公开(公告)号：WO2002016599A3

公开(公告)日：2002-02-28

申请号：PCT/US2001/026510

申请日：2001-08-27

Applicant: CURAGEN CORPORATION ,  COR THERAPEUTICS, INC. ,  BURGESS, Catherine, E. ,  CONLEY, Pamela, B. ,  GROSSE, William, M. ,  HART, Matthew ,  KEKUDA, Ramesh ,  SHIMKETS, Richard, A. ,  SPYTEK, Kimberly, A. ,  SZEKERES, Edward, S., Jr. ,  TOMLINSON, James, E. ,  TOPPER, James, N. ,  YANG, Ruey-Bin

Inventor： BURGESS, Catherine, E. ,  CONLEY, Pamela, B. ,  GROSSE, William, M. ,  HART, Matthew ,  KEKUDA, Ramesh ,  SHIMKETS, Richard, A. ,  SPYTEK, Kimberly, A. ,  SZEKERES, Edward, S., Jr. ,  TOMLINSON, James, E. ,  TOPPER, James, N. ,  YANG, Ruey-Bin

IPC: C12N15/00

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses tehrapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：WO0156989A3

公开(公告)日：2002-02-28

申请号：PCT/US0103175

申请日：2001-02-01

Applicant: COR THERAPEUTICS INC ,  ZHU BING YAN ,  SCARBOROUGH ROBERT

Inventor： ZHU BING-YAN ,  SCARBOROUGH ROBERT

IPC: C07D211/46 ,  C07D295/135 ,  C07D295/195 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  A61K31/445 ,  A61P7/02

CPC classification number: C07D295/195 ,  C07D211/46 ,  C07D295/135 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

Abstract: Novel compounds of general formula (I): including its pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa is described. Compositions containing such compounds are also described. The compounds and compositions are useful in vitro or in vivo for preventing or treating conditions in mammals characterized by undesired thrombosis.

Abstract translation: 描述了具有对哺乳动物因子Xa具有活性的通式（I）的新型化合物：包括其药学上可接受的异构体，盐，水合物，溶剂合物和前药衍生物。 还描述了含有这些化合物的组合物。 化合物和组合物在体外或体内用于预防或治疗特征在于不期望的血栓形成的哺乳动物中的病症。

公开(公告)号：WO0157021A3

公开(公告)日：2002-02-14

申请号：PCT/US0103176

申请日：2001-02-01

Applicant: COR THERAPEUTICS INC ,  ZHU BING YAN ,  SCARBOROUGH ROBERT

Inventor： ZHU BING-YAN ,  SCARBOROUGH ROBERT

IPC: A61P7/02 ,  A61P9/02 ,  C07D241/44 ,  C07D401/12 ,  C07D401/14 ,  A61K31/497

CPC classification number: C07D401/12 ,  C07D241/44 ,  C07D401/14

Abstract: Novel compounds of general formula I, including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivative having activity against mammalian factor Xa is described. Compositions containing such compounds are also described. The compounds and compositions are useful in vitro or in vivo for preventing or treating conditions in mammals characterized by undesired thrombosis.

Abstract translation: 描述了具有对哺乳动物因子Xa具有活性的新型通式I化合物，包括其药学上可接受的异构体，盐，水合物，溶剂合物和前药衍生物。 还描述了含有这些化合物的组合物。 化合物和组合物在体外或体内用于预防或治疗特征在于不期望的血栓形成的哺乳动物中的病症。

公开(公告)号：WO0206280A2

公开(公告)日：2002-01-24

申请号：PCT/US0122077

申请日：2001-07-13

Applicant: COR THERAPEUTICS INC ,  ZHU BING YAN ,  YANG HUA ,  SCARBOROUGH ROBERT

Inventor： ZHU BING-YAN ,  YANG HUA ,  SCARBOROUGH ROBERT

IPC: C07D209/14 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  A61K31/33 ,  A61K31/425 ,  C07D209/16

CPC classification number: C07D401/12 ,  C07D209/14 ,  C07D403/12 ,  C07D413/12 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14

Abstract: Compounds, having the formula (I), their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.

Abstract translation: 公开了具有式（I）的化合物，其与其相关的盐和组合物具有抗哺乳动物因子Xa的活性。 该化合物在体外或体内可用于预防或治疗凝血障碍。

公开(公告)号：WO0130780A3

公开(公告)日：2001-11-29

申请号：PCT/US0029804

申请日：2000-10-27

Applicant: COR THERAPEUTICS INC ,  SCARBOROUGH ROBERT M ,  MEHROTA MUKUND ,  PANDEY ANJALI ,  SMYTH MARK

Inventor： SCARBOROUGH ROBERT M ,  MEHROTA MUKUND ,  PANDEY ANJALI ,  SMYTH MARK

IPC: A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/551 ,  A61P7/02 ,  A61P9/00 ,  A61P9/10 ,  C07D401/04 ,  C07D413/14 ,  C07D471/10 ,  A61K31/438

CPC classification number: C07D401/04 ,  C07D413/14 ,  C07D471/10

Abstract: This invention relates to certain substituted or unsubstituted pyridyl-containing spirocyclic compounds substituted with both basic and acidic functionality, which are useful in inhibition of platelet aggregation.

Abstract translation: 本发明涉及用碱性和酸性官能团取代的某些取代或未取代的含吡啶基螺环化合物，其可用于抑制血小板聚集。

公开(公告)号：WO0047553A8

公开(公告)日：2001-09-20

申请号：PCT/US0003404

申请日：2000-02-11

Applicant: COR THERAPEUTICS INC

Inventor： SONG YOUNGHONG ,  SCARBOROUGH ROBERT M ,  ZHU BING-YAN

IPC: C07D295/14 ,  A61K31/18 ,  A61K31/192 ,  A61K31/195 ,  A61K31/216 ,  A61K31/341 ,  A61K31/40 ,  A61K31/41 ,  A61K31/415 ,  A61K31/4174 ,  A61K31/44 ,  A61K31/4409 ,  A61K31/472 ,  A61K31/4725 ,  A61K31/495 ,  A61K31/505 ,  A61K31/517 ,  A61P7/00 ,  A61P7/02 ,  A61P7/04 ,  A61P9/00 ,  A61P9/10 ,  A61P11/00 ,  A61P31/04 ,  A61P43/00 ,  C07C257/18 ,  C07C311/29 ,  C07C311/46 ,  C07C311/51 ,  C07D213/56 ,  C07D213/58 ,  C07D213/70 ,  C07D213/74 ,  C07D213/75 ,  C07D217/22 ,  C07D231/12 ,  C07D233/61 ,  C07D239/42 ,  C07D239/94 ,  C07D257/04 ,  C07D295/16 ,  C07D307/54 ,  C07D401/12 ,  C07D521/00

CPC classification number: C07D231/12 ,  C07C311/46 ,  C07C311/51 ,  C07C2601/10 ,  C07D217/22 ,  C07D233/56 ,  C07D239/94 ,  C07D249/08 ,  C07D307/54 ,  C07D401/12

Abstract: L'invention porte sur des composés alcényle and alkynyle s'avérant de puissants inhibiteurs du facteur Xa isolés ou rassemblés dans le complexe de prothrombinase et sur des compositions contenant lesdits composés qui montrent une sélectivité vis à vis du facteur Xa supérieure à celle des autres protéases de la coagulation (par exemple la thrombine, le fVIIa, le fIXa) ou des cascades fibrinolytiques (par exemple les activateurs du plasminogène, la plasmine). L'invention porte également sur des procédés d'utilisation desdits composés comme agents de diagnostic ou thérapeutiques en vue de la prévention ou du traitement chez les mammifères de troubles de la coagulation tels que les thromboses.

公开(公告)号：WO0071508A3

公开(公告)日：2001-08-23

申请号：PCT/US0014208

申请日：2000-05-24

Applicant: COR THERAPEUTICS INC

Inventor： ZHU BING-YAN ,  ZHANG PENGLIE ,  SCARBOROUH ROBERT M

IPC: C07D213/74 ,  A61K31/18 ,  A61K31/198 ,  A61K31/341 ,  A61K31/397 ,  A61K31/40 ,  A61K31/401 ,  A61K31/4164 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/4427 ,  A61K31/4453 ,  A61K31/472 ,  A61K31/4725 ,  A61K31/495 ,  A61K31/496 ,  A61K31/5375 ,  A61K31/55 ,  A61P7/02 ,  A61P9/00 ,  A61P9/10 ,  A61P43/00 ,  C07C311/16 ,  C07C311/21 ,  C07C311/46 ,  C07D205/04 ,  C07D207/16 ,  C07D207/20 ,  C07D207/325 ,  C07D213/40 ,  C07D213/64 ,  C07D213/72 ,  C07D213/75 ,  C07D213/82 ,  C07D217/22 ,  C07D231/12 ,  C07D233/68 ,  C07D295/18 ,  C07D295/192 ,  C07D295/22 ,  C07D295/26 ,  C07D307/38 ,  C07D307/52 ,  C07D401/12 ,  A61L31/33 ,  C07D333/20

CPC classification number: C07D213/40 ,  C07C311/16 ,  C07C311/46 ,  C07D217/22 ,  C07D295/192 ,  C07D295/26 ,  C07D307/52 ,  C07D401/12

Abstract: Compounds of the formula A - Y - D - E - G - J - Z - L in which D is a direct link, a substituted or unsubstituted phenyl or naphthyl group or a heterocyclic ring system and the other variables are as defined in the claims, their salts and other derivatives and compositions relating thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.

公开(公告)号：WO0100657A3

公开(公告)日：2001-07-12

申请号：PCT/US0018018

申请日：2000-06-29

Applicant: ORTHO MCNEIL PHARM INC ,  COR THERAPEUTICS INC

Inventor： ZHANG HAN-CHENG ,  HOEKSTRA WILLIAM J ,  MARYANOFF BRUCE E ,  MCCOMSEY DAVID F

IPC: A61K38/00 ,  C07K5/065 ,  C07K5/078 ,  A61K38/05

CPC classification number: C07K5/06078 ,  A61K38/00 ,  C07K5/06139

Abstract: The invention is directed to novel indole peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, angiogenesis related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted indole peptidomimetics of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.

Abstract translation: 本发明涉及作为凝血酶受体拮抗剂用于治疗与血栓形成，再狭窄，高血压，心力衰竭，心律失常，炎症，心绞痛，中风，动脉粥样硬化，缺血性病症，血管生成相关病症，癌症相关的疾病的新型吲哚拟肽化合物 和神经退行性疾病。 还公开了包含本发明的取代的吲哚拟肽的药物组合物和治疗由凝血酶受体介导的病症的方法。

公开(公告)号：WO2001012600A1

公开(公告)日：2001-02-22

申请号：PCT/US2000/021742

申请日：2000-08-10

Applicant: COR THERAPEUTICS, INC. ,  ZHU, Bing-Yan ,  SCARBOROUGH, Robert, M. ,  CLIZBE, Lane ,  DOUGHAN, Brandon ,  JIA, Zhaozhong-Jon ,  KANE-MAGUIRE, Kim ,  MARLOWE, Charles ,  SONG, Yonghong ,  SU, Ting ,  TENG, Willy ,  ZHANG, Penglie

Inventor： ZHU, Bing-Yan ,  SCARBOROUGH, Robert, M. ,  CLIZBE, Lane ,  DOUGHAN, Brandon ,  JIA, Zhaozhong-Jon ,  KANE-MAGUIRE, Kim ,  MARLOWE, Charles ,  SONG, Yonghong ,  SU, Ting ,  TENG, Willy ,  ZHANG, Penglie

IPC: C07D209/04

CPC classification number: C07D215/227 ,  C07D209/08 ,  C07D209/34 ,  C07D209/38 ,  C07D215/08 ,  C07D231/56 ,  C07D235/06 ,  C07D235/26 ,  C07D241/38 ,  C07D241/44 ,  C07D243/24 ,  C07D265/36 ,  C07D401/06 ,  C07D401/10 ,  C07D401/14 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D409/06 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

Abstract: Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds of formula (I) are useful in vitro or in vivo for preventing or treating coagulation disorders.

Abstract translation: 公开了与哺乳动物因子Xa有关的新型化合物，其盐和与其有关的组合物。 式（I）的化合物可用于体内或体内用于预防或治疗凝血障碍。

公开(公告)号：WO9822500A3

公开(公告)日：1998-10-15

申请号：PCT/US9722422

申请日：1997-11-21

Applicant: COR THERAPEUTICS INC

Inventor： JENKINS ALISON L ,  PHILLIPS DAVID R

IPC: A61K45/00 ,  A61K38/00 ,  A61P7/02 ,  A61P9/00 ,  A61P21/02 ,  A61P29/00 ,  A61P35/00 ,  C07K14/705 ,  C07K14/78 ,  C07K14/405 ,  A61K38/39

CPC classification number: C07K14/70546 ,  A61K38/00 ,  C07K14/70557

Abstract: The present invention describes a direct interaction between myosin and the cytoplasmic domain of membrane proteins, particularly the phosphorylated cytoplasmic domains of the β-subunit of integrins. The invention provides methods of identifying agents which block integrin binding to myosin, methods of using agents which block integrin binding to myosin to modulate biological and pathological processes, and provides agents that block integrin mediated binding to myosin and thereby modulate related cellular or cellular component movement.