公开(公告)号：WO9700638A3

公开(公告)日：1997-02-20

申请号：PCT/US9607887

申请日：1996-06-06

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MCCREERY THOMAS ,  YELLOWHAIR DAVID ,  BARRETTE TERRENCE R

IPC: A61K49/00 ,  A61B5/055 ,  A61B8/00 ,  A61J3/00 ,  A61K8/14 ,  A61K8/70 ,  A61K9/127 ,  A61K41/00 ,  A61K47/48 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B01F3/04 ,  B01F11/00 ,  B01F15/00 ,  A61B

CPC classification number: A61K49/22 ,  A61J3/00 ,  A61K9/127 ,  A61K9/1277 ,  A61K9/1278 ,  A61K41/0028 ,  A61K41/0052 ,  A61K49/1815 ,  A61K49/223 ,  A61K49/227 ,  A61K2800/87 ,  A61M5/3145 ,  B01F3/04099 ,  B01F11/0025 ,  B01F13/0033 ,  B01F15/00435 ,  Y10S366/605

Abstract: A method and apparatus for making vesicles suitable for use as contrast agents in which a container containing an aqueous suspension phase and a separate gas phase is shaken using reciprocating motion. The reciprocating motion is produced by a shaker arm that moves the container in two, substantially perpendicular directions, with the motion in the first direction being along an arcuate path. The overall path of the motion occurs in a figure-8 pattern. The frequency of shaking is at least approximately 2800 RPM, the length of the shaker arm is at least approximately 6 cm, and the angle through which the shaker arm rotates in the first direction is at least approximately 3°. The total length of travel around the figure-8 pattern is at least 0.7 cm.

公开(公告)号：EP0923383A4

公开(公告)日：2001-06-13

申请号：EP97920281

申请日：1997-04-02

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  FRITZ THOMAS ,  MATSUNAGA TERRY ,  RAMASWAMI VARADARAJAN ,  YELLOWHAIR DAVID ,  WU GUANLI

IPC: A61B8/08 ,  A61K8/14 ,  A61K9/127 ,  A61K41/00 ,  A61K47/30 ,  A61K47/48 ,  A61K49/00 ,  A61K49/04 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B01J13/02 ,  G01R33/28

CPC classification number: A61K9/1277 ,  A61K9/127 ,  A61K9/1271 ,  A61K9/1278 ,  A61K41/0028 ,  A61K41/0052 ,  A61K49/22 ,  A61K49/223 ,  A61K49/227 ,  A61M5/3145 ,  G01R33/5601

公开(公告)号：EP0840570A4

公开(公告)日：2001-05-30

申请号：EP96938613

申请日：1996-06-06

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MCCREERY THOMAS ,  YELLOWHAIR DAVID ,  BARRETTE TERRENCE R

IPC: A61K49/00 ,  A61B5/055 ,  A61B8/00 ,  A61J3/00 ,  A61K8/14 ,  A61K8/70 ,  A61K9/127 ,  A61K41/00 ,  A61K47/48 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B01F3/04 ,  B01F11/00 ,  B01F15/00

CPC classification number: A61K49/22 ,  A61J3/00 ,  A61K9/127 ,  A61K9/1277 ,  A61K9/1278 ,  A61K41/0028 ,  A61K41/0052 ,  A61K49/1815 ,  A61K49/223 ,  A61K49/227 ,  A61K2800/87 ,  A61M5/3145 ,  B01F3/04099 ,  B01F11/0025 ,  B01F13/0033 ,  B01F15/00435 ,  Y10S366/605

Abstract: A method and apparatus for making vesicles suitable for use as contrast agents in which a container containing an aqueous suspension phase and a separate gas phase is shaken using reciprocating motion. The reciprocating motion is produced by a shaker arm that moves the container in two, substantially perpendicular directions, with the motion in the first direction being along an arcuate path. The overall path of the motion occurs in a figure-8 eight pattern. The frequency of shaking is at least approximately 2800 RPM, the length of the shaker arm is at least approximately 6 cm, and the angle through which the shaker arm rotates in the first direction is at least approximately 3 DEG . The total length of travel around the figure-8 pattern is at least 0.7 cm.

公开(公告)号：EP0788348A4

公开(公告)日：1998-04-01

申请号：EP95927429

申请日：1995-07-26

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MATSUNAGA TERRY ,  YELLOWHAIR DAVID

IPC: G01R33/28 ,  A61B5/055 ,  A61J1/00 ,  A61K8/04 ,  A61K8/14 ,  A61K8/70 ,  A61K9/127 ,  A61K9/133 ,  A61K41/00 ,  A61K47/48 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B65D81/20

CPC classification number: A61K49/227 ,  A61K8/046 ,  A61K8/14 ,  A61K8/70 ,  A61K9/127 ,  A61K9/1277 ,  A61K9/1278 ,  A61K41/0028 ,  A61K41/0052 ,  A61K47/51 ,  A61K47/6925 ,  A61K49/1815 ,  A61K49/22 ,  A61K49/223 ,  A61K2800/87 ,  A61M5/3145 ,  A61Q19/00 ,  G01R33/5601 ,  Y10T428/2984

Abstract: A container comprising an aqueous lipid suspension and a gaseous phase substantially separate from the aqueous stabilizing phase, useful in diagnostic imaging such as ultrasound and magnetic resonance imaging and in therapeutic applications, is disclosed.

公开(公告)号：AT246956T

公开(公告)日：2003-08-15

申请号：AT96938613

申请日：1996-06-06

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MCCREERY THOMAS ,  YELLOWHAIR DAVID ,  BARRETTE TERRENCE R

IPC: A61K49/00 ,  A61B5/055 ,  A61B8/00 ,  A61J3/00 ,  A61K8/14 ,  A61K8/70 ,  A61K9/127 ,  A61K41/00 ,  A61K47/48 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B01F3/04 ,  B01F11/00 ,  B01F15/00

Abstract: A method and apparatus for making vesicles suitable for use as contrast agents in which a container containing an aqueous suspension phase and a separate gas phase is shaken using reciprocating motion. The reciprocating motion is produced by a shaker arm that moves the container in two, substantially perpendicular directions, with the motion in the first direction being along an arcuate path. The overall path of the motion occurs in a figure-8 eight pattern. The frequency of shaking is at least approximately 2800 RPM, the length of the shaker arm is at least approximately 6 cm, and the angle through which the shaker arm rotates in the first direction is at least approximately 3 DEG . The total length of travel around the figure-8 pattern is at least 0.7 cm.

公开(公告)号：DK0712293T3

公开(公告)日：2003-06-30

申请号：DK94919208

申请日：1994-05-20

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  FRITZ THOMAS A ,  MATSUNAGA TERRY ,  RAMASWAMI VARADARAJAN ,  YELLOWHAIR DAVID ,  WU GUANLI

IPC: A61B8/00 ,  A61K8/14 ,  A61K9/127 ,  A61K41/00 ,  A61K47/48 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  A61K37/22 ,  B01J13/02

Abstract: Methods of and apparatus for preparing temperature activated gaseous precursor-filled liposomes are described. Gaseous precursor-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.

公开(公告)号：PT711127E

公开(公告)日：2003-04-30

申请号：PT94919184

申请日：1994-05-19

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  FRITZ THOMAS A ,  MATSUNAGA TERRY ,  RAMASWAMI VARADARAJAN ,  YELLOWHAIR DAVID ,  WU GUANLI

IPC: A61B8/00 ,  A61K8/14 ,  A61K9/127 ,  A61K41/00 ,  A61K47/48 ,  A61K48/00 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B01J13/02

Abstract: Methods of and apparatus for preparing gas-filled liposomes are described. Gas-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.

公开(公告)号：BR9609343A

公开(公告)日：1999-12-28

申请号：BR9609343

申请日：1996-06-06

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MCCREERY THOMAS ,  YELLOWHAIR DAVID ,  BARRETTE TERRENCE R

IPC: A61K49/00 ,  A61B5/055 ,  A61B8/00 ,  A61J3/00 ,  A61K8/14 ,  A61K8/70 ,  A61K9/127 ,  A61K41/00 ,  A61K47/48 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B01F3/04 ,  B01F11/00 ,  B01F15/00 ,  A61B5/00 ,  A61K9/133

Abstract: A method and apparatus for making vesicles suitable for use as contrast agents in which a container containing an aqueous suspension phase and a separate gas phase is shaken using reciprocating motion. The reciprocating motion is produced by a shaker arm that moves the container in two, substantially perpendicular directions, with the motion in the first direction being along an arcuate path. The overall path of the motion occurs in a figure-8 eight pattern. The frequency of shaking is at least approximately 2800 RPM, the length of the shaker arm is at least approximately 6 cm, and the angle through which the shaker arm rotates in the first direction is at least approximately 3 DEG . The total length of travel around the figure-8 pattern is at least 0.7 cm.

公开(公告)号：AU696056B2

公开(公告)日：1998-08-27

申请号：AU6953794

申请日：1994-05-19

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  FRITZ THOMAS A ,  MATSUNAGA TERRY ,  RAMASWAMI VARADARAJAN ,  YELLOWHAIR DAVID ,  WU GUANLI

IPC: A61K8/14 ,  A61K9/127 ,  A61K9/14 ,  A61K41/00 ,  A61K47/48 ,  A61K49/04 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B28B1/54

公开(公告)号：AU7594796A

公开(公告)日：1997-01-22

申请号：AU7594796

申请日：1996-06-06

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MCCREERY THOMAS ,  YELLOWHAIR DAVID ,  BARRETTE TERRENCE R

IPC: A61K49/00 ,  A61B5/055 ,  A61B8/00 ,  A61J3/00 ,  A61K8/14 ,  A61K8/70 ,  A61K9/127 ,  A61K41/00 ,  A61K47/48 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B01F3/04 ,  B01F11/00 ,  B01F15/00 ,  A61B5/00

Abstract: A method and apparatus for making vesicles suitable for use as contrast agents in which a container containing an aqueous suspension phase and a separate gas phase is shaken using reciprocating motion. The reciprocating motion is produced by a shaker arm that moves the container in two, substantially perpendicular directions, with the motion in the first direction being along an arcuate path. The overall path of the motion occurs in a figure-8 eight pattern. The frequency of shaking is at least approximately 2800 RPM, the length of the shaker arm is at least approximately 6 cm, and the angle through which the shaker arm rotates in the first direction is at least approximately 3 DEG . The total length of travel around the figure-8 pattern is at least 0.7 cm.