-
公开(公告)号：HK1151803A1
公开(公告)日：2012-02-10
申请号：HK11105794
申请日：2008-03-10
Applicant: AMGEN INC
Inventor： PASZTY CHRISTOPHER , ROBINSON MARTYN KIM , GRAHAM KEVIN , HENRY ALISTAIR JAMES , HOFFMANN KELLY SUE , LATHAM JOHN , LAWSON ALASTAIR , LU HSIENG SEN , WINTERS AARON GEORGE , WINKLER DAVID , SHEN WENYAN , POPPLEWELL ANDY
IPC: C07K20060101 , A61K20060101
Abstract: Compositions and methods relating to epitopes of sclerostin protein, and sclerostin-binding agents, such as antibodies capable of binding to sclerostin, are provided.
-
公开(公告)号：NZ563539A
公开(公告)日：2011-04-29
申请号：NZ56353906
申请日：2006-04-28
Applicant: UCB PHARMA SA , AMGEN INC
Inventor： PASZTY CHRISTOPHER , ROBINSON MARTYN KIM , GRAHAM KEVIN , HENRY ALISTAIR JAMES , HOFFMAN KELLY SUE , LATHAM JOHN , LAWSON ALASTAIR , LU HSIENG SEN , POPPLEWELL ANDY , SHEN WENYAN , WINKLER DAVID , WINTERS AARON GEORGE
Abstract: Provided is an antibody or functional fragment thereof that cross-blocks or is cross-blocked from binding of at least one of antibodies Ab-A, Ab-1, Ab-4, Ab-5, Ab-19, Ab-20, and Ab-23 to sclerostin. The antibodies are useful for treating bone-related disorders in mammals.
-
公开(公告)号：ZA200709480B
公开(公告)日：2010-07-28
申请号：ZA200709480
申请日：2007-11-02
Applicant: UCB PHARMA SA , AMGEN INC
Inventor： PASZTY CHRISTOPHER , GRAHAM KEVIN , HOFFMAN KELLY SUE , LAWSON ALASTAIR , POPPLEWELL ANDY , WINKLER DAVID G , ROBINSON MARTYN KIM , HENRY ALISTAIR JAMES , LATHAM JOHN , LU HSIENG SEN , SHEN WENYAN , WINTERS AARON GEORGE
IPC: C07K20060101
Abstract: Compositions and methods relating to epitopes of sclerostin protein, and sclerostin-binding agents, such as antibodies capable of binding to sclerostin, are provided.
-
公开(公告)号：PE20070317A1
公开(公告)日：2007-04-27
申请号：PE2006000459
申请日：2006-05-02
Inventor： PASZTY CHRISTOPHER , GRAHAM KEVIN , HOFFMANN KELLY SUE , LAWSON ALASTAIR , POPPLEWELL ANDY , WINKLER DAVID , WINTERS AARON GEORGE , SHEN WENYAN , LU HSIENG SEN , LATHAM JOHN , HENRY ALISTAIR JAMES , ROBINSON MARTYN KIM
IPC: C07K14/435 , C07K14/51 , C07K16/18
Abstract: SE REFIERE A UN AGENTE DE UNION A ESCLEROSTINA O ANTICUERPO QUE CRUZA-BLOQUEA LA UNION DE LOS ANTICUERPOS Ab-A, Ab-B, Ab-C, Ab-D, Ab-1, Ab-2, ENTRE OTROS, A ESCLEROSTINA; Y SE UNE A UN EPITOPE T20.6 (NUDO DE CISTINA + 4 BRAZOS). DICHO ANTICUERPO TIENE AL MENOS UN 75% DE UN CDR QUE COMPRENDE: A) CDR-H1 ES LA SEQ ID Nº: 245 O SEQ ID Nº: 269; CDR-H2 ES LA SEQ ID Nº: 246 O SEQ ID Nº: 270 Y CDR-H3 ES LA SEQ ID Nº: 247 O SEQ ID Nº: 271; Y B) CDR-L1 ES LA SEQ ID Nº: 78 O SEQ ID Nº: 239; CDR-L2 ES LA SEQ ID Nº: 79 O SEQ ID Nº: 240 Y CDR-L3 ES LA SEQ ID Nº: 80 O SEQ ID Nº: 241. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. EL AGENTE DE UNION A ESCLEROSTINA O ANTICUERPO INCREMENTA LA FORMACION DE HUESO, DENSIDAD MINERAL OSEA, MASA OSEA, ENTRE OTROS, SIENDO UTIL EN EL TRATAMIENTO DE ACONDROPLASIA, DISPLASIA FIBROSA, PSEUDOARTROSIS, OSTEOARTRITIS, ENFERMEDAD DE PAGET JUVENIL
-
公开(公告)号：CA2607276A1
公开(公告)日：2006-11-09
申请号：CA2607276
申请日：2006-04-28
Inventor： ROBINSON MARTYN KIM , PASZTY CHRISTOPHER , HOFFMANN KELLY SUE , LAWSON ALASTAIR , LATHAM JOHN , WINKLER DAVID , HENRY ALISTAIR JAMES , LU HSIENG SEN , WINTERS AARON GEORGE
Abstract: The invention relates to polypeptide fragments of sclerostin and antibodies that bind to the fragments. The antibodies are useful in treating diseases of low bone density, such as osteoporosis, and in accelerating the healing of bone fractures.
-
Patent Agency Ranking
公开(公告)号：CA2607197A1
公开(公告)日：2006-11-09
申请号：CA2607197
申请日：2006-04-28
Applicant: AMGEN INC , UCB PHARMA SA
Inventor： WINTERS AARON GEORGE , LATHAM JOHN , HOFFMANN KELLY SUE , WINKLER DAVID , LAWSON ALASTAIR , LU HSIENG SEN , HENRY ALISTAIR JAMES , SHEN WENYAN , ROBINSON MARTYN KIM , GRAHAM KEVIN , PASZTY CHRISTOPHER , POPPLEWELL ANDY
Abstract: Compositions and methods relating to epitopes of sclerostin protein, and sclerostin-binding agents, such as antibodies capable of binding to sclerostin, are provided.
-
公开(公告)号：RS62685B1
公开(公告)日：2021-12-31
申请号：RSP20211488
申请日：2006-04-28
Applicant: UCB PHARMA SA , AMGEN INC
-
公开(公告)号：UA123695C2
公开(公告)日：2021-05-19
申请号：UAA201202580
申请日：2006-04-28
Applicant: UCB PHARMA SA , AMGEN INC
Inventor： PASZTY CHRISTOPHER , ROBINSON MARTYN KIM , GRAHAM KEVIN , HENRY ALISTAIR JAMES , HOFFMANN KELLY SUE , LATHAM JOHN , LAWSON ALASTAIR , LU HSIENG SEN , POPPLEWELL ANDY , SHEN WENYAN , WINKLER DAVID , WINTERS AARON GEORGE
Abstract: Винахідналежитьдополіпептиду, щоявляєсобоюепітопбілкасклеростинулюдини, способуодержанняантитіла, якезв’язуєвказанийепітоп, антитіла, здатногозв'язуватисяізвказанимепітопомсклеростину, виділеногополінуклеотиду, клонуючогоабоекспресуючоговектора, клітини-хазяїна, фармацевтичноїкомпозиції, застосуванняфармацевтичноїкомпозиціїдлялікуванняпорушення, опосередкованогопідвищенимрівнемсклеростинутадіагностичногонабору, щоміститьзазначенеантитіло.
-
公开(公告)号：UY38207A
公开(公告)日：2020-11-30
申请号：UY38207
申请日：2006-05-02
Inventor： PASZTY CHRISTOPHER , MARTYN KIM ROBINSON , GRAHAM KEVIN , ALISTAIR JAMES HENRY , KELLY SUE HOFFMANN , LATHAM JOHN , LAWSON ALASTAIR , HSIENG SEN LU , P0PPLEWELL ANDY , SHEN WENYAN , WINKLER DAVID , AARON GEORGE WINIERS
IPC: C07K16/18 , A61K38/17 , A61K39/395 , A61K39/44 , C07K14/51 , C07K16/22 , C07K16/46 , C12N5/10 , C12N15/85
Abstract: Se proveen composiciones y métodos relacionados a epítopes de la proteína de esclerostina, y agentes de union, tales como anticuerpos capaces de unirse a la esclerostina. Se proveen composiciones y métodos relacionados a epítopes de la proteína de esclerostina, y agentes de union, tales como anticuerpos capaces de unirse a la esclerostina.
-
公开(公告)号：HUE032092T2
公开(公告)日：2017-08-28
申请号：HUE10014373
申请日：2006-04-28
Applicant: AMGEN INC
-
-
-
-
-
-
-
-
-
Search Results
88
records
(took 0.024 seconds)
