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公开(公告)号：KR20180043850A
公开(公告)日：2018-04-30
申请号：KR20187011418
申请日：2009-12-18
Applicant: AMGEN INC
Inventor： BOONE THOMAS C , BRANKOW DAVID W , GEGG JR COLIN V , HU SHAW FEN SYLVIA , KING CHADWICK T , LU HSIENG SEN , SHI LICHENG , XU CEN
IPC: C07K16/28
CPC classification number: C07K16/2869 , A61K39/395 , A61K39/39533 , A61K2039/505 , C07K2317/21 , C07K2317/32 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
Abstract: 인간 CGRP 수용체 (CGRP R)에결합하는항원결합단백질이제시된다. 항원결합단백질을인코딩하는핵산, 벡터, 그리고이들을인코딩하는세포역시제시된다. 이러한항원결합단백질은 CGRP에대한 CGRP R의결합을저해할수 있고, 편두통의치료및/또는예방을비롯한다수의 CGRP R 관련질환에유용하다.
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公开(公告)号：JP2014210815A
公开(公告)日：2014-11-13
申请号：JP2014164088
申请日：2014-08-12
Applicant: アムジェン インコーポレイテッド , Amgen Inc , アムジェン インコーポレイテッド
Inventor： THOMAS C BOONE , DAVID W BRANKOW , COLIN V GEGG JR , SHAW-FEN SYLVIA HU , CHADWICK T KING , LU HSIENG SEN , SHI LICHENG , XU CEN
IPC: C07K16/28 , A61K38/00 , A61K39/395 , A61P25/04 , A61P25/06 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/08
CPC classification number: C07K16/2869 , A61K39/395 , A61K39/39533 , A61K2039/505 , C07K2317/21 , C07K2317/32 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
Abstract: 【課題】ヒトCGRP受容体結合タンパク質の提供。【解決手段】ヒトCGRP受容体(CGRP R)に結合する抗原結合タンパク質を提供する。抗原結合タンパク質をコードする核酸、ベクター、および抗原結合タンパク質をコードする細胞も提供される。本抗原結合タンパク質は、CGRP RのCGRPへの結合を阻害することができ、片頭痛の治療および/または予防を含む、多数のCGRP R関連疾患において有用である。したがって、CGRP Rに対する所定の抗原結合タンパク質の結合は、以下の活性のうちの1つまたは複数を有し得る:CGRP Rの阻害、干渉、または調節、血管拡張の阻害、神経性炎症の減少、および慢性疼痛または片頭痛の症状の緩和、改善、治療、予防、または軽減。【選択図】なし
Abstract translation: 要解决的问题：提供人CGRP受体结合蛋白。解决方案：提供了结合人CGRP受体（CGRP R）的抗原结合蛋白。 还提供编码抗原结合蛋白，载体和编码抗原结合蛋白的核酸的核酸。 抗原结合蛋白可以抑制CGRP R与CGRP的结合，并且可用于多种CGRP R相关疾病，包括治疗和/或预防偏头痛。 因此，某些抗原结合蛋白与CGRP R的结合可以具有以下一种或多种活性：抑制，干扰或调节CGRP R，抑制血管扩张，减少神经源性炎症，减轻，改善，治疗，预防或 减少慢性疼痛或偏头痛的症状。
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公开(公告)号：JP2011212022A
公开(公告)日：2011-10-27
申请号：JP2011167756
申请日：2011-07-29
Applicant: Amgen Inc , アムジェン インコーポレイテッド
Inventor： LI JI , SHEN WENYAN , LU HSIENG SEN , RICHARDS WILLIAM GLEASON
IPC: C12N15/09 , A61K39/395 , A61P1/04 , A61P3/10 , A61P9/04 , A61P11/00 , A61P13/12 , A61P17/00 , A61P17/06 , A61P19/02 , A61P19/08 , A61P21/00 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/28 , A61P27/02 , A61P29/00 , C07K16/18 , C07K16/28 , C07K16/46 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/08
CPC classification number: C07K16/18 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: PROBLEM TO BE SOLVED: To provide a variety of binding agents that selectively bind Dkk-1.SOLUTION: The present invention provides antibodies and immunologically functional fragments thereof that specifically bind Dkk-1 polypeptides. The subject antibodies and fragments bind with high affinity to a conformational epitope located in the carboxy region of the Dkk-1 protein. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases including bone disorders, inflammatory diseases, neurological diseases, ocular diseases, renal diseases, pulmonary diseases, and skin diseases are also disclosed.
Abstract translation: 要解决的问题：提供选择性结合Dkk-1的各种结合剂。解决方案：本发明提供特异性结合Dkk-1多肽的抗体及其免疫功能片段。 受试抗体和片段以高亲和力结合位于Dkk-1蛋白的羧基区域的构象表位。 还提供了制备此类抗体或其片段的方法以及含有抗体或片段的生理上可接受的组合物。 还公开了使用抗体和片段来治疗各种疾病，包括骨骼疾病，炎性疾病，神经疾病，眼部疾病，肾脏疾病，肺部疾病和皮肤疾病。
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公开(公告)号：WO2006119107A3
公开(公告)日：2006-12-28
申请号：PCT/US2006016441
申请日：2006-04-28
Applicant: UCB SA , AMGEN INC , PASZTY CHRISTOPHER , ROBINSON MARTYN KIM , GRAHAM KEVIN , HENRY ALISTAIR JAMES , HOFFMANN KELLY SUE , LATHAM JOHN , LAWSON ALASTAIR , LU HSIENG SEN , POPPLEWELL ANDY , SHEN WENYAN , WINKLER DAVID , WINTERS AARON GEORGE
Inventor： PASZTY CHRISTOPHER , ROBINSON MARTYN KIM , GRAHAM KEVIN , HENRY ALISTAIR JAMES , HOFFMANN KELLY SUE , LATHAM JOHN , LAWSON ALASTAIR , LU HSIENG SEN , POPPLEWELL ANDY , SHEN WENYAN , WINKLER DAVID , WINTERS AARON GEORGE
CPC classification number: C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/60 , A61K2039/505 , C07K14/76 , C07K14/79 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
Abstract: Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
Abstract translation: 提供了与硬骨素蛋白表位有关的组合物和方法，以及硬骨素结合剂，例如能结合硬化蛋白的抗体。
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公开(公告)号：WO2006119062A3
公开(公告)日：2007-06-28
申请号：PCT/US2006016345
申请日：2006-04-28
Applicant: UCB SA , AMGEN INC , LU HSIENG SEN , PASZTY CHRISTOPHER , ROBINSON MARTYN KIM , HENRY ALISTAIR JAMES , HOFFMANN KELLY SUE , LATHAM JOHN , LAWSON ALASTAIR , WINKLER DAVID , WINTERS AARON GEORGE
Inventor： LU HSIENG SEN , PASZTY CHRISTOPHER , ROBINSON MARTYN KIM , HENRY ALISTAIR JAMES , HOFFMANN KELLY SUE , LATHAM JOHN , LAWSON ALASTAIR , WINKLER DAVID , WINTERS AARON GEORGE
CPC classification number: C07K16/18 , A61K2039/505 , C07K14/51 , C07K16/22 , C07K2317/24 , C07K2317/76 , C07K2317/92 , C12N15/63
Abstract: Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
Abstract translation: 提供了与硬骨素蛋白表位有关的组合物和方法，以及硬骨素结合剂，例如能结合硬化蛋白的抗体。
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Patent Agency Ranking
公开(公告)号：WO2012058393A3
公开(公告)日：2012-10-04
申请号：PCT/US2011058025
申请日：2011-10-27
Applicant: AMGEN INC , RICHARDS WILLIAM GLEASON , LU HSIENG SEN , KE HUA ZHU , LI CHAOYANG , JACOBSEN FREDERICK W
Inventor： RICHARDS WILLIAM GLEASON , LU HSIENG SEN , KE HUA ZHU , LI CHAOYANG , JACOBSEN FREDERICK W
CPC classification number: C07K16/18 , A61K39/3955 , A61K2039/505 , A61K2039/507 , C07K16/22 , C07K2317/21 , C07K2317/34 , C07K2317/76 , C07K2317/92
Abstract: The present invention provides antibodies and immunologically functional fragments thereof that specifically bind DKK1 polypeptides. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases are also disclosed.
Abstract translation: 本发明提供了特异性结合DKK1多肽的抗体及其免疫功能片段。 还提供了制备此类抗体或其片段的方法以及含有抗体或片段的生理上可接受的组合物。 还公开了使用抗体和片段来治疗各种疾病。
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公开(公告)号：WO2006119107A9
公开(公告)日：2007-09-20
申请号：PCT/US2006016441
申请日：2006-04-28
Applicant: UCB SA , AMGEN INC , PASZTY CHRISTOPHER , ROBINSON MARTYN KIM , GRAHAM KEVIN , HENRY ALISTAIR JAMES , HOFFMANN KELLY SUE , LATHAM JOHN , LAWSON ALASTAIR , LU HSIENG SEN , POPPLEWELL ANDY , SHEN WENYAN , WINKLER DAVID , WINTERS AARON GEORGE
Inventor： PASZTY CHRISTOPHER , ROBINSON MARTYN KIM , GRAHAM KEVIN , HENRY ALISTAIR JAMES , HOFFMANN KELLY SUE , LATHAM JOHN , LAWSON ALASTAIR , LU HSIENG SEN , POPPLEWELL ANDY , SHEN WENYAN , WINKLER DAVID , WINTERS AARON GEORGE
CPC classification number: C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/60 , A61K2039/505 , C07K14/76 , C07K14/79 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
Abstract: Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
Abstract translation: 提供了与硬骨素蛋白表位有关的组合物和方法，以及硬骨素结合剂，例如能结合硬化蛋白的抗体。
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公开(公告)号：WO2006015373A3
公开(公告)日：2006-07-27
申请号：PCT/US2005027689
申请日：2005-08-04
Applicant: AMGEN INC , LI JI , SHEN WENYAN , LU HSIENG SEN , RICHARDS WILLIAM GLEASON
Inventor： LI JI , SHEN WENYAN , LU HSIENG SEN , RICHARDS WILLIAM GLEASON
IPC: C07K16/18 , A61K39/395
CPC classification number: C07K16/18 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: The present invention provides antibodies and immunologically functional fragments thereof that specifically bind Dkk-1 polypeptides. The subject antibodies and fragments bind with high affinity to a conformational epitope located in the carboxy region of the Dkk-1 protein. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases including bone disorders, inflammatory diseases, neurological diseases, ocular diseases, renal diseases, pulmonary diseases and skin diseases are also disclosed.
Abstract translation: 本发明提供了特异性结合Dkk-1多肽的抗体及其免疫功能片段。 受试抗体和片段以高亲和力结合位于Dkk-1蛋白的羧基区域的构象表位。 还提供了制备此类抗体或其片段的方法以及含有抗体或片段的生理上可接受的组合物。 还公开了使用抗体和片段来治疗各种疾病，包括骨骼疾病，炎性疾病，神经疾病，眼部疾病，肾脏疾病，肺部疾病和皮肤疾病。
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公开(公告)号：HRP20211904T3
公开(公告)日：2022-03-04
申请号：HRP20211904
申请日：2006-04-28
Applicant: UCB PHARMA SA , AMGEN INC
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公开(公告)号：HRP20211904T1
公开(公告)日：2022-03-04
申请号：HRP20211904
申请日：2006-04-28
Applicant: UCB PHARMA SA , AMGEN INC
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