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    42.
    发明专利
    未知

    公开(公告)号：NO20061576L

    公开(公告)日：2006-04-07

    申请号：NO20061576

    申请日：2006-04-07

    Applicant: CELLTECH R&D LTD

    Inventor： SEHDEV MUKESH ,  REEKS DOMINIC GAMBIER ,  GLOVER DAVID JOHN

    IPC: C12N1/21 ,  C07K16/00 ,  C12N1/20 ,  C12N15/72 ,  C12P21/02

    Abstract: The present invention provides a method for controlling the partitioning of a recombinant protein between the supernatant and the periplasm in E. coli host cell cultures wherein expression of the recombinant protein by said cells is under the control of an inducible system, which method comprises: a) providing an E. coli host cell culture b) changing the growth rate of the E. coli host cells c) inducing expression of the recombinant protein wherein steps (b) and (c) can be performed in any order or simultaneously; and subsequently d) determining the yield of recombinant protein in the culture supernatant and the E. coli host cell periplasm e) comparing the yield determined in step (d) with the yield determined when at least one other growth rate has been used in step (b) f) selecting a growth rate from the comparison made in step (e) in which the partitioning of the recombinant protein between the supernatant and the periplasm is most suited to the primary recovery of the recombinant protein.

    PROCESS FOR THE PREPARATION OF PHENYLALANINE ENAMIDE DERIVATIVES
    45.
    发明专利
    PROCESS FOR THE PREPARATION OF PHENYLALANINE ENAMIDE DERIVATIVES 未知

    公开(公告)号：PL375370A1

    公开(公告)日：2005-11-28

    申请号：PL37537003

    申请日：2003-07-16

    Applicant: CELLTECH R&D LTD

    Inventor： SKEAD BENJAMIN MARK ,  TYRRELL NICHOLAS DAVID ,  JONES STEPHEN WILFRED ,  BROOKES MICHAEL HANDFORTH

    IPC: C07B61/00 ,  C07C229/36 ,  C07D213/81 ,  C07D311/96 ,  C07D471/04 ,  C07C227/18 ,  C07C231/02 ,  C07C303/38

    Abstract: A process for the preparation of a class of phenylalanine enamide derivatives is described: wherein: Ar 1 is an optionally substituted aromatic or heteroaromatic group; L 2 is a linker group selected from -N(R 4 )- [where R 4 is a hydrogen atom or an optionally substituted straight or branched C 1-6 alkyl group], -CON(R 4 )-, or -S(O) 2 N(R 4 )-; R 1 is a carboxylic acid (-CO 2 H) or a derivative or biostere thereof; R 2 is a hydrogen atom or a C 1-6 alkyl group; R x , R y and R z which may be the same or different is each an atom or group -L 1 (Alk 1 ) n (R 3 ) v ; and the salts, solvates, hydrates and N-oxides thereof; which comprises reacting a compound of formula (2): wherein: Q a is a group -N(R 4 )H; and the salts, solvates, hydrates and N-oxides thereof; with a compound Ar 1 W wherein W is a group selected from X 1 (wherein X 1 is a leaving atom or group), -COX 2 (wherein X 2 is a halogen atom or a -OH group) or -SO 2 X 3 (in which X 3 is a halogen atom).

    Biological products
    46.
    发明专利
    Biological products 未知

    公开(公告)号：GB0520169D0

    公开(公告)日：2005-11-09

    申请号：GB0520169

    申请日：2005-10-04

    Applicant: CELLTECH R&D LTD

    IPC: C07K16/24

    Abstract: The present invention provides a dicistronic message for producing an antibody molecule, in which the upstream cistron contains DNA coding for the light chain of the antibody and the downstream cistron contains DNA coding for the corresponding heavy chain, characterised in that the dicistronic message comprises a sequence selected from AEOS1 (SEQ ID NO:1), AEOS2 (SEQ ID NO:2), AEOS3 (SEQ ID NO:3), AEOS4 (SEQ ID NO: 4), AEOS5 (SEQ ID NO:5), AEOS6 (SEQ ID NO:6), AEOS7 (SEQ ID NO:7), AEOS8 (SEQ ID NO:8), AEOS9 (SEQ ID NO:9), AEOS1O (SEQ ID NO:10) and AEOS11 (SEQ ID NO:11).

    49.
    发明专利
    未知

    公开(公告)号：DE69434041T2

    公开(公告)日：2005-10-06

    申请号：DE69434041

    申请日：1994-12-21

    Applicant: CELLTECH R&D LTD

    Inventor： WARRELLOW JOHN ,  BOYD CAMPBELL ,  ALEXANDER PETER ,  EATON ANTHONY

    IPC: A61K31/41 ,  A61K31/415 ,  A61K31/42 ,  A61K31/44 ,  A61K31/4418 ,  A61P11/08 ,  A61P29/00 ,  A61P43/00 ,  C07D213/64 ,  C07D231/20 ,  C07D261/12

    Abstract: Compounds of general formula (1): (1) wherein Y is a halogen atom or a group -OR1 where R1 is an optionally substituted alkyl group; X is -O-, -S- or -N(R8)-, where R8 is a hydrogen atom or an alkyl group; R2 is an optionally substituted alkyl, alkenyl, cycloalkyl or cycloalkenyl group; R3 is a hydrogen or halogen atom or an -OR9 group, where R9 is a hydrogen atom or an optionally substituted alkyl, alkenyl, alkoxyalkyl, or alkanoyl group, or a formyl, carboxamido or thiocarboxamido group; R4 is a group -(CH2)nAr, where Ar is a monocyclic or bicyclic aryl group optionally containing one or more heteroatoms selected from oxygen, sulphur or nitrogen atoms and n is zero or an integer 1,2 or 3; R5 is a C3-9 carbocyclic ketone optionally containing one or more heteroatoms selected from oxygen, sulphur or nitrogen atoms; R6 is a hydrogen atom or an optionally substituted alkyl group; R7 is a hydrogen atom or an optionally substituted alkyl group; and the salts, solvates, hydrates and N-oxides thereof. Compounds according to the invention are potent and selective phosphodiesterase type IV inhibitors and are useful in the prophylaxis and treatment of diseases such as asthma where an unwanted inflammatory response or muscular spasm is present.

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