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    METHOD OF PHOTODYNAMIC THERAPY (PDT) FOR BLADDER CANCER
    44.
    发明申请
    METHOD OF PHOTODYNAMIC THERAPY (PDT) FOR BLADDER CANCER 有权

    公开(公告)号：US20220152411A1

    公开(公告)日：2022-05-19

    申请号：US17588978

    申请日：2022-01-31

    Applicant: PHOTOCURE ASA

    Inventor： Kjetil Hestdal ,  Aslak Godal

    IPC: A61N5/06 ,  A61K41/00

    Abstract: This invention relates to a method of photodynamic therapy (PDT) for bladder cancer and its use as an adjuvant or neoadjuvant therapy in the treatment of bladder cancer. The invention provides a composition comprising hexyl 5-ALA ester (HAL) or a pharmaceutically acceptable salt thereof for use in a method of photodynamic therapy for bladder cancer, wherein said composition is instilled into the bladder of a patient in need of such treatment and the inside of said bladder is exposed to blue light having a fluence rate of 1.5 to 12.5 mW/cm2.

    Use of aminolevulinic acid and derivatives thereof
    45.
    发明授权
    Use of aminolevulinic acid and derivatives thereof 有权

    公开(公告)号：US10543272B2

    公开(公告)日：2020-01-28

    申请号：US14873566

    申请日：2015-10-02

    Applicant: Photocure ASA

    Inventor： Hans Christian Wulf ,  Aslak Godal ,  Jo Klaveness ,  Per Harald Fuglerud

    IPC: A61K41/00 ,  A61N5/06 ,  A61K31/221

    Abstract: The invention provides the use of a photosensitiser which is a derivative (e.g. an ester) of 5-aminolevulinic acid (5-ALA), or a pharmaceutically acceptable salt thereof, in the manufacture of a composition for use in methods of photodynamic therapy (PDT) on an animal, wherein said PDT comprises: (a) administering to said animal a composition comprising said photosensitiser; and (b) photoactivating said photosensitiser, and side-effects (e.g. pain and/or erythema) of said PDT are prevented or reduced by use of one or more of (i)-(iv): (i) said composition comprises said photosensitiser in a concentration of less than 10% wt (e.g. 0.5 to 8% wt), (ii) said composition is administered for less than 2 hours (e.g. 30 minutes to 90 minutes) prior to said photoactivation, (iii) said photoactivation is carried out with a light source having a fluence rate of less than 50 mW/cm2 (e.g. 5 to 40 mW/cm2), (iv) said photoactivation is carried out with sunlight. Preferably, side effects of PDT are prevented or reduced by using (ii) or (iv) in combination with (i) and/or (ii).

    IRRADIATION DEVICE
    46.
    发明申请
    IRRADIATION DEVICE 审中-公开

    公开(公告)号：US20180264283A1

    公开(公告)日：2018-09-20

    申请号：US15985214

    申请日：2018-05-21

    Applicant: PHOTOCURE ASA

    Inventor： Morten Groseth

    IPC: A61N5/06 ,  A61K41/00

    CPC classification number: A61N5/062 ,  A61K41/0061 ,  A61N5/0603 ,  A61N2005/0605 ,  A61N2005/0607 ,  A61N2005/0608 ,  A61N2005/0611 ,  A61N2005/0632 ,  A61N2005/0645 ,  A61N2005/0651 ,  A61N2005/0652

    Abstract: An irradiation device for insertion into an orifice of the body to provide photodynamic therapy comprises: a housing moulded from a resilient material and adapted to be fully inserted and secured in the orifice, the housing enclosing an LED lamp system 22 and a power source 41 for powering the LED lamp system 22; wherein the device is independently operational while located in the orifice; characterized in that: the housing comprises a first housing part 2 for holding the power source 41 and a second housing part 4 for holding the LED lamp system 22, the first and second housing parts 2, 4 being separable and being preferably formed separately from the LED lamp system 22; and in that the first housing part 2 consists of a chamber 6 for holding the power source 41 and an opening 26 into the chamber 6 is provided through a resilient opening part 8, wherein the chamber 6 is closed when the first housing part 2 is joined to the second housing part 4.

    Compounds
    50.
    发明申请
    Compounds 有权
    化合物

    公开(公告)号：US20150191419A1

    公开(公告)日：2015-07-09

    申请号：US14419125

    申请日：2013-08-02

    Applicant: Photocure ASA

    Inventor： Jon Erik Brænden ,  Colin Barry Charnock ,  Aslak Godal ,  Jo Klaveness ,  Nils Olav Nilsen

    IPC: C07C229/24 ,  A61K41/00 ,  C07C229/22

    CPC classification number: C07C229/24 ,  A61K41/0061 ,  C07C229/22

    Abstract: The invention relates to new derivatives of 5-aminolevulinic acid (5-ALA) and their use as photosensitizing agents. In particular, it relates to compounds of general formula I and their pharmaceutically acceptable salts, to methods for preparing such compounds and their medical and cosmetic use, for example in methods of photodynamic therapy and diagnosis: wherein R1 represents a hydrogen atom or an optionally substituted alkyl or cycloalkyl group; R2, each of which may be the same or different, represents a hydrogen atom or an optionally substituted alkyl group; and X is a linking group.

    Abstract translation: 本发明涉及5-氨基乙酰丙酸（5-ALA）的新衍生物及其作为光敏剂的用途。 具体地说，本发明涉及通式Ⅰ化合物及其药学上可接受的盐，制备这些化合物的方法及其医疗和化妆品用途，例如在光动力学治疗和诊断方法中：其中R1表示氢原子或任选取代的 烷基或环烷基; R2各自可以相同或不同，表示氢原子或任选取代的烷基; X是连接基团。

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