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    System for indicating a location within a body of a patient
    41.
    发明公开
    System for indicating a location within a body of a patient 失效
    用于指示患者身体内的位置的系统

    公开(公告)号：EP1210916A3

    公开(公告)日：2002-06-12

    申请号：EP02004099.4

    申请日：1991-10-17

    Applicant: ST. Louis University

    Inventor： The designation of the inventor has not yet been filed

    IPC: A61B19/00 ,  A61B5/103 ,  A61B6/08

    CPC classification number: A61B5/0073 ,  A61B5/0064 ,  A61B5/055 ,  A61B5/06 ,  A61B5/1077 ,  A61B6/12 ,  A61B6/501 ,  A61B6/5247 ,  A61B8/00 ,  A61B8/0808 ,  A61B8/5238 ,  A61B34/20 ,  A61B90/10 ,  A61B90/14 ,  A61B90/36 ,  A61B90/39 ,  A61B2017/00738 ,  A61B2034/105 ,  A61B2034/2055 ,  A61B2034/2068 ,  A61B2034/2072 ,  A61B2090/363 ,  A61B2090/364 ,  A61B2090/378 ,  A61B2090/3788 ,  A61B2090/3945 ,  A61B2090/3954 ,  A61B2090/3983 ,  B82Y15/00

    Abstract: A system for indicating a location within a body of a patient comprises: a reference contour (394) having a position in fixed relation to the body for providing reference points; means (320, 324) for generating images of the body, said images including reference images corresponding to the reference contour; reference means (300) having a location outside the body for providing a reference; a surgical probe (302) including a tip (301, 541) having a position; first means (360) for determining the position of the tip of the surgical probe relative to the reference means; second means (306) for determining the position of the reference contour of the body relative to the reference means so that the position of the tip relative to the reference contour of the body is a known position; means (314) for translating the known position of the surgical probe to provide a translated position within a coordinate system corresponding to the images of the body; and means (326) for displaying an image of the body to provide a displayed image that corresponds to the translated position of the tip of the surgical probe.

    Abstract translation: 一种用于指示患者身体内的位置的系统，包括：参考轮廓（394），具有与身体固定关系的位置，用于提供参考点; 用于生成身体图像的装置（320,324），所述图像包括对应于参考轮廓的参考图像; 参考装置（300），具有位于身体外部的位置以提供参考; 包括具有位置的尖端（301,541）的外科手术探针（302） 第一装置（360），用于确定手术探针的尖端相对于参考装置的位置; 用于确定身体的参考轮廓相对于参考装置的位置的第二装置（306），使得尖端相对于身体的参考轮廓的位置是已知位置; 用于平移手术探针的已知位置以提供对应于身体图像的坐标系内的平移位置的装置（314） 以及用于显示身体的图像以提供与手术探针的尖端的平移位置相对应的显示图像的装置（326）。

    Apoptosis-regulating proteins
    43.
    发明公开
    Apoptosis-regulating proteins 失效
    细胞凋亡调节蛋白

    公开(公告)号：EP0733706A2

    公开(公告)日：1996-09-25

    申请号：EP96104542.4

    申请日：1996-03-21

    Applicant: ST. LOUIS UNIVERSITY

    Inventor： Chinnadurai, Govindaswamy

    IPC: C12N15/12 ,  C07K14/47 ,  C07K14/075 ,  C12N15/33 ,  C12N15/62 ,  A61K38/16 ,  G01N33/68 ,  C12N1/21 ,  C12N5/10

    CPC classification number: C07K14/005 ,  A61K38/00 ,  C07K14/4747 ,  C07K2319/00 ,  C12N2710/10322

    Abstract: Adenovirus E1B 19 kD protein protects against cell death induced by viral infection and certain external physical and chemical stimuli. Activity of the 19 kD protein is similar to the cell death suppressing activity of the protein coded by the Bcl-2 protooncogene. Bcl-2 protein can functionally substitute for the E1B 19 kD protein during adenovirus infection and in transformation of primary cells with adenovirus E1A. Five different cDNA's for proteins, designated Nip1, Nip2, Nip3, Bip1A and Bip13 that specifically interact with the 19 kD protein were found. Mutational analysis of the interaction indicates that at least four of the proteins (Nip1, Nip2, Nip3 and Bip1A) associate with 19 kD protein at specific sites thereof. Homologous motifs are found on Bcl2. An additional protein, (Bip5), interacts with Bcl-2 but not with the 19K protein.

    Abstract translation: 腺病毒E1B 19 kD蛋白可防止病毒感染引起的细胞死亡和某些外部物理和化学刺激。 19kD蛋白的活性与由Bcl-2原癌基因编码的蛋白质的细胞死亡抑制活性相似。 Bcl-2蛋白可以在腺病毒感染期间以及用腺病毒E1A转化原代细胞的功能上替代E1B19kD蛋白。 发现与9kD蛋白特异性相互作用的5种不同cDNA的cDNA，称为Nip1，Nip2，Nip3，Bip1A和Bip13。 相互作用的突变分析表明，至少有四种蛋白质（Nip1，Nip2，Nip3和Bip1A）在其特定位点与19kD蛋白质结合。 在Bcl2上发现同源基序。 另外一种蛋白质（Bip5）与Bcl-2相互作用，但不与19K蛋白质相互作用。

    Immobilized enzymes in biocathodes
    44.
    发明公开
    Immobilized enzymes in biocathodes 审中-公开
    生物灭菌剂中的不动杆菌酶

    公开(公告)号：EP2273596A2

    公开(公告)日：2011-01-12

    申请号：EP10179483.2

    申请日：2004-11-04

    Applicant: St. Louis University

    Inventor： Minteer, Shelley D. ,  Topcagic, Sabina ,  Treu, Becky

    IPC: H01M8/16 ,  H01M4/90 ,  C12Q1/00

    CPC classification number: B82Y30/00 ,  H01M4/8605 ,  H01M8/16 ,  Y02E60/527

    Abstract: Disclosed is an improved biofuel cell having a cathode comprising a dual function membrane, which contains an oxygen oxidoreductase enzyme immobilized within a buffered compartment of the membrane and an electron transport mediator which transfers electrons from an electron conducting electrode to the redox reaction catalyzed by the oxygen oxidoreductase enzyme. The improved biofuel cell also has an anode that contains an oxidoreductase enzyme that uses an organic fuel, such as alcohol, as a substrate. An electric current can flow between the anode and the cathode.

    Abstract translation: 公开了一种改进的生物燃料电池，其具有包含双功能膜的阴极，其包含固定在膜的缓冲隔室中的氧氧化还原酶，以及将电子从电子传导电极转移到由氧气催化的氧化还原反应的电子传输介体 氧化还原酶。 改进的生物燃料电池还具有含有使用有机燃料如醇的氧化还原酶作为底物的阳极。 电流可以在阳极和阴极之间流动。

    System for indicating a location within a body of a patient
    47.
    发明公开
    System for indicating a location within a body of a patient 失效
    系统zum Anzeigen einer Stelle在demKörpereines Patienten

    公开(公告)号：EP1210916A2

    公开(公告)日：2002-06-05

    申请号：EP02004099.4

    申请日：1991-10-17

    Applicant: ST. Louis University

    Inventor： The designation of the inventor has not yet been filed

    IPC: A61B19/00 ,  A61B5/103 ,  A61B6/08

    CPC classification number: A61B5/0073 ,  A61B5/0064 ,  A61B5/055 ,  A61B5/06 ,  A61B5/1077 ,  A61B6/12 ,  A61B6/501 ,  A61B6/5247 ,  A61B8/00 ,  A61B8/0808 ,  A61B8/5238 ,  A61B34/20 ,  A61B90/10 ,  A61B90/14 ,  A61B90/36 ,  A61B90/39 ,  A61B2017/00738 ,  A61B2034/105 ,  A61B2034/2055 ,  A61B2034/2068 ,  A61B2034/2072 ,  A61B2090/363 ,  A61B2090/364 ,  A61B2090/378 ,  A61B2090/3788 ,  A61B2090/3945 ,  A61B2090/3954 ,  A61B2090/3983 ,  B82Y15/00

    Abstract: A system for indicating a location within a body of a patient comprises:

    a reference contour (394) having a position in fixed relation to the body for providing reference points;
    means (320, 324) for generating images of the body, said images including reference images corresponding to the reference contour;
    reference means (300) having a location outside the body for providing a reference;
    a surgical probe (302) including a tip (301, 541) having a position;
    first means (360) for determining the position of the tip of the surgical probe relative to the reference means;
    second means (306) for determining the position of the reference contour of the body relative to the reference means so that the position of the tip relative to the reference contour of the body is a known position;
    means (314) for translating the known position of the surgical probe to provide a translated position within a coordinate system corresponding to the images of the body; and
    means (326) for displaying an image of the body to provide a displayed image that corresponds to the translated position of the tip of the surgical probe.

    Abstract translation: 用于指示患者体内的位置的系统包括：具有与身体固定的位置的参考轮廓（394），用于提供参考点; 用于生成身体图像的装置（320,324），所述图像包括对应于参考轮廓的参考图像; 参考装置（300）具有位于身体外部的位置以提供参考; 包括具有位置的尖端（301,541）的手术探针（302） 用于确定所述外科探头相对于所述参考装置的尖端的位置的第一装置（360）; 用于确定身体相对于参考装置的参考轮廓的位置的第二装置（306），使得尖端相对于身体的基准轮廓的位置是已知位置; 用于平移外科探针的已知位置的装置（314），以提供对应于身体图像的坐标系统内的平移位置; 以及用于显示身体的图像以提供与手术探针的尖端的翻译位置相对应的显示图像的装置（326）。

    Surgical probe locating system for head use
    49.
    发明公开
    Surgical probe locating system for head use 失效
    系统zur Lokalisierung einer chirurgischen Sonde相关zom Kopf

    公开(公告)号：EP0931516A1

    公开(公告)日：1999-07-28

    申请号：EP99108026.8

    申请日：1991-10-17

    Applicant: ST. LOUIS UNIVERSITY

    Inventor： Bucholz, Richard D.

    IPC: A61B19/00 ,  A61B5/103 ,  A61B6/08

    CPC classification number: A61B5/0073 ,  A61B5/0064 ,  A61B5/055 ,  A61B5/06 ,  A61B5/1077 ,  A61B6/12 ,  A61B6/501 ,  A61B6/5247 ,  A61B8/00 ,  A61B8/0808 ,  A61B8/5238 ,  A61B34/20 ,  A61B90/10 ,  A61B90/14 ,  A61B90/36 ,  A61B90/39 ,  A61B2017/00738 ,  A61B2034/105 ,  A61B2034/2055 ,  A61B2034/2068 ,  A61B2034/2072 ,  A61B2090/363 ,  A61B2090/364 ,  A61B2090/378 ,  A61B2090/3788 ,  A61B2090/3945 ,  A61B2090/3954 ,  A61B2090/3983 ,  B82Y15/00

    Abstract: A system is described for use in imaging a subject which comprises memory (320) including a first scan image (FIG. 5C) of the subject, an imaging probe (500) configured to scan the subject and provide a second scan image (FIG. 5B) of the subject, means (502) for sending a signal representing a position of the subject, means (370) for sending a signal representing a position of the imaging probe (500), an array of receivers (300) in communication with the subject position signalling means and the imaging probe position signalling means, and a processor (314) in communication with the array. The processor (314) is configured to determine the position of the subject relative to the array (300), to determine the position of the imaging probe (500) relative to the array (300), to determine the position of the imaging probe (500) relative to the subject, and to determine the position in the first scan image (FIG. 5C) and the second scan image (FIG. 5B) corresponding to the position of the imaging probe (500) relative to the subject.

    Abstract translation: 描述了一种用于成像对象的系统，其包括包括被摄体的第一扫描图像（图5C）的存储器（320），被配置为扫描对象并提供第二扫描图像（图5C）的成像探针（500） 5B），用于发送表示被摄体位置的信号的装置（502），用于发送表示成像探针（500）的位置的信号的装置（370），与 被摄体位置信号装置和成像探针位置信号装置，以及与阵列通信的处理器（314）。 处理器（314）被配置为确定对象相对于阵列（300）的位置，以确定成像探针（500）相对于阵列（300）的位置，以确定成像探针（300）的位置 500），并且确定对应于成像探针（500）相对于被摄体的位置的第一扫描图像（图5C）和第二扫描图像（图5B）中的位置。

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