公开(公告)号：EP1255978A1

公开(公告)日：2002-11-13

申请号：EP01901127.9

申请日：2001-01-16

Applicant: RADIOMETER MEDICAL A/S

Inventor： FODGAARD, Henrik

IPC: G01N21/49 ,  G01N21/01 ,  G01N33/48

CPC classification number: G01N21/05 ,  G01N21/31 ,  G01N21/51 ,  G01N2021/0346 ,  G01N2021/513

Abstract: An apparatus, a sample cuvette and a method for optical measurements on samples which show variable level of scattering. The apparatus, sample cuvette and method may be used for optical measurements on biological, physiological and chemical samples, however, are especially applicable for optical measurements on whole blood. The apparatus and the sample cuvette comprise an absorption filter or an interference filter, which provide correction for variations in the detector sensitivity and in the effective optical pathlength as observed upon varying level of scattering. The absorption filter filter has an absorbance profile characterised by the scattering angle α of scattered light which decreases from the center towards the periphery, and the interference filter has a center or a cut-off wavelength, which is longer than the wavelength of the light from the light emission means. The method for optical measurements uses the apparatus or the sample cuvette of the invention.

公开(公告)号：EP0754298A1

公开(公告)日：1997-01-22

申请号：EP94923676.0

申请日：1994-08-01

Applicant: RADIOMETER MEDICAL A/S

Inventor： FODGAARD, Henrik ,  SINGER, Rolf ,  FABRICIUS, Paul, Erik

IPC: G01N21 ,  G01N33 ,  G01J3

CPC classification number: G01N21/359 ,  A61B5/14535 ,  A61B5/14539 ,  A61B5/14542 ,  A61B5/14546 ,  A61B5/14551 ,  A61M1/14 ,  A61M1/36 ,  A61M1/3607 ,  A61M1/3609 ,  A61M1/367 ,  A61M2205/3306 ,  A61M2205/3313 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3334 ,  A61M2205/3375 ,  A61M2205/50 ,  G01J3/2803 ,  G01N2021/058 ,  G01N2201/129

Abstract: A method and an apparatus for determining the content of a constituent of blood of an individual are disclosed. In the method a whole blood stream is extracted from a blood vessel of said individual, the stream being directed through a path defining a substantially non-varying flow-through area wherein is provided a flow-through measuring cuvette including opposite first and second optical transparent surface parts defining an optical transmission path of the order of 0.5 - 2.0 mm. The whole blood stream flowing through the measuring cuvette is irradiated by irradiating the first optical transparent surface part of the measuring cuvette with multi-wavelength near infrared light. The near infrared absorption spectrum is detected and the content of the constituent is quantified on the basis of the detected near infrared absorption data. The method is particularly suited for measuring constituents of whole blood in an extracorporeal loop, for example in hemodialysis.

Abstract translation: PCT号 PCT / DK94 / 00297秒。 371日期1996年4月26日二段。 102（e）中的日期1996年4月26日提交的PCT 1994年8月1日的PCT公布。 号 WO95 / 04266的PCT公布。 2月9日的日期，1995年的方法和的个体的血液的成分，以用于确定性采矿装置的内容是盘游离缺失。 在该方法的整个血流被从所述个体的血管萃取，将流被引导通过一个路径限定基本上非变化的流通区域worin提供一种流通测定比色皿包括相对的第一和第二光学透明 表面限定的0.5-2.0毫米的量级光传输路径的部分。 流动通过测量试管中的全血流通过照射多波长的近红外光的测量试管的第一光学透明表面部分照射。 检测到近红外吸收光谱和构成的内容被近红外线吸收数据所检测的基础上进行定量。 该方法特别适合于血液透析的体外循环测量成分的全血，对于实施例。