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公开(公告)号：KR1020070085422A
公开(公告)日：2007-08-27
申请号：KR1020077011568
申请日：2005-11-30
Applicant: (주)아모레퍼시픽
IPC: C07C251/44 , C07C251/32
CPC classification number: C07C317/32 , C07C251/44 , C07C255/61 , C07C259/18 , C07C323/47 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07D209/08 , C07D213/53 , C07D307/91 , C07D317/58 , C07D333/22 , C07D333/58 , C07D339/08
Abstract: Provided are a 2-cyclopenten-1-one oxime derivative which inhibits the production of TNF-alpha or PEF4, its pharmaceutically acceptable salt, and a pharmaceutical composition containing the derivative for treating or preventing the TNF-alpha mediated disease. A 2-cyclopenten-1-one oxime derivative is represented by the formula(1), wherein R1 is a linear or branched C1-C10 alkyl group or a C3-C7 cycloalkyl group; and R2 is a substituted or unsubstituted aromatic group. Preferably the aromatic group of R2 is selected from a phenyl group, a pyridyl group, a naphthyl group, an indolyl group, a thienyl group, a benzo[b]thienyl group, a dibenzofuranyl group, or a thianthrenyl group.
Abstract translation: 提供抑制TNF-α或PEF4的生成的2-环戊烯-1-酮肟衍生物及其药学上可接受的盐，以及含有用于治疗或预防TNF-α介导的疾病的衍生物的药物组合物。 2-环戊烯-1-酮肟衍生物由式（1）表示，其中R 1是直链或支链C 1 -C 10烷基或C 3 -C 7环烷基; R2是取代或未取代的芳基。 优选R2的芳基选自苯基，吡啶基，萘基，吲哚基，噻吩基，苯并[b]噻吩基，二苯并呋喃基或噻蒽基。
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公开(公告)号：KR101729140B1
公开(公告)日：2017-04-26
申请号：KR1020100085038
申请日：2010-08-31
Applicant: (주)아모레퍼시픽
IPC: C08K5/20 , C08L33/00 , C08J3/12 , A61K31/194
Abstract: 본발명은분지쇄아미노산및 카르복실기를포함하는고분자화합물을포함하는조성물을개시한다. 상기조성물은아미노산의쓴 맛또는냄새가차폐되어복용하기편리하다. 또한본 발명은분지쇄아미노산과카르복실기를포함하는고분자화합물을혼합하는단계를포함하는분지쇄아미노산의쓴 맛또는냄새차폐방법을개시한다.
Abstract translation: 本发明公开了包含含有支链氨基酸和羧基的聚合物的组合物。 该组合物很容易摄入，因为它可以防止苦味或氨基酸的味道。 本发明还公开了支链氨基酸的苦味或气味遮蔽方法，其包括混合包含支链氨基酸和羧基的聚合物化合物的步骤。
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公开(公告)号：KR1020160101554A
公开(公告)日：2016-08-25
申请号：KR1020150024334
申请日：2015-02-17
Applicant: (주)아모레퍼시픽
IPC: C07C303/36 , C07C311/08 , C07C303/42
CPC classification number: C07C303/36 , C07C303/42 , C07C311/08
Abstract: 본명세서는비대칭탄소원자에아민기가결합된화합물의입체이성질체혼합물을카이랄보조체및 염-형성보조화합물과혼합시키는단계를포함하는입체이성질체혼합물의카이랄분할방법에관한것이다. 이때, 카이랄보조체는 2,3-디벤조일-타르타르산또는-디--톨루오일타르타르산이고, 염-형성보조화합물은만델산또는캄포르술폰산이며, 이러한방법에의하면높은수준의광학순도를가지는광학이성질체를얻는것이가능하다. 따라서, 본발명의일 측면에따른방법은약학또는제약분야에서단일한형태의광학이성질체를가지는화합물을높은순도로수득하고자하는경우에유용하게사용될수 있다.
Abstract translation: 本发明涉及立体异构体混合物的手性拆分方法，其包括将通过与不对称碳原子连接的胺基组成的化合物的立体异构体混合物与手性助剂和成盐助剂混合的步骤 复合。 同时，手性助剂为2,3-二苯甲酰酒石酸或O，O-二对甲苯酰酒石酸。 形成盐的辅助化合物是扁桃酸或樟脑磺酸。 根据本发明，可以得到光学纯度高的光学异构体。 因此，当以高纯度获得具有单一类型的光学异构体的化合物时，根据本发明的一个方面的方法可以有用地用于药房或药物领域。
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公开(公告)号：KR1020150062443A
公开(公告)日：2015-06-08
申请号：KR1020130147098
申请日：2013-11-29
Applicant: (주)아모레퍼시픽
IPC: C07C235/24 , A61K31/166 , A61P17/18
Abstract: 본발명은일측면에서아이오논유도체화합물, 이의이성질체, 이의약학적으로허용가능한염, 이의프로드럭, 이의수화물또는이의용매화물에관한것이다. 본발명은다른일측면에서아이오논유도체화합물, 이의이성질체, 이의약학적으로허용가능한염, 이의프로드럭, 이의수화물또는이의용매화물을포함하는피부노화방지용조성물에관한것이다.
Abstract translation: 本发明的一个方面涉及紫罗兰酮衍生物化合物，其异构体，其异构体，其药学上可接受的盐，其前体药物，其水合物或其溶剂合物。 本发明的另一方面涉及一种用于防止皮肤老化的组合物，其中紫罗兰酮衍生物化合物，其异构体，其药学上可接受的盐，其前药，其水合物或 包括其中的溶剂合物。
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Patent Agency Ranking
公开(公告)号：KR1020140117842A
公开(公告)日：2014-10-08
申请号：KR1020130032634
申请日：2013-03-27
Applicant: (주)아모레퍼시픽
IPC: C07C233/05 , A61K31/165 , A61P17/16
Abstract: The present invention relates to a novel phenylacetic acid amide derivative compound, isomers thereof, pharmaceutically acceptable salt thereof, prodrug thereof, a hydrate or a solvate thereof, and a composition for skin whitening comprising the same. The novel compound or the like has excellent skin whitening effect.
Abstract translation: 本发明涉及一种新的苯乙酸酰胺衍生物化合物，其异构体，其药学上可接受的盐，其前体药物，其水合物或溶剂合物，以及包含其的皮肤美白组合物。 新颖的化合物等具有优异的皮肤美白效果。
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47.发明授权바닐로이드 수용체 길항제로서의 신규 화합물, 그의 이성질체, 또는 약제학적으로 허용가능한 그의 염, 및 이를함유하는 약제학적 조성물 有权新化合物，其异构体或其药学上可接受的盐作为VANILLOID受体拮抗剂;以及含有其的药物组合物
公开(公告)号：KR101410318B1
公开(公告)日：2014-06-27
申请号：KR1020097004333
申请日：2007-07-26
Applicant: (주)아모레퍼시픽
Inventor： 김선영 , 김진관 , 이기화 , 우병영 , 신송석 , 모주현 , 김성일 , 정연수 , 임경민 , 최진규 , 하준용 , 고현주 , 박영호 , 서영거 , 김희두 , 박형근 , 오우택
IPC: C07D419/08 , C07D411/04 , C07D413/04 , A61P29/00
CPC classification number: C07D213/74 , C07C311/08 , C07D213/56 , C07D213/61 , C07D213/64 , C07D295/155
Abstract: 본 발명은 바닐로이드 수용체(바닐로이드 수용체 1; VR1; TRPV1) 길항제로서의 신규 화합물, 그의 이성질체 또는 약제학적으로 허용가능한 그의 염; 및 이를 함유하는 약제학적 조성물에 관한 것이다. 본 발명은 통증, 편두통, 관절통, 신경통, 신경 장해, 신경 손상, 피부 질환, 방광 과민증, 과민성 대장 증후군, 대변절박증, 호흡 질환, 피부자극, 눈 또는 점막의 염증, 위-십이지장 궤양, 염증성 질환, 귀 질환, 심장 질환 등과 같은 질병의 예방 또는 치료를 위한 약제학적 조성물을 제공한다.
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公开(公告)号：KR1020140069931A
公开(公告)日：2014-06-10
申请号：KR1020120137822
申请日：2012-11-30
Applicant: (주)아모레퍼시픽
IPC: C07C233/09 , C07C233/02
Abstract: The present invention provides a novel pseudo-ceramide compound represented by Chemical Formula 1, an isomer thereof, a pharmaceutically acceptable salt thereof, a pro-drug thereof, a hydrate thereof, and a solvate thereof. [Chemical Formula 1] (In Chemical Formula 1, R is a C9 to 17 saturated or unsaturated aliphatic chain, and R′ is an amino group or an alkoxy group having a C10 to 18 saturated aliphatic chain.) According to the present invention, the novel pseudo-ceramide compound has a skin protecting effect by having excellent stability, dissolubility, and skin moisturization, so that the novel pseudo-ceramide compound can be used as an active ingredient for protecting the skin from external stimuli without side effects, preventing the skin from damage, and recovering damaged skin. Accordingly, the novel pseudo-ceramide compound can be used as a skin-moisturizing composition for external application on skin, a cosmetic composition, or a pharmaceutical composition.
Abstract translation: 本发明提供由化学式1表示的新型假神经酰胺化合物，其异构体，药学上可接受的盐，其前体药物，其水合物及其溶剂合物。 [化学式1]（化学式1中，R为C 9〜17饱和或不饱和脂肪族链，R'为氨基或碳原子数为10〜18的饱和脂肪族链的烷氧基。）根据本发明， 新型伪神经酰胺化合物通过具有优异的稳定性，溶解性和皮肤保湿性而具有皮肤保护效果，因此新颖的假神经酰胺化合物可以用作保护皮肤免受外部刺激的活性成分而没有副作用，从而防止 皮肤受损，并恢复受损皮肤。 因此，新颖的假神经酰胺化合物可以用作皮肤外用的皮肤保湿组合物，化妆品组合物或药物组合物。
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公开(公告)号：KR1020130026626A
公开(公告)日：2013-03-14
申请号：KR1020110089286
申请日：2011-09-02
Applicant: (주)아모레퍼시픽
IPC: C07D407/12 , C07D407/14 , A61K8/49 , A61Q19/02
Abstract: PURPOSE: A method for preparing a kojic acid derivative is provided to obtain a high purity kojic acid derivative by reacting halogenated kojic acid, which is the product of substituting a halogen element for a hydroxyl group of a hydroxyl methyl group, with benzoate or cinnamate. CONSTITUTION: A method for preparing a kojic acid derivative of chemical formula 1 comprises a step of reacting halogenated kojic acid with benzoate or cinnamate under the presence of acid. In chemical formula 1, R_1 is -CH_2- or -CH_2CH_2-; and R_2 is -C(O)OCH_2- or -CH=CHC(O)OCH_2-.
Abstract translation: 目的：提供制备曲酸衍生物的方法，通过将卤代醇酸（羟基甲基的羟基取代卤素）与苯甲酸酯或肉桂酸酯反应得到高纯度曲酸衍生物。 构成：制备化学式1的曲酸衍生物的方法包括在酸存在下使卤代曲酸与苯甲酸酯或肉桂酸酯反应的步骤。 在化学式1中，R 1是-CH 2 - 或-CH 2 CH 2 - ; 和R 2是-C（O）OCH 2 - 或-CH = CHC（O）OCH 2 - 。
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50.发明公开바닐로이드 수용체 길항제로 작용하는 신규 화합물, 이의 이성질체 또는 이의 약제학적으로 허용 가능한 염, 및 이를 포함하는 약학 조성물 有权新型化合物，异构体或其药学上可接受的盐作为VANILLOID受体拮抗剂和含有其的药物组合物
公开(公告)号：KR1020110029160A
公开(公告)日：2011-03-22
申请号：KR1020117002414
申请日：2009-07-02
Applicant: (주)아모레퍼시픽
Inventor： 우병영 , 김선영 , 김연준 , 신송석 , 김진관 , 이기화 , 김동현 , 임경민 , 모주현 , 정연수 , 최진규 , 고현주 , 이정오 , 김혁 , 윤정훈 , 리,푸난 , 김지숙 , 서영거
IPC: C07D263/36 , C07D277/22 , A61K31/421 , A61P25/00
CPC classification number: C07D263/42 , C07D263/34 , C07D263/38 , C07D263/48 , C07D277/42 , C07D277/56 , C07D307/52 , C07D307/68 , C07D333/38 , C07D413/04 , C07D413/12
Abstract: PURPOSE: A compound is provided to treat heart diseases, pain, and hair growth-associated diseases. CONSTITUTION: A pharmaceutical composition for preventing and treating pharmacological stimulation and/or abnormal expression of vaniloid receptor 1(VR1) contains a compound of chemical formula I, II, III, or IV, isomer thereof, or pharmaceutically acceptable salt and pharmaceutically acceptable carrier. The pharmaceutical composition is applied to rat, mouse, livestock, and human. The pharmaceutical composition is used by rectal, intravenous, intramuscular, or subcutaneous administration.
Abstract translation: 目的：提供化合物治疗心脏病，疼痛和毛发生长相关疾病。 构成：用于预防和治疗紫杉醇受体1（VR1）的药理学刺激和/或异常表达的药物组合物含有化学式I，II，III或IV的化合物，其异构体或其药学上可接受的盐和药学上可接受的载体。 药物组合物适用于大鼠，小鼠，家畜和人类。 药物组合物通过直肠，静脉内，肌肉内或皮下给药使用。
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