公开(公告)号：CA2261628A1

公开(公告)日：1998-02-05

申请号：CA2261628

申请日：1997-07-14

Applicant: BASF AG

Inventor： PFEIFFER THOMAS ,  ZIERKE THOMAS ,  BALKENHOHL FRIEDHELM ,  LANGE UDO ,  MACK HELMUT ,  SEITZ WERNER

IPC: C12P17/04 ,  C07D207/22 ,  C07D401/12 ,  C12P17/10 ,  C12P41/00 ,  C07D403/12

Abstract: A process is disclosed for preparing 3-pyrroline-2-carboxylic acid derivatives of formula (I), in which R1 stands for H, C1-C6-alkyl, benzyl, benzyl substituted at the phenyl radical, allyloxycarbonyl, C1-C6-alkyloxycarbonyl, benzyloxycarbonyl, in which the benzyl radical can be substituted by OCH3 radicals, or for C1-C4-alkylcarbonyl; or R1 stands for an amino acid radical which can be alkylated or acylated at the nitrogen and is linked by the Cterminal; and R2 stands for OH, C1-C4-alkyloxy, benzyloxy or an N3R4 group, in which R3 and R4 represent independently from each other H, C1-C4-alkyl, benzyl, phenyl or pyridyl, in which the aromatic compounds in R3 and R4 can be substituted by up to three identical or different substituents selected from the group composed of methyl, methoxy, hydroxy, cyano or halogen. According to this process, the sulphonic acid radical is eliminated by means of a base from a compound having the formula (II), in which R1 and R2 have the above meanings and R5 stands for C1-C6-alkyl, benzyl, trifluoromethyl, naphthyl or phenyl optionally substituted by radicals from the group composed of methyl, nitro and halogen.

公开(公告)号：CA2210519A1

公开(公告)日：1996-08-08

申请号：CA2210519

申请日：1996-01-20

Applicant: BASF AG

Inventor： DITRICH KLAUS ,  BALKENHOHL FRIEDHELM ,  NUEBLING CHRISTOPH

IPC: C12P13/00 ,  C12P41/00

公开(公告)号：NO932860D0

公开(公告)日：1993-08-11

申请号：NO932860

申请日：1993-08-11

Applicant: BASF AG

Inventor： KAISER KLAUS ,  BALKENHOHL FRIEDHELM ,  PAUST JOACHIM

IPC: C07F9/655 ,  C07F

Abstract: Process for obtaining the calcium salt of ascorbyl 2-monophosphate from aqueous/alkaline reaction mixtures as they are obtained when ascorbic acid is reacted with a molar excess of phosphorus oxychloride in the presence of a tertiary amine while maintaining a pH of 12 to 13 during the reaction by means of an aqueous alkali metal solution, which process is characterised in that a) starting from a reaction mixture which has been obtained by reacting ascorbic acid with phosphorus oxychloride in the presence of pyridine while maintaining a pH of 12 to 13 by means of an aqueous potassium hydroxide solution, b) the phosphoric acid ions formed during this reaction are precipitated by means of magnesium chloride in amounts of approximately 1 mol per mol of phosphoric acid ions as potassium magnesium phosphate, c) the potassium magnesium phosphate is separated off, d) the pyridine together with some of the water is removed from the remaining aqueous solution by distillation, e) the resulting aqueous solution is reacted with calcium chloride and f) the calcium salt of ascorbyl 2-monophosphate, which crystallises out during this process in the form of the calcium salt, is isolated, or in that, after process step a), the pyridine/water mixture is first removed as described in process step d) and process steps (b), (c), (e) and (f) are subsequently carried out.