公开(公告)号：DE69430479D1

公开(公告)日：2002-05-29

申请号：DE69430479

申请日：1994-07-28

Applicant: MONASH UNIVERSITY CLAYTON

Inventor： GANI SUSAN ,  WIRTH HANS-JURGEN ,  AGUILAR ISABEL ,  HEARN THOMAS ,  VANSELOW GEORGE ,  CHEANG HONG ,  ERIKSSON KJELL-OVE

IPC: B01J20/281 ,  B01J20/06 ,  B01J20/32 ,  C01G25/02 ,  C02F1/28 ,  C04B35/14 ,  C04B35/48 ,  C04B35/626 ,  C04B38/00 ,  C04B38/08 ,  C12N11/14 ,  G01N30/88 ,  G01N33/551 ,  C04B35/482 ,  G01N30/48

Abstract: Porous zirconia or zirconium-containing particles, methods of making such particles and methods of using such particles including modifications to the surface of the particles are described. The method comprises heating zirconia particles to provide a substantially homogeneously liquid melt, quenching the particles of melt to effect spinodal decomposition to provide quench particles of a silica rich phase and a zirconia rich phase, annealing the quenched particles to provide non porous solid particles of zirconia and silica and, leaching the silica from these particles to produce porous solid zirconia particles comprising a three dimensionally substantially continuous interpenetrating network of interconnected pores.

公开(公告)号：DE69231291T2

公开(公告)日：2001-01-18

申请号：DE69231291

申请日：1992-03-25

Applicant: CSL LTD ,  MONASH UNIVERSITY CLAYTON

Inventor： BARR GEORGE ,  THIEL JAMES

IPC: A61K9/00 ,  A61K9/22 ,  A61K9/32 ,  A61K9/50 ,  A61K31/70 ,  A61K35/12 ,  A61K38/00 ,  A61K38/22 ,  A61K39/00 ,  A61K39/08 ,  A61K35/18 ,  A61K39/02 ,  A61K39/39

Abstract: PCT No. PCT/AU92/00124 Sec. 371 Date Nov. 17, 1993 Sec. 102(e) Date Nov. 17, 1993 PCT Filed Mar. 25, 1992 PCT Pub. No. WO92/17165 PCT Pub. Date Oct. 15, 1992The invention provides a pharmaceutical or veterinary implant, which when parenterally administered releases a pulse of at least one biologically active material at a controllable time interval after implantation. The implant comprises the biologically active material; an excipient comprising at least one water soluble material and at least one water insoluble material; and a polymer film coating adapted to rupture at a predetermined period of time after implantation, and wherein the excipients and polymers are biocompatible. The biologically active material is selected from the group consisting of antigens, antibodies, hormones, growth promotants, antibiotics, nutrients, minerals and vitamins. Preferably the excipient comprises a combination of two or more water-soluble and water-insoluble materials.

公开(公告)号：DE2635277C3

公开(公告)日：1982-11-25

申请号：DE2635277

申请日：1976-08-05

Applicant: THE BROKEN HILL ASSOCIATED SMELTERS PROPRIETARY LTD., MELBOURNE, VICTORIA, AU ,  MONASH UNIVERSITY, CLAYTON, VICTORIA, AU

Inventor： LAWSON, FRANK WAVERLEY, VICTORIA, SUED AUSTRALIEN, AU ,  WARD, DENBY HARCOURT ,  KELLY, ROBERT GEORGE, PORT PIRIE, SUED AUSTRALIEN, AU

IPC: C22B13/06 ,  C22B13/08

Abstract: Apparatus for the continuous sulphur drossing of lead to reduce its copper content including a plurality of reaction vessels arranged in series, each reaction vessel having a curved bottom and a stirrer for creating a vortex of the contents. Bullion and sulphur are fed into the series through a vortex at controlled rates and through the series at controlled temperatures and a controlled total reaction time, optimally between 8 and 15 minutes. The bullion, dross and unreacted sulphur, if any, are overflowed from vessel to vessel and into an unagitated vessel for separation of the dross and bullion. The bullion feed device splits the undrossed bullion into a metered stream and an unmetered stream, the unmetered stream being utilized to carry away the separated dross for further processing.

公开(公告)号：DE2635277B2

公开(公告)日：1978-03-30

申请号：DE2635277

申请日：1976-08-05

Applicant: THE BROKEN HILL ASSOCIATED SMELTERS PROPRIETARY LTD., MELBOURNE ,  MONASH UNIVERSITY, CLAYTON

Inventor： LAWSON, FRANK WAVERLEY, VICTORIA ,  WARD, DENBY HARCOURT ,  KELLY, ROBERT GEORGE, PORT PIRIE, SUED AUSTRALIEN

IPC: C22B13/06 ,  C22B13/08

Abstract: Apparatus for the continuous sulphur drossing of lead to reduce its copper content including a plurality of reaction vessels arranged in series, each reaction vessel having a curved bottom and a stirrer for creating a vortex of the contents. Bullion and sulphur are fed into the series through a vortex at controlled rates and through the series at controlled temperatures and a controlled total reaction time, optimally between 8 and 15 minutes. The bullion, dross and unreacted sulphur, if any, are overflowed from vessel to vessel and into an unagitated vessel for separation of the dross and bullion. The bullion feed device splits the undrossed bullion into a metered stream and an unmetered stream, the unmetered stream being utilized to carry away the separated dross for further processing.

公开(公告)号：DE69937368T2

公开(公告)日：2008-07-17

申请号：DE69937368

申请日：1999-12-20

Applicant: MONASH UNIVERSITY CLAYTON

Inventor： COMPER WAYNE D

IPC: G01N33/68 ,  A61K45/00 ,  A61P1/18 ,  A61P3/10 ,  A61P7/00 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P13/12 ,  A61P17/00 ,  A61P17/06 ,  A61P21/00 ,  A61P25/30 ,  A61P29/00 ,  A61P31/18 ,  A61P35/00 ,  G01N27/447 ,  G01N30/88 ,  G01N33/493 ,  G01N33/53 ,  G01N33/532

Abstract: A method is disclosed for diagnosing early stage of a disease in which an intact protein found in urine is an indicator of the disease. The method includes assaying urine sample to detect the presence of modified protein using either immunological or non-immunological technique. Methods for preventing and treating the disease are also disclosed.

公开(公告)号：DE69736739T2

公开(公告)日：2007-08-16

申请号：DE69736739

申请日：1997-02-12

Applicant: CSL LTD ,  MONASH UNIVERSITY CLAYTON

Inventor： MCNAMARA KEVIN ,  CHARMAN NEIL ,  CHARMAN ANN

IPC: A61K38/27 ,  A61K47/00 ,  A61K47/10 ,  A61K47/28 ,  A61K47/38 ,  A61P5/06

Abstract: A method for the preparation of a stable, liquid formulation of growth hormone, comprising growth hormone, a buffer and a stabilizing effective amount of at least one stabilizing agent selected from the group consisting of: (i) polyethylene-polypropylene glycol non-ionic surfactants, (ii) taurocholic acid or salts or derivatives thereof, and (iii) methyl cellulose derivatives, wherein the method comprises admixing the growth hormone with the buffer and the stabilizing agent(s) under conditions such that the growth hormone is not exposed to concentrations of the buffer or stabilizing agent(s) which are greater than 2x the final concentrations of the buffer or stabilizing agent(s) in the formulation.

公开(公告)号：DE69929173T2

公开(公告)日：2006-08-24

申请号：DE69929173

申请日：1999-01-29

Applicant: MONASH UNIVERSITY CLAYTON ,  NEURO THERAPEUTICS LTD

Inventor： JACKSON WILLIAM ,  SUBASINGHE RUPIKA ,  BOURA LOUIS

IPC: C07D221/26 ,  C07D489/02 ,  A61K31/435 ,  A61K31/445 ,  A61K31/451 ,  A61K31/472 ,  A61K31/485 ,  A61K47/48 ,  A61P25/04 ,  C07D211/32 ,  C07D211/64 ,  C07D221/28 ,  C07D223/06 ,  C07D223/14 ,  C07D489/04 ,  C07D489/08 ,  C07D489/12

公开(公告)号：DE60210741D1

公开(公告)日：2006-05-24

申请号：DE60210741

申请日：2002-01-23

Applicant: MONASH UNIVERSITY CLAYTON

Inventor： SMALL HENRY ,  FODERO LISA

IPC: G01N33/68

Abstract: The invention provides a method for the diagnosis of dementia and transmissible spongiform encephalopathies in a subject by detecting the levels of glycoproteins that bind wheat germ agglutinin. The invention also provides a method for diagnosis of dementia and transmissible spongiform encephalopathies in a subject by comparing the levels of glycoproteins that bind wheat germ agglutinin with the glycosylation patterns of biomarkers, acetylcholinesterase and butyrylcholinesterase.

公开(公告)号：DE69919885D1

公开(公告)日：2004-10-07

申请号：DE69919885

申请日：1999-10-20

Applicant: MONASH UNIVERSITY CLAYTON

Inventor： DOPHEIDE MARIE ,  COOKE MARK ,  JACKSON PHILLIP

IPC: G01N33/49 ,  C12M1/00 ,  C12Q1/02 ,  G01N33/15 ,  G01N33/50 ,  G01N33/543 ,  G01N33/554 ,  G01N33/566 ,  F26B9/04 ,  G01N33/88

公开(公告)号：DE69724422T2

公开(公告)日：2004-03-11

申请号：DE69724422

申请日：1997-05-12

Applicant: MONASH UNIVERSITY CLAYTON

Inventor： JARROTT BEVYN ,  BEART MARK ,  JACKSON ROY ,  KENCHE BHASKAR ,  ROBERTSON DUNCAN ,  COLLIS PATRICIA

IPC: C07D295/04 ,  A61K31/00 ,  A61K31/34 ,  A61K31/343 ,  A61K31/357 ,  A61K31/495 ,  A61K31/496 ,  A61P9/00 ,  A61P25/04 ,  A61P25/18 ,  A61P39/00 ,  A61P39/06 ,  A61P43/00 ,  C07D209/12 ,  C07D213/30 ,  C07D213/38 ,  C07D295/08 ,  C07D295/084 ,  C07D295/18 ,  C07D295/185 ,  C07D307/81 ,  C07D311/58 ,  C07D311/72 ,  C07D317/58 ,  C07D333/28 ,  C07D333/54 ,  C07D405/12 ,  C07D409/12 ,  C07D209/14 ,  C07D295/096 ,  C07D295/192 ,  C07D311/66

Abstract: Arylalkylpiperazine compounds (1) wherein B is aryl or optionally substituted aryl; R1 is hydroxy; R2 and R3 are the same or different and are independently selected from hydrogen or C1-3 alkyl; m is 0, 1 or 2; D is a linking chain of atoms which may be optionally substituted and which contains from 1 to 8 atoms in the chain; E is a phenolic antioxidant group or a corresponding amino derivative thereof wherein the phenolic hydroxyl is replaced by amino, are disclosed. The compounds have both free radical scavenging activity and block excitatory amino acid activity. Some compounds of the present invention also display an affinity for voltage-sensitive sodium channels.