公开(公告)号：WO0230885A3

公开(公告)日：2002-09-12

申请号：PCT/US0132126

申请日：2001-10-11

Applicant: ARCH DEV CORP

Inventor： MRKSICH MILAN ,  LUK YAN-YEUNG

IPC: B05D1/18 ,  C07C323/12

CPC classification number: B82Y30/00 ,  B05D1/185 ,  B82Y5/00 ,  C07C323/12

Abstract: Alkanethiols of formula (1) and the enantimomers of the alkanethiol of formula (1), and disulfides of formula (3) and the anantimomers of the disulfide of formula (3), where -T is a moiety of formula (2) R1 and R2 are each individually selected from the group consisting of H and OH; a is 0 to 3; b is 0 to 3; and indicates that the chirality of the carbon atom to which it is attached is either R or S; may form inert surfaces that prevent the unwanted adsorption of proteins and cells.

Abstract translation: 式（1）的烷基硫醇和式（1）的烷硫醇的对映异构体和式（3）的二硫化物和式（3）的二硫化物的非对映体，其中-T是式（2）的部分R1和 R2各自独立地选自H和OH; a是0到3; b为0〜3; 并且表示其所连接的碳原子的手性为R或S; 可形成惰性表面，防止蛋白质和细胞的不必要的吸附。

公开(公告)号：WO0148247A3

公开(公告)日：2002-09-06

申请号：PCT/US0035579

申请日：2000-12-22

Applicant: ARCH DEV CORP

Inventor： WANG SAN MING ,  CHEN JIANJUN ,  ROWLEY JANET D

IPC: C07H21/02 ,  C07H21/04 ,  C12N15/10 ,  C12P19/34 ,  C12Q1/68

CPC classification number: C12Q1/6853 ,  C12N15/1096

Abstract: Generation of longer cDNA fragments from SAGE tags for gene identification (GLGI) is disclosed. This method converts SAGE tags, which are about 10 base pairs in length, into their corresponding 3'cDNA fragments covering hundred bases. This added information provides for more accurate genome-wide analysis and overcomes the inherent deficiencies of SAGE. The generation of longer cDNA fragments from isolated and purified protein fragments for gene identification is also disclosed. This method converts a short amino acid sequence into extended version of the DNA sequences encoding the protein/protein fragment and additional 3' end sequences of the gene encoding the protein. This additional sequence information allows gene identification from purified protein sequences. The invention also provides a high-throughput GLGI procedure for identifying genes corresponding to a set of unidentified SAGE tags.

Abstract translation: 公开了用于基因鉴定（GLGI）的SAGE标签的较长cDNA片段的产生。 该方法将长度约为10个碱基对的SAGE标签转换成覆盖百个碱基的相应的3'cDNA片段。 这个增加的信息提供了更准确的全基因组分析，并克服了SAGE的固有缺陷。 还公开了用于基因鉴定的分离和纯化的蛋白质片段产生更长的cDNA片段。 该方法将短氨基酸序列转化为编码蛋白质/蛋白质片段的DNA序列和编码蛋白质的基因的另外的3'末端序列的扩增形式。 这个额外的序列信息允许从纯化的蛋白质序列中进行基因鉴定。 本发明还提供了用于鉴定与一组不明身份的SAGE标签相对应的基因的高通量GLGI程序。

公开(公告)号：WO0143622A2

公开(公告)日：2001-06-21

申请号：PCT/US0041378

申请日：2000-10-20

Applicant: ARCH DEV CORP

Inventor： CHEN CHIN-TU ,  PAN XIAOCHUAN ,  KAO CHIEN-MIN

IPC: G01T1/164 ,  G01T1/29 ,  G01V5/00 ,  G06T11/00 ,  A61B

CPC classification number: G01V5/0008 ,  A61B6/037 ,  G01T1/2985 ,  G06T11/005

Abstract: A method and apparatus are provided for reconstructing images from data obtained from scintillation events occurring within a projection space of a depth-of-interaction positron emission tomography system. The method includes the steps of identifying a segment of each depth-of-interaction detector of respective pairs of depth-of-interaction detectors detecting the scintillation events of the data obtained within the projection space and estimating a set of sinograms from the data based upon a set of depth-independent point spread functions of the identified segments of the respective pairs of depth-of-interaction detectors.

Abstract translation: 提供了一种方法和装置，用于根据在相互作用的深度正电子发射断层摄影系统的投影空间内发生的闪烁事件获得的数据重建图像。 该方法包括以下步骤：识别检测在投影空间内获得的数据的闪烁事件的相互对的深度相互作用检测器的每个深度相互作用检测器的段，并基于来自该数据的一组正弦图 相关的相互作用深度检测器对的识别的段的深度无关的点扩散函数的集合。

公开(公告)号：WO0045853A3

公开(公告)日：2001-05-31

申请号：PCT/US0002814

申请日：2000-02-04

Applicant: ARCH DEV CORP ,  U A B RES FOUNDATION

Inventor： WEICHSELBAUM RALPH ,  ROIZMAN BERNARD ,  WHITLEY RICHARD

IPC: A61K48/00 ,  A61K35/76 ,  A61K38/00 ,  A61P35/00 ,  C07K14/035

CPC classification number: C07K14/005 ,  A61K35/763 ,  C12N2710/16622 ,  C12N2710/16632

Abstract: Disclosed are methods for treating cancer by administering an effective amount of a modified Herpes simplex virus.

Abstract translation: 公开了通过施用有效量的改良的单纯疱疹病毒来治疗癌症的方法。

公开(公告)号：WO0031134A9

公开(公告)日：2000-11-23

申请号：PCT/US9927490

申请日：1999-11-19

Applicant: ARCH DEV CORP ,  GAT URI ,  DASGUPTA RAMANUJ ,  DEGENSTEIN LINDA ,  FUCHS ELAINE

Inventor： GAT URI ,  DASGUPTA RAMANUJ ,  DEGENSTEIN LINDA ,  FUCHS ELAINE

IPC: A61K8/60 ,  A61K8/64 ,  A61K8/65 ,  A61P17/14 ,  A61Q7/00 ,  C07K14/47

CPC classification number: A61K8/606 ,  A61K8/64 ,  A61K8/65 ,  A61K2800/52 ,  A61K2800/86 ,  A61Q7/00

Abstract: The present invention provides a method for inducing hair growth by providing beta-catenin activity to a skin cell. This may be achieved by providing a beta-catenin polypeptide, providing a beta-catenin agonist, providing a polynucleotide encoding a beta-catenin polypeptide, enhancing the de novo synthesis of beta-catenin, increasing the stability or decreasing the degradation of beta-catenin polypeptides.

Abstract translation: 本发明提供了通过向皮肤细胞提供β-连环蛋白活性来诱导毛发生长的方法。 这可以通过提供β-连环蛋白多肽，提供β-连环蛋白激动剂，提供编码β-连环蛋白多肽的多核苷酸，增强β-连环蛋白的从头合成，增加β-连环蛋白的稳定性或降低β-连环蛋白的降解来实现 多肽。

公开(公告)号：WO0023603A8

公开(公告)日：2000-10-26

申请号：PCT/US9924890

申请日：1999-10-21

Applicant: ARCH DEV CORP ,  UNIV TEXAS ,  POLONSKY KENNETH S ,  HORIKAWA YUKIO ,  ODA NAOHISA ,  SREENAN SEAMUS ,  ZHOU YUN PING ,  OTANI KENICHI ,  HANIS CRAIG L ,  BELL GRAEME I ,  COX NANCY J

Inventor： POLONSKY KENNETH S ,  HORIKAWA YUKIO ,  ODA NAOHISA ,  SREENAN SEAMUS ,  ZHOU YUN-PING ,  OTANI KENICHI ,  HANIS CRAIG L ,  BELL GRAEME I ,  COX NANCY J

IPC: A61P3/10 ,  C12N9/64 ,  C12N15/12 ,  C12Q1/68 ,  C12N15/63 ,  A61K38/55

CPC classification number: C12N9/6472 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172

Abstract: The present invention relates generally to the field of diabetes. More particularly, it concerns the identification of genes responsible for NIDDM1 for use in diagnostic and therapeutic applications. The present invention demonstrates that the NIDDM1 locus is, in fact, the calpain 10 gene. The invention further relates to the discovery that analysis of mutations in calpain genes and gene products can be diagnostic for type 2 diabetes. The invention also contemplates methods of treating diabetes in view of the fact that calpain mutations can cause diabetes. Further, the invention relates to novel polynucleotides of the NIDDM1 locus and polypeptides encoded by such polynucleotides.

Abstract translation: 本发明一般涉及糖尿病领域。 更具体地说，它涉及鉴定负责用于诊断和治疗应用的NIDDM1的基因。 本发明证明NIDDM1基因座实际上是钙蛋白酶10基因。 本发明进一步涉及钙蛋白酶基因和基因产物中的突变分析可以诊断2型糖尿病的发现。 鉴于钙蛋白酶突变可导致糖尿病的事实，本发明还考虑治疗糖尿病的方法。 此外，本发明涉及NIDDM1基因座的新颖多核苷酸和由此类多核苷酸编码的多肽。

公开(公告)号：WO0030021A9

公开(公告)日：2000-10-19

申请号：PCT/US9925998

申请日：1999-11-12

Applicant: ARCH DEV CORP ,  DOI KUNIO ,  NAKAMURA KATSUMI

Inventor： DOI KUNIO ,  NAKAMURA KATSUMI

IPC: A61B6/03 ,  A61B6/00 ,  G06K9/00 ,  G06T1/00 ,  G06T7/00

CPC classification number: G06T7/0012 ,  G06K9/00127

Abstract: A method, computer program product, and system (100) for computerized analysis of the likelihood of malignancy in a pulmonary nodule using artificial neural networks (ANNs) (S4). The method, on which the computer program product and the system is based on, includes obtaining a digital outline of a nodule; generating objective measures corresponding to physical features of the outline of the nodule; applying the generated objective measures to an ANN; and determining a likelihood of malignancy of the nodule based on an output of the ANN. Techniques include novel developments and implementations of artificial neural networks and feature extraction for digital images. Output from the inventive method yields an estimate of the likelihood of malignancy (S7) for a pulmonary nodule.

Abstract translation: 一种使用人工神经网络（ANN）（S4）对肺结节中的恶性可能性进行计算机化分析的方法，计算机程序产品和系统（100）。 计算机程序产品和系统所基于的方法包括获得结节的数字轮廓; 产生与结节轮廓的物理特征相对应的客观量度; 将所产生的客观措施应用于ANN; 以及基于ANN的输出确定结节恶性的可能性。 技术包括人工神经网络的新颖开发和实现以及数字图像的特征提取。 本发明方法的输出产生肺结节恶性可能性的估计（S7）。

公开(公告)号：WO9905685A8

公开(公告)日：1999-03-25

申请号：PCT/US9815280

申请日：1998-07-23

Applicant: ARCH DEV CORP

Inventor： WEGERICH STEPHAN W ,  JARMAN KRISTIN K ,  GROSS KENNETH C

IPC: G06F7/00 ,  G06F19/00 ,  G21C7/36

CPC classification number: G05B23/0221 ,  G05B23/0254

Abstract: A method and system for automatically establishing operational parameters of a statistical surveillance system. The method and system performs a frequency domain transition (20) on time dependent data, first Fourier composite (30) is formed, serial correlation (35) is removed, a series of Gaussian whiteness tests (50) are performed along with an autocorrelation (35) test, Fourier coefficients (80) are stored and a second Fourier composite is formed. Pseudorandom noise is added, a Monte Carlo simulation is performed to establish SPRT missed alarm probabilities and tested with a synthesized signal. A false alarm test is then empirically evaluated and if less than a desired target value, then SPRT probabilities are used for performing surveillance.

Abstract translation: 自动建立统计监视系统运行参数的方法和系统。 该方法和系统对时间相关数据执行频域转换（20），形成第一傅里叶复合（30），去除串行相关（35），执行一系列高斯白度测试（50）以及自相关 35）测试，存储傅里叶系数（80）并形成第二傅里叶复合物。 添加伪随机噪声，执行蒙特卡洛模拟以建立SPRT漏检概率并用合成信号进行测试。 然后通过实验评估虚警测试，如果测试结果低于预期目标值，则使用SPRT概率进行监测。

公开(公告)号：WO9846637A3

公开(公告)日：1999-01-28

申请号：PCT/US9807573

申请日：1998-04-16

Applicant: ARCH DEV CORP ,  LEOPARDI ROSARIO ,  ROIZMAN BERNARD

Inventor： LEOPARDI ROSARIO ,  ROIZMAN BERNARD

IPC: A61K38/00 ,  C07K14/035 ,  C12N5/02 ,  C07K14/00

CPC classification number: C07K14/005 ,  A61K38/00 ,  C12N2710/16622

Abstract: The ICP4 protein of herpes simplex virus plays an important role in the transactivation of viral genes. The present invention discloses that ICP4 also has the ability to inhibit apoptosis. This function appears to reside in functional domain distinct from the transactivating function, as indicated by studies using temperature sensitive mutants of ICP4 that have transactivating function at elevated temperatures. Also disclosed are methods for inhibition of apoptosis using ICP4 or an ICP4 encoding gene, such as an α4 gene, methods for inhibiting ICP4's apoptosis-inhibiting function, and methods for the production of recombinant proteins and treatment of HSV infections. Further, the present invention discloses that the HSV-1 mutant lacking the α4 gene, has a secondary mutation in the gene US3 specifying a protein kinase. Thus a functional US3, a viral gene encoding a protein kinase known to phosphorylate serine/threonine within a specific arginine rich consensus sequence, is required in order to block apoptosis. Also disclosed are methods for inhibition of apoptosis using US3 or an US3 encoding gene, methods for inhibiting US3's apoptosis-inhibiting function, and methods for the production of recombinant proteins and treatment of HSV infections.

公开(公告)号：WO9803661A3

公开(公告)日：1998-10-08

申请号：PCT/US9712497

申请日：1997-07-18

Applicant: ARCH DEV CORP ,  MCLEOD RIMA L W ,  ROBERTS CRAIG W ,  ROBERTS FIONA ,  JOHNSON JENNIFER J ,  METS LAURENS

Inventor： MCLEOD RIMA L W ,  ROBERTS CRAIG W ,  ROBERTS FIONA ,  JOHNSON JENNIFER J ,  METS LAURENS

IPC: A61K38/00 ,  A61K39/002 ,  C12N9/88 ,  C12N9/90 ,  G01N33/569 ,  C12N15/52 ,  A61K39/012 ,  A61K39/015 ,  C07K14/445 ,  C07K14/45 ,  C07K16/40 ,  C12Q1/68 ,  G01N33/577

CPC classification number: A61K39/002 ,  A61K38/00 ,  C12N9/88 ,  C12N9/90 ,  G01N33/56905

Abstract: This invention relates to uses of components of plant-like metabolic pathways not including psbA or PPi phosphofructokinase and not generally operative in animals or encoded by the plastid DNA, to develop compositions that interfere with Apicomplexan growth and survival. Components of the pathways include enzymes, transit peptides and nucleotide sequences encoding the enzymes and peptides, or promoters of these nucleotide sequences to which antibodies, antisense molecules and other inhibitors are directed. Diagnostic and therapeutic reagents and vaccines are developed based on the components and their inhibitors.