-
公开(公告)号：US20210373313A1
公开(公告)日：2021-12-02
申请号：US17274295
申请日：2019-09-10
Applicant: Fluidigm Canada Inc.
Inventor： DAAF SANDKUIJL , Alexander V. Loboda , ADAM CAREW , KHASHAYAR ASKARPOUR
Abstract: We describe in this application systems and methods for autofocusing in imaging mass spectrometry. The present application describes improvements over current IMS and IMC apparatus and methods through an autofocus component including a plurality of apertures in the autofocus system, such as a plurality of apertures arranged in 2 dimensions. As a plurality of apertures is used, the autofocus system provides redundancy in the event that measurement of focus on the sample from the illuminating radiation passed through one or more of the apertures fails so as to reduce the number of unsuccessful autofocus attempts.
-
公开(公告)号：US10472600B2
公开(公告)日：2019-11-12
申请号：US15966432
申请日：2018-04-30
Applicant: Fluidigm Canada Inc.
Inventor： Alexander V. Loboda
Abstract: Apparatus and methods for delivering biological samples to an ICP source of a mass cytometer are disclosed. Biological material is disposed on a plurality of discrete sites on a carrier. The plurality of discrete sites are configured to retain biological material and to release the biological material upon application of energy. The carrier is positioned in proximity to a gas conduit and upon release from the discrete sites, the biological material becomes entrained in a gas flow, which delivers discrete portions of biological material through the conduit to the ICP source for analysis by mass cytometry. The apparatus and methods can provide a continuous stream of discrete portions of biological material to a mass cytometer or mass spectrometer.
-
公开(公告)号：US09874567B2
公开(公告)日：2018-01-23
申请号：US15013880
申请日：2016-02-02
Applicant: Fluidigm Canada Inc.
Inventor： Olga Ornatsky
IPC: C12Q1/42 , G01N33/68 , C12Q1/48 , G01N33/569 , G01N33/58
CPC classification number: G01N33/6848 , C12Q1/42 , C12Q1/485 , G01N33/569 , G01N33/58 , G01N33/6842 , G01N2333/91205 , G01N2333/916 , G01N2440/14 , G01N2458/15 , G01N2560/00 , Y10S435/975
Abstract: Methods and kits for enzymes involved in post-translational modifications are provided. The methods employ elemental analysis, including ICP-MS. The methods allow for the convenient and accurate analysis of post-translation modifications of substrates by enzymes involved in post-translational modifications, including kinase and phosphatase enzymes. Kits may include an element tag for directly tagging an affinity product that recognizes phosphorylated substrates, as well as a non-phosphorylated substrate or an expression plasmid.
-
公开(公告)号：US20170089821A1
公开(公告)日：2017-03-30
申请号：US15231645
申请日：2016-08-08
Applicant: Fluidigm Canada Inc.
Inventor： Vladimir Baranov
IPC: G01N15/10 , G01N1/04 , G01N33/483
CPC classification number: G01N15/10 , C12M1/343 , G01N1/04 , G01N33/4833 , G01N33/569 , G01N2001/045 , G01N2015/1006 , G01N2015/1093
Abstract: A combination of mutually exclusive cell-based analytical techniques can be applied to the same group of cells for analysis. The same group of cells can be prepared for analysis by each technique resulting with candidate cells targeted for mass cytometry analysis. This configuration allows for the correlation of the information between each technique to produce a matrix of multi dimension of cellular information with the same group of cells.
-
45.发明申请公开(公告)号：US20170023583A1
公开(公告)日：2017-01-26
申请号：US15039797
申请日：2014-11-26
Applicant: Fluidigm Canada Inc.
Inventor： Olga Ornatsky
CPC classification number: G01N33/6848 , C07K1/13 , C12Q1/37 , G01N33/58 , G01N2333/95 , G01N2458/15
Abstract: The present invention generally relates to methods for the detection of enzymes using elemental analysis.
Abstract translation: 本发明一般涉及使用元素分析检测酶的方法。
-
Patent Agency Ranking
公开(公告)号：US09435787B2
公开(公告)日：2016-09-06
申请号：US15001589
申请日：2016-01-20
Applicant: Fluidigm Canada Inc.
Inventor： Vladimir Baranov
IPC: G01N15/10 , G01N33/483 , C12M1/34 , G01N33/569 , G01N1/04
CPC classification number: G01N15/10 , C12M1/343 , G01N1/04 , G01N33/4833 , G01N33/569 , G01N2001/045 , G01N2015/1006 , G01N2015/1093
Abstract: A combination of mutually exclusive cell-based analytical techniques can be applied to the same group of cells for analysis. The same group of cells can be prepared for analysis by each technique resulting with candidate cells targeted for mass cytometry analysis. This configuration allows for the correlation of the information between each technique to produce a matrix of multi dimension of cellular information with the same group of cells.
-
公开(公告)号：US20160231327A1
公开(公告)日：2016-08-11
申请号：US15013880
申请日：2016-02-02
Applicant: Fluidigm Canada Inc.
Inventor： Olga Ornatsky
IPC: G01N33/68
CPC classification number: G01N33/6848 , C12Q1/42 , C12Q1/485 , G01N33/569 , G01N33/58 , G01N33/6842 , G01N2333/91205 , G01N2333/916 , G01N2440/14 , G01N2458/15 , G01N2560/00 , Y10S435/975
Abstract: Methods and kits for enzymes involved in post-translational modifications are provided. The methods employ elemental analysis, including ICP-MS. The methods allow for the convenient and accurate analysis of post-translation modifications of substrates by enzymes involved in post-translational modifications, including kinase and phosphatase enyzmes
-
公开(公告)号：US09284598B2
公开(公告)日：2016-03-15
申请号：US14327960
申请日：2014-07-10
Applicant: Fluidigm Canada Inc.
Inventor： Olga Ornatsky
IPC: C12Q1/42 , C12Q1/48 , G01N33/569 , G01N33/58 , G01N33/68
CPC classification number: G01N33/6848 , C12Q1/42 , C12Q1/485 , G01N33/569 , G01N33/58 , G01N33/6842 , G01N2333/91205 , G01N2333/916 , G01N2440/14 , G01N2458/15 , G01N2560/00 , Y10S435/975
Abstract: Methods and kits for enzymes involved in post-translational modifications are provided. The methods employ elemental analysis, including ICP-MS. The methods allow for the convenient and accurate analysis of post-translation modifications of substrates by enzymes involved in post-translational modifications, including kinase and phosphatase enyzmes.
Abstract translation: 提供了涉及翻译后修饰的酶的方法和试剂盒。 该方法采用元素分析法，包括ICP-MS。 这些方法允许通过参与翻译后修饰的酶（包括激酶和磷酸酶酶）方便和准确地分析底物的翻译后修饰。
-
公开(公告)号：US09261503B2
公开(公告)日：2016-02-16
申请号：US14060125
申请日：2013-10-22
Applicant: FLUIDIGM CANADA INC.
Inventor： Vladimir Baranov
IPC: G01N15/10 , G01N33/569 , C12M1/34 , G01N33/483 , G01N1/04
CPC classification number: G01N15/10 , C12M1/343 , G01N1/04 , G01N33/4833 , G01N33/569 , G01N2001/045 , G01N2015/1006 , G01N2015/1093
Abstract: A combination of mutually exclusive cell-based analytical techniques can be applied to the same group of cells for analysis. The same group of cells can be prepared for analysis by each technique resulting with candidate cells targeted for mass cytometry analysis. This configuration allows for the correlation of the information between each technique to produce a matrix of multi dimension of cellular information with the same group of cells.
Abstract translation: 相互排斥的基于细胞的分析技术的组合可以应用于同一组细胞用于分析。 可以通过用针对质粒细胞分析的候选细胞产生的每种技术来制备相同组的细胞用于分析。 该配置允许每个技术之间的信息的相关性，以产生具有相同组的单元的蜂窝信息的多维矩阵。
-
公开(公告)号：US09218949B2
公开(公告)日：2015-12-22
申请号：US13909721
申请日：2013-06-04
Applicant: FLUIDIGM CANADA INC.
Inventor： Scott D. Tanner
CPC classification number: H01J49/40 , H01J49/025
Abstract: A mass spectrometer of the type useful in mass cytometry includes an ion detector. A digitizing system for converting analog signals from the ion detector includes two analog-to-digital converters. The analog-to-digital converters are configured to provide an increased dynamic range for a targeted period while limiting the amount of data generated.
Abstract translation: 用于质量分析的类型的质谱仪包括离子检测器。 用于转换离子检测器的模拟信号的数字化系统包括两个模拟 - 数字转换器。 模数转换器被配置为为目标周期提供增加的动态范围，同时限制所生成的数据量。
-
-
-
-
-
-
-
-
-
Search Results
210
records
(took 0.036 seconds)
