to the patient, the wearable window will again form an interface between the spectrometer and the same location of skin as before.
Abstract translation: 提供了一种用于非侵入性光学测量系统（例如热梯度光谱仪）的装置和方法，用于改善活体组织内分析物浓度的测定。 在一个实施例中，可佩戴的窗户被固定到患者的前臂，从而隔离患者皮肤上的测量部位以确定血糖水平。 穿戴式窗户有效地代替了光谱仪的窗口，从而形成了患者皮肤与光谱仪的热质量窗口之间的界面。 当光谱仪必须临时从患者皮肤上移除时，例如允许患者移动，则将可佩戴的窗口固定在前臂上，以便在皮肤上保持一致的测量部位。 当光谱仪后来重新连接到患者身上时，穿戴式窗户将再次形成光谱仪与以前相同的皮肤位置之间的界面。
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公开(公告)号：JP4933271B2
公开(公告)日：2012-05-16
申请号：JP2006551100
申请日：2005-01-04
Applicant: ゼネラル・エレクトリック・カンパニイ
Inventor： シャオ，カイビン , ボイェット，スコット・エム , ポティライロ，ラディスラブ・エイ
CPC classification number: G01N21/7703 , G01N21/253 , G01N21/272 , G01N21/274 , G01N21/314 , G01N21/552 , G01N21/8483 , G01N2021/7783 , G01N2201/0221 , G01N2201/0245 , G01N2201/0461 , G01N2201/122
Abstract: A portable system and method for measuring the concentration of multiple chemical or biological substances where an onsite analysis of such substances is needed. The new and original handheld sensor system uses a disposable optical test element and a spectroscopic detector that measures the test element response to specific analytes through a change in light absorbance, luminescence, and other forms of light-based response. In this way, reflection light intensities indicative of the test element response can be used to measure the concentration of the target analytes. The sensor system is also capable of being interfaced to an information processing unit or computer so that analytical data can be manipulated or stored electronically.
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公开(公告)号：JP2005274579A
公开(公告)日：2005-10-06
申请号：JP2005119102
申请日：2005-04-15
Applicant: Applera Corp , アプレラ コーポレイション
Inventor： GAMBINI MICHAEL R , ATWOOD JOHN G , YOUNG EUGENE F , LAKATOS EDWARD J , CERRONE ANTHONY L
CPC classification number: G01N21/6428 , B01L3/5085 , B01L7/52 , B01L2200/10 , B01L2300/0654 , B01L2300/0663 , B01L2300/1811 , C12Q1/686 , C12Q2545/101 , G01N21/0303 , G01N21/274 , G01N21/645 , G01N21/6452 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6463 , G01N2021/6482 , G01N2201/0245 , G01N2201/06113 , G01N2201/0628 , G01N2201/0635 , G01N2201/0636 , G01N2201/068 , C12Q2563/107
Abstract: PROBLEM TO BE SOLVED: To provide a PCR (polymerase chain reaction) equipment being an optical equipment for quantitative monitoring of replicative DNA which is improved in a dynamic range, capable of automatically selecting the exposure time for expanding a dynamic range, capable of automatic drift adjustment, easy to operate, relatively low price, and easy to change the optical system for storing a different fluorescence dye. SOLUTION: The equipment includes a light source, a light guide means for guiding a light beam, an optical detector, and a means for processing a data signal. The light source emits source beam containing at least one frequency of primary excitation frequency capable of making fluorescence emit with emission frequency. A 1st means is so arranged as to activate an excitation beam of excitation frequency while receiving the source beam. A 1st focus means is arranged to focus the excitation beam in each suspension to make the primary dye emit emission beams with intensity indicating the emission frequency and the DNA concentration of each suspension. A focus means receives an emission beam and makes it pass through. A 2nd means is arranged to receive the emission beam to pass through the emission beam of emission frequency to the other focus means which focuses the emission beam on the detector. The detector generates a primary data signal representing the emission beam and generates the concentration corresponding to the DNA of each small bottle. The processor displays the concentration of DNA by acquiring the primary data signal. COPYRIGHT: (C)2006,JPO&NCIPI
Abstract translation: 要解决的问题：为了提供PCR（聚合酶链反应）设备，其是用于定量监测在动态范围内改进的复制DNA的光学设备，能够自动选择用于扩大动态范围的曝光时间，能够 的自动漂移调整，操作方便，价格相对较低，并且易于更换用于存储不同荧光染料的光学系统。 解决方案：设备包括光源，用于引导光束的光导装置，光学检测器和用于处理数据信号的装置。 光源发射含有能够使荧光发射具有发射频率的初级激发频率的至少一个频率的源束。 第一装置被布置为在接收源光束的同时激活激发频率的激发光束。 第一焦点装置被布置成将激发光束聚焦在每个悬浮液中，以使主染料发射具有指示每个悬浮液的发射频率和DNA浓度的强度的发射光束。 聚焦装置接收发射光束并使其通过。 第二装置被布置为接收发射光束以将发射频率的发射光束传递到将发射光束聚焦在检测器上的另一个聚焦装置。 检测器产生表示发射光束的主要数据信号，并产生与每个小瓶子的DNA相对应的浓度。 处理器通过获取主数据信号显示DNA的浓度。 版权所有（C）2006，JPO＆NCIPI
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公开(公告)号：JP6086755B2
公开(公告)日：2017-03-01
申请号：JP2013035581
申请日：2013-02-26
Applicant: 国立大学法人九州大学 , ウシオ電機株式会社
CPC classification number: G01N21/6428 , B01L3/502715 , B01L3/50273 , B01L3/502753 , G01N21/03 , G01N33/5304 , B01L2200/0647 , B01L2300/0654 , B01L2300/0816 , B01L2300/0861 , B01L2400/0403 , B01L2400/0442 , B01L2400/046 , G01N2021/6482 , G01N21/05 , G01N2201/0245 , G01N33/536 , G01N33/56966
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公开(公告)号：JP2011022166A
公开(公告)日：2011-02-03
申请号：JP2010249225
申请日：2010-11-05
Applicant: Applied Biosystems Llc , アプライド バイオシステムズ, エルエルシー
Inventor： BOEGE STEVEN , OLDHAM MARK , ILKOVA LIANA
CPC classification number: G01N21/6452 , G01N21/253 , G01N2021/6439 , G01N2021/6471 , G01N2021/6476 , G01N2021/6478 , G01N2201/0245
Abstract: PROBLEM TO BE SOLVED: To provide a system capable of solving the problems encountered by spatial non-uniformities.
SOLUTION: An apparatus and method for fluorescent detection in biological samples are provided in which non-uniformities in the emitted light due to the optical systems rather than the specimens are corrected by using special optical elements. The apparatus includes a light source (105), illuminating a dichroic beam splitter (110) which reflects excitation light via a first optical element (130) onto a sample region (120) including a tray of samples (122). The emitted light is redirected to a detector (125) through the first optical element (130) and the beam splitter (110). The first optical element (130) collimates and reduces non-uniformities in the emission light.
COPYRIGHT: (C)2011,JPO&INPITAbstract translation: 要解决的问题：提供能够解决空间不均匀性遇到的问题的系统。 提供了一种用于生物样品中的荧光检测的装置和方法，其中通过使用特殊的光学元件来校正由于光学系统而不是样本的发射光的不均匀性。 所述设备包括光源（105），其照射经由第一光学元件（130）将激发光反射到包括样品盘（122）的样品区域（120）上的二向色分束器（110）。 发射的光通过第一光学元件（130）和分束器（110）被重定向到检测器（125）。 第一光学元件（130）准直并降低发射光中的不均匀性。 版权所有（C）2011，JPO＆INPIT
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Patent Agency Ranking
公开(公告)号：KR1020140146665A
公开(公告)日：2014-12-26
申请号：KR1020147032990
申请日：2013-04-23
Applicant: 지멘스 헬쓰케어 다이아그노스틱스 인크.
Inventor： 재스퍼스,제프리,알. , 데스마라이스,노르망,피.
CPC classification number: G01N21/76 , G01N21/645 , G01N2021/6463 , G01N2021/6471 , G01N2021/6476 , G01N2201/0245 , G01N2201/0634 , G01N2201/0636 , G01N2201/0666
Abstract: 샘플분석기는발광을야기하기위해검정샘플을조명하기위한조명장치, 및검정샘플을담고있는샘플용기를위한지지부를갖는다. 지지부는조명장치에근접하게검정샘플을위치시키도록구성된다. 검출기는조명장치로부터, 위치된검정샘플을통하여, 검출기로연장하는광축을따라위치되어, 검정샘플로부터의발광을검출한다. 반사기는조명장치와검정샘플사이에제거가능하게배치되어발광의일부를위치된검정샘플을통하여검출기를향하여다시반사한다.
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公开(公告)号：KR1020170054393A
公开(公告)日：2017-05-17
申请号：KR1020177006121
申请日：2015-08-05
Applicant: 산와 바이오테크 엘티디
Inventor： 뒤트리이자벨세실안젤 , 입킨쑨 , 치우캘빈 , 임와이램윌리암 , 라우이우팅리차드
IPC: B01L3/00 , G01N21/84 , G01N21/77 , G01N33/543
CPC classification number: B01L3/502715 , B01L3/50273 , B01L2200/0684 , B01L2300/0654 , B01L2300/069 , B01L2300/0887 , B01L2300/16 , B01L2400/0493 , G01N21/6428 , G01N21/77 , G01N21/8483 , G01N33/54366 , G01N2021/7786 , G01N2201/0245 , G01N2201/0612 , G01N2333/11
Abstract: 피분석물을검출하는휴대용의완전하게자체적으로포함된장치(20) 및그것의사용방법이설명된다. 상기장치(20)는미소유체카트리지드라이버유닛(30), 광학검사유닛(32) 및제어유닛(28)과전력공급유닛을구비하고, 이것은기구에대한그 어떤유체인터페이스없이도피분석물의검출및 바인딩(binding)을수행할수 있다. 미소유체카트리지드라이버유닛(30)은미소유체카트리지(22)를수용하며, 이것은피분석물의검출에서상이한프로세스단계들을수행하도록피분석물을전달하기위한마이크로어레이및 통합미소유체칩(24)을유지한다. 본발명을이용하는피분석물의완전한검출에는오직수 분이걸린다.
Abstract translation: 描述了用于检测分析物的便携式完全独立装置20及其使用方法。 装置20包括微流体盒驱动单元30，光学检测单元32以及控制单元28和电源单元，其能够检测并结合逃逸的分析物，而没有与仪器的任何流体接口 你可以执行绑定。 微流体盒驱动器单元30接收微流体盒22，微流体盒22包括微阵列和集成微流体芯片24，用于递送分析物以在检测分析物中执行不同的处理步骤 的。 使用本发明完成对分析物的检测仅需要几分钟。
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公开(公告)号：KR101530168B1
公开(公告)日：2015-06-19
申请号：KR1020147032990
申请日：2013-04-23
Applicant: 지멘스 헬쓰케어 다이아그노스틱스 인크.
Inventor： 재스퍼스,제프리,알. , 데스마라이스,노르망,피.
CPC classification number: G01N21/76 , G01N21/645 , G01N2021/6463 , G01N2021/6471 , G01N2021/6476 , G01N2201/0245 , G01N2201/0634 , G01N2201/0636 , G01N2201/0666
Abstract: 샘플분석기는발광을야기하기위해검정샘플을조명하기위한조명장치, 및검정샘플을담고있는샘플용기를위한지지부를갖는다. 지지부는조명장치에근접하게검정샘플을위치시키도록구성된다. 검출기는조명장치로부터, 위치된검정샘플을통하여, 검출기로연장하는광축을따라위치되어, 검정샘플로부터의발광을검출한다. 반사기는조명장치와검정샘플사이에제거가능하게배치되어발광의일부를위치된검정샘플을통하여검출기를향하여다시반사한다.
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公开(公告)号：US10006855B2
公开(公告)日：2018-06-26
申请号：US15359296
申请日：2016-11-22
Applicant: California Institute of Technology
Inventor： Axel Scherer , Frank T. Hartley
CPC classification number: G01N21/35 , G01J3/0208 , G01J3/0256 , G01J3/108 , G01J3/18 , G01J3/36 , G01J3/42 , G01J2003/1213 , G01N21/3563 , G01N21/3577 , G01N2021/3148 , G01N2201/0245 , G01N2201/0638
Abstract: MIR spectroscopy systems comprising hierarchical spectral dispersion that enables fine spectral resolution and high sensitivity spectroscopy are disclosed. Hierarchical spectral dispersion is derived by employing at least two diffractive lens arrays, located on either side of a test sample, each receiving input radiation having an input spectral range and distributing the input radiation into a plurality of output signals, each having a fraction of the spectral range of the input radiation. As a result, the signal multiplication factor of the two arrays is multiplied in a manner that mitigates the propagation of wavelength harmonics through the system. In some embodiments, an emitter array comprising a plurality of spectrally selective emitters provides the input MIR radiation to a spectroscopy system. In some embodiments, spectrally selective detectors are used to detect narrow spectral components in the radiation after they have passed through the test sample.
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公开(公告)号：US20160178521A1
公开(公告)日：2016-06-23
申请号：US14997832
申请日：2016-01-18
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Michael R. GAMBINI , Edward J. LAKATOS , Anthony L. CERRONE , Eugene F. YOUNG , John G. ATWOOD
IPC: G01N21/64
CPC classification number: G01N21/6428 , B01L3/5085 , B01L7/52 , B01L2200/10 , B01L2300/0654 , B01L2300/0663 , B01L2300/1811 , C12Q1/686 , C12Q2545/101 , G01N21/274 , G01N21/645 , G01N21/6452 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6463 , G01N2021/6482 , G01N2201/0245 , G01N2201/06113 , G01N2201/0628 , G01N2201/0635 , G01N2201/0636 , G01N2201/068 , C12Q2563/107
Abstract: An optical instrument monitors PCR replication of DNA in a reaction apparatus having a temperature cycled block with vials of reaction ingredients including dye that fluoresces in presence of double-stranded DNA. A beam splitter passes an excitation beam to the vials to fluoresce the dye. An emission beam from the dye is passed by the beam splitter to a CCD detector from which a processor computes DNA concentration. A reference strip with a plurality of reference emitters emit reference beams of different intensity, from which the processor selects an optimum emitter for compensating for drift. Exposure time is automatically adjusted for keeping within optimum dynamic ranges of the CCD and processor. A module of the beam splitter and associated optical filters is associated with selected dye, and is replaceable for different dyes.
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