Abstract:
Disclosed is a biomarker having the amount of gene expression be specifically increased or reduced for sensitive skin. The biomarker specific to sensitive skin is used in such a diagnostic kit for sensitive skin and a screening method of an abirritant. The biomarker for diagnosis of sensitive skin according to the present invention one or more gene selected from a group composed of HLA-C, TCEA1, IGHA1, TFRC, S100A8, LOC652128, SERPINB13, EHF, FLJ10781, TP63, CDH1, TNFRSF19, GM2A, FKBP5, PI3, PSPH, HORMAD1, SPRR2G, and ACTR2 or a group composed of KBTBD10, TTN, ACTA1, MYBPC1, MB, MYOZ1, TPM1, CA3, CASQ1, ENO3, RBP4, GYG2, PPP1R1A, PYGM, G0S2, NEB, H19, LIPE, PLIN, H19, GPAM, FABP4, CIDEC, LPL, PCK1, ADIPOQ, PDE3B, ACVR1C, LPL, FABP4, DKFZP761N09121, TNMD, ATP6V1B1, C8orf22, and CRISP3.
Abstract:
Disclosed is a biomarker by which the amount of gene expression is increased or the gene expression is inhibited specifically with respect to sensitive skin. The biomarker can be used for a kit for testing sensitive skin and a method for screening an agent for alleviating irritation. The test kit includes: a polynucleotide of a TNFRSF19 gene, one or more polynucleotides which are fragments of the polynucleotide of the TNFRSF19 gene and include 10 or more serial nucleotides, or a polynucleotide complementary to the polynucleotide stated earlier and fragments thereof; and a solid scaffold having the surface on which the polynucleotides are bound.
Abstract:
The present invention discloses a biomarker of which a gene expression level increases or decreases specifically with respect to sensitive skin. The biomarker specific to sensitive skin can be applied to a kit for identifying sensitive skin and a screening method of an irritation reliever. The biomarker for identifying sensitive skin includes one or more genes selected from a group constituted by HLA-C, TCEA1, IGHA1, TFRC, S100A8, LOC652128, SERPINB13, EHF, FLJ10781, TP63, CDH1, TNFRSF19, GM2A,FKBP5, PI3, PSPH, HORMAD1, SPRR2G and ACTR2.
Abstract:
PURPOSE: A novel soil microorganism and oxidoreductase isolated from the microorganism are provided to ensure saccharide decomposition of natural products and to obtain various flavonoid aglycons. CONSTITUTION: A method for preparing flavonoid aglycons comprises a step of using Rhizobium sp. GIN611(KCTC11708BP) or cell extract thereof. The strain is isolated from soil. The flavonoid aglycon is prepared using Rhizobium sp. GIN611-derived oxidoreductase as a biocatalyst. The flavonoid aglycons are prepared by decomposing saccharides from flavonoid glycoside.
Abstract:
본 발명은 신경 통증감각 수용체(TRPV-1, VR1, Transient Receptor Potential family V-1)의 활성을 억제하는 단계를 포함하는 피부 미용방법, 피부 미용 물질 스크리닝(screening) 방법, 및 신경 통증감각 수용체의 활성을 억제하는 물질을 유효 성분으로 함유하는 피부 미용 조성물을 제공한다. 본 발명에 따르면, 신경 통증감각 수용체의 활성 억제를 통해 피부 미용을 증대시킬 수 있고, 피부 미용에 유효한 타겟 물질을 선정할 수 있으며, 선정된 물질은 신경 통증감각 수용체의 활성 억제로 인한 콜라겐 분해효소의 발현 감소, 피부 자극 완화, 및 혈행촉진을 유도할 수 있는 바, 피부 노화 방지 등을 통한 피부 미용에 특히 유효하다. 신경 통증감각 수용체, 피부 미용