公开(公告)号：US20050036142A1

公开(公告)日：2005-02-17

申请号：US10887528

申请日：2004-07-08

Applicant: Mark Oldham ,  Eric Nordman ,  Richard Reel ,  John Shigeura ,  Janice Shigeura

Inventor： Mark Oldham ,  Eric Nordman ,  Richard Reel ,  John Shigeura ,  Janice Shigeura

IPC: G01N21/00 ,  G01N21/63 ,  G01N27/27

CPC classification number: G01N21/6456 ,  B82Y10/00 ,  B82Y20/00 ,  G01N27/44721 ,  G01N2021/6417 ,  G01N2021/6419 ,  G01N2021/6471 ,  G01N2201/0628

Abstract: Apparatus and methods for detecting analytes in a sample are provided. The apparatus can include: one or more channels having a detection zone; one or more irradiation sources disposed for irradiating the detection zone with radiation; a detector capable of collecting at least one charge corresponding to an emission beam emitted from the detection zone, the detector having an output; and a time delay integration system coupled to the detector for effecting time delay integration of the at least one charge by accumulating the at least one charge before reading the at least one charge at the output of the detector. Various embodiments provide an apparatus with a multi-notch filter. Various embodiments provide a solid state laser, a micro-wire laser, or an organic light-emitting diode as a irradiation source.

Abstract translation: 提供了用于检测样品中分析物的装置和方法。 该装置可以包括：具有检测区域的一个或多个通道; 设置用于辐射照射检测区域的一个或多个照射源; 检测器，其能够收集对应于从所述检测区域发射的发射光束的至少一个电荷，所述检测器具有输出; 以及耦合到所述检测器的时间延迟积分系统，用于通过在所述检测器的输出读取所述至少一个电荷之前积累所述至少一个电荷来实现所述至少一个电荷的时间延迟积分。 各种实施例提供具有多陷波滤波器的装置。 各种实施例提供固态激光器，微线激光器或有机发光二极管作为照射源。

公开(公告)号：US20030148505A1

公开(公告)日：2003-08-07

申请号：US10370846

申请日：2003-02-20

Inventor： Michael R. Gambini ,  John G. Atwood ,  Susan Atwood Stone ,  Judith K. Atwood ,  Eugene F. Young ,  Edward J. Lakatos ,  Anthony L. Cerrone

IPC: C12M001/34

CPC classification number: G01N21/6428 ,  B01L3/5085 ,  B01L7/52 ,  B01L2200/10 ,  B01L2300/0654 ,  B01L2300/0663 ,  B01L2300/1811 ,  C12Q1/686 ,  C12Q2545/101 ,  G01N21/274 ,  G01N21/645 ,  G01N21/6452 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6439 ,  G01N2021/6441 ,  G01N2021/6463 ,  G01N2021/6482 ,  G01N2201/0245 ,  G01N2201/06113 ,  G01N2201/0628 ,  G01N2201/0635 ,  G01N2201/0636 ,  G01N2201/068 ,  C12Q2563/107

Abstract: An optical instrument monitors PCR replication of DNA in a reaction apparatus having a temperature cycled block with vials of reaction ingredients including dye that fluoresces in presence of double-stranded DNA. A beam splitter passes an excitation beam to the vials to fluoresce the dye. An emission beam from the dye is passed by the beam splitter to a CCD detector from which a processor computes DNA concentration. A reference strip with a plurality of reference emitters emit reference beams of different intensity, from which the processor selects an optimum emitter for compensating for drift. Exposure time is automatically adjusted for keeping within optimum dynamic ranges of the CCD and processor. A module of the beam splitter and associated optical filters is associated with selected dye, and is replaceable for different dyes.

公开(公告)号：US20190234877A1

公开(公告)日：2019-08-01

申请号：US16311647

申请日：2017-06-09

Applicant: Cambridge Display Technology Limited ,  Sumitomo Chemical Company Limited

Inventor： Jonathan Behrendt

IPC: G01N21/64 ,  G01N21/77 ,  B01L3/00 ,  C12Q1/26 ,  G01N33/18

CPC classification number: G01N21/6428 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2300/0636 ,  C12Q1/26 ,  C12Y101/0304 ,  C12Y107/99004 ,  G01N21/77 ,  G01N33/182 ,  G01N2021/1765 ,  G01N2021/6439 ,  G01N2021/7786 ,  G01N2201/0628

Abstract: A method of testing a sample for the presence of nitrate or nitrite, the method comprising the steps of: forming a mixture by contacting the sample with a composition comprising hydrogen peroxide or a hydrogen peroxide precursor and a fluorescent indicator precursor capable of forming a fluorescent indicator in the presence of peroxynitrite; irradiating the mixture; and measuring fluorescence from the fluorescent indicator. The method may be carried out using a device in which the mixture in a channel or chamber 101 of a microfluidic device is irradiated by light from light source 103 and emission from the fluorescent indicator is detected by photodetector 105.

公开(公告)号：US20180231464A1

公开(公告)日：2018-08-16

申请号：US15751074

申请日：2016-08-19

Applicant: Molecular Vision Limited

Inventor： Chris Hand ,  Oliver Hofmann ,  Gihan Ryu ,  Miguel Ramon ,  Dene Baldwin

IPC: G01N21/64 ,  G01N21/84 ,  G01N33/558 ,  G01N21/78

CPC classification number: G01N21/645 ,  G01N21/6428 ,  G01N21/78 ,  G01N21/8483 ,  G01N33/558 ,  G01N2021/6439 ,  G01N2021/7786 ,  G01N2201/0628

Abstract: An assay device for the quantitative determination of the concentration of at least one analyte in a liquid sample comprises a planar emitter (2), a planar detector (3), a lateral flow membrane (4) interposed between the emitter (2) and the detector (3), a conjugate pad (5) in fluid communication with a proximal end of the lateral flow membrane (4), the conjugate pad (5) comprising optically detectable tagging particles bound to a first assay component, a sample pad (6) in fluid communication with the conjugate pad (5) and arranged to receive the liquid sample, and a wicking pad (7) in fluid communication with a distal end of the lateral flow membrane (4). The lateral flow membrane (4) is formed from a light transmissive material and is capable of transporting fluid from the conjugate pad (5) to the wicking pad (7) by capillary action. The lateral flow membrane (4) comprises at least one test region (8, 12) comprising an immobilised second assay component for retaining the tagging particles in the test region (8, 12) in dependence on the binding between the analyte, the first assay component and the second assay component in order to generate a concentration of tagging particles in the test region (8, 12) that is indicative of the concentration of the analyte in the liquid sample. The emitter (2) comprises an emission layer (9, 16) of an organic electroluminescent material and the emission layer (9, 16) is aligned with the test region (8, 12) of the lateral flow membrane 4, whereby the emitter (2) is capable of illuminating the test region (8, 12). The detector (3) comprises an absorption layer (10, 15) of an organic photovoltaic material and the absorption layer (10, 15) is aligned with the test region (8, 12) of the lateral flow membrane 4, whereby the detector (3) is capable of detecting light from the test region (8, 12).

公开(公告)号：US20170248463A1

公开(公告)日：2017-08-31

申请号：US15329096

申请日：2015-07-10

Applicant: FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.

Inventor： Norbert DANZ ,  Christoph WAECHTER

IPC: G01J1/42 ,  H01L33/10 ,  H01L33/58 ,  H01L51/52

CPC classification number: G01J1/4228 ,  G01J3/10 ,  G01J3/42 ,  G01J3/505 ,  G01J2001/4252 ,  G01N21/553 ,  G01N2201/0628 ,  H01L33/105 ,  H01L33/58 ,  H01L51/5036 ,  H01L51/5265 ,  H01L51/5275

Abstract: The invention relates to an arrangement for a spatially resolved and wavelength-resolved detection of light radiation emitted from at least one OLED or LED. A multilayer system is arranged between an electrode, an OLED or an LED, and a substrate and is formed using layers formed alternately above one another from a material having higher and lower optical refractive indices n. In this respect, light radiation from the at least one OLED or LED and having a plurality of different wavelengths λ1, λ2, λ3, . . . λn thus exits the multilayer system. Light radiation that exits at different wavelengths λ1, λ2, λ3, . . . λn at different angles is incident onto at least one detector array after at least a simple refraction at an optical element or after reflection at a layer or at a layer system of a sensor such that light radiation at a wavelength λ1, λ2, λ3, . . . or λn is incident onto a respective detector element of the detector array. The detector elements of the detector array are arranged discretely from one another.

公开(公告)号：US09651482B2

公开(公告)日：2017-05-16

申请号：US14783170

申请日：2014-04-16

Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH

Inventor： Gertrud Blei ,  Mario Bock

IPC: G01N21/55 ,  G01N21/47 ,  A61M5/315 ,  G06F19/00 ,  A61M5/31

CPC classification number: G01N21/4738 ,  A61M5/31 ,  A61M5/3155 ,  A61M5/31568 ,  A61M2005/3126 ,  A61M2205/3306 ,  A61M2205/3379 ,  A61M2205/3553 ,  A61M2205/3592 ,  A61M2205/502 ,  A61M2205/505 ,  A61M2205/52 ,  A61M2205/581 ,  A61M2205/6081 ,  A61M2205/8206 ,  A61M2209/04 ,  G01N2201/021 ,  G01N2201/0628 ,  G01N2201/0634 ,  G06F19/00 ,  G06F19/3468

Abstract: A sensor device configured to be attached to a drug delivery device and configured to illuminate the drug delivery device when attached, the sensor device having an OLED having a transparent first electrode, a transparent second electrode and a central layer disposed between the first and second electrodes, the central layer comprising at least one organic layer, the at least one organic layer configured to emit light through the transparent first electrode, and an optical sensor arranged to receive light reflected from a surface of the drug delivery device, wherein the central layer of the OLED has a region without the at least one organic layer and wherein the optical sensor is arranged, when the sensor device is attached to the drug delivery device, to view a predetermined area of the surface of the drug delivery device through the region without the at least one organic layer.

公开(公告)号：US09594019B1

公开(公告)日：2017-03-14

申请号：US13963931

申请日：2013-08-09

Applicant: Lester F. Ludwig

Inventor： Lester F. Ludwig ,  Karen Hao ,  Frank Hu ,  Alice Huang ,  Pooncharas Tipgunlakant

IPC: G01N21/59

CPC classification number: G01N21/59 ,  G01N15/0227 ,  G01N15/1434 ,  G01N15/1459 ,  G01N15/1475 ,  G01N15/1484 ,  G01N21/253 ,  G01N21/51 ,  G01N21/534 ,  G01N21/6452 ,  G01N21/6458 ,  G01N2015/0294 ,  G01N2015/1006 ,  G01N2015/1445 ,  G01N2015/1493 ,  G01N2015/1497 ,  G01N2021/1787 ,  G01N2201/062 ,  G01N2201/0626 ,  G01N2201/0628

Abstract: An optical tomography system including a light emitting array having one or more light emitting diodes (LEDs), a sample holding module and a light sensing array comprising one or more light emitting diodes (LEDs), wherein the light sensing array is configured to sense light emitted from the light emitting array, which has passed through the sample holding module.

Abstract translation: 一种光学断层摄影系统，包括具有一个或多个发光二极管（LED）的发光阵列，样品保持模块和包括一个或多个发光二极管（LED）的光感测阵列，其中光感测阵列被配置为感测光 从已经通过样品保持模块的发光阵列发射。

公开(公告)号：US20160178521A1

公开(公告)日：2016-06-23

申请号：US14997832

申请日：2016-01-18

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Michael R. GAMBINI ,  Edward J. LAKATOS ,  Anthony L. CERRONE ,  Eugene F. YOUNG ,  John G. ATWOOD

IPC: G01N21/64

CPC classification number: G01N21/6428 ,  B01L3/5085 ,  B01L7/52 ,  B01L2200/10 ,  B01L2300/0654 ,  B01L2300/0663 ,  B01L2300/1811 ,  C12Q1/686 ,  C12Q2545/101 ,  G01N21/274 ,  G01N21/645 ,  G01N21/6452 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6439 ,  G01N2021/6441 ,  G01N2021/6463 ,  G01N2021/6482 ,  G01N2201/0245 ,  G01N2201/06113 ,  G01N2201/0628 ,  G01N2201/0635 ,  G01N2201/0636 ,  G01N2201/068 ,  C12Q2563/107

Abstract: An optical instrument monitors PCR replication of DNA in a reaction apparatus having a temperature cycled block with vials of reaction ingredients including dye that fluoresces in presence of double-stranded DNA. A beam splitter passes an excitation beam to the vials to fluoresce the dye. An emission beam from the dye is passed by the beam splitter to a CCD detector from which a processor computes DNA concentration. A reference strip with a plurality of reference emitters emit reference beams of different intensity, from which the processor selects an optimum emitter for compensating for drift. Exposure time is automatically adjusted for keeping within optimum dynamic ranges of the CCD and processor. A module of the beam splitter and associated optical filters is associated with selected dye, and is replaceable for different dyes.

公开(公告)号：US20150322488A1

公开(公告)日：2015-11-12

申请号：US14730989

申请日：2015-06-04

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Michael R. GAMBINI ,  John G. ATWOOD ,  Anthony L. CERRONE ,  Edward J. LAKATOS ,  Eugene F. YOUNG

IPC: C12Q1/68 ,  G01N21/64 ,  B01L7/00

CPC classification number: G01N21/6428 ,  B01L3/5085 ,  B01L7/52 ,  B01L2200/10 ,  B01L2300/0654 ,  B01L2300/0663 ,  B01L2300/1811 ,  C12Q1/686 ,  C12Q2545/101 ,  G01N21/274 ,  G01N21/645 ,  G01N21/6452 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6439 ,  G01N2021/6441 ,  G01N2021/6463 ,  G01N2021/6482 ,  G01N2201/0245 ,  G01N2201/06113 ,  G01N2201/0628 ,  G01N2201/0635 ,  G01N2201/0636 ,  G01N2201/068 ,  C12Q2563/107

Abstract: An optical instrument monitors PCR replication of DNA in a reaction apparatus having a temperature cycled block with vials of reaction ingredients including dye that fluoresces in presence of double-stranded DNA. A beam splitter passes an excitation beam to the vials to fluoresce the dye. An emission beam from the dye is passed by the beam splitter to a CCD detector from which a processor computes DNA concentration. A reference strip with a plurality of reference emitters emit reference beams of different intensity, from which the processor selects an optimum emitter for compensating for drift. Exposure time is automatically adjusted for keeping within optimum dynamic ranges of the CCD and processor. A module of the beam splitter and associated optical filters is associated with selected dye, and is replaceable for different dyes.

Abstract translation: 光学仪器监测具有温度循环阻滞的反应装置中DNA的PCR复制，所述反应装置具有小瓶反应成分，包括在双链DNA存在下发荧光的染料。 分束器将激发光束传递到小瓶以使染料发荧光。 来自染料的发射光束通过分束器传递到CCD检测器，处理器从该CCD检测器计算DNA浓度。 具有多个参考发射器的参考条发射不同强度的参考光束，处理器从该参考光束选择用于补偿漂移的最佳发射器。 自动调整曝光时间以保持CCD和处理器的最佳动态范围。 分束器和相关的滤光器的模块与选定的染料相关联，并且可替代不同的染料。

公开(公告)号：US20150107993A1

公开(公告)日：2015-04-23

申请号：US14396218

申请日：2013-04-18

Applicant: Transfert Plus, s.e.c.

Inventor： Ricardo Izquierdo ,  Philippe Juneau ,  Florent Lefèvre

IPC: G01N33/18 ,  G01N27/30 ,  G01N21/64

CPC classification number: G01N33/1866 ,  C12M21/02 ,  C12M23/16 ,  C12Q1/02 ,  G01N21/64 ,  G01N21/6486 ,  G01N27/30 ,  G01N33/1893 ,  G01N2033/184 ,  G01N2201/0628 ,  G01N2201/068 ,  G01N2520/00

Abstract: There are provided methods and apparatuses for evaluating water pollution. The apparatus comprises at least one light source for exciting or causing activity of at least one type of microorganism or biological material; at least one photodetector for detecting a level of fluorescent light; and a chip disposed between the at least one light source and the detector, the chip comprising at least one microfluidic channel disposed for being exposed to light from the at least one light source and dimensioned for receiving a composition comprising the at least one type of microorganism or biological material and a water sample to be evaluated.

Abstract translation: 提供了评估水污染的方法和设备。 该装置包括用于激发或引起至少一种类型的微生物或生物材料的活性的至少一个光源; 用于检测荧光水平的至少一个光电检测器; 以及设置在所述至少一个光源和所述检测器之间的芯片，所述芯片包括至少一个微流体通道，所述至少一个微流体通道被设置用于暴露于来自所述至少一个光源的光，并被设计成用于接收包含所述至少一种类型的微生物 或生物材料和要评估的水样。