公开(公告)号：EP2480876A1

公开(公告)日：2012-08-01

申请号：EP10818176.9

申请日：2010-09-22

Applicant: Corporation De L'école Polytechnique De Montréal

Inventor： LESAGE, Frédéric ,  BÉLANGER, Samuel ,  ABRAN, Maxime ,  PROVOST, Jean

IPC: G01N21/49 ,  G01N21/64 ,  G01N21/76 ,  A61B6/00

CPC classification number: G01N21/4795 ,  A61B5/0073 ,  A61B5/0091 ,  A61B5/4312 ,  G01N21/6456 ,  G01N21/763 ,  G01N2021/1787 ,  G01N2021/479 ,  G01N2201/0675

Abstract: A system and method for optical data acquisition of an illuminated turbid medium object, the system comprises a variable structured light detector and a controller. The light detector is adapted to retrieve light from a plurality of detection points of an output surface of the illuminated turbid medium object with a plurality of detection patterns. The controller is adapted to control the variable structured light detector for the variable structured light detector to use a detection pattern corresponding to an illumination pattern of the illuminated turbid medium object. The light detector is further adapted to optically measure a combination of retrieved light from the plurality of detection points as an optical measurement. The controller is further adapted to store an illumination pattern identifier indicative of the illumination pattern, a detection pattern identifier indicative of the detection pattern and the corresponding optical measurement.

公开(公告)号：EP0587020A3

公开(公告)日：1994-08-24

申请号：EP93113897.8

申请日：1993-08-31

Applicant: TEXAS INSTRUMENTS INCORPORATED

Inventor： Sampsell, Jeffrey B. ,  Bienstock, Rachelle J.

IPC: G01N21/88 ,  G02B27/46 ,  G06K9/74 ,  G06E3/00

CPC classification number: G06K9/745 ,  G01N21/95623 ,  G01N2201/0675 ,  G02B27/46 ,  G06E3/005

Abstract: An optical correlation unit (10) for correlating the images of an inspection object and a reference object. The unit uses two phase modulating reflective spatial light modulators (12a, 12b). A first spatial light modulator (12a) receives electronic input in the form of image data representing the inspection object. It modulates incoming light (15) with this input and reflects the modulated output to a first Fourier transform lens (13). This lens provides the optical input to second spatial light modulator (12b), whose electronic input is transform data presenting the complex conjugate of the Fourier transform of the reference image. The electronic input modulates the optical input, resulting in the Fourier product of the two images, which is then transformed to provide correlation data.

公开(公告)号：EP3403067A1

公开(公告)日：2018-11-21

申请号：EP17739034.1

申请日：2017-01-13

Applicant: NxGen Partners IP, LLC

Inventor： ASHRAFI, Solyman

IPC: G01N21/59

CPC classification number: G01N21/65 ,  A61B5/0075 ,  A61B5/14532 ,  A61B5/1455 ,  G01J3/021 ,  G01J3/0224 ,  G01J3/0229 ,  G01J3/2803 ,  G01J3/36 ,  G01J3/44 ,  G01N21/21 ,  G01N21/3586 ,  G01N2021/6417 ,  G01N2021/655 ,  G01N2201/0675

Abstract: An apparatus for detecting a material within a sample includes a light emitting unit for directing at least one light beam through the sample. A plurality of units receive the light beam that has passed through the sample and performs a spectroscopic analysis of the sample based on the received light beam. Each of the plurality of units analyze a different parameter with respect to the sample a provide a separate output signal with respect to the analysis. A processor detects the material with respect each of the provided separate output signals.

公开(公告)号：EP3394579A1

公开(公告)日：2018-10-31

申请号：EP16823462.3

申请日：2016-12-20

Applicant: Verily Life Sciences LLC

Inventor： WU, Cheng-Hsun ,  ACOSTA, Victor, Marcel ,  PEIKON, lan ,  LEBEL, Paul ,  SCHWARTZ, Jerrod, Joseph

IPC: G01J3/02 ,  G01J3/18 ,  G02B21/36 ,  G02B5/18 ,  G02B26/08 ,  G01N21/64

CPC classification number: G01N21/6458 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0224 ,  G01J3/0229 ,  G01J3/0237 ,  G01J3/08 ,  G01J3/14 ,  G01J3/18 ,  G01J3/2823 ,  G01J3/32 ,  G01J3/4406 ,  G01J2003/1213 ,  G01J2003/2826 ,  G01N21/6408 ,  G01N21/6428 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2021/6463 ,  G01N2201/0633 ,  G01N2201/0675 ,  G02B5/1828 ,  G02B21/16 ,  G02B21/361 ,  G02B21/367 ,  G02B26/0808 ,  G02B26/0833 ,  G02F1/29 ,  G02F2201/34 ,  G02F2203/12 ,  G06T7/90 ,  G06T2207/10004 ,  G06T2207/10056

Abstract: Methods are provided to identify spatially and spectrally multiplexed probes in a biological environment. Such probes are identified by the ordering and color of fluorophores of the probes. The devices and methods provided facilitate determination of the locations and colors of such fluorophores, such that a probe can be identified. In some embodiments, probes are identified by applying light from a target environment to a spatial light modulator that can be used to control the direction and magnitude of chromatic dispersion of the detected light; multiple images of the target, corresponding to multiple different spatial light modulator settings, can be deconvolved and used to determine the colors and locations of fluorophores. In some embodiments, light from a region of the target can be simultaneously imaged spatially and spectrally. Correlations between the spatial and spectral images over time can be used to determine the color of fluorophores in the target.

公开(公告)号：EP2997353A1

公开(公告)日：2016-03-23

申请号：EP14797836.5

申请日：2014-05-15

Applicant: The Administrators of The Tulane Educational Fund

Inventor： BROWN, Jonathon Quincy

IPC: G01N21/64 ,  G01N21/01 ,  G02B21/36 ,  G02B21/06

CPC classification number: G02B21/16 ,  A61B5/0071 ,  A61B10/02 ,  A61B2090/366 ,  A61B2090/3941 ,  G01N1/30 ,  G01N21/6458 ,  G01N2001/302 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2201/0635 ,  G01N2201/0675 ,  G01N2201/129 ,  G02B21/0076 ,  G02B21/365 ,  G02B21/367 ,  G06K9/52 ,  G06K9/6267 ,  H04N5/2256

Abstract: Systems and methods are provided for evaluating a fresh tissue sample, prepared as to fluoresce under illumination, during a medical procedure. A structured light source is configured to project a spatially patterned light beam onto the fresh tissue sample. An imaging system is configured to produce an image from fluorescence emitted from the illuminated fresh tissue sample. A system control is configured to provide a human-comprehensible clinically useful output associated with the medical procedure.

Abstract translation: 提供的系统和方法用于评估在医疗过程中制备为在照明下发荧光的新鲜组织样品。 结构化光源被配置为将空间图案化的光束投影到新鲜组织样本上。 成像系统被配置为从照亮的新鲜组织样品发射的荧光产生图像。 系统控制被配置为提供与医疗过程相关联的人类可理解的临床有用的输出。

公开(公告)号：EP2561393A1

公开(公告)日：2013-02-27

申请号：EP11712192.1

申请日：2011-03-02

Applicant: Leica Microsystems CMS GmbH

Inventor： SEYFRIED, Volker ,  KNEBEL, Werner

IPC: G02B21/36 ,  G02B21/00 ,  G01N21/64 ,  G03H1/08

CPC classification number: G02B21/0076 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2201/0675 ,  G02B21/0056 ,  G03H1/0404 ,  G03H1/08 ,  G03H1/0866

Abstract: In order to examine a sample (30) with the aid of a microscope (20), dye particles (40, 42) in the sample (30) are excited to fluorescence with the aid of a first illumination light beam (24). Fluorescent light emerging from the sample (30) is directed onto an area sensor (36) via an optical arrangement (34), wherein the optical arrangement (34) acts on the fluorescent light in such a way that partial beams of the fluorescent light interfere with themselves, such that interference patterns arising on account of the interference are imaged on a sensitive surface of the area sensor (36) and detected by the latter. Positions of the dye particles (40, 42) within the sample (30) are determined depending on the interference patterns.

公开(公告)号：EP2478466A1

公开(公告)日：2012-07-25

申请号：EP10816257.9

申请日：2010-09-14

Applicant: Bio-Rad Laboratories, Inc.

Inventor： HENG, Xin

IPC: G06K9/00

CPC classification number: A61B18/203 ,  A61B2018/00452 ,  A61B2018/00642 ,  A61B2018/00779 ,  G01N21/4795 ,  G01N2201/0675 ,  G02B26/06 ,  G03H1/0443 ,  G03H1/2294 ,  G03H2001/0072

Abstract: An optical system and associated method enable near real time optical phase conjugation. In the method, a translucent medium is illuminated by a sample illumination beam. Light scattered by the medium is directed to an electronic image sensor while a reference beam is also directed to the electronic image sensor. The scattered light and the reference beam form an interference pattern at the electronic image sensor. A digital representation of the interference pattern is recorded using the electronic image sensor, and the characteristics of a conjugate of the sample beam are computed from the numerical representation. A conjugate beam having the computed characteristics is generated using a configurable optical element and directed back to the translucent medium. The generation of the conjugate beam may be accomplished using a spatial light modulator.

公开(公告)号：EP2384431A2

公开(公告)日：2011-11-09

申请号：EP09787366.5

申请日：2009-10-06

Applicant: Koninklijke Philips Electronics N.V.

Inventor： VAN BEEK, Michael, C. ,  RENSEN, Wouter, H., J. ,  HARBERS, Rik

IPC: G01N21/47 ,  G01N21/49 ,  G01N21/59 ,  A61B5/00

CPC classification number: A61B5/0059 ,  A61B5/4528 ,  G01N21/4795 ,  G01N2201/0626 ,  G01N2201/0635 ,  G01N2201/0675 ,  G01N2201/124

Abstract: A device (1; 10; 20; 30; 40) for optically examining the interior of a turbid medium (5) is provided. The device comprises an illumination system (2; 12; 22; 32; 42) adapted for illuminating a turbid medium (5) to be examined and an imaging device (106) adapted for generating images from detected light. The illumination system (2; 12; 22; 32; 42) is adapted to be operable in at least a first mode in which a wide area image is acquired by illuminating the turbid medium (5) and a surrounding area. From this wide area image, the region or regions of interest (110) at which the turbid medium (5) is actually situated can be determined. Then, these regions of interest (110) can be illuminated in a second mode. Thus, no light which has not been coupled to the turbid medium (5) and which might cause overexposure of the detector unit of the imaging device (106) will reach the imaging device (106).

Abstract translation: 的装置（1; 10; 20; 30; 40），用于光学检查混浊介质的内部设置。 照明系统的装置包括：（2; 42 12; 22 32 ;;）方便照射混浊介质待检查并于成像适于从检测到的光产生图像设备（106）。 的照明系统（2; 12; 22; 32; 42）是angepasst成可操作在大面积中哪一个大面积被照亮的至少第一模式和其中一个第二模式的至少一个选定区域（110） 被照亮。

公开(公告)号：KR1020150069516A

公开(公告)日：2015-06-23

申请号：KR1020140164291

申请日：2014-11-24

Applicant: 오츠카 일렉트로닉스 가부시키가이샤

Inventor： 스기타가즈히로 ,  야마자키유스케 ,  오츠카하루카

IPC: G01J4/04 ,  G01N21/21

CPC classification number: G01N21/211 ,  G01N2021/213 ,  G01N2201/0675

Abstract: 샘플의편광특성을신속히측정하는것이가능한편광해석장치를제공한다. 본발명의편광해석장치는, 소정의파장영역을갖는광을출사하는광원(2)과, 광원(2)으로부터출사된광이투과하는편광자(32)와, 샘플 S로부터의광이투과하는공간위상변조기(5)와, 공간위상변조기(5)를투과한광이투과하는검광자(42)와, 검광자(42)를투과한광을수광하는이미지분광기(6)를구비한다. 공간위상변조기(5)는복굴절재료를포함하고, 광축과직교하는면 내의제1 방향의각 위치에서위상차가서로다르다. 이미지분광기(6)는광축과직교하는면 내의제1 방향과는다른제2 방향으로분광한다.

Abstract translation: 提供了一种可以快速测量样品的偏振特性的偏振分析装置。 本发明的偏振分析装置包括：发射具有一定波长区域的光的光源（2）; 偏振器（32），其被从光源（2）发射的光穿透; 由来自样品S的光穿透的空间相位调制器（5）; 由穿过空间相位调制器（5）的光穿透的分析器（42）; 以及接收穿过分析器（42）的光的图像分光计（6）。 空间相位调制器（5）包括双折射材料，并且在与光轴成直角交叉的平面中的第一方向上的位置具有不同的相位差。 图像分光器（6）在与光轴成直角交叉的平面中的与第一方向不同的第二方向上进行光谱。

公开(公告)号：KR1020050059221A

公开(公告)日：2005-06-17

申请号：KR1020057005557

申请日：2003-09-18

Applicant: 고쿠리츠켄큐카이하츠호진 카가쿠기쥬츠신코키코

Inventor： 하야시데루타케 ,  마에카와가쓰히로 ,  시바타다카유키

IPC: G02B21/00 ,  G02B21/06 ,  G01N37/00 ,  C12N15/09

CPC classification number: G01N21/6458 ,  G01N21/21 ,  G01N21/6445 ,  G01N21/6452 ,  G01N2021/6471 ,  G01N2021/6478 ,  G01N2201/0675 ,  G02B21/0024 ,  G02B21/0068 ,  G02B21/0076 ,  G02B5/3016

Abstract: A cofocal microscope, and a fluorescence measuring method and a polarized light measuring method using it, the microscope comprising an incident optical system (10, 10') for beaming a polarized light from a lighting light source (11) into an object of observation (2) via a matrix type liquid crystal element (22) having a micro-lens array (21) disposed thereon and an object lens (23), a detection optical system (30, 30') for detecting a reflection light from the object of observation or a fluorescence, and a liquid crystal control unit (52) for controlling the liquid crystal element (22), wherein each micro-lens-related light passed through the micro-lens array (21) is allowed to pass through each pixel (22a) of the liquid crystal element (22) and then into an object lens (23) that forms a plurality of focal points (24) on the object of observation (2), and the polarizing directions of lights passing through respective pixels of the liquid crystal element (22) are controlled by the liquid crystal control unit (52) so as to be orthogonal to one another.

Abstract translation: 一种共焦显微镜以及使用它的荧光测量方法和偏振光测量方法，所述显微镜包括用于将来自照明光源（11）的偏振光发射到观察对象（10,10'）的入射光学系统（10,10' 2）通过其上设置有微透镜阵列（21）的矩阵型液晶元件（22）和物镜（23），检测光学系统（30,30'），用于检测来自物镜 观察或荧光，以及用于控制液晶元件（22）的液晶控制单元（52），其中通过微透镜阵列（21）的每个微透镜相关光都允许穿过每个像素（ 22a），然后变成在观察对象物（2）上形成多个焦点（24）的物镜（23），并且通过各个像素的光的偏振方向 液晶元件（22）由液体控制 id水晶控制单元（52），以便彼此正交。