公开(公告)号：KR101710276B1

公开(公告)日：2017-02-24

申请号：KR1020150116880

申请日：2015-08-19

Applicant: 부경대학교 산학협력단

Inventor： 최재수 ,  남택정 ,  정희진

IPC: A61K35/60 ,  A61K35/34 ,  A23L1/30

Abstract: 본발명은참치심장에탄올추출물을유효성분으로포함하는항당뇨용조성물에관한것이다. 본발명에따른참치심장에탄올추출물은 PTP1B, α-글루코시다아제및 인간재조합알도즈환원효소를억제하는활성이있어당뇨또는당뇨합병증의예방또는치료에유용하게이용될수 있다. 또한, 본발명의참치심장에탄올추출물은천연물질로서체내에안정한특징이있어기능성건강식품의소재로도사용될수 있다.

公开(公告)号：KR1020140081339A

公开(公告)日：2014-07-01

申请号：KR1020120150980

申请日：2012-12-21

Applicant: 부경대학교 산학협력단

Inventor： 최재수 ,  정현아 ,  정차균

IPC: A61K31/56 ,  A61K36/28 ,  A61P25/28 ,  A61P25/00

CPC classification number: A61K36/03 ,  A61K31/56

Abstract: The present invention relates to a novel use of fucosterol to treat degenerative nervous diseases and, specifically, to a pharmaceutical composition and a health functional food including fucosterol as an active ingredient for preventing or treating degenerative nervous diseases. The fucosterol of the present invention can effectively increase the expression of ADAM10 which is α-secretase. Accordingly, the composition of the present invention which includes the same as an active ingredient has an excellent effect in controlling the formation of amyloid beta (Aβ) peptides so that the composition can be usefully used for a pharmaceutical product and a functional food for preventing or treating (alleviating) degenerative nervous diseases. The fucosterol of the present invention is especially a material derived from a natural material so as to have stability without cytotoxicity. Thus, the composition of the present invention which includes the same as an active ingredient is advantageously safe without causing side effects in the human body even after used for a long time.

Abstract translation: 本发明涉及岩藻甾醇治疗退行性神经疾病的新用途，具体涉及药物组合物和包含岩藻糖醇作为预防或治疗退行性神经疾病的有效成分的保健功能性食品。 本发明的岩藻甾醇能够有效地增加作为α-分泌酶的ADAM10的表达。 因此，包括与活性成分相同的本发明的组合物在控制淀粉样蛋白β（Aβ）肽的形成方面具有优异的效果，使得该组合物可有效地用于药物产品和用于预防或 治疗（减轻）退行性神经疾病。 本发明的岩藻甾醇特别是衍生自天然材料的材料，以具有无细胞毒性的稳定性。 因此，即使长时间使用，本发明的包含与活性成分相同的组合物也是安全的，而不会在人体内引起副作用。

公开(公告)号：KR1020140040359A

公开(公告)日：2014-04-03

申请号：KR1020120106857

申请日：2012-09-26

Applicant: 부경대학교 산학협력단

Inventor： 윤진수 ,  김군도 ,  최재수

IPC: A61K31/4709 ,  A61K36/62 ,  A61P35/00

CPC classification number: A61K36/62 ,  A61K31/4725

Abstract: The present invention relates the use of neferine for treating liver cancer and, more specifically, to a pharmaceutical composition and health functional foods containing the neferine as an active ingredient for preventing or treating liver cancer. The neferine in the present invention has an anticancer effect by stopping the cell cycle of liver cancer cells, inducing apoptosis and autophagy, and inhabiting vascularization and cell migration. Particularly, the neferine shows specific cytotoxicity on the viral infection-mediated liver cancer cells, thereby having an optimum therapeutic effect against the liver cancer induced by viral infection. Thus, the neferine in the present invention can be used as the pharmaceutical composition and health functional food, as an ingredient for preventing or treating the liver cancer, thereby being expected to be of good value in case of applying in the food or pharmaceutical industry. Also, the composition containing the neferine as the active ingredient in the present invention is safe to use for a long time since the neferine shows no cytotoxicity except the specific liver cancer cells.

Abstract translation: 本发明涉及炔诺酮用于治疗肝癌的用途，更具体地，涉及含有神经纤维作为预防或治疗肝癌的活性成分的药物组合物和保健功能性食品。 本发明中的炔诺酮通过停止肝癌细胞的细胞周期，诱导细胞凋亡和自噬，并且维持血管形成和细胞迁移，具有抗癌作用。 特别地，neferine对病毒感染介导的肝癌细胞表现出特异性细胞毒性，从而对由病毒感染诱导的肝癌具有最佳治疗效果。 因此，本发明中的炔诺酮可以作为药物组合物和保健功能性食品而使用，作为预防或治疗肝癌的成分，因此在应用于食品或制药工业的情况下被认为具有良好的价值。 此外，本发明中含有作为活性成分的炔诺酮的组合物长时间使用是安全的，因为除了特定的肝癌细胞之外，neferine不显示细胞毒性。

公开(公告)号：KR1020130140448A

公开(公告)日：2013-12-24

申请号：KR1020120063862

申请日：2012-06-14

Applicant: 부경대학교 산학협력단 ,  대구가톨릭대학교산학협력단

Inventor： 정현아 ,  우미희 ,  김형락 ,  우희철 ,  최재수

IPC: A61K36/05 ,  A61P3/10 ,  A61P3/00

Abstract: The present invention relates to novel uses of capsosiphon fulvescens extract or compounds isolated therefrom for preventing or treating diabetic complications and, more specifically, to a pharmaceutical composition and a health supplement for preventing or treating diabetic complications which include capsosiphon fulvescens extract, soluble extract of non-polar solvent, or compounds isolated therefrom (capsofulvesin A, capsofulvesin B, chalinasterol) as active ingredients. The capsosiphon fulvescens extracts or compounds isolated therefrom (capsofulvesin A, capsofulvesin B, chalinasterol) have excellent suppression activities on aldose reductase and excellent suppression activities on final glycation products. Therefore, the capsosiphon fulvescens extracts or compounds isolated therefrom can be utilized as medicines such as pharmaceutical compositions and health supplements for preventing or treating diabetic complications so that the value of the capsosiphon fulvescens extracts or compounds isolated therefrom can be extremely high when applying in food and medical industries. Specially, the capsosiphon fulvescens extracts or compounds isolated therefrom in the present invention are substances derived from natural substances and have stability without cytotoxicity so that the compositions of the present invention which includes the same as active ingredients can be safely used for long time.

Abstract translation: 本发明涉及一种用于预防或治疗糖尿病并发症的胆红素提取物或其分离的化合物的新用途，更具体地，涉及用于预防或治疗糖尿病并发症的药物组合物和健康补充剂，其包括辣椒皂苷提取物，非可溶性提取物， - 极性溶剂，或从其分离的化合物（海藻多柔比星A，棉铃藓素B，沙拉宁醇）作为活性成分。 辣椒油提取物或从其中分离的化合物（海藻多糖A，血浆壳多糖B，沙利度醇）对醛糖还原酶具有优异的抑制活性，对最终糖基化产物具有优异的抑制活性。 因此，辣椒油提取物或其分离的化合物可用作药物，例如用于预防或治疗糖尿病并发症的药物组合物和健康补充剂，从而当应用于食物中时，辣椒素提取物或从其分离的化合物的值可能非常高 医疗行业。 特别地，在本发明中，辣椒油提取物或从其分离的化合物是天然物质衍生的物质，具有稳定性而没有细胞毒性，因此本发明的包含与活性成分相同的组合物可以长时间安全使用。

公开(公告)号：KR100542751B1

公开(公告)日：2006-01-20

申请号：KR1020030028736

申请日：2003-05-06

Applicant: 부경대학교 산학협력단

Inventor： 최재수 ,  강혜숙 ,  손병화

IPC: A61K8/97 ,  A61Q19/02

Abstract: 본 발명은 티로시나제(tyrosinase) 저해활성을 갖는 곰피 추출물 또는 그로부터 분리된 플로로탄닌류의 화합물을 함유하는 미백용 화장료 조성물 또는 식품의 갈변방지용 조성물에 관한 것으로, 본 발명의 곰피 추출물 또는 그로부터 분리된 플로로탄닌류의 화합물은 멜라닌 생합성 과정에 핵심적으로 작용하는 효소인 티로시나제에 대해 작용하여, 그 효소 활성을 효과적으로 저해하므로, 멜라닌 과다 생성을 예방하기 위한 미백용 화장료 조성물 또는 식품 등의 갈변 방지용 조성물로써 유용하게 이용될 수 있다.
곰피, 티로시나제 저해, 플로로탄닌류, 화합물, 미백, 화장료 조성물, 식품, 갈변 방지용 조성물.

公开(公告)号：KR1020040095125A

公开(公告)日：2004-11-12

申请号：KR1020030028737

申请日：2003-05-06

Applicant: 부경대학교 산학협력단

Inventor： 최재수 ,  강혜숙 ,  손병화 ,  정지형 ,  정해영

IPC: A61K31/357 ,  A61P39/06

CPC classification number: A61K31/357 ,  A23L33/105 ,  A23V2002/00 ,  A23V2200/02 ,  A61K36/03 ,  A61K2236/33

Abstract: PURPOSE: Provided is a composition comprising phlorotannin isolated from extract of Ecklonia stolonifera Okamura which has anti-oxidative activity, wherein the phlorotannin effectively scavenges free radicals. Therefore, it is used for pharmaceutical compositions for preventing aging and foods for preventing oxidation. CONSTITUTION: The anti-oxidative composition contains, as an active ingredient, phlorotannin isolated from the extract of Ecklonia stolonifera Okamura, wherein the phlorotannin is selected from the group consisting of phloroglucinol, eckstolonol, eckstolonol pentaacetate, eckol, phlorofucofuroeckol A and dieckol.

Abstract translation: 目的：提供了从具有抗氧化活性的Ecklonia stolonifera Okamura的提取物中分离出的氯光亮苷的组合物，其中氯光亮苷有效清除自由基。 因此，其用于防止老化的药物组合物和用于防止氧化的食品。 构成：抗氧化剂组合物含有从枸杞子的提取物中分离出的氯光亮素作为活性成分，其中顺氯新霉素选自间苯三酚，埃克斯托醇，戊酸依托酚醇五乙酸酯，eckol，间苯三酚和甲羟甲酚。

公开(公告)号：KR1020040072146A

公开(公告)日：2004-08-18

申请号：KR1020030008105

申请日：2003-02-10

Applicant: 부경대학교 산학협력단

Inventor： 최재수 ,  정해영 ,  김정은 ,  정현아

IPC: A61K36/62 ,  A61P39/06

CPC classification number: A61K36/62 ,  A23L2/38 ,  A23L33/105 ,  A23V2002/00 ,  A23V2200/308 ,  A61K9/14 ,  A61K31/352 ,  A61K2236/33

Abstract: PURPOSE: A composition having antioxidation activity comprising the extract and flavonoid compounds isolated from Nelumbo nucifera stamen is provided, thereby inhibiting formation of reactive oxygen species(ROS) and inhibiting activity of DPPH radical and lipid peroxide ion, so that it can be useful for prevention and treatment of diseases caused by oxidative stresses. CONSTITUTION: The composition having antioxidation activity comprises a crude extract of Nelumbo nucifera stamen, wherein the crude extract of Nelumbo nucifera stamen is prepared by using a polar solvent selected from water, methanol, butanol or a mixture thereof or a nonpolar solvent selected from ethylacetate, n-hexane, methylene chloride, and chloroform. The composition having antioxidation activity comprises flavonoid compounds isolated from Nelumbo nucifera stamen represented by formula (I), and pharmaceutically acceptable salts thereof, wherein R1 is hydrogen, hydroxy, C1-C4 alkyl or alkoxy, gluco, rhamnogluco(Rha(1>6)-Glu), galacto, glucurono, or lower alkyl glucurono; and R2 and R3 are independently hydrogen, hydroxy, C1-C4 alkyl or alkoxy.

Abstract translation: 目的：提供具有抗氧化活性的组合物，其含有从Nelumbo nucifera雄蕊中分离的提取物和类黄酮化合物，从而抑制活性氧（ROS）的形成和抑制DPPH自由基和脂质过氧化物离子的活性，从而可用于预防 并治疗由氧化应激引起的疾病。 构成：具有抗氧化活性的组合物包括Nelumbo nucifera雄蕊的粗提物，其中Nelumbo nucifera雄蕊的粗提物通过使用选自水，甲醇，丁醇或其混合物的极性溶剂或选自乙酸乙酯， 正己烷，二氯甲烷和氯仿。 具有抗氧化活性的组合物包括从由式（I）表示的Nelumbo nucifera雄蕊分离的类黄酮化合物及其药学上可接受的盐，其中R1是氢，羟基，C1-C4烷基或烷氧基，葡萄糖，鼠李糖醇（Rha（1） -Glu），半乳糖，葡糖醛酸或低级烷基葡糖苷酸; R2和R3独立地是氢，羟基，C1-C4烷基或烷氧基。