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    USE OF RETINOID GLYCOSIDES IN TOPICAL PHARMACEUTICAL COMPOSITIONS
    41.
    发明申请
    USE OF RETINOID GLYCOSIDES IN TOPICAL PHARMACEUTICAL COMPOSITIONS 审中-公开
    在局部药物组合物中使用灭鼠糖苷

    公开(公告)号：WO1996010403A1

    公开(公告)日：1996-04-11

    申请号：PCT/US1995011314

    申请日：1995-09-07

    Applicant: ALCON LABORATORIES, INC.

    Inventor： ALCON LABORATORIES, INC. ,  BHAGAT, Haresh, G. ,  AIRY, Subhash, C.

    IPC: A61K31/20

    CPC classification number: A61K31/7004 ,  A61K31/203 ,  A61K31/7012

    Abstract: Certain stable analogues of retinoic acid are found to be useful in the treatment of dry eye and related aliments, and skin disorders such as acne, psoriasis, skin aging and wound healing. These compounds are much more soluble than retinoic acid, and may therefore be formulated in standard.

    Abstract translation: 发现视黄酸的一些稳定的类似物可用于治疗干眼症和相关的营养物质，以及皮肤疾病如痤疮，牛皮癣，皮肤老化和伤口愈合。 这些化合物比视黄酸更易溶，因此可以配制成标准。

    BLOCK AND GRAFT COPOLYMERS AND METHODS RELATING THERETO
    42.
    发明申请
    BLOCK AND GRAFT COPOLYMERS AND METHODS RELATING THERETO 审中-公开
    嵌段和共聚物及其相关方法

    公开(公告)号：WO1995024430A2

    公开(公告)日：1995-09-14

    申请号：PCT/US1995002638

    申请日：1995-03-03

    Applicant: UNIVERSITY OF WASHINGTON ,  ALCON LABORATORIES, INC.

    Inventor： UNIVERSITY OF WASHINGTON ,  ALCON LABORATORIES, INC. ,  HOFFMAN, Allan, S. ,  CHEN, Guohua ,  YORK, Billie, M.

    IPC: C08F00/00

    CPC classification number: A61K9/0014 ,  A61K8/91 ,  A61K9/2027 ,  A61K9/2031 ,  A61K47/32 ,  A61K47/34 ,  A61K2800/54 ,  A61Q19/00 ,  C08F265/10 ,  C08F291/00 ,  C08G81/00 ,  C08L71/02 ,  C08F220/06 ,  C08L2666/24 ,  C08L2666/04

    Abstract: There is disclosed block and graft copolymers which, in one embodiment, contain both a temperature-sensitive polymer component and a pH-sensitive polymer component, and the use of such copolymers for topical drug delivery to a treatment area. The block and graft copolymers may be physically mixed with one or more drugs to form a copolymer-drug mixture. This mixture may be applied to the treatment as solid particles suspended in a pharmaceutically acceptable carrier, or as a liquid which gels upon contact with the treatment area. Upon contact with the treatment area, the pH-sensitive polymer component hydrates and swells, thereby causing release of the drug from the mixture. In addition, such hydration and swelling causes the pH-sensitive polymer component to adhere to the tissue of the treatment area, thus prolonging contact time. The temperature-sensitive polymer component resists hydration and swelling of the mixture, thereby imparting a sustained and controlled release of the drug to the treatment area. In another embodiment of this invention, bloc and graft copolymers, and hydrogels thereof, are disclosed having broad industrial applicability.

    Abstract translation: 公开了一种在一个实施方案中含有温度敏感性聚合物组分和pH敏感性聚合物组分的嵌段和接枝共聚物，以及这些共聚物用于局部药物递送至处理区域的用途。 嵌段和接枝共聚物可以与一种或多种药物物理混合以形成共聚物 - 药物混合物。 该混合物可以作为悬浮在药学上可接受的载体中的固体颗粒或作为与处理区域接触时凝胶化的液体施用于处理。 与处理区域接触时，pH敏感的聚合物组分水合并溶胀，从而导致药物从混合物中释放出来。 此外，这种水合和溶胀导致pH敏感聚合物组分粘附到处理区域的组织，从而延长接触时间。 温度敏感的聚合物组分抵抗混合物的水合和溶胀，由此赋予药物持续且受控的释放到治疗区域。 在本发明的另一个实施方案中，公开了具有广泛的工业实用性的团和接枝共聚物及其水凝胶。

    IMPROVED INTRAOCULAR IRRIGATING SOLUTION CONTAINING NON-STEROIDAL ANTIINFLAMMATORY AGENT
    43.
    发明申请
    IMPROVED INTRAOCULAR IRRIGATING SOLUTION CONTAINING NON-STEROIDAL ANTIINFLAMMATORY AGENT 审中-公开
    含有非甾体抗炎药物的改善的室内灌注溶液

    公开(公告)号：WO1995016435A2

    公开(公告)日：1995-06-22

    申请号：PCT/US1994014196

    申请日：1994-12-13

    Applicant: ALCON LABORATORIES, INC.

    Inventor： ALCON LABORATORIES, INC. ,  CAGLE, Gerald, D. ,  LORENZETTI, Ole, J. ,  GAN, Owen

    IPC: A61K09/08

    CPC classification number: A61K9/0048

    Abstract: Pharmaceutical compositions useful in ophthalmic surgery are described. The compositions include one or more non-steroidal antiinflammatory drugs, and are useful for preventing or treating ophthalmic inflammation and other conditions associated with ophthalmic surgery. Methods of using the compositions in connection with ophthalmic surgical procedures are also described.

    Abstract translation: 描述了可用于眼科手术的药物组合物。 组合物包括一种或多种非甾体抗炎药，并且可用于预防或治疗眼科炎症和与眼科手术相关的其它病症。 还描述了使用组合物与眼科外科手术相关的方法。

    NON-RACEMIC COMPOSITIONS OF SPIROFLUORENEHYDANTOINS
    44.
    发明申请
    NON-RACEMIC COMPOSITIONS OF SPIROFLUORENEHYDANTOINS 审中-公开
    非特异性组合物

    公开(公告)号：WO1995003800A1

    公开(公告)日：1995-02-09

    申请号：PCT/US1994008521

    申请日：1994-07-28

    Applicant: ALCON LABORATORIES, INC.

    Inventor： ALCON LABORATORIES, INC. ,  YORK, Billie, M.

    IPC: A61K31/415

    CPC classification number: A61K31/415 ,  Y10S514/866 ,  Y10S514/922

    Abstract: Disclosed are novel compositions comprising mixtures useful to treat the metabolically impaired and to improve patient compliance. Included are non-racemic mixtures of certain chiral spirofluorenehydantoins. Methods of use to treat glucose toxicity and complications arising from diabetes mellitus are also disclosed.

    Abstract translation: 公开了包含可用于治疗代谢障碍并改善患者依从性的混合物的新型组合物。 包括某些手性螺芴壬内酯的非外消旋混合物。 还公开了用于治疗葡萄糖毒性的方法和由糖尿病引起的并发症。

    COMBINATIONS OF CELLULOSIC POLYMERS AND CARBOXY VINYL POLYMERS AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS
    48.
    发明申请
    COMBINATIONS OF CELLULOSIC POLYMERS AND CARBOXY VINYL POLYMERS AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS 审中-公开
    纤维素聚合物和羧基乙烯基聚合物的组合及其在药物组合物中的应用

    公开(公告)号：WO1993017664A1

    公开(公告)日：1993-09-16

    申请号：PCT/US1993001565

    申请日：1993-02-22

    Applicant: ALCON LABORATORIES, INC.

    Inventor： ALCON LABORATORIES, INC. ,  ALI, Yusuf ,  BHAGAT, Haresh, G.

    IPC: A61K09/08

    CPC classification number: A61K9/0048

    Abstract: Combinations of at least one cellulosic polymer and at least one carboxy vinyl polymer have an unexpectedly high viscosity. Compositions containing these polymeric combinations have a number of applications, such as in pharmaceuticals, especially in the field of ophthalmics. Topical ophthalmic compositions containing these polymeric combinations are contemplated for the relief of the symptoms of dry eye syndrome.

    Abstract translation: 至少一种纤维素聚合物和至少一种羧乙烯基聚合物的组合具有出乎意料的高粘度。 含有这些聚合物组合的组合物具有许多应用，例如在药物中，特别是在眼科领域。 预期含有这些聚合物组合物的局部眼用组合物用于缓解干眼综合征的症状。

    OPHTHALMIC COMPOSITION
    50.
    发明申请
    OPHTHALMIC COMPOSITION 审中-公开
    眼科组合物

    公开(公告)号：WO1991003245A1

    公开(公告)日：1991-03-21

    申请号：PCT/US1990004071

    申请日：1990-07-25

    Applicant: ALCON LABORATORIES, INC.

    Inventor： ALCON LABORATORIES, INC. ,  CLARK, Abbot, F.

    IPC: A61K31/58

    CPC classification number: A61K31/569 ,  A61K31/565 ,  A61K31/57 ,  A61K31/573 ,  A61K31/58 ,  A61K31/665 ,  C07J3/00 ,  C07J5/0053 ,  C07J9/00 ,  C07J11/00 ,  C07J41/0005 ,  C07J41/0027 ,  C07J51/00 ,  A61K2300/00

    Abstract: Pharmaceutical compositions useful in the treatment of ophthalmic inflammation and methods of treating ophthalmic inflammation with those compositions ar disclosed. The compositions contain a combination of a glucocorticoid and an angiostatic steroid. The angiostatic steroid substantially prevents any significant increases in intraocular pressure which might otherwise be experienced by the patient as a side effect of the glucocorticoid component of the compositions. The therapeutic interaction of the two components therefore allows the potent anti-inflammatory properties of the glucocorticoids to be utilized without fear of elevating intraocular pressure.

    Abstract translation: 可用于治疗眼部炎症的药物组合物和所公开的那些组合物治疗眼部炎症的方法。 组合物含有糖皮质激素和血管抑制类固醇的组合。 血管抑制类固醇基本上防止了眼睛压力的任何显着增加，否则患者可能会经历该组合物的糖皮质激素成分的副作用。 因此，两种组分的治疗相互作用允许使用糖皮质激素的有效抗炎特性，而不用担心升高眼内压。

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