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公开(公告)号：CA2409366A1
公开(公告)日：2001-11-08
申请号：CA2409366
申请日：2001-05-03
Applicant: ASPECT MEDICAL SYSTEMS INC
Inventor： STRUYS MICHEL , VERSICHELEN LINDA , DE SMET TOM
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公开(公告)号：AU6558001A
公开(公告)日：2001-10-25
申请号：AU6558001
申请日：2001-08-31
Applicant: ASPECT MEDICAL SYSTEMS INC
Inventor： DELVIN PHILLIP H , MCDANIEL TERRIE L , FENDROCK CHARLES , SHAMBROOM JOHN R , CHAMOUN NASSIB B , CORDERO RAFAEL M
IPC: A61B5/0402 , A61B5/0408
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公开(公告)号：DE69330710D1
公开(公告)日：2001-10-11
申请号：DE69330710
申请日：1993-09-23
Applicant: ASPECT MEDICAL SYSTEMS INC
Inventor： FENDROCK CHARLES
IPC: A61B5/0408 , A61B5/0402
Abstract: Disclosed is a disposable self-prepping electrode which utilizes an array or mat of flexile tines which serve to part the high impedance outer layers of skin to expose the low impedance, blood enriched layers without scratching or abrading. The tines are preferably imbedded in a conductive gel layer. In an alternate embodiment, a self prepping layer of flexile tines embedded in gel may be a single disposable self-prepping layer that is mounted over a permanent electrode.
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公开(公告)号：AT205065T
公开(公告)日：2001-09-15
申请号：AT93921721
申请日：1993-09-23
Applicant: ASPECT MEDICAL SYSTEMS INC
Inventor： FENDROCK CHARLES
IPC: A61B5/0408 , A61B5/0402
Abstract: Disclosed is a disposable self-prepping electrode which utilizes an array or mat of flexile tines which serve to part the high impedance outer layers of skin to expose the low impedance, blood enriched layers without scratching or abrading. The tines are preferably imbedded in a conductive gel layer. In an alternate embodiment, a self prepping layer of flexile tines embedded in gel may be a single disposable self-prepping layer that is mounted over a permanent electrode.
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公开(公告)号：AU732539B2
公开(公告)日：2001-04-26
申请号：AU5615098
申请日：1997-12-19
Applicant: ASPECT MEDICAL SYSTEMS INC
Inventor： GREENWALD SCOTT D , SMITH CHARLES P
IPC: A61B5/0476
Abstract: The disclosed filter removes cardiac artifacts from signals representative of a patient's cerebral activity. The filter preferably replaces portions of the signal including artifacts with temporally adjacent artifact free portions.
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Patent Agency Ranking
公开(公告)号：DE69032771T2
公开(公告)日：1999-07-29
申请号：DE69032771
申请日：1990-03-13
Applicant: ASPECT MEDICAL SYSTEMS INC
Inventor： CHAMOUN NASSIB
IPC: A61B5/0452 , A61B10/00 , G06F17/00 , G06F17/18
Abstract: Disclosed is a cardiac biopotential analysis system and method for detecting and quantifying in a noninvasive manner nonlinear dynamic patterns of depolarization and repolarization on a beat to beat basis in real time using bispectral analysis. A suitable body surface electrode acquires the signal from a region of interest. The signal is then amplified, digitized, and transmitted to a host microcomputer where an arrhythmia-free QRST complex is chosen interactively. Using standard cross-correlation methods a suitable number of complexes are extracted from the record. The extracted complexes are used to compute bispectral parameters using a frequency domain or a parametric based approach. A reference clinical database is used to identify frequency pairs most sensitive to particular interventions or diagnostic states of interest. The values at these frequency pairs are then extracted from the patient's bispectral arrays. The ensemble of values for the particular diagnostic determination under consideration is used to compute a single value index which serves as the diagnostic criterion by which the patient's state is judged. In this way the quantification of nonlinear dynamic properties of the frequency structure of the QRST yields information about the presence and extent of coronary artery disease (CAD), myocardial ischemia, cardiac electrical stability, risk of malignant ventricular arrhydthmia, site(s) of origin of malignant arrhythmias, extent of malignancy of arrhythmias, degree of antiarrhythmic drug efficacy, neural and humoral inputs to the heart, pump function/ejection fraction, and ongoing organ rejection in cardiac transplant patients.
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公开(公告)号：DE69228823D1
公开(公告)日：1999-05-06
申请号：DE69228823
申请日：1992-10-23
Applicant: ASPECT MEDICAL SYSTEMS INC
Inventor： CHAMOUN NASSIB , MEAD PETER , CHIANG HSING-HSING , SAINI VIKAS
Abstract: A method of generating a diagnostic index for quantifying the presence or absence of a phenomena which is represented by spectral values generated from acquired electrical signals of the phenomena, comprises the steps of: sorting said spectral values into predetermined bins of ranges of spectral values; summing all of the spectral values in each bin; multiplying the sum of spectral values in each bin by a predetermined coefficient to obtain a bin product; summing said bin products to obtain a diagnostic index which represents a degree of presence or absence of said phenomena.
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公开(公告)号：DE69032771D1
公开(公告)日：1998-12-24
申请号：DE69032771
申请日：1990-03-13
Applicant: ASPECT MEDICAL SYSTEMS INC
Inventor： CHAMOUN NASSIB
IPC: A61B5/0452 , A61B10/00 , G06F17/00 , G06F17/18
Abstract: Disclosed is a cardiac biopotential analysis system and method for detecting and quantifying in a noninvasive manner nonlinear dynamic patterns of depolarization and repolarization on a beat to beat basis in real time using bispectral analysis. A suitable body surface electrode acquires the signal from a region of interest. The signal is then amplified, digitized, and transmitted to a host microcomputer where an arrhythmia-free QRST complex is chosen interactively. Using standard cross-correlation methods a suitable number of complexes are extracted from the record. The extracted complexes are used to compute bispectral parameters using a frequency domain or a parametric based approach. A reference clinical database is used to identify frequency pairs most sensitive to particular interventions or diagnostic states of interest. The values at these frequency pairs are then extracted from the patient's bispectral arrays. The ensemble of values for the particular diagnostic determination under consideration is used to compute a single value index which serves as the diagnostic criterion by which the patient's state is judged. In this way the quantification of nonlinear dynamic properties of the frequency structure of the QRST yields information about the presence and extent of coronary artery disease (CAD), myocardial ischemia, cardiac electrical stability, risk of malignant ventricular arrhydthmia, site(s) of origin of malignant arrhythmias, extent of malignancy of arrhythmias, degree of antiarrhythmic drug efficacy, neural and humoral inputs to the heart, pump function/ejection fraction, and ongoing organ rejection in cardiac transplant patients.
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公开(公告)号：DE69031118D1
公开(公告)日：1997-09-04
申请号：DE69031118
申请日：1990-03-13
Applicant: ASPECT MEDICAL SYSTEMS INC
Inventor： CHAMOUN NASSIB
Abstract: Disclosed is a real time cerebral diagnostic apparatus and method for quantitatively evaluating, in a noninvasive manner, cerebral phenomena such as the depth and adequacy of anesthesia pain responses during surgical stress, acute cerebral ischemia, level of consciousness, degree of intoxication and ongoing normal and abnormal cognitive processes. A suitable electrode and amplifier system is used to obtain high resolution biopotentials from the regions of interest. Surface electroencephalographic (EEG) signals are filtered to allow the acquisition of frequencies between 2 and 500 Hz, then digitized and transmitted over a high speed serial line to a host computer where a 32 second long signal is divided into 128 consecutive 0.25 second intervals. Digital EEG data from unipolar leads is normalized and the dynamic phase and density relations within the signal are then characterized by estimating the third-order autocorrelation function or autobispectrum using either a frequency domain, or parametric approach. Paired EEG data from corresponding left and right hemisphere leads is used to characterize the dynamic phase and density relations between hemispheres by estimating the third order crosscorrelation function or crossbispectrum using either frequency domain or parametric techniques. Under certain specific filtering circumstances the power spectrum and crosspower spectrum are also computed. A reference clinical database is used to identify frequency pairs most sensitive to particular interventions or diagnostic states of interest. The values at these frequency pairs are then extracted from the patient's autobicoherence, autobispectral density, autobiphase, crossbicoherence, crossbispectral density, and crossbiphase arrays. The ensemble of values for the particular diagnostic determination is used to compute an index which serves as the diagnostic criterion by which the patient's state is judged. Any diagnostic index can be continuously displayed on a graphics terminal for real-time diagnostic monitoring or can be sent to a hard copy device to generate reports for the medical record.
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公开(公告)号：AT155908T
公开(公告)日：1997-08-15
申请号：AT90905998
申请日：1990-03-13
Applicant: ASPECT MEDICAL SYSTEMS INC
Inventor： CHAMOUN NASSIB G
Abstract: Disclosed is a real time cerebral diagnostic apparatus and method for quantitatively evaluating, in a noninvasive manner, cerebral phenomena such as the depth and adequacy of anesthesia pain responses during surgical stress, acute cerebral ischemia, level of consciousness, degree of intoxication and ongoing normal and abnormal cognitive processes. A suitable electrode and amplifier system is used to obtain high resolution biopotentials from the regions of interest. Surface electroencephalographic (EEG) signals are filtered to allow the acquisition of frequencies between 2 and 500 Hz, then digitized and transmitted over a high speed serial line to a host computer where a 32 second long signal is divided into 128 consecutive 0.25 second intervals. Digital EEG data from unipolar leads is normalized and the dynamic phase and density relations within the signal are then characterized by estimating the third-order autocorrelation function or autobispectrum using either a frequency domain, or parametric approach. Paired EEG data from corresponding left and right hemisphere leads is used to characterize the dynamic phase and density relations between hemispheres by estimating the third order crosscorrelation function or crossbispectrum using either frequency domain or parametric techniques. Under certain specific filtering circumstances the power spectrum and crosspower spectrum are also computed. A reference clinical database is used to identify frequency pairs most sensitive to particular interventions or diagnostic states of interest. The values at these frequency pairs are then extracted from the patient's autobicoherence, autobispectral density, autobiphase, crossbicoherence, crossbispectral density, and crossbiphase arrays. The ensemble of values for the particular diagnostic determination is used to compute an index which serves as the diagnostic criterion by which the patient's state is judged. Any diagnostic index can be continuously displayed on a graphics terminal for real-time diagnostic monitoring or can be sent to a hard copy device to generate reports for the medical record.
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