公开(公告)号：BR9604786A

公开(公告)日：1998-07-07

申请号：BR9604786

申请日：1996-03-27

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61K9/133 ,  A61K8/14 ,  A61K8/70 ,  A61K9/127 ,  A61K41/00 ,  A61K47/30 ,  A61K47/48 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  A61K9/14

公开(公告)号：AU5161298A

公开(公告)日：1998-06-22

申请号：AU5161298

申请日：1997-11-03

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61K49/22 ,  A61K49/04 ,  C07C19/08 ,  C07C41/00

公开(公告)号：DE69128422T2

公开(公告)日：1998-04-09

申请号：DE69128422

申请日：1991-05-31

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  WU GUANLI

IPC: A61K49/00 ,  A61K49/22 ,  A61K31/70 ,  A61K31/695 ,  A61K31/715 ,  A61K31/73

公开(公告)号：AU4089897A

公开(公告)日：1998-04-02

申请号：AU4089897

申请日：1997-08-26

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61K49/22 ,  A61K49/04 ,  A61B8/14

Abstract: A method for providing an image of an internal region of a patient has been developed. The method reduces imaging artifacts by providing enhanced contrast between tissue and blood during imaging. The method comprises administering to a patient a contrast agent in combination with a renal vasodilator and performing ultrasound imaging of the region. Renal disease, including renal arterial stenosis, may be diagnosed using the method.

公开(公告)号：CA2263568A1

公开(公告)日：1998-03-19

申请号：CA2263568

申请日：1997-08-26

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61K9/10 ,  A61K31/401 ,  A61K45/08 ,  A61K49/00 ,  A61K49/22 ,  A61B5/0275 ,  A61B8/14

Abstract: A method for providing an image of an internal region of a patient has been developed. The method reduces imaging artifacts by providing enhanced contrast between tissue and blood during imaging. The method comprises administering to a patient a contrast agent in combination with a renal vasodilator and performing ultrasound imaging of the region. Renal disease, including renal arterial stenosis, may be diagnosed using the method.

公开(公告)号：MX9707633A

公开(公告)日：1997-12-31

申请号：MX9707633

申请日：1996-03-27

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61K9/133 ,  A61K8/14 ,  A61K8/70 ,  A61K9/127 ,  A61K41/00 ,  A61K47/30 ,  A61K47/48 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  A61K09/127 ,  A61K09/14

Abstract: Composiciones que comprenden, en un portador acuoso, un lípido y un material que es capaz de estabilizar la composicion. El material estabilizante está asociado de manera no covalente con el lípido, y está presente en una cantidad suficiente para cubrir el lípido, pero insuficiente para elevar la viscosidad de la composicion. Las composiciones son particularmente adecuadas para usarse en aplicaciones de diagnostico, incluyendo el ultrasonido. Las composiciones pueden tomar la forma de composiciones vesiculares, tales como micelas y liposomas.

公开(公告)号：AT160940T

公开(公告)日：1997-12-15

申请号：AT91910712

申请日：1991-05-31

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  WU GUANLI

IPC: A61K49/00 ,  A61K49/22 ,  A61K31/70 ,  A61K31/695 ,  A61K31/715 ,  A61K31/73

公开(公告)号：DE69126429D1

公开(公告)日：1997-07-10

申请号：DE69126429

申请日：1991-04-09

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61B5/055 ,  A61K49/00 ,  A61K49/18 ,  G01R33/28 ,  A61B5/05 ,  A61K33/40 ,  G01N24/00 ,  G01N31/00

公开(公告)号：AU7594796A

公开(公告)日：1997-01-22

申请号：AU7594796

申请日：1996-06-06

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MCCREERY THOMAS ,  YELLOWHAIR DAVID ,  BARRETTE TERRENCE R

IPC: A61K49/00 ,  A61B5/055 ,  A61B8/00 ,  A61J3/00 ,  A61K8/14 ,  A61K8/70 ,  A61K9/127 ,  A61K41/00 ,  A61K47/48 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B01F3/04 ,  B01F11/00 ,  B01F15/00 ,  A61B5/00

Abstract: A method and apparatus for making vesicles suitable for use as contrast agents in which a container containing an aqueous suspension phase and a separate gas phase is shaken using reciprocating motion. The reciprocating motion is produced by a shaker arm that moves the container in two, substantially perpendicular directions, with the motion in the first direction being along an arcuate path. The overall path of the motion occurs in a figure-8 eight pattern. The frequency of shaking is at least approximately 2800 RPM, the length of the shaker arm is at least approximately 6 cm, and the angle through which the shaker arm rotates in the first direction is at least approximately 3 DEG . The total length of travel around the figure-8 pattern is at least 0.7 cm.

公开(公告)号：CA2218860A1

公开(公告)日：1997-01-09

申请号：CA2218860

申请日：1996-06-06

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： MCCREERY THOMAS ,  UNGER EVAN C ,  BARRETTE TERRENCE R ,  YELLOWHAIR DAVID

IPC: A61K49/00 ,  A61B5/055 ,  A61B8/00 ,  A61J3/00 ,  A61K8/14 ,  A61K8/70 ,  A61K9/127 ,  A61K41/00 ,  A61K47/48 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B01F3/04 ,  B01F11/00 ,  B01F15/00 ,  B01J13/06

Abstract: A method and apparatus for making vesicles suitable for use as contrast agents in which a container containing an aqueous suspension phase and a separate gas phase is shaken using reciprocating motion. The reciprocating motion is produced by a shaker arm that moves the container in two, substantially perpendicular directions, with the motion in the first direction being along an arcuate path. The overall path of the motion occurs in a figure-8 pattern. The frequency of shaking is at least approximately 2800 RPM, the length of the shaker arm is at least approximately 6 cm, and the angle through which the shaker arm rotates in the first direction is at least approximately 3~. The total length of travel around the figure-8 pattern is at least 0.7 cm.