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    BLOCK AND GRAFT COPOLYMERS AND METHODS RELATING THERETO
    1.
    发明申请
    BLOCK AND GRAFT COPOLYMERS AND METHODS RELATING THERETO 审中-公开
    嵌段和共聚物及其相关方法

    公开(公告)号：WO1995024430A2

    公开(公告)日：1995-09-14

    申请号：PCT/US1995002638

    申请日：1995-03-03

    Applicant: UNIVERSITY OF WASHINGTON ,  ALCON LABORATORIES, INC.

    Inventor： UNIVERSITY OF WASHINGTON ,  ALCON LABORATORIES, INC. ,  HOFFMAN, Allan, S. ,  CHEN, Guohua ,  YORK, Billie, M.

    IPC: C08F00/00

    CPC classification number: A61K9/0014 ,  A61K8/91 ,  A61K9/2027 ,  A61K9/2031 ,  A61K47/32 ,  A61K47/34 ,  A61K2800/54 ,  A61Q19/00 ,  C08F265/10 ,  C08F291/00 ,  C08G81/00 ,  C08L71/02 ,  C08F220/06 ,  C08L2666/24 ,  C08L2666/04

    Abstract: There is disclosed block and graft copolymers which, in one embodiment, contain both a temperature-sensitive polymer component and a pH-sensitive polymer component, and the use of such copolymers for topical drug delivery to a treatment area. The block and graft copolymers may be physically mixed with one or more drugs to form a copolymer-drug mixture. This mixture may be applied to the treatment as solid particles suspended in a pharmaceutically acceptable carrier, or as a liquid which gels upon contact with the treatment area. Upon contact with the treatment area, the pH-sensitive polymer component hydrates and swells, thereby causing release of the drug from the mixture. In addition, such hydration and swelling causes the pH-sensitive polymer component to adhere to the tissue of the treatment area, thus prolonging contact time. The temperature-sensitive polymer component resists hydration and swelling of the mixture, thereby imparting a sustained and controlled release of the drug to the treatment area. In another embodiment of this invention, bloc and graft copolymers, and hydrogels thereof, are disclosed having broad industrial applicability.

    Abstract translation: 公开了一种在一个实施方案中含有温度敏感性聚合物组分和pH敏感性聚合物组分的嵌段和接枝共聚物，以及这些共聚物用于局部药物递送至处理区域的用途。 嵌段和接枝共聚物可以与一种或多种药物物理混合以形成共聚物 - 药物混合物。 该混合物可以作为悬浮在药学上可接受的载体中的固体颗粒或作为与处理区域接触时凝胶化的液体施用于处理。 与处理区域接触时，pH敏感的聚合物组分水合并溶胀，从而导致药物从混合物中释放出来。 此外，这种水合和溶胀导致pH敏感聚合物组分粘附到处理区域的组织，从而延长接触时间。 温度敏感的聚合物组分抵抗混合物的水合和溶胀，由此赋予药物持续且受控的释放到治疗区域。 在本发明的另一个实施方案中，公开了具有广泛的工业实用性的团和接枝共聚物及其水凝胶。

    INFUSION SLEEVE
    4.
    发明申请
    INFUSION SLEEVE 审中-公开
    输液管

    公开(公告)号：WO1997028769A1

    公开(公告)日：1997-08-14

    申请号：PCT/US1997000746

    申请日：1997-01-09

    Applicant: ALCON LABORATORIES, INC.

    Inventor： ALCON LABORATORIES, INC. ,  INJEV, Valentine, P.

    IPC: A61F09/007

    CPC classification number: A61F9/00745 ,  A61B2017/320084 ,  A61M1/0084 ,  A61M39/1055

    Abstract: An infusion sleeve having a two-piece body. The first piece is conical in shape and is attached to the handpiece by conventional methods. The distal end of the first piece contains a series of annular grooves. The second piece is tubular in shape and contains an annular rim or lip on the proximal end that interlocks within the annular grooves on the first piece.

    Abstract translation: 输液套管，具有两件式的身体。 第一件是圆锥形的，并且通过常规方法附接到手持件上。 第一件的远端包含一系列环形槽。 第二件是管状的，并且包括在近端上的环形边缘或唇缘，其在第一件上的环形槽内互锁。

    STABLE LIQUID ENZYME COMPOSITIONS AND METHODS OF USE
    9.
    发明申请
    STABLE LIQUID ENZYME COMPOSITIONS AND METHODS OF USE 审中-公开
    稳定的液体组合物和使用方法

    公开(公告)号：WO1996040853A1

    公开(公告)日：1996-12-19

    申请号：PCT/US1996009688

    申请日：1996-06-07

    Applicant: ALCON LABORATORIES, INC. ,  VAN DUZEE, Barry, F. ,  STONE, Ralph, P.

    Inventor： ALCON LABORATORIES, INC.

    IPC: C11D03/386

    CPC classification number: C11D3/38663 ,  C11D3/0078

    Abstract: Compositions containing an ophthalmically acceptable enzyme of high purity and integrity in a liquid medium and methods involving the use of these compositions for cleaning a contact lens, and in combination with an antimicrobial agent for the simultaneous cleaning and disinfecting of contact lens are disclosed.

    Abstract translation: 公开了含有在液体介质中具有高纯度和完整性的眼科可接受的酶的组合物和涉及使用这些组合物用于清洁隐形眼镜的方法，以及与用于同时清洁和消毒隐形眼镜的抗微生物剂组合。

    USE OF TGF-'beta'3 TO REDUCE THE FORMATION OF SCAR TISSUE IN RESPONSE TO CORNEAL TRAUMA
    10.
    发明申请
    USE OF TGF-'beta'3 TO REDUCE THE FORMATION OF SCAR TISSUE IN RESPONSE TO CORNEAL TRAUMA 审中-公开
    TGF-β3用于减少脊髓组织在脊髓损伤中的形成

    公开(公告)号：WO1996032131A1

    公开(公告)日：1996-10-17

    申请号：PCT/US1995004572

    申请日：1995-04-14

    Applicant: ALCON LABORATORIES, INC.

    Inventor： ALCON LABORATORIES, INC. ,  NIXON, Jon, C. ,  YORK, Billie, M.

    IPC: A61K38/18

    CPC classification number: A61K38/1841

    Abstract: The use of TGF- beta 3 to reduce the formation of scar tissue as a result of trauma to the cornea of the eye is described. The invention is particularly directed to the use of TGF- beta 3 to reduce the formation of scar tissue in connection with ophthalmic surgical procedures involving the cornea, such as laser irradiation of the cornea. A composition containing TGF- beta 3 is applied to the site of the trauma to alter the production and composition of extracellular matrix synthesized by fibroblasts, and thereby reduce the formation of scar tissue and consequent impairment of vision.

    Abstract translation: 描述了使用TGF-β3来减少由眼睛角膜创伤引起的瘢痕组织的形成。 本发明特别涉及使用TGF-β3来减少与涉及角膜的眼科手术相关的瘢痕组织的形成，例如角膜的激光照射。 将包含TGF-β3的组合物应用于创伤部位，以改变由成纤维细胞合成的细胞外基质的生成和组成，从而减少瘢痕组织的形成，从而减少视力。

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