公开(公告)号：IE920020A1

公开(公告)日：1992-07-15

申请号：IE920020

申请日：1992-01-03

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT ,  ENGLERT HEINRICH ,  KLEEMANN HEINZ-WERNER ,  GERHARDS HERMANN ,  LKENS BERNWARD SCH ,  BECKER REINHARD ,  LINZ WOLFGANG ,  CAILLE M JEAN-CLAUDE ,  VEVERT M JEAN-PAUL

IPC: A61K31/40 ,  A61K31/415 ,  A61K31/425 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61K31/505 ,  A61K31/535 ,  A61K31/54 ,  A61K31/64 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P43/00 ,  C07D207/34 ,  C07D207/36 ,  C07D233/54 ,  C07D233/66 ,  C07D233/68 ,  C07D233/70 ,  C07D233/84 ,  C07D233/90 ,  C07D249/02 ,  C07D255/02 ,  C07D257/02 ,  C07D257/04 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D453/02 ,  C07D521/00 ,  C07D233/00 ,  C07D403/00 ,  C07D417/00 ,  C07D405/00 ,  C07D453/00 ,  C07D409/00

Abstract: Azole derivative of the general formula (I) in which A, L, O, R , X, Y, Z and q have the meanings given, a process for their preparation, pharmaceutical preparations and the use of the compounds are described. Azole derivatives of the formula I where the symbols have, for example, the following meanings: R = (C2-C10)-alkyl Z = nitrogen X and Y = independently of one another CR L = -CH2- q = zero or 1 A = biphenyl radical which is substituted, for example, by R R = halogen or hydrogen R = SO2-NH-CO-OR and R = phenyl, are highly active antagonists of angiotensin II receptors.

公开(公告)号：NO920048A

公开(公告)日：1992-07-06

申请号：NO920048

申请日：1992-01-03

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT ,  ENGLERT HEINRICH ,  KLEEMANN HEINZ-WERNER ,  GERHARDS HERMANN ,  SCHOELKENS BERNWARD ,  BECKER REINHARD ,  LINZ WOLFGANG

IPC: A61K31/40 ,  A61K31/415 ,  A61K31/425 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61K31/505 ,  A61K31/535 ,  A61K31/54 ,  A61K31/64 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P43/00 ,  C07D207/34 ,  C07D207/36 ,  C07D233/54 ,  C07D233/66 ,  C07D233/68 ,  C07D233/70 ,  C07D233/84 ,  C07D233/90 ,  C07D249/02 ,  C07D255/02 ,  C07D257/02 ,  C07D257/04 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D453/02 ,  C07D521/00 ,  C07D233/64

CPC classification number: C07D231/12 ,  C07D233/56 ,  C07D233/68 ,  C07D233/70 ,  C07D233/90 ,  C07D249/08 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D453/02

公开(公告)号：CA2058198A1

公开(公告)日：1992-07-05

申请号：CA2058198

申请日：1991-12-20

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT ,  ENGLERT HEINRICH ,  KLEEMANN HEINZ-WERNER ,  GERHARDS HERMANN ,  SCHOELKENS BERNWARD ,  BECKER REINHARD ,  LINZ WOLFGANG

IPC: A61K31/40 ,  A61K31/415 ,  A61K31/425 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61K31/505 ,  A61K31/535 ,  A61K31/54 ,  A61K31/64 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P43/00 ,  C07D207/34 ,  C07D207/36 ,  C07D233/54 ,  C07D233/66 ,  C07D233/68 ,  C07D233/70 ,  C07D233/84 ,  C07D233/90 ,  C07D249/02 ,  C07D255/02 ,  C07D257/02 ,  C07D257/04 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D453/02 ,  C07D521/00 ,  C07D413/12 ,  A61K31/41 ,  A61K31/495 ,  C07F9/6506

Abstract: HOE 91/F 001 K Azole derivatives, process for their preparation, and their use Azole derivatives of the formula (I) (I) in which A, L, O, R1, X, Y, Z and q have the meanings given, process for their preparation, pharmaceutical preparations and the use of the compounds are described. Azole derivatives of the formula I where the symbols have for example the following meanings: R1 is (C2-C10)-alkyl, Z is nitrogen, X and Y are independently of one another CR2, L is -CH2-, q is zero or 1, A is a biphenyl radical which is substituted for example by R15 R2 is halogen or hydrogen R15 is SO2-NH-CO-OR6 and R6 is phenyl, are highly active antagonists of angiotensin II receptors.

公开(公告)号：AU8785891A

公开(公告)日：1992-05-21

申请号：AU8785891

申请日：1991-11-15

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER ,  HENNING RAINER ,  LINZ WOLFGANG ,  SCHOLKENS BERNWARD ,  URBACH HANSJORG

IPC: A61K31/41 ,  A61K31/415 ,  A61K31/495 ,  A61K31/675 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P43/00 ,  C07D233/64 ,  C07D233/68 ,  C07D233/90 ,  C07D249/04 ,  C07D249/08 ,  C07D257/04 ,  C07D403/10

Abstract: The invention relates to a method for the treatment of cardiac and of vascular hypertrophy and/or hyperplasia by administration of angiotensin II receptor blockers, preferably of the imidazole, pyrrole, pyrazole, triazole or tetrazole type.

公开(公告)号：IE913992A1

公开(公告)日：1992-05-20

申请号：IE399291

申请日：1991-11-15

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER ,  HENNING RAINER ,  LINZ WOLFGANG ,  SCHOLKENS BERNWARD ,  URBACH HANSJOERG

IPC: A61K31/41 ,  A61K31/415 ,  A61K31/495 ,  A61K31/675 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P43/00 ,  C07D233/64 ,  C07D233/68 ,  C07D233/90 ,  C07D249/04 ,  C07D249/08 ,  C07D257/04 ,  C07D403/10

Abstract: The invention relates to a method for the treatment of cardiac and of vascular hypertrophy and/or hyperplasia by administration of angiotensin II receptor blockers, preferably of the imidazole, pyrrole, pyrazole, triazole or tetrazole type.

公开(公告)号：CA2055637A1

公开(公告)日：1992-05-18

申请号：CA2055637

申请日：1991-11-15

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER ,  HENNING RAINER ,  LINZ WOLFGANG ,  SCHOELKENS BERNWARD ,  URBACK HANSJOERG

IPC: A61K31/41 ,  A61K31/415 ,  A61K31/495 ,  A61K31/675 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P43/00 ,  C07D233/64 ,  C07D233/68 ,  C07D233/90 ,  C07D249/04 ,  C07D249/08 ,  C07D257/04 ,  C07D403/10

Abstract: HOE 90/F 349 of the disclosure Method for the treatment of cardiac and of vascular hypertrophy and hyperplasia The invention relates to a method for the treatment of cardiac and of vascular hypertrophy and/or hyperplasia by administration of angiotensin II receptor blockers, preferably of the imidazole, pyrrole, pyrazole, triazole or tetraxaole type.

公开(公告)号：DD297646A5

公开(公告)日：1992-01-16

申请号：DD34382990

申请日：1990-09-05

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH CH ,  LANG HANS-JOCHEN ,  LINZ WOLFGANG ,  SCHOELKENS BERNWARD ,  SCHOLZ WOLFGANG

IPC: C12N15/09 ,  C12N1/21 ,  C12N9/54 ,  C12N15/57 ,  C12R1/07 ,  C12R1/125 ,  C12R1/19 ,  C07D295/155 ,  A61K31/155 ,  A61K31/18 ,  C07C311/15 ,  C07C311/29 ,  C07C317/32 ,  C07C321/28 ,  C07C323/20 ,  C07C323/65

公开(公告)号：FI920017A0

公开(公告)日：1992-01-02

申请号：FI920017

申请日：1992-01-02

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT ,  ENGLERT HEINRICH ,  KLEEMANN HEINZ-WERNER ,  GERHARDS HERMANN ,  SCHOELKENS BERNWARD ,  BECKER REINHARD ,  LINZ WOLFGANG

IPC: A61K31/40 ,  A61K31/415 ,  A61K31/425 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61K31/505 ,  A61K31/535 ,  A61K31/54 ,  A61K31/64 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P43/00 ,  C07D207/34 ,  C07D207/36 ,  C07D233/54 ,  C07D233/66 ,  C07D233/68 ,  C07D233/70 ,  C07D233/84 ,  C07D233/90 ,  C07D249/02 ,  C07D255/02 ,  C07D257/02 ,  C07D257/04 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D453/02 ,  C07D521/00 ,  C07D

Abstract: Azole derivative of the general formula (I) in which A, L, O, R , X, Y, Z and q have the meanings given, a process for their preparation, pharmaceutical preparations and the use of the compounds are described. Azole derivatives of the formula I where the symbols have, for example, the following meanings: R = (C2-C10)-alkyl Z = nitrogen X and Y = independently of one another CR L = -CH2- q = zero or 1 A = biphenyl radical which is substituted, for example, by R R = halogen or hydrogen R = SO2-NH-CO-OR and R = phenyl, are highly active antagonists of angiotensin II receptors.

公开(公告)号：ZA9102363B

公开(公告)日：1991-12-24

申请号：ZA9102363

申请日：1991-03-29

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH CHRISTIAN ,  HEINRICH CHRISTIAN ENGLERT ,  MANIA DIETER ,  DIETER MANIA ,  LINZ WOLFGANG ,  WOLFGANG LINZ

IPC: A61K31/535 ,  A61P9/00 ,  A61P9/06 ,  A61P9/12 ,  A61P11/08 ,  A61P17/00 ,  C07D265/20 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D ,  A61K

CPC classification number: C07D413/04 ,  C07D265/20

公开(公告)号：HU911053D0

公开(公告)日：1991-10-28

申请号：HU105391

申请日：1991-03-29

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH CHRISTIAN ,  MANIA DIETER ,  LINZ WOLFGANG

IPC: A61K31/535 ,  A61P9/00 ,  A61P9/06 ,  A61P9/12 ,  A61P11/08 ,  A61P17/00 ,  C07D265/20 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14

Abstract: Benzoxazine derivatives of the formula I where R(1) and R(2) equal H, OH, alkoxy, Hal or a multiplicity of other substituents, R(3) equals alkyl or alkanoyl; R(4) equals H, alkyl or alkanoyl, and R(5) equals pyrid(azin)yloxy, pyrimidinyloxy, pyridazinyloxy and other heterocycles and their salts are useful medicaments for the treatment of disorders of the cardiovascular system, asthma, smooth muscle disorders, high blood pressure, cardiac arrhythmias and circulatory disorders of the brain; they are also used for topical application to control hair loss.