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公开(公告)号：KR1020130025768A
公开(公告)日：2013-03-12
申请号：KR1020110089285
申请日：2011-09-02
Applicant: (주)아모레퍼시픽
IPC: C07D407/14 , C07D407/12 , A61K8/49 , A61Q19/02
Abstract: PURPOSE: A novel kojic acid derivative with a skin whitening effect is provided to suppress pigmentation. CONSTITUTION: A novel kojic acid derivative with a skin whitening effect contains a kojic acid derivative of chemical formula 1 or an isomer, a pharmaceutically acceptable salt, a prodrug, a hydrate, or a solvate thereof. In chemical formula 1, R1 is -CH2- or -CH2CH2-; R2 is -CH2OC(O)- or -CH2OC(O)CH=CH-; and n is 1, 2, or 3.
Abstract translation: 目的：提供一种具有皮肤美白效果的新型曲酸衍生物，以抑制色素沉着。 构成：具有皮肤美白效果的新型曲酸衍生物含有化学式1的曲酸衍生物或其异构体，药学上可接受的盐，前药，水合物或溶剂化物。 在化学式1中，R 1是-CH 2 - 或-CH 2 CH 2 - ; R 2是-CH 2 OC（O） - 或-CH 2 OC（O）CH = CH-; 且n为1,2或3。
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公开(公告)号：KR1020130004616A
公开(公告)日：2013-01-14
申请号：KR1020110065010
申请日：2011-06-30
Applicant: (주)아모레퍼시픽
IPC: C07D309/40 , A61K8/49 , A61K8/35 , A61Q19/02
Abstract: PURPOSE: A kojic acid derivative and a cosmetic composition containing the same for skin whitening are provided to suppress melanogenesis and pigmentation with skin safety and to be applied to an external use skin formulation. CONSTITUTION: A kojic acid derivative is denoted by chemical formula 1. A method for preparing the derivative of chemical formula 1 and a pharmaceutically acceptable salt thereof comprises a step of reacting halo kojic acid of chemical formula 2 and inorganic salts of benzoic acid containing an adamantane group of chemical formula 3 to prepare a kojic ester compound. A method for preparing a derivative and pharmaceutically acceptable salt comprises: a step of reacting the kojic acid with halo-thionyl and preparing halo kojic acid; a step of reacting adamantane with benzoic acid containing a substituent of hydrogen, hydroxyl, or alkoxy of 1-3 carbon atoms and preparing benzoic acid containing the adamantane group; a step of reacting an inorganic compound with the benzoic acid and preparing inorganic salts; and a step of reacting prepared kojic acid chloride and inorganic salt of benzoic acid and preparing a kojic acid ester compound. A composition for whitening contains 0.01-20 wt% of the derivative and pharmaceutically acceptable salts thereof as active ingredients.
Abstract translation: 目的：提供曲酸衍生物和含有其的用于皮肤美白的化妆品组合物以抑制黑色素生成和皮肤安全性的色素沉积并施用于外用皮肤制剂。 组合物：曲酸衍生物由化学式1表示。制备化学式1的衍生物的方法及其药学上可接受的盐包括使化学式2的卤代曲酸与含有金刚烷的苯甲酸的无机盐反应的步骤 化学式3组，以制备曲酸酯化合物。 制备衍生物和药学上可接受的盐的方法包括：使曲酸与卤代亚硫酰基反应并制备卤代曲酸的步骤; 使金刚烷与含有1-3个碳原子的氢，羟基或烷氧基的取代基的苯甲酸反应并制备含有金刚烷基的苯甲酸的步骤; 使无机化合物与苯甲酸反应并制备无机盐的步骤; 和使制备的曲酸酰氯和苯甲酸的无机盐反应并制备曲酸酯化合物的步骤。 用于增白的组合物含有0.01-20重量％的衍生物和其药学上可接受的盐作为活性成分。
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公开(公告)号：KR1020110060689A
公开(公告)日：2011-06-08
申请号：KR1020090117350
申请日：2009-11-30
Applicant: (주)아모레퍼시픽
IPC: A61K31/327 , A61K31/10 , A61K31/70 , A61P17/10
Abstract: PURPOSE: A composition for preventing or treating acne is provided to ensure high stability and excellent usability. CONSTITUTION: A composition for preventing or treating acne contains 0.001-50 weight% of benzoyl peroxide, derivative thereof, hydrous form, or pharmaceutically salt thereof; 0.001-50 weight% of clindamycin, derivative thereof, hydrous form, or pharmaceutically acceptable salt thereof; and 0.01-10 weight% of sodium pyrosulfite.
Abstract translation: 目的：提供一种预防或治疗痤疮的组合物，以确保高稳定性和优异的使用性。 构成：用于预防或治疗痤疮的组合物含有0.001-50重量％的过氧化苯甲酰，其衍生物，含水形式或其药学上的盐; 克林霉素0.001-50重量％，其衍生物，含水形式或其药学上可接受的盐; 和0.01-10重量％的焦亚硫酸钠。
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公开(公告)号：KR1020070085422A
公开(公告)日：2007-08-27
申请号：KR1020077011568
申请日：2005-11-30
Applicant: (주)아모레퍼시픽
IPC: C07C251/44 , C07C251/32
CPC classification number: C07C317/32 , C07C251/44 , C07C255/61 , C07C259/18 , C07C323/47 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07D209/08 , C07D213/53 , C07D307/91 , C07D317/58 , C07D333/22 , C07D333/58 , C07D339/08
Abstract: Provided are a 2-cyclopenten-1-one oxime derivative which inhibits the production of TNF-alpha or PEF4, its pharmaceutically acceptable salt, and a pharmaceutical composition containing the derivative for treating or preventing the TNF-alpha mediated disease. A 2-cyclopenten-1-one oxime derivative is represented by the formula(1), wherein R1 is a linear or branched C1-C10 alkyl group or a C3-C7 cycloalkyl group; and R2 is a substituted or unsubstituted aromatic group. Preferably the aromatic group of R2 is selected from a phenyl group, a pyridyl group, a naphthyl group, an indolyl group, a thienyl group, a benzo[b]thienyl group, a dibenzofuranyl group, or a thianthrenyl group.
Abstract translation: 提供抑制TNF-α或PEF4的生成的2-环戊烯-1-酮肟衍生物及其药学上可接受的盐，以及含有用于治疗或预防TNF-α介导的疾病的衍生物的药物组合物。 2-环戊烯-1-酮肟衍生物由式（1）表示，其中R 1是直链或支链C 1 -C 10烷基或C 3 -C 7环烷基; R2是取代或未取代的芳基。 优选R2的芳基选自苯基，吡啶基，萘基，吲哚基，噻吩基，苯并[b]噻吩基，二苯并呋喃基或噻蒽基。
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Patent Agency Ranking
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公开(公告)号：KR101902242B1
公开(公告)日：2018-10-01
申请号：KR1020110108051
申请日：2011-10-21
Applicant: (주)아모레퍼시픽
IPC: A61K8/9789 , A61K8/66 , A61Q19/02
Abstract: 본발명은효소처리오가피를유효성분으로함유하는피부미백용조성물을제공한다. 본발명의효소처리오가피추출물을함유하는피부미백용조성물은효소를처리한오가피추출물을함유함으로써멜라닌생성의주효소인티로시나제를억제효과를나타내고, 멜라닌생성억제효과를나타내어기미또는주근깨개선, 색소침착억제및 피부미백효과가우수하므로, 피부외용제, 화장료조성물및 약학조성물등에사용될수 있다.
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公开(公告)号：KR1020170063238A
公开(公告)日：2017-06-08
申请号：KR1020150169379
申请日：2015-11-30
Applicant: (주)아모레퍼시픽
Abstract: 본명세서에는유효성분으로서청귤수를포함하는콩 발아촉진제로서, 상기청귤수는시트러스(Citrus)속식물의미숙과실에서수득된액체인, 콩발아촉진제및 이의제조방법, 상기콩 발아촉진제로발아된발아콩 및이의제조방법이개시된다.
Abstract translation: 这里是一个含有数cheonggyul作为活性成分，其中，所述豆发芽加速器发芽豆发芽促进剂，柑橘的在植物的未成熟果实中得到的液体的cheonggyul数（柑桔），豆发芽促进剂及其制备方法， 公开了一种发芽豆及其生产方法。
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公开(公告)号：KR1020160118481A
公开(公告)日：2016-10-12
申请号：KR1020150046643
申请日：2015-04-02
Applicant: (주)아모레퍼시픽
IPC: A61K36/258 , A61K9/20 , A61K9/48 , A23L1/30
CPC classification number: A61K36/258
Abstract: 본발명은난소노화를개선하는인삼열매추출물에관한것으로, 보다상세하게는인삼열매성분이난포수를증가시켜난소노화를개선하는데효과가있는인삼열매추출물을함유하는조성물에관한것이다. 본발명의인삼열매추출물을유효성분으로함유하는조성물은노화에의한난포의고갈을억제함으로써, 조기폐경의예방및 폐경기지연에이용할수 있다.
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