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    SWARM INTELLIGENCE-ENHANCED DIAGNOSIS AND THERAPY SELECTION FOR CANCER USING TUMOR- EDUCATED PLATELETS
    44.
    发明申请
    SWARM INTELLIGENCE-ENHANCED DIAGNOSIS AND THERAPY SELECTION FOR CANCER USING TUMOR- EDUCATED PLATELETS 审中-公开

    公开(公告)号：WO2018151601A1

    公开(公告)日：2018-08-23

    申请号：PCT/NL2018/050110

    申请日：2018-02-19

    Applicant: STICHTING VUMC

    Inventor： WURDINGER, Thomas ,  BEST, Myron Ghislain

    IPC: C12Q1/68 ,  C12Q1/6886

    Abstract: The invention provides methods of administering immunotherapy that modulates an interaction between PD- i and its ligand, to a cancer patient, based on tumor-educated gene expression profiles obtained from anucleated cells. The invention further provides methods of typing a sample of a subject for the presence or absence of a cancer, based on tumor- educated gene expression profiles obtained from anucleated cells. The invention further provides a method for obtaining a biomarker panel for typing of a sample from a subject using particle swarm optimization-based algorithms.

    METHOD, SYSTEM AND COMPUTER READABLE MEDIUM TO DETERMINE A STRABISMUS ANGLE BETWEEN THE EYES OF AN INDIVIDUAL
    45.
    发明申请
    METHOD, SYSTEM AND COMPUTER READABLE MEDIUM TO DETERMINE A STRABISMUS ANGLE BETWEEN THE EYES OF AN INDIVIDUAL 审中-公开
    方法，系统和计算机可读介质确定个体眼睛之间的视觉角度

    公开(公告)号：WO2017123086A1

    公开(公告)日：2017-07-20

    申请号：PCT/NL2017/050011

    申请日：2017-01-11

    Applicant: STICHTING VU-VUMC ,  STICHTING VUMC

    Inventor： VAN DIJK, Bob Wilhelm

    IPC: A61B3/08

    CPC classification number: A61B3/085

    Abstract: The invention relates to a method, system and computer readable medium for determining a strabismus angle of the eyes of an individual by: positioning the individual with his or her eyes in front of an eye tracker device and in front of a screen at a viewing distance; displaying a small image element on the screen; measuring a position and line of sight of the eyes of the individual with the eye tracker device while the individual is focussing on the small image element; forwarding the measured position and line of sight of the eyes from the eye tracker device to a computer system; and, calculating the strabismus angle between the eyes by calculating the difference in line of sight of the left and right eyes of the individual.

    Abstract translation: 本发明涉及一种用于通过以下步骤确定个体眼睛的斜视角的方法，系统和计算机可读介质：将他的或她的眼睛定位在眼睛跟踪器装置的前方， 观看距离的屏幕前方; 在屏幕上显示小图像元素; 当个体聚焦在小图像元件上时用眼睛跟踪器装置测量个体眼睛的位置和视线; 将眼睛追踪装置的眼睛的测量位置和视线转发到计算机系统; 并通过计算个体左右眼视线的差异来计算眼睛之间的斜视角。

    DETECTION OF NUCLEIC ACID MARKERS IN URINE USING DNA METHYLATION ANALYSIS
    46.
    发明申请
    DETECTION OF NUCLEIC ACID MARKERS IN URINE USING DNA METHYLATION ANALYSIS 审中-公开

    公开(公告)号：WO2022139581A1

    公开(公告)日：2022-06-30

    申请号：PCT/NL2021/050784

    申请日：2021-12-23

    Applicant: STICHTING VUMC

    Inventor： STEENBERGEN, Renske Daniëla Maria ,  KAZEMIER, Geert ,  BACH, Sander

    IPC: C12Q1/6886

    Abstract: The invention relates to means and methods for detecting or determining the level of nucleic acid in urine of a human subject, the method comprising the steps of collecting nucleic acid from a sample of at least 1.0 ml, preferably at least 20 ml of urine of said subject, processing the sample to isolate cell free nucleic acid enriched for fragments of 150 nucleic acid bases or less, and determining whether the enriched nucleic acid comprises methylated nucleic acid of the SEPTIN-9 gene or a promoter region thereof and methylated nucleic acid of the SDC2 gene or a promoter region thereof. The means and methods may be used to arrive at a diagnosis of colorectal cancer, colorectal metastasis, recurrent colorectal cancer or a combination thereof in the human subject. The invention further relates to methods of treatment of human subjects with colorectal cancer, colorectal metastasis, recurrent colorectal cancer or a combination thereof comprising using the means and methods.

    HYPER-LOADED METAL-COMPLEXED POLYMERS
    47.
    发明申请
    HYPER-LOADED METAL-COMPLEXED POLYMERS 审中-公开

    公开(公告)号：WO2021086180A1

    公开(公告)日：2021-05-06

    申请号：PCT/NL2020/050666

    申请日：2020-10-28

    Applicant: STICHTING VUMC

    Inventor： GARCIA VALLEJO, Juan Jesus ,  KALAY, Hakan

    IPC: A61K47/00 ,  B82Y5/00 ,  C12Q1/6816

    Abstract: The invention relates to an isotope-containing tag, a method of preparing an isotope-containing tag, a tracer comprising an isotope-containing tag, a method of preparing a tracer, a method of labeling biological material, a use of the isotope-containing tag, a kit-of-parts for preparing a tracer. The isotope-containing tag comprises a monodisperse backbone to which at least one ligand and at least one functional group for attaching the backbone to a macromolecule are attached, wherein essentially every ligand attached to the backbone comprises an isotope.

    INHIBITION OF MYCOBACTERIAL TYPE VII SECRETION
    48.
    发明申请
    INHIBITION OF MYCOBACTERIAL TYPE VII SECRETION 审中-公开

    公开(公告)号：WO2021040519A1

    公开(公告)日：2021-03-04

    申请号：PCT/NL2020/050527

    申请日：2020-08-26

    Applicant: STICHTING VUMC ,  STICHTING VU

    Inventor： RUIJTER, Eelco ,  RONG, Mark Karsten ,  SPEER, Alexander ,  BITTER, Wilhelmus ,  COLE, Stewart Thomas

    IPC: C07D285/08 ,  C07D417/04 ,  A61K31/4436 ,  A61K31/42 ,  A61K31/426 ,  A61K31/4245 ,  A61K31/433 ,  A61K31/506 ,  A61P31/04 ,  A61P31/06

    Abstract: The invention relates to compounds and pharmaceutically acceptable salts thereof, and to their medical use. Exemplary medical uses are the prevention and treatment of a bacterial infection, for example, a mycobacterial infection, such as a Mycobacterium tuberculosis infection, e.g., in a respiratory system and/or extrapulmonic. The invention further relates to a use of such compounds, pharmaceutically acceptable salts thereof or prodrugs of the compounds as chemotherapeutic agents. Also, the invention relates to a use of such compounds, pharmaceutically acceptable salts thereof or prodrugs of the compounds for inhibiting mycobacterial type VII secretion. The compounds have the following formula (Ia), wherein Q and X are, respectively, CH and C, CR2 and C, CH and N, CR2 and N, or N and C; R1 is hydrogen, halide or optionally substituted linear or branched alkoxy having 1 or 2 carbon atoms; R2 is independently selected from hydrogen, halide or optionally substituted linear or branched alkoxy having 1 or 2 carbon atoms, and R3 is optionally substituted linear or branched alkoxy having 1-6 carbon atoms, haloalkyl having 1-6 carbon atoms, n-propyl, 2-propenyl, 2-propynyl, or n-pentyl, or a pharmaceutically acceptable salt of the compound, for use in the prevention or treatment of a bacterial infection.

    BIOMARKERS FOR ATRIAL FIBRILLATION
    49.
    发明申请
    BIOMARKERS FOR ATRIAL FIBRILLATION 审中-公开

    公开(公告)号：WO2020022891A2

    公开(公告)日：2020-01-30

    申请号：PCT/NL2019/050480

    申请日：2019-07-24

    Applicant: STICHTING VUMC ,  ERASMUS UNIVERSITY MEDICAL CENTER ROTTERDAM

    Inventor： BRUNDEL, Bianca Johanna Josephina Maria ,  WIERSMA, Marit ,  DE GROOT, Natasja Mireille Silvia ,  ZHANG, Deli

    IPC: A61P9/06 ,  C12Q1/68

    Abstract: The invention relates to methods of typing an individual as suffering from, or at risk of suffering from, atrial fibrillation, comprising the steps of providing a bodily fluid from said individual and quantifying a biomarker in said bodily fluid. The invention further relates to methods for assigning standard-of-care therapy to an individual that is typed as suffering from, or at risk of suffering from, atrial fibrillation, according to the methods of typing of the invention, and to a standard- of-care therapy for use in a method of treating an individual that is typed as suffering from, or at risk of suffering from, atrial fibrillation, according to the methods of the invention.

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