公开(公告)号：AU6051198A

公开(公告)日：1998-08-25

申请号：AU6051198

申请日：1998-01-30

Applicant: BIO RAD LABORATORIES

Inventor： BARTLING DONALD J ,  BINDER STEVEN R ,  VLASENKO SERGEY

IPC: C12Q1/26 ,  C12Q1/527 ,  C12N15/00

公开(公告)号：EP1047931A4

公开(公告)日：2004-04-21

申请号：EP98936864

申请日：1998-07-21

Applicant: BIO RAD LABORATORIES

Inventor： BINDER STEVEN R ,  SCOLARI CAROLINE ,  LIKUSKI ROBERT K

IPC: G01N27/447 ,  G01N27/26 ,  G01N33/561 ,  G01N33/574 ,  G01N33/68 ,  G06F17/14

CPC classification number: G01N27/44721 ,  G01N27/44717

Abstract: Identification and quantification of paraproteins in a sample is achieved by Fourier analysis of mobility-based electropherograms obtained from capillary electrophoresis. The use of a computer algorithm to analyze capillary electrophoresis data, provides the clinician with methods of detecting levels of paraproteins in serum as low as 0.05 g/dL. Additionally, an individual paraprotein can be located on an electropherogram and used to monitor its increased or decreased production in an individual.

公开(公告)号：EP1499892A4

公开(公告)日：2006-06-28

申请号：EP03746571

申请日：2003-03-28

Applicant: BIO RAD LABORATORIES

Inventor： WATKINS MICHAEL I ,  BINDER STEVEN R ,  RASKIN ALEKSANDER

IPC: G01N33/543 ,  G01N33/53

CPC classification number: G01N33/54393 ,  Y10S435/962

Abstract: Water-soluble polymer is added to the liquid phase in a heterogeneous immunoassay of serum, the polymer having monomers in common with monomers of the solid phase surface. This reduces non-specific binding of IgG's from the serum to the solid phase surface and thereby reduces the occurrence of false positive readings in the immunoassay.

公开(公告)号：EP1397388A4

公开(公告)日：2005-04-13

申请号：EP02726954

申请日：2002-05-28

Applicant: BIO RAD LABORATORIES

Inventor： BINDER STEVEN R ,  GOODRICH JODI L ,  SAFARIAN ZARA

IPC: G01N33/53 ,  G01N33/96 ,  C07K16/36 ,  C07K16/00

CPC classification number: G01N33/96 ,  G01N2333/9108 ,  Y10S435/973

Abstract: Analyses of serum samples for the presence and amount of either of the two subunits of human Factor XIII protein are used as a means of eliminating a significant source of error that arises in the testing of serum and plasma. For serum samples, a negative result of an analysis for the presence of subunit a is a means of verifying that a sample is indeed serum, while a negative or positive result for subunit a serves to distinguish serum (negative) from plasma (positive). A positive result for the presence of subunit b is a means of verifying that the sample is either serum or plasma and not any other biological fluid. A quantitative analysis of subunit b is a means of verifying that the sample is of the intended volume rather than having been reduced in volume due to improper sampling. A quantitative analysis of subunit b is also a means of verifying the dilution of a sample of either serum or plasma.