公开(公告)号：AT189927T

公开(公告)日：2000-03-15

申请号：AT93203737

申请日：1993-07-22

Applicant: APPLIED SPECTRAL IMAGING LTD

Inventor： CABIB DARIO ,  FRIEDMAN ZVI ,  LIPSON STEPHEN G ,  BUCKWALD ROBERT A

IPC: G01J3/26 ,  G01J3/28 ,  G01B9/02

公开(公告)号：IL129842D0

公开(公告)日：2000-02-29

申请号：IL12984299

申请日：1999-05-07

Applicant: APPLIED SPECTRAL IMAGING LTD

IPC: A61B3/14 ,  G02B20060101 ,  G02B

公开(公告)号：AU1610299A

公开(公告)日：1999-06-16

申请号：AU1610299

申请日：1998-11-27

Applicant: APPLIED SPECTRAL IMAGING LTD

Inventor： SOENKSEN DIRK G ,  MCNAMARA GEORGE ,  GARINI YUVAL ,  KATZIR NIR

IPC: G01J3/46 ,  C12Q1/68 ,  G01B11/06 ,  G01J3/02 ,  G01J3/12 ,  G01J3/26 ,  G01J3/28 ,  G01J3/44 ,  G01J3/453 ,  G01J5/10 ,  G01N1/30 ,  G01N21/27 ,  G01N21/64 ,  G01N21/78 ,  G01N33/483 ,  G01N33/50 ,  G01N33/569 ,  G01N33/58 ,  G06K9/00 ,  G06K9/76 ,  G06T1/00 ,  G01B9/02

Abstract: A method for cancer cell detection including the steps of (a) staining an analyzed sample with at least first and second dyes, the dyes being selected such that the first dye better adheres to normal cells whereas the second dye better adheres to cancer cells; (b) spectrally imaging the sample through an optical device being optically connected to an imaging spectrometer thereby obtaining a spectrum of each pixel of the sample; (c) based on the spectra, evaluating concentrations of the first and second dyes for each of the pixels; and (d) based on the concentrations detecting the presence of cancer cells in the sample.

公开(公告)号：AU9592098A

公开(公告)日：1999-04-23

申请号：AU9592098

申请日：1998-09-29

Applicant: APPLIED SPECTRAL IMAGING LTD

Inventor： CABIB DARIO ,  ADEL MICHAEL ,  BUCKWALD ROBERT A

IPC: A61B3/11 ,  A61B3/12 ,  A61B5/00 ,  C12Q1/68 ,  G01J3/02 ,  G01J3/12 ,  G01J3/26 ,  G01J3/28 ,  G01J3/44 ,  G01J3/453 ,  G01N21/64 ,  G01N33/50 ,  G01N33/569 ,  G01N33/58 ,  G06K9/00 ,  G06K9/76 ,  A61B5/05

Abstract: A spectral bio-imaging method for enhancing pathologic, physiologic, metabolic and health related spectral signatures of an eye tissue, the method comprising the steps of (a) providing an optical device for eye inspection being optically connected to a spectral imager; (b) illuminating the eye tissue with light via the iris, viewing the eye tissue through the optical device and spectral imager and obtaining a spectrum of light for each pixel of the eye tissue; and (c) attributing each of the pixels a color or intensity according to its spectral signature, thereby providing an image enhancing the spectral signatures of the eye tissue.

公开(公告)号：IL125915D0

公开(公告)日：1999-04-11

申请号：IL12591598

申请日：1998-08-25

Applicant: APPLIED SPECTRAL IMAGING LTD

IPC: G01N15/14 ,  G01N21/64 ,  G01N21/78 ,  G01N33/533 ,  G01N33/566 ,  G01N33/58 ,  G02B21/06 ,  G01N

Abstract: Classification of pixels into groups of pixels according to their association with a single fluorophore or a combination of fluorophores, comprises: (a) providing a number of wide-band emission filters; (b) for each of the pixels, recording emitted light intensity as retrieved after passing through each one of the emission filters, such that each of the pixels is representable by a vector of a number of dimensions equal to the number of wide-band emission filters; and (c) using an algorithm for evaluating the presence of each of the fluorophores associated with each of the pixels, thus classifying each of the pixels into a group of pixels according to its association with the fluorophores. Each fluorophore has a characterising emission spectrum and a specifying emission peak.

公开(公告)号：IL124848D0

公开(公告)日：1999-01-26

申请号：IL12484897

申请日：1997-05-12

Applicant: APPLIED SPECTRAL IMAGING LTD

IPC: A61B3/14 ,  G01B9/02 ,  G01J3/45 ,  G02B20060101 ,  G02B

公开(公告)号：AU6744998A

公开(公告)日：1998-10-22

申请号：AU6744998

申请日：1998-04-01

Applicant: APPLIED SPECTRAL IMAGING LTD

Inventor： CABIB DARIO ,  FRIEDMAN ZVI ,  LIPSON STEPHEN G ,  BUCKWALD ROBERT A

IPC: C12Q1/68 ,  G01J3/02 ,  G01J3/12 ,  G01J3/26 ,  G01J3/28 ,  G01J3/44 ,  G01J3/453 ,  G01N21/64 ,  G01N33/50 ,  G01N33/569 ,  G01N33/58 ,  G06K9/00 ,  G06K9/76 ,  G01B9/02

Abstract: A method and apparatus for analyzing an optical image of a scene to determine the spectral intensity of each pixel thereof, by: collecting incident light from the scene; scanning the incident light; passing the scanned light through an interferometer which outputs modulated light corresponding to a predetermined set of linear combinations of the spectral intensity of the light emitted from each pixel; focusing the light outputted from the interferometer on a detector array; and processing the output of the detector array to determine the spectral intensity of each pixel thereof.

公开(公告)号：CA2900747A1

公开(公告)日：2014-05-01

申请号：CA2900747

申请日：2013-10-24

Applicant: APPLIED SPECTRAL IMAGING LTD

Inventor： KATZIR NIR

IPC: G01B9/02 ,  A61B6/00 ,  G01B11/02 ,  G02B27/10

Abstract: A method of calibrating a spectral imaging system is disclosed. The spectral imaging system comprises an interferometer having a beam splitter and at least a first reflector and a second reflector. The method comprises: obtaining data pertaining to an interference pattern model, operating the spectral imaging system to provide an interference pattern of a received light beam, and varying a relative orientation between at least two of: the beam splitter, the first reflector and the second reflector, until the interference pattern of the input light beam substantially matches the interference pattern model.

公开(公告)号：DE69940270D1

公开(公告)日：2009-02-26

申请号：DE69940270

申请日：1999-11-16

Applicant: APPLIED SPECTRAL IMAGING LTD

Inventor： GARINI YUVAL ,  MCNAMARA GEORGE ,  SOENKSEN DIRK G ,  CABIB DARIO ,  BUCKWALD ROBERT A

IPC: G01N33/53 ,  C12Q1/00 ,  C12Q1/28 ,  C12Q1/42 ,  C12Q1/54 ,  C12Q1/68 ,  C12Q1/6841 ,  C12Q1/6883 ,  G01J3/02 ,  G01J3/12 ,  G01J3/26 ,  G01J3/28 ,  G01J3/44 ,  G01J3/453 ,  G01N1/30 ,  G01N21/64 ,  G01N21/78 ,  G01N33/50 ,  G01N33/533 ,  G01N33/535 ,  G01N33/569 ,  G01N33/58 ,  G06K9/00 ,  G06K9/76

Abstract: A method of in situ analysis of a biological sample comprising the steps of (a) staining the biological sample with N stains of which a first stain is selected from the group consisting of a first immunohistochemical stain, a first histological stain and a first DNA ploidy stain, and a second stain is selected from the group consisting of a second immunohistochemical stain, a second histological stain and a second DNA ploidy stain, with provisions that N is an integer greater than three and further that (i) if the first stain is the first immunohistochemical stain then the second stain is either the second histological stain or the second DNA ploidy stain; (ii) if the first stain is the first histological stain then the second stain is either the second immunohistochemical stain or the second DNA ploidy stain; whereas (iii) if the first stain is the first DNA ploidy stain then the second stain is either the second immunohistochemical stain or the second histological stain; and (b) using a spectral data collection device for collecting spectral data from the biological sample, the spectral data collection device and the N stains are selected such that a spectral component associated with each of the N stains is collectable.

公开(公告)号：AU1547101A

公开(公告)日：2001-06-04

申请号：AU1547101

申请日：2000-11-23

Applicant: APPLIED SPECTRAL IMAGING LTD

Inventor： GIL AMIR ,  GIL TAMIR ,  HORN ELI ,  GARINI YUVAL

IPC: A61B5/00

Abstract: A method of functional brain mapping of a subject is disclosed. The method is effected by (a) illuminating an exposed cortex of a brain or portion thereof of the subject with incident light; (b) acquiring a reflectance spectrum of each picture element of at least a portion of the exposed cortex of the subject; (c) stimulating the brain of the subject; (d) during or after step (c) acquiring at least one additional reflectance spectrum of each picture element of at least the portion of the exposed cortex of the subject; and (e) generating an image highlighting differences among spectra of the exposed cortex acquired in steps (b) and (d), so as to highlight functional brain regions. Algorithms for calculating oxygen saturation and blood volume maps which can be used to practice the method are also disclosed. Systems for practicing the method are also disclosed.