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    METHOD OF PHOTOMETRIC $i(IN VITRO) DETERMINATION OF THE CONTENT OF AN ANALYTE IN A SAMPLE
    43.
    发明授权
    METHOD OF PHOTOMETRIC $i(IN VITRO) DETERMINATION OF THE CONTENT OF AN ANALYTE IN A SAMPLE 失效
    METHOD FOR光度法（体外）测定样品中分析物的含量的

    公开(公告)号：EP0605598B1

    公开(公告)日：1997-07-30

    申请号：EP92920833.8

    申请日：1992-09-17

    Applicant: RADIOMETER MEDICAL A/S

    Inventor： FRISCHAUF, Peter, Aage

    IPC: G01N21/03 ,  G01N33/48

    CPC classification number: G01N21/0303 ,  G01N21/314 ,  G01N2021/036 ,  G01N2021/0364 ,  G01N2021/3129 ,  G01N2035/1062 ,  G01N2201/0662

    Abstract: The present method is a method of photometric in vitro determination of the content of an analyte in a sample. The sample is located in a measuring chamber device with a measuring chamber, which has a defined radiation path length and has at least one at least partially transparent wall part. The measuring chamber is in optical communication with an optical system adapted for the analyte and comprising a radiation source and a radiation detector. Further, the measuring chamber is adjustable in shape thereby controlling the setting of the radiation path length across the measuring chamber. In a first measuring step a first radiation path length across the measuring chamber is set and radiation at at least one wavelength is transmitted from the radiation source through the measuring chamber and to the radiation detector. Then in a second step the measuring chamber is adjusted in shape thereby setting a second wavelength across the measuring chamber. Radiation at the same wavelength as during the first step is again transmitted from the radiation source through the measuring chamber and to the radiation detector. The analyte content is then determined on the basis of radiation detected in each of the measuring steps.

    SENSOR FOR NON-INVASIVE, IN VIVO DETERMINATION OF AN ANALYTE AND BLOOD FLOW
    44.
    发明授权
    SENSOR FOR NON-INVASIVE, IN VIVO DETERMINATION OF AN ANALYTE AND BLOOD FLOW 失效
    无创传感器进行配料体内测定和血液流过

    公开(公告)号：EP0656760B1

    公开(公告)日：1997-04-16

    申请号：EP93914658.5

    申请日：1993-07-12

    Applicant: RADIOMETER MEDICAL A/S

    Inventor： PEDERSEN, Knud Grönlund

    IPC: A61B5/00 ,  A61B5/14

    CPC classification number: A61B5/14542 ,  A61B5/1477 ,  A61B5/1491

    Abstract: The sensor (1) comprises a sensor body (3) thermostatable by means of a first thermostating system (14, 15) and having an outer surface (3a, 40a) for application to the human body (28) in heat conductive relationship therewith, said outer surface (3a, 40a) forming the measuring surface of the sensor (1). The sensor (1) further comprises analyte sensing means (7, 8) arranged in said sensor body (3) and being thermostated through said body (3) by means of the first thermostating system (14, 15). The sensor (1) further comprises means (16, 41) arranged in the sensor body (3) in heat insulated relationship therewith while in heat conductive relationship with a delimited surface part of the sensor measuring surface (3a, 40a). The means (16, 41) is thermostatable by means of a second thermostating system. The delimited surface part is located within the outer periphery of the sensor measuring surface (3a, 40a). When using the sensor (1) the heat flux (34) from the measuring surface surrounding said delimited surface part provides a heat shield in the tissue, said heat shield surrounding the heat flux (35) from the delimited surface part. Thus, the heat flux (35) from the delimited surface part will be guided substantially unidirectionally to the tissue (28) located directly beneath the delimited surface part and absorbed therein.

    A METHOD AND AN APPARATUS FOR DETERMINING THE CONTENT OF A CONSTITUENT OF BLOOD OF AN INDIVIDUAL
    45.
    发明公开
    A METHOD AND AN APPARATUS FOR DETERMINING THE CONTENT OF A CONSTITUENT OF BLOOD OF AN INDIVIDUAL 失效
    方法和设备，用来确定一个人的血液成分的百分比

    公开(公告)号：EP0754298A1

    公开(公告)日：1997-01-22

    申请号：EP94923676.0

    申请日：1994-08-01

    Applicant: RADIOMETER MEDICAL A/S

    Inventor： FODGAARD, Henrik ,  SINGER, Rolf ,  FABRICIUS, Paul, Erik

    IPC: G01N21 ,  G01N33 ,  G01J3

    CPC classification number: G01N21/359 ,  A61B5/14535 ,  A61B5/14539 ,  A61B5/14542 ,  A61B5/14546 ,  A61B5/14551 ,  A61M1/14 ,  A61M1/36 ,  A61M1/3607 ,  A61M1/3609 ,  A61M1/367 ,  A61M2205/3306 ,  A61M2205/3313 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3334 ,  A61M2205/3375 ,  A61M2205/50 ,  G01J3/2803 ,  G01N2021/058 ,  G01N2201/129

    Abstract: A method and an apparatus for determining the content of a constituent of blood of an individual are disclosed. In the method a whole blood stream is extracted from a blood vessel of said individual, the stream being directed through a path defining a substantially non-varying flow-through area wherein is provided a flow-through measuring cuvette including opposite first and second optical transparent surface parts defining an optical transmission path of the order of 0.5 - 2.0 mm. The whole blood stream flowing through the measuring cuvette is irradiated by irradiating the first optical transparent surface part of the measuring cuvette with multi-wavelength near infrared light. The near infrared absorption spectrum is detected and the content of the constituent is quantified on the basis of the detected near infrared absorption data. The method is particularly suited for measuring constituents of whole blood in an extracorporeal loop, for example in hemodialysis.

    Abstract translation: PCT号 PCT / DK94 / 00297秒。 371日期1996年4月26日二段。 102（e）中的日期1996年4月26日提交的PCT 1994年8月1日的PCT公布。 号 WO95 / 04266的PCT公布。 2月9日的日期，1995年的方法和的个体的血液的成分，以用于确定性采矿装置的内容是盘游离缺失。 在该方法的整个血流被从所述个体的血管萃取，将流被引导通过一个路径限定基本上非变化的流通区域worin提供一种流通测定比色皿包括相对的第一和第二光学透明 表面限定的0.5-2.0毫米的量级光传输路径的部分。 流动通过测量试管中的全血流通过照射多波长的近红外光的测量试管的第一光学透明表面部分照射。 检测到近红外吸收光谱和构成的内容被近红外线吸收数据所检测的基础上进行定量。 该方法特别适合于血液透析的体外循环测量成分的全血，对于实施例。

    METHOD OF PERFORMING CALIBRATION AND QUALITY CONTROL OF A SENSOR AND APPARATUS FOR PERFORMING SAID METHOD
    48.
    发明公开
    METHOD OF PERFORMING CALIBRATION AND QUALITY CONTROL OF A SENSOR AND APPARATUS FOR PERFORMING SAID METHOD 有权
    方法用于进行传感器和设备的校准和质量控制实施过程

    公开(公告)号：EP1558921A1

    公开(公告)日：2005-08-03

    申请号：EP03757747.5

    申请日：2003-10-29

    Applicant: RADIOMETER MEDICAL A/S

    Inventor： FRISCHAUF, Peter, Aage ,  LARSEN, Eiler

    IPC: G01N27/00 ,  G01N33/00

    CPC classification number: G01N33/4915

    Abstract: The present invention provides a method of performing calibration and quality control of a sensor for determining a parameter in a test fluid in which method a calibration and quality control cycle is repeated. A cycle comprises the steps of performing a calibration and a quality control of the sensor using independent reference materials. In the method a reference material is in one cycle used in the quality control step which in another cycle is used in the calibration step. The present invention further provides an apparatus for performing said method.

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