公开(公告)号：WO9700638A3

公开(公告)日：1997-02-20

申请号：PCT/US9607887

申请日：1996-06-06

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MCCREERY THOMAS ,  YELLOWHAIR DAVID ,  BARRETTE TERRENCE R

IPC: A61K49/00 ,  A61B5/055 ,  A61B8/00 ,  A61J3/00 ,  A61K8/14 ,  A61K8/70 ,  A61K9/127 ,  A61K41/00 ,  A61K47/48 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B01F3/04 ,  B01F11/00 ,  B01F15/00 ,  A61B

CPC classification number: A61K49/22 ,  A61J3/00 ,  A61K9/127 ,  A61K9/1277 ,  A61K9/1278 ,  A61K41/0028 ,  A61K41/0052 ,  A61K49/1815 ,  A61K49/223 ,  A61K49/227 ,  A61K2800/87 ,  A61M5/3145 ,  B01F3/04099 ,  B01F11/0025 ,  B01F13/0033 ,  B01F15/00435 ,  Y10S366/605

Abstract: A method and apparatus for making vesicles suitable for use as contrast agents in which a container containing an aqueous suspension phase and a separate gas phase is shaken using reciprocating motion. The reciprocating motion is produced by a shaker arm that moves the container in two, substantially perpendicular directions, with the motion in the first direction being along an arcuate path. The overall path of the motion occurs in a figure-8 pattern. The frequency of shaking is at least approximately 2800 RPM, the length of the shaker arm is at least approximately 6 cm, and the angle through which the shaker arm rotates in the first direction is at least approximately 3°. The total length of travel around the figure-8 pattern is at least 0.7 cm.

公开(公告)号：DE69629478D1

公开(公告)日：2003-09-18

申请号：DE69629478

申请日：1996-06-06

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MCCREERY THOMAS ,  YELLOWHAIR DAVID ,  BARRETTE TERRENCE R

IPC: A61K49/00 ,  A61B5/055 ,  A61B8/00 ,  A61J3/00 ,  A61K8/14 ,  A61K8/70 ,  A61K9/127 ,  A61K41/00 ,  A61K47/48 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B01F3/04 ,  B01F11/00 ,  B01F15/00

Abstract: A method and apparatus for making vesicles suitable for use as contrast agents in which a container containing an aqueous suspension phase and a separate gas phase is shaken using reciprocating motion. The reciprocating motion is produced by a shaker arm that moves the container in two, substantially perpendicular directions, with the motion in the first direction being along an arcuate path. The overall path of the motion occurs in a figure-8 eight pattern. The frequency of shaking is at least approximately 2800 RPM, the length of the shaker arm is at least approximately 6 cm, and the angle through which the shaker arm rotates in the first direction is at least approximately 3 DEG . The total length of travel around the figure-8 pattern is at least 0.7 cm.

公开(公告)号：CA2252617A1

公开(公告)日：1997-11-06

申请号：CA2252617

申请日：1997-04-30

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MCCREERY THOMAS

IPC: C12N15/09 ,  A61K9/127 ,  A61K41/00 ,  A61K45/08 ,  A61K47/02 ,  A61K47/18 ,  A61K47/30 ,  A61K47/42 ,  A61K48/00 ,  A61P3/10 ,  A61P7/00 ,  A61P9/10 ,  A61P11/00 ,  A61P21/00 ,  A61P31/18 ,  A61P35/00 ,  C12N5/10 ,  C12N15/87 ,  C12N15/88 ,  C12P21/02 ,  A61K49/00 ,  A61M37/00 ,  A61N7/00 ,  A61K51/04 ,  A61K47/06 ,  A61K31/70 ,  C12N15/85

Abstract: The present invention is directed, inter alia, to a method for delivering a compound into a cell comprising administering to the cell the compound to be delivered, an organic halide, and/or a carrier. Ultrasound may also be applied, if desired.

公开(公告)号：EP0935415A4

公开(公告)日：2002-08-14

申请号：EP97921460

申请日：1997-04-30

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MCCREERY THOMAS

IPC: C12N15/09 ,  A61K9/127 ,  A61K41/00 ,  A61K45/08 ,  A61K47/02 ,  A61K47/18 ,  A61K47/30 ,  A61K47/42 ,  A61K48/00 ,  A61P3/10 ,  A61P7/00 ,  A61P9/10 ,  A61P11/00 ,  A61P21/00 ,  A61P31/18 ,  A61P35/00 ,  C12N5/10 ,  C12N15/87 ,  C12N15/88 ,  C12P21/02 ,  A01N43/04 ,  A61K31/70 ,  C07H21/04 ,  C12N15/12 ,  C12N15/85

CPC classification number: A61K48/00 ,  A61K9/1272 ,  A61K41/0028 ,  C12N15/87 ,  C12N15/88

公开(公告)号：EP0840570A4

公开(公告)日：2001-05-30

申请号：EP96938613

申请日：1996-06-06

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MCCREERY THOMAS ,  YELLOWHAIR DAVID ,  BARRETTE TERRENCE R

IPC: A61K49/00 ,  A61B5/055 ,  A61B8/00 ,  A61J3/00 ,  A61K8/14 ,  A61K8/70 ,  A61K9/127 ,  A61K41/00 ,  A61K47/48 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B01F3/04 ,  B01F11/00 ,  B01F15/00

CPC classification number: A61K49/22 ,  A61J3/00 ,  A61K9/127 ,  A61K9/1277 ,  A61K9/1278 ,  A61K41/0028 ,  A61K41/0052 ,  A61K49/1815 ,  A61K49/223 ,  A61K49/227 ,  A61K2800/87 ,  A61M5/3145 ,  B01F3/04099 ,  B01F11/0025 ,  B01F13/0033 ,  B01F15/00435 ,  Y10S366/605

Abstract: A method and apparatus for making vesicles suitable for use as contrast agents in which a container containing an aqueous suspension phase and a separate gas phase is shaken using reciprocating motion. The reciprocating motion is produced by a shaker arm that moves the container in two, substantially perpendicular directions, with the motion in the first direction being along an arcuate path. The overall path of the motion occurs in a figure-8 eight pattern. The frequency of shaking is at least approximately 2800 RPM, the length of the shaker arm is at least approximately 6 cm, and the angle through which the shaker arm rotates in the first direction is at least approximately 3 DEG . The total length of travel around the figure-8 pattern is at least 0.7 cm.

公开(公告)号：HK1010127A1

公开(公告)日：1999-06-17

申请号：HK98111007

申请日：1998-09-28

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MCCREERY THOMAS ,  YELLOWHAIR DAVID ,  BARRETTE TERRENCE R

IPC: A61B5/055 ,  A61B8/00 ,  A61J3/00 ,  A61K49/00 ,  A61K8/14 ,  A61K8/70 ,  A61K9/127 ,  A61K41/00 ,  A61K47/48 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B01F3/04 ,  B01F11/00 ,  B01F15/00 ,  A61B ,  A61K ,  B01J

Abstract: A method and apparatus for making vesicles suitable for use as contrast agents in which a container containing an aqueous suspension phase and a separate gas phase is shaken using reciprocating motion. The reciprocating motion is produced by a shaker arm that moves the container in two, substantially perpendicular directions, with the motion in the first direction being along an arcuate path. The overall path of the motion occurs in a figure-8 eight pattern. The frequency of shaking is at least approximately 2800 RPM, the length of the shaker arm is at least approximately 6 cm, and the angle through which the shaker arm rotates in the first direction is at least approximately 3 DEG . The total length of travel around the figure-8 pattern is at least 0.7 cm.

公开(公告)号：MX9709717A

公开(公告)日：1998-07-31

申请号：MX9709717

申请日：1997-12-05

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGAR EVAN C ,  MCCREERY THOMAS ,  YELLOWHAIR DAVID ,  BARRETTE TERRENCE R

IPC: A61B5/055 ,  A61B8/00 ,  A61J3/00 ,  A61K8/14 ,  A61K8/70 ,  A61K9/127 ,  A61K49/00 ,  A61K41/00 ,  A61K47/48 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B01F3/04 ,  B01F11/00 ,  B01F15/00 ,  A61B08/00 ,  A61K09/66 ,  B01J13/02 ,  B01J13/04 ,  B01J13/20 ,  B01J13/22

Abstract: Un método y aparato para hacer vesículas adecuadas para usarlas como agentes de contraste en el cual e contenedor que contene una fase en suspension acuosa y una fase de gas separada se agita usando un movimiento alternativo El movimiento alternativo se produce mediante un brazo agitador que mueve el contenedor en dos direcciones sustancialmente perpendiculares, siendo el movimiento en la primera direccion perpendiculares, siendo el mivimiento en la primero direccion a lo largo de una trayectoria arqueada. La trayectoria total del movimiento ocurre en un patron de figura en 8. La frecuencia de agitacion es de cuando menos aproximadamente 2800 rpm, la longitud del brazo agitador es de cuando menos aproximadamente 6cm, y el ángulo a través del cual el brazo agitador gira en la primero direccion es de cuando menos aproximadamente 3o. La longitud total de recorrido alrededor del patron de figura en 8 es de cuando menos 0.7 centímetros.

公开(公告)号：AT246956T

公开(公告)日：2003-08-15

申请号：AT96938613

申请日：1996-06-06

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MCCREERY THOMAS ,  YELLOWHAIR DAVID ,  BARRETTE TERRENCE R

IPC: A61K49/00 ,  A61B5/055 ,  A61B8/00 ,  A61J3/00 ,  A61K8/14 ,  A61K8/70 ,  A61K9/127 ,  A61K41/00 ,  A61K47/48 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B01F3/04 ,  B01F11/00 ,  B01F15/00

Abstract: A method and apparatus for making vesicles suitable for use as contrast agents in which a container containing an aqueous suspension phase and a separate gas phase is shaken using reciprocating motion. The reciprocating motion is produced by a shaker arm that moves the container in two, substantially perpendicular directions, with the motion in the first direction being along an arcuate path. The overall path of the motion occurs in a figure-8 eight pattern. The frequency of shaking is at least approximately 2800 RPM, the length of the shaker arm is at least approximately 6 cm, and the angle through which the shaker arm rotates in the first direction is at least approximately 3 DEG . The total length of travel around the figure-8 pattern is at least 0.7 cm.

公开(公告)号：BR9609343A

公开(公告)日：1999-12-28

申请号：BR9609343

申请日：1996-06-06

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MCCREERY THOMAS ,  YELLOWHAIR DAVID ,  BARRETTE TERRENCE R

IPC: A61K49/00 ,  A61B5/055 ,  A61B8/00 ,  A61J3/00 ,  A61K8/14 ,  A61K8/70 ,  A61K9/127 ,  A61K41/00 ,  A61K47/48 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B01F3/04 ,  B01F11/00 ,  B01F15/00 ,  A61B5/00 ,  A61K9/133

Abstract: A method and apparatus for making vesicles suitable for use as contrast agents in which a container containing an aqueous suspension phase and a separate gas phase is shaken using reciprocating motion. The reciprocating motion is produced by a shaker arm that moves the container in two, substantially perpendicular directions, with the motion in the first direction being along an arcuate path. The overall path of the motion occurs in a figure-8 eight pattern. The frequency of shaking is at least approximately 2800 RPM, the length of the shaker arm is at least approximately 6 cm, and the angle through which the shaker arm rotates in the first direction is at least approximately 3 DEG . The total length of travel around the figure-8 pattern is at least 0.7 cm.

公开(公告)号：AU1390699A

公开(公告)日：1999-06-07

申请号：AU1390699

申请日：1998-11-11

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MCCREERY THOMAS ,  SADEWASSER DAVID

IPC: A61K41/00 ,  A61K48/00 ,  A61N7/00 ,  A61H1/00