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41.发明授权나문재(Ｓｕａｅｄａ ａｓｐａｒａｇｏｉｄｅｓ) 추출물을 포함하는 치매 예방 또는 치료 및 인지능 개선용 약학적 조성물 또는 기능성 식품 조성물 失效用于预防或治疗感染的药物或功能食品组合物，并提高包含芦荟汁的提取物的认知能力
公开(公告)号：KR101118901B1
公开(公告)日：2012-03-19
申请号：KR1020090099386
申请日：2009-10-19
Applicant: 한림대학교 산학협력단
IPC: A61K36/185 , A61P25/28 , A23L1/30
Abstract: 본 발명은 알츠하이머질병(Alzheimer's Disease)의 예방, 치료 및 인지능 개선을 목적으로, 상기 나문재 추출물은 아세틸콜린에스테라제의 활성을 저해함으로써 아세틸콜린의 농도를 증가시켜, 콜린성 신경기능 퇴화로 인한 알츠하이머병의 예방 및 치료에 효과적이다. 또한 베타아밀로이드 펩타이드의 생성과정에 관여하는 효소의 하나인 β-세크레타제(β-site Amyloid precursor protein Cleaving Enzyme, BACE)의 활성을 특이적으로 저해하는 나문재 추출물을 포함하는 것을 특징으로 하는 치매 예방 또는 치료 및 인지능 개선용 약학적 조성물 또는 기능성 식품 조성물에 관한 것이다.
치매, 예방, 치료, 아세틸콜린에스테라아제, 베타세크레타제-
公开(公告)号：KR101090749B1
公开(公告)日：2011-12-08
申请号：KR1020090097602
申请日：2009-10-14
Applicant: 한림대학교 산학협력단
CPC classification number: Y02A50/411
Abstract: 본발명은재조합이나화학적결합방법으로단백질수송도메인과결합된슈퍼옥사이드디스뮤테이즈(SOD) 융합단백질에들쭉추출물을가함으로써이 융합단백질의세포내도입능력을증가시키는방법을제공한다.
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公开(公告)号：KR1020110092179A
公开(公告)日：2011-08-17
申请号：KR1020100011694
申请日：2010-02-08
Applicant: 한림대학교 산학협력단
IPC: A61K36/899 , A61P3/10 , A61P3/00
Abstract: PURPOSE: A composition containing purple corn extract for suppressing diabetic renal fibrosis is provided to reduce type IV collagen generation and to relieve renal fibrosis. CONSTITUTION: A composition for suppressing diabetic renal fibrosis contains purple corn extract. The purple corn extract is prepared by mixing 100% of purple corn powder with ethanol in a weight ratio of 1:7-10, performing sonication for 20-40 minutes, centrifuging at 2500-3000rpm for 10-20 minutes, collecting supernatant, and concentrating. The composition is manufactured in the form of beverage, powder, concentrate, capsule, and medicine.
Abstract translation: 目的：提供含有用于抑制糖尿病肾纤维化的紫玉米提取物的组合物，以减少IV型胶原蛋白的产生并减轻肾纤维化。 构成：用于抑制糖尿病肾纤维化的组合物含有紫玉米提取物。 紫玉米提取物通过将100％的紫玉米粉与乙醇以1:7-10的重量比混合，超声处理20-40分钟，以2500-3000rpm离心10-20分钟，收集上清液和 集中。 该组合物以饮料，粉末，浓缩物，胶囊和药物的形式制造。
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公开(公告)号：KR1020110087420A
公开(公告)日：2011-08-03
申请号：KR1020100006833
申请日：2010-01-26
Applicant: 한림대학교 산학협력단
Abstract: PURPOSE: A composition containing Anthemis tinctoria extract for preventing or treating diabetes complication is provided to suppress glycation end product with less side effects and safety. CONSTITUTION: A composition for preventing or treating diabetes complication contains Anthemis tinctoria extract as an active ingredient. The Anthemis tinctoria extract is prepared by isolating Anthemis tinctoria flower using water, alcohol of 1-5 carbon atoms, or mixture thereof. The diabetes complication is diabetic retinopathy, cataract, diabetic cornea, diabetic nephropathy, diabetic neuropathy, diabetic peripheral nerve failure, or atherosis. A food composition for preventing or treating diabetes complication contains the Anthemis tinctoria flower extract as an active ingredient. The Anthemis tinctoria extract is contained in 0.001-99.9 weight%. The composition for preventing or treating diabetes complication is taken by oral or parenteral administration.
Abstract translation: 目的：提供含有用于预防或治疗糖尿病并发症的抗黄疸提取物的组合物以抑制副作用和安全性较低的糖基化终产物。 构成：用于预防或治疗糖尿病并发症的组合物含有抗黄连提取物作为活性成分。 通过使用水，1-5个碳原子的醇或其混合物分离抗烟曲霉花卉来制备天竺葵提取物。 糖尿病并发症是糖尿病性视网膜病变，白内障，糖尿病性角膜，糖尿病性肾病，糖尿病性神经病变，糖尿病性周围神经衰竭或无症状。 用于预防或治疗糖尿病并发症的食物组合物含有作为活性成分的抗烟曲霉花提取物。 天竺葵提取物含量为0.001-99.9重量％。 用于预防或治疗糖尿病并发症的组合物通过口服或肠胃外给药进行。
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公开(公告)号：KR1020110079421A
公开(公告)日：2011-07-07
申请号：KR1020100012585
申请日：2010-02-10
Applicant: 한림대학교 산학협력단
Abstract: PURPOSE: A pharmaceutical composition containing Eupatorium japonicum extract is provided to suppress cancer metastasis without side effects and cytotoxicity. CONSTITUTION: An anticancer composition contains 0.001-99.9 weight% of Eupatorium japonicum extract as an active ingredient. The Eupatorium japonicum extract is isolated from Eupatorium japonicum flower using water, alcohol of 1-5 carbon atoms, or mixture thereof. The Eupatorium japonicum extract is a fraction prepared using hexane, methylene chloride, or ethyl acetate. A composition for preventing or treating cancer contains the anticancer composition as an active ingredient.
Abstract translation: 目的：提供含有日本E um提取物的药物组合物，以抑制癌转移而无副作用和细胞毒性。 构成：抗癌组合物含有0.001-99.9重量％的日本E um提取物作为活性成分。 使用水，1-5个碳原子的醇或其混合物，从日本um花中分离出日本E The提取物。 日本E um提取物是使用己烷，二氯甲烷或乙酸乙酯制备的级分。 用于预防或治疗癌症的组合物含有抗癌组合物作为活性成分。
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Patent Agency Ranking
公开(公告)号：KR1020110077104A
公开(公告)日：2011-07-07
申请号：KR1020090133566
申请日：2009-12-30
Applicant: 한림대학교 산학협력단
Abstract: PURPOSE: An analgesic composition containing Dianthus sinensis extract is provided to prevent side effects of gastrointestinal disturbance, allergy, and hepatotoxicity. CONSTITUTION: An analgesic composition contains Dianthus sinensis extract as an active ingredient, isolated using water and alcohol of 1-4 carbon atoms. A food composition for treating pain contains the analgesic composition. A method for preparing the analgesic composition comprises: a step of preparing dried Dianthus sinensis; and a step of isolating Dianthus sinensis using water or alcohol of 1-4 carbon atoms at 50-100°C for 1-10 hours.
Abstract translation: 目的：提供含有石竹提取物的镇痛组合物，以防止胃肠道紊乱，过敏和肝毒性的副作用。 构成：镇痛组合物含有石竹提取物作为活性成分，使用1-4个碳原子的水和醇分离。 用于治疗疼痛的食物组合物包含镇痛组合物。 制备镇痛组合物的方法包括：制备干燥的石竹的步骤; 并且在50-100℃下使用1-4个碳原子的水或醇分离石竹1-10小时的步骤。
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公开(公告)号：KR1020110075336A
公开(公告)日：2011-07-06
申请号：KR1020090131764
申请日：2009-12-28
Applicant: 한림대학교 산학협력단 , 대한민국(농촌진흥청장)
CPC classification number: A61K36/73 , A23V2200/322 , A61K2236/333
Abstract: PURPOSE: An analgesic composition containing Agrimonia pilosa Ledeb plant extract is provided to ensure effective pain killing effect and without side effects. CONSTITUTION: An analgesic composition contains Agrimonia pilosa Ledeb extract as an active ingredient, isolated from leaves of Agrimonia pilosa Ledeb using water or alcohol solvent of 1-4 carbon atoms. A food composition for pain killing contains the analgesic composition. A method for manufacturing the analgesic composition comprises: a step of preparing dried Agrimonia pilosa Ledeb; a step of adding 5-20 time of water or alcohol solvent of 1-4 carbon atoms; and a step of extracting at 50-100°C for 1-10 hours.
Abstract translation: 目的：提供含有Agrimonia pilosa Ledeb植物提取物的止痛组合物，以确保有效的止痛效果，无副作用。 构成：镇痛组合物含有Agrimonia pilosa Ledeb提取物作为活性成分，使用1-4碳原子的水或醇溶剂从Agrimonia pilosa Ledeb的叶中分离。 用于止痛药物的食物组合物含有镇痛组合物。 一种镇痛组合物的制造方法，其特征在于，包括：制备干燥的Agrimonia pilosa Ledeb的步骤; 加入5-20次的1-4个碳原子的水或醇溶剂的步骤; 和在50-100℃下提取1-10小时的步骤。
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公开(公告)号：KR1020090075481A
公开(公告)日：2009-07-08
申请号：KR1020080001352
申请日：2008-01-04
Applicant: 한림대학교 산학협력단
IPC: A61K31/35 , A61K36/484 , A61P17/18
Abstract: An antioxidation composition containing a Glycyrrhiza glabra extract with excellent antioxidation activity is provided to improve stability without side effect and raise the contents of 7-O-methylluteone and dehydroglyasperin C. An antioxidation composition comprises a Glycyrrhiza glabra extract. The Glycyrrhiza glabra extract is obtained using C1-5 alcohol, hexane, dichloromethane, methylene chloride, chloroform, ethylacetate or ethylether. A solvent for extracting is mixture solvent of methylene chloride or normal hexane and ethanol in a ratio of 10:1-8:1. The Glycyrrhiza glabra extract comprises 0.4-0.6 weight part of 7-O-methyllutheone and 0.2-0.4 weight part of dehydroglyasperin C based on 100 weight part.
Abstract translation: 提供含有具有优异抗氧化活性的甘草提取物的抗氧化组合物，以提高稳定性而不会产生副作用，并提高7-O-甲基黄酮和脱氢甘油三酯C的含量。抗氧化组合物包含甘草提取物。 甘草提取物采用C 1-5醇，己烷，二氯甲烷，二氯甲烷，氯仿，乙酸乙酯或乙醚得到。 提取的溶剂是二氯甲烷或正己烷和乙醇的混合溶剂，比例为10：1-8：1。 甘草提取物包含基于100重量份的0.4-0.6重量份的7-O-甲基异丙基酮和0.2-0.4重量份的脱氢甘氨酸C。
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